HRP20180123T1 - Soj bacteroides thetaiotaomicron i njegova upotreba za smanjenje upale - Google Patents
Soj bacteroides thetaiotaomicron i njegova upotreba za smanjenje upale Download PDFInfo
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- HRP20180123T1 HRP20180123T1 HRP20180123TT HRP20180123T HRP20180123T1 HR P20180123 T1 HRP20180123 T1 HR P20180123T1 HR P20180123T T HRP20180123T T HR P20180123TT HR P20180123 T HRP20180123 T HR P20180123T HR P20180123 T1 HRP20180123 T1 HR P20180123T1
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- 241000606123 Bacteroides thetaiotaomicron Species 0.000 title claims 24
- 206010061218 Inflammation Diseases 0.000 title claims 3
- 230000004054 inflammatory process Effects 0.000 title claims 3
- 235000015872 dietary supplement Nutrition 0.000 claims 26
- 235000013305 food Nutrition 0.000 claims 18
- 239000002778 food additive Substances 0.000 claims 13
- 235000013373 food additive Nutrition 0.000 claims 13
- 239000000825 pharmaceutical preparation Substances 0.000 claims 12
- 238000002360 preparation method Methods 0.000 claims 11
- 241001465754 Metazoa Species 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 235000019728 animal nutrition Nutrition 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 210000002919 epithelial cell Anatomy 0.000 claims 5
- 239000012752 auxiliary agent Substances 0.000 claims 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 210000000981 epithelium Anatomy 0.000 claims 2
- 210000004400 mucous membrane Anatomy 0.000 claims 2
- 235000016709 nutrition Nutrition 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- 230000000770 proinflammatory effect Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 208000012657 Atopic disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000019399 Colonic disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010017964 Gastrointestinal infection Diseases 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 206010051606 Necrotising colitis Diseases 0.000 claims 1
- 208000002389 Pouchitis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
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- 206010009887 colitis Diseases 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000000378 dietary effect Effects 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- 210000002175 goblet cell Anatomy 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000004995 necrotizing enterocolitis Diseases 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
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Claims (19)
1. Bacteroides thetaiotaomicron naznačen time da je deponiran pod pristupnim brojem 42341 u NCIMB.
2. Pripravak naznačen time da sadrži Bacteroides thetaiotaomicron koji je definiran u zahtjevu 1.
3. Farmaceutski pripravak naznačen time da sadrži Bacteroides thetaiotaomicron koji je definiran u zahtjevu 1, te farmaceutski prihvatljivo pomoćno sredstvo, nosač ili otapalo.
4. Dodatak za prehranu naznačen time da sadrži Bacteroides thetaiotaomicron kao što je definiran u zahtjevu 1, te pomoćno sredstvo koje je prihvatljivo za prehranu, nosač ili otapalo.
5. Pripravak naznačen time da sadrži Bacteroides thetaiotaomicron kao što je definiran u zahtjevu 2, farmaceutski pripravak koji sadrži Bacteroides thetaiotaomicron kao što je definiran u zahtjevu 3, ili dodatak za prehranu koji sadrži Bacteroides thetaiotaomicron kao što je definiran u zahtjevu 4, naznačen time da je navedeni Bacteroides thetaiotaomicron inkapsuliran.
6. Prehrana za životinje, prehrambeni proizvod, dijetetski dodatak, ili aditiv za hranu naznačen time da sadrži Bacteroides thetaiotaomicron kao što je definiran u zahtjevu 1.
7. Prehrana za životinje, prehrambeni proizvod, dijetetski dodatak, ili aditiv za hranu prema zahtjevu 6 naznačen time da je navedena prehrana za životinje, prehrambeni proizvod, dijetetski dodatak, ili dodatak za hranu inkapsuliran.
