HRP20231282T1 - Stabilna formulacija antitijela - Google Patents
Stabilna formulacija antitijela Download PDFInfo
- Publication number
- HRP20231282T1 HRP20231282T1 HRP20231282TT HRP20231282T HRP20231282T1 HR P20231282 T1 HRP20231282 T1 HR P20231282T1 HR P20231282T T HRP20231282T T HR P20231282TT HR P20231282 T HRP20231282 T HR P20231282T HR P20231282 T1 HRP20231282 T1 HR P20231282T1
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- Croatia
- Prior art keywords
- antibody
- pharmaceutical formulation
- formulation according
- concentration
- histidine
- Prior art date
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- 238000009472 formulation Methods 0.000 title claims 3
- 239000000203 mixture Substances 0.000 title claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 14
- 229960002885 histidine Drugs 0.000 claims 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 7
- 229930006000 Sucrose Natural products 0.000 claims 7
- 239000005720 sucrose Substances 0.000 claims 7
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 6
- 229920000136 polysorbate Polymers 0.000 claims 6
- 229950008882 polysorbate Drugs 0.000 claims 6
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 5
- 150000001413 amino acids Chemical group 0.000 claims 5
- CMXXUDSWGMGYLZ-XRIGFGBMSA-N (2s)-2-amino-3-(1h-imidazol-5-yl)propanoic acid;hydron;chloride;hydrate Chemical compound O.Cl.OC(=O)[C@@H](N)CC1=CN=CN1 CMXXUDSWGMGYLZ-XRIGFGBMSA-N 0.000 claims 4
- 239000011521 glass Substances 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 229940090047 auto-injector Drugs 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 229940071643 prefilled syringe Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 229910052721 tungsten Inorganic materials 0.000 claims 1
- 239000010937 tungsten Substances 0.000 claims 1
- 239000004034 viscosity adjusting agent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Claims (17)
1. Stabilna tekuća farmaceutska formulacija koja sadrži:
(a) antitijelo koje se specifično veže za humani programirane smrti tipa 1 (PD-1), pri čemu antitijelo sadrži tri regije koje određuju komplementarnost teškog lanca (CDR) (HCDR1, HCDR2 i HCDR3) sadržane u varijabilnoj regiji teškog lanca (HCVR) i tri CDR lakog lanca (LCDR1, LCDR2 i LCDR3) sadržane u varijabilnoj regiji lakog lanca (LCVR), pri čemu HCDR1 sadrži SEQ ID NO: 3, HCDR2 sadrži SEQ ID NO: 4, HCDR3 sadrži SEQ ID NO: 5, LCDR1 sadrži SEQ ID NO: 6, LCDR2 sadrži SEQ ID NO: 7 i LCDR3 sadrži SEQ ID NO: 8;
(b) pufer koji sadrži histidin;
(c) organsko otapalo koje sadrži polisorbat;
(d) saharozu kao stabilizator; i
(e) prolin kao modifikator viskoznosti;
pri čemu je pH stabilne tekuće farmaceutske formulacije 6,0 ± 0,3.
2. Farmaceutska formulacija prema patentnom zahtjevu 1, gdje je koncentracija antitijela:
(a) od 5 mg/mL ± 0,75 mg/mL do 250 mg/mL ± 37,5 mg/mL;
(b) 25 mg/mL ± 3,75 mg/mL;
(c) 50 mg/mL ± 7,5 mg/mL;
(d) 150 mg/mL ± 22,5 mg/mL; ili
(e) 175 mg/mL ± 26,25 mg/mL.
3. Farmaceutska formulacija prema patentnom zahtjevu 1 ili 2, gdje je koncentracija histidinskog pufera od 5 mM ± 1 mM do 20 mM ± 4 mM, opcionalno gdje:
(a) koncentracija histidinskog pufera je 10 mM ± 2 mM; i/ili
(b) histidinski pufer se priprema od L-histidina i L-histidin monohidrokloridnog monohidrata, dalje opcionalno pri čemu se histidinski pufer priprema od 4,8 mM ± 0,96 mM L-histidina i 5,2 mM ± 1,04 mM L-histidin monohidrokloridnog monohidrata.
