MA49043B1 - Formulation stable d'anticorps - Google Patents

Formulation stable d'anticorps

Info

Publication number
MA49043B1
MA49043B1 MA49043A MA49043A MA49043B1 MA 49043 B1 MA49043 B1 MA 49043B1 MA 49043 A MA49043 A MA 49043A MA 49043 A MA49043 A MA 49043A MA 49043 B1 MA49043 B1 MA 49043B1
Authority
MA
Morocco
Prior art keywords
antibodies
muc16
bind
antibody formulation
stable antibody
Prior art date
Application number
MA49043A
Other languages
English (en)
Other versions
MA49043A (fr
Inventor
Qingyan Hu
Dingjiang Liu
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MA49043A publication Critical patent/MA49043A/fr
Publication of MA49043B1 publication Critical patent/MA49043B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des anticorps bispécifiques (bsabs) : anticorps anti-muc16 qui se lient à la fois à muc16 et à cd3 et activent les cellules t par l'intermédiaire du complexe cd3 en présence de tumeurs exprimant muc16. L'invention concerne également des anticorps igg humains qui se lient à des anticorps anti-muc16 humains (anticorps monospécifiques), des conjugués anticorps-médicament anti-muc16 qui inhibent la croissance tumorale in vivo, les anticorps sont utiles pour le traitement de divers cancers, y compris le cancer de l'ovaire.
MA49043A 2017-04-06 2018-03-23 Formulation stable d'anticorps MA49043B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762482270P 2017-04-06 2017-04-06
PCT/US2018/024032 WO2018187057A1 (fr) 2017-04-06 2018-03-23 Formulation stable d'anticorps

Publications (2)

Publication Number Publication Date
MA49043A MA49043A (fr) 2020-02-12
MA49043B1 true MA49043B1 (fr) 2023-11-30

Family

ID=62028099

Family Applications (1)

Application Number Title Priority Date Filing Date
MA49043A MA49043B1 (fr) 2017-04-06 2018-03-23 Formulation stable d'anticorps

Country Status (29)

Country Link
US (2) US11603407B2 (fr)
EP (2) EP3606504B1 (fr)
JP (1) JP7229171B2 (fr)
KR (1) KR102667484B1 (fr)
CN (1) CN110709062B (fr)
AR (1) AR111455A1 (fr)
AU (1) AU2018247501A1 (fr)
BR (1) BR112019020246A2 (fr)
CA (1) CA3059087A1 (fr)
CL (1) CL2019002828A1 (fr)
CO (1) CO2019011021A2 (fr)
DK (1) DK3606504T3 (fr)
EA (1) EA201992377A1 (fr)
ES (1) ES2955062T3 (fr)
FI (1) FI3606504T3 (fr)
HR (1) HRP20231282T1 (fr)
HU (1) HUE063509T2 (fr)
IL (1) IL269499A (fr)
LT (1) LT3606504T (fr)
MA (1) MA49043B1 (fr)
MX (1) MX2019011207A (fr)
PH (1) PH12019502123A1 (fr)
PL (1) PL3606504T3 (fr)
PT (1) PT3606504T (fr)
RS (1) RS64680B1 (fr)
SG (2) SG10202111008QA (fr)
SI (1) SI3606504T1 (fr)
TW (1) TWI795396B (fr)
WO (1) WO2018187057A1 (fr)

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