HRP20180157T1 - Spojevi pirazolopirimidina kao jak-inhibitori i odgovarajući postupci - Google Patents

Spojevi pirazolopirimidina kao jak-inhibitori i odgovarajući postupci Download PDF

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Publication number
HRP20180157T1
HRP20180157T1 HRP20180157TT HRP20180157T HRP20180157T1 HR P20180157 T1 HRP20180157 T1 HR P20180157T1 HR P20180157T T HRP20180157T T HR P20180157TT HR P20180157 T HRP20180157 T HR P20180157T HR P20180157 T1 HRP20180157 T1 HR P20180157T1
Authority
HR
Croatia
Prior art keywords
disease
colitis
pyrazolo
carboxamide
methoxyphenyl
Prior art date
Application number
HRP20180157TT
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English (en)
Croatian (hr)
Inventor
Paul Gibbons
Emily Hanan
Wendy Liu
Joseph P. Lyssikatos
Steven R. Magnuson
Rohan Mendonca
Richard Pastor
Thomas E. Rawson
Michael Siu
Mark E. Zak
Aihe Zhou
Bing-Yan Zhu
Christopher Hurley
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of HRP20180157T1 publication Critical patent/HRP20180157T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HRP20180157TT 2009-07-02 2010-07-02 Spojevi pirazolopirimidina kao jak-inhibitori i odgovarajući postupci HRP20180157T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22291809P 2009-07-02 2009-07-02
EP10794815.0A EP2448941B1 (en) 2009-07-02 2010-07-02 Pyrazolopyrimidine jak inhibitor compounds and methods
PCT/US2010/040906 WO2011003065A2 (en) 2009-07-02 2010-07-02 Pyrazolopyrimidine jak inhibitor compounds and methods

Publications (1)

Publication Number Publication Date
HRP20180157T1 true HRP20180157T1 (hr) 2018-03-09

Family

ID=43411778

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20180157TT HRP20180157T1 (hr) 2009-07-02 2010-07-02 Spojevi pirazolopirimidina kao jak-inhibitori i odgovarajući postupci

Country Status (35)

Country Link
US (6) US8999998B2 (OSRAM)
EP (3) EP2448941B1 (OSRAM)
JP (4) JP5769261B2 (OSRAM)
KR (3) KR101825754B1 (OSRAM)
CN (2) CN104910161B (OSRAM)
AU (1) AU2010266188B2 (OSRAM)
BR (1) BRPI1010197A2 (OSRAM)
CA (1) CA2767097A1 (OSRAM)
CL (1) CL2012000001A1 (OSRAM)
CO (1) CO6491081A2 (OSRAM)
CR (2) CR20170115A (OSRAM)
DK (1) DK2448941T3 (OSRAM)
EC (1) ECSP12011645A (OSRAM)
ES (1) ES2657839T3 (OSRAM)
HR (1) HRP20180157T1 (OSRAM)
HU (1) HUE035537T2 (OSRAM)
IL (3) IL217224B (OSRAM)
IN (1) IN2012DN00755A (OSRAM)
LT (1) LT2448941T (OSRAM)
MA (1) MA33502B1 (OSRAM)
MX (1) MX2012000169A (OSRAM)
MY (1) MY160156A (OSRAM)
NO (1) NO2448941T3 (OSRAM)
NZ (4) NZ719972A (OSRAM)
PE (2) PE20151249A1 (OSRAM)
PH (1) PH12015500666A1 (OSRAM)
PL (1) PL2448941T3 (OSRAM)
PT (1) PT2448941T (OSRAM)
RS (1) RS56671B1 (OSRAM)
RU (2) RU2567238C2 (OSRAM)
SG (2) SG10201509607XA (OSRAM)
SI (1) SI2448941T1 (OSRAM)
UA (1) UA110324C2 (OSRAM)
WO (1) WO2011003065A2 (OSRAM)
ZA (2) ZA201200490B (OSRAM)

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