4. Farmaceutska formulacija prema bilo kojem od patentnih zahtjeva 1-3, gdje je koncentracija polisorbata od 0,01% ± 0,005% do 0,5% ± 0,25% w/v, opcionalno gdje:
(a) koncentracija polisorbata je 0,1% ± 0,05% w/v ili 0,2% ± 0,1% w/v; i/ili
(b) polisorbat je polisorbat 80.
5. Farmaceutska formulacija prema bilo kojem od patentnih zahtjeva 1-4, gdje je koncentracija saharoze od 1% ± 0,2% do 20% ± 4% w/v, opcionalno gdje je koncentracija saharoze od 1% ± 0,2% do 10% ± 2 % w/v, kao što je 5% ± 1% w/v.
6. Farmaceutska formulacija prema patentnom zahtjevu 5, gdje je koncentracija saharoze 5% ± 1% w/v, a koncentracija prolina je od 1% ± 0,2% do 5% ± 1% w/v, kao što je 1,5% ± 0,3% w/v.
7. Farmaceutska formulacija prema patentnom zahtjevu 1, koja sadrži:
(a) 5 mg/mL ± 0,75 mg/mL do 250 mg/mL ± 37,5 mg/mL antitijela,
(b) 10 mM ± 2 mM histidinskog pufera,
(c) 0,2% ± 0,1% w/v polisorbata,
(d) 5% ± 1% w/v saharoze, i
(e) 1,5% ± 0,3% w/v prolina;
pri pH 6,0 ± 0,3;
opcionalno, gdje je koncentracija antitijela: (i) 175 mg/mL ± 26,25 mg/mL antitijela; (ii) 150 mg/mL ± 22,5 mg/mL antitijela; (iii) 50 mg/mL ± 7,5 mg/mL antitijela; ili (iv) 25 mg/mL ± 3,75 mg/mL antitijela.
8. Farmaceutska formulacija prema patentnom zahtjevu 1, koja sadrži:
(a) 5 mg/mL ± 0,75 mg/mL do 250 mg/mL ± 37,5 mg/mL antitijela,
(b) 0,74 mg/mL L-histidina,
(c) 1,1 mg/mL L-histidin monohidrokloridnog monohidrata,
(d) 2 mg/mL polisorbata,
(e) 50 mg/mL saharoze, i
(f) 15 mg/mL prolina;
pri pH 6,0 ± 0,3;
opcionalno, gdje je koncentracija antitijela: (i) 175 mg/mL ± 26,25 mg/mL antitijela; (ii) 150 mg/mL ± 22,5 mg/mL antitijela; (iii) 50 mg/mL ± 7,5 mg/mL antitijela; ili (iv) 25 mg/mL ± 3,75 mg/mL antitijela.
9. Farmaceutska formulacija prema bilo kojem od patentnih zahtjeva 1-8, gdje:
(a) najmanje 90% antitijela ima nativnu konformaciju nakon 28 dana na 45°C; i/ili
(b) najmanje 35% antitijela je glavna varijanta naboja antitijela nakon 28 dana na 45°C; i/ili
(c) najmanje 94% antitijela ima nativnu konformaciju nakon tri mjeseca na 25°C; i/ili
(d) najmanje 44% antitijela je glavna varijanta naboja antitijela nakon tri mjeseca na 25°C; i/ili
(e) najmanje 96% antitijela ima nativnu konformaciju nakon 12 mjeseci na 5°C; i/ili
(f) najmanje 45% antitijela glavna varijanta naboja antitijela nakon 12 mjeseci na 5°C; i/ili
(g) najmanje 96% antitijela ima nativnu konformaciju nakon 12 mjeseci na -20°C, -30°C i/ili -80°C; i/ili
(h) najmanje 40% antitijela je glavna varijanta naboja antitijela nakon 12 mjeseci na -20°C, -30°C i/ili -80°C.