8. Bacteroides thetaiotaomicron kao što je definiran u zahtjevu 1, pripravak kao što je definiran u zahtjevu 2 ili 5, farmaceutski pripravak kao što je definiran u zahtjevu 3 ili 5, prehrambeni dodatak kao što je definiran u zahtjevu 4 ili 5 ili prehrana za životinje, prehrambeni proizvod, dijetetski dodatak, ili aditiv za hranu kao što je definiran u zahtjevu 6 ili 7, naznačen time da je za upotrebu u smanjenju upale tkiva ili organa kod subjekta.
9. Bacteroides thetaiotaomicron, pripravak, farmaceutski pripravak, prehrambeni dodatak, prehrana za životinje, prehrambeni proizvod, dijetetski dodatak, ili aditiv za hranu za upotrebu prema zahtjevu 8 što navedeni Bacteroides thetaiotaomicron smanjuje upalu epitelnih stanica tkiva ili organa, proizvoljno kada su navedene epitelne stanice, epitelne stanice probavnog kanala.
10. Bacteroides thetaiotaomicron kao što je definiran u zahtjevu 1, pripravak kao što je definiran u zahtjevu 2 ili 5, farmaceutski pripravak kao što je definiran u zahtjevu 3 ili 5, prehrambeni dodatak kao što je definiran u zahtjevu 4 ili 5 ili prehrana za životinje, prehrambeni proizvod, dijetetski dodatak, ili aditiv za hranu kao što je definiran u zahtjevu 6 ili 7, naznačen time da je za upotrebu u liječenju i/ili prevenciji poremećaja kod subjekta; kada je navedeni poremećaj upalni poremećaj i/ili autoimuni poremećaj i/ili alergijski poremećaj, proizvoljno što navedeni poremećaj pogađa probavni kanal, dio probavnog kanala i/ili epitelne stanice.
11. Bacteroides thetaiotaomicron, pripravak, farmaceutski pripravak, prehrambeni dodatak, prehrana za životinje, prehrambeni proizvod, dijetetski dodatak, ili aditiv za hranu za upotrebu prema zahtjevu 10 naznačen time da se navedeni poremećaj bira iz grupe koja se sastoji od upalnog poremećaja crijeva (IBD), kolitisa, reumatoidnog artritisa, psorijaze, multiple skleroze, dijabetesa tipa I, celijakije, atopijskog dermatitisa, rinitisa, sindroma iritabilnih crijeva (IBS), ulcerativnog kolitisa, pouchitisa, Crohnove bolesti, funkcionalne dispepsije, atopijskih bolesti, nekrozirajućeg enterokolitisa, nealkoholne bolesti masne jetre, gastrointestinalne infekcije i njihovih kombinacija.
12. Bacteroides thetaiotaomicron kao što je definiran u zahtjevu 1, pripravak kao što je definiran u zahtjevu 2 ili 5, farmaceutski pripravak kao što je definiran u zahtjevu 3 ili 5, prehrambeni dodatak kao što je definiran u zahtjevu 4 ili 5 ili prehrana za životinje, prehrambeni proizvod, dijetetski dodatak, ili aditiv za hranu kao što je definiran u zahtjevu 6 ili 7 za upotrebu u smanjenju poremećaja debelog crijeva kod subjekta, proizvoljno pri čemu navedeni subjekt ima IBD.
13. Bacteroides thetaiotaomicron, pripravak, farmaceutski pripravak, prehrambeni dodatak, prehrana za životinje, prehrambeni proizvod, dijetetski dodatak, ili prehrambeni aditiv za upotrebu prema zahtjevu 12 naznačen time da navedeni Bacteroides thetaiotaomicron, pripravak, farmaceutski pripravak, prehrambeni dodatak, prehrana za životinje, prehrambeni proizvod, dijetetski proizvod, ili aditiv za hranu smanjuje ili sprječava integritet mukoznog epitela i/ili smanjuje ili sprječava smanjenje broja vrčastih stanica u epitelu i/ili smanjuje ili sprječava infiltriranje imunih stanica u sloj lamina propria.
14. Bacteroides thetaiotaomicron kao što je definiran u zahtjevu 1, pripravak kao što je definiran u zahtjevu 2 ili 5, farmaceutski pripravak kao što je definiran u zahtjevu 