10. Farmaceutska formulacija prema bilo kojem od patentnih zahtjeva 1-9, pri čemu antitijelo sadrži HCVR iz SEQ ID NO: 1 i LCVR iz SEQ ID NO: 2.
11. Farmaceutska formulacija prema patentnom zahtjevu 10, gdje je koncentracija antitijela: (i) 175 mg/mL ± 26,25 mg/mL antitijela; (ii) 150 mg/mL ± 22,5 mg/mL antitijela; (iii) 50 mg/mL ± 7,5 mg/mL antitijela; ili (iv) 25 mg/mL ± 3,75 mg/mL antitijela.
12. Farmaceutska formulacija prema patentnom zahtjevu 11, gdje:
(a) ≥ 90% antitijela ima molekulsku težinu od 143 kDa ± 1 kDa; i/ili
(b) farmaceutska formulacija ima viskoznost manju od 20 mPa-s na 25°C, opcionalno manju od 15 mPa-s na 25°C.
13. Farmaceutska formulacija prema bilo kojem od patentnih zahtjeva 1 - 12, pri čemu antitijelo sadrži teški i laki lanac, gdje:
(a) teški lanac sadrži aminokiselinsku sekvencu SEQ ID NO: 9;
(b) teški lanac sadrži aminokiselinsku sekvencu SEQ ID NO: 11;
(c) laki lanac sadrži aminokiselinsku sekvencu SEQ ID NO: 10;
(d) antitijelo sadrži teški /laki lanac koji sadrži aminokiselinske sekvence SEQ ID NO: 9/10; ili
(e) antitijelo sadrži teški lanac/laki lanac koji sadrži aminokiselinske sekvence SEQ ID NO: 11/10.
14. Farmaceutska formulacija prema bilo kojem od patentnih zahtjeva 1-13, pri čemu je formulacija pogodna za podkožno ili intravenozno davanje.
15. Farmaceutska formulacija prema bilo kojem od patentnih zahtjeva 1-14, pri čemu se navedena formulacija nalazi u kontejneru, opcionalno pri čemu:
(a) kontejner je bočica;
(b) kontejner je bočica, a bočica je prozirna bočica od stakla Tipa 1 od 10 mL;
(c) kontejner je šprica;
(d) kontejner je šprica, a šprica je od stakla s niskim sadržajem volframa;
(e) kontejner je prethodno napunjena šprica; ili
(f) kontejner je autoinjektor.
16. Komplet koji sadrži farmaceutsku formulaciju prema bilo kojem od patentnih zahtjeva 1-14, kontejner i uputstva, opcionalno gdje:
(a) kontejner je staklena bočica;
(b) kontejner je prethodno napunjena šprica; ili
(c) kontejner je autoinjektor.
17. Farmaceutska formulacija prema patentnom zahtjevu 1, koja sadrži:
(a) 50 mg/mL ± 7,5 mg/mL antitijela,
(b) 0,74 mg/mL L-histidina,
(c) 1,1 mg/mL L-histidin monohidrokloridnog monohidrata,
(d) 2 mg/mL polisorbata 80,
(e) 50 mg/mL saharoze, i
(f) 15 mg/mL prolina;
u vodi, pri pH 6,0 ± 0,3.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762482270P | 2017-04-06 | 2017-04-06 | |
| PCT/US2018/024032 WO2018187057A1 (en) | 2017-04-06 | 2018-03-23 | Stable antibody formulation |
| EP18719338.8A EP3606504B1 (en) | 2017-04-06 | 2018-03-23 | Stable antibody formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20231282T1 true HRP20231282T1 (hr) | 2024-02-02 |
Family
ID=62028099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20231282TT HRP20231282T1 (hr) | 2017-04-06 | 2018-03-23 | Stabilna formulacija antitijela |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US11603407B2 (hr) |
| EP (2) | EP4249512A3 (hr) |
| JP (1) | JP7229171B2 (hr) |
| KR (1) | KR102667484B1 (hr) |
| CN (1) | CN110709062B (hr) |
| AR (1) | AR111455A1 (hr) |
| AU (1) | AU2018247501A1 (hr) |
| BR (1) | BR112019020246A2 (hr) |
| CA (1) | CA3059087A1 (hr) |
| CL (1) | CL2019002828A1 (hr) |
| CO (1) | CO2019011021A2 (hr) |
| DK (1) | DK3606504T5 (hr) |
| EA (1) | EA201992377A1 (hr) |
| ES (1) | ES2955062T3 (hr) |
| FI (1) | FI3606504T3 (hr) |
| HR (1) | HRP20231282T1 (hr) |
| HU (1) | HUE063509T2 (hr) |
| IL (1) | IL269499B1 (hr) |
| LT (1) | LT3606504T (hr) |
| MA (1) | MA49043B1 (hr) |
| MX (1) | MX2019011207A (hr) |
| PH (1) | PH12019502123A1 (hr) |
| PL (1) | PL3606504T3 (hr) |
| PT (1) | PT3606504T (hr) |
| RS (1) | RS64680B1 (hr) |
| SG (2) | SG11201908540PA (hr) |
| SI (1) | SI3606504T1 (hr) |
| TW (1) | TWI795396B (hr) |
| WO (1) | WO2018187057A1 (hr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| FI3394103T3 (fi) | 2015-12-22 | 2023-08-30 | Regeneron Pharma | Anti-PD-1-vasta-aineiden ja bispesifisten anti-CD20-/anti-CD3-vasta-aineiden yhdistelmä syövän hoitoon |
| KR102628557B1 (ko) | 2017-02-21 | 2024-01-29 | 리제너론 파아마슈티컬스, 인크. | 폐암의 치료를 위한 항-pd-1 항체 |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| CN110913906A (zh) | 2017-05-02 | 2020-03-24 | 默沙东公司 | 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂 |
| WO2020097141A1 (en) | 2018-11-07 | 2020-05-14 | Merck Sharp & Dohme Corp. | Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| EP3880186B1 (en) | 2018-11-14 | 2024-04-03 | Regeneron Pharmaceuticals, Inc. | Intralesional administration of pd-1 inhibitors for treating skin cancer |
| US11634485B2 (en) | 2019-02-18 | 2023-04-25 | Eli Lilly And Company | Therapeutic antibody formulation |
| JP2022521800A (ja) | 2019-02-28 | 2022-04-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 皮膚がんを治療するためのｐｄ－１阻害剤の投与 |
| CA3129963A1 (en) | 2019-03-06 | 2020-09-10 | Regeneron Pharmaceuticals, Inc. | Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer |
| US20200369760A1 (en) * | 2019-05-24 | 2020-11-26 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-angptl3 antibodies |
| KR20220113355A (ko) * | 2019-10-02 | 2022-08-12 | 알라맵 테라퓨틱스, 인크. | 항-코넥신 항체 제제 |
| BR112022008164A2 (pt) * | 2019-11-04 | 2022-07-12 | Inovio Pharmaceuticals Inc | Terapia de combinação para tratar câncer cerebral |
| WO2021096278A1 (ko) * | 2019-11-15 | 2021-05-20 | 삼성바이오에피스 주식회사 | 항체 의약품용 액상 조성물 |
| WO2021123202A1 (en) | 2019-12-20 | 2021-06-24 | Formycon Ag | Formulations of anti-pd1 antibodies |
| KR20210097882A (ko) * | 2020-01-30 | 2021-08-10 | 삼성바이오에피스 주식회사 | 안정한 항-pd-1 항체 약제학적 제제 |
| WO2021187897A1 (ko) * | 2020-03-18 | 2021-09-23 | (주)지아이이노베이션 | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 제제 |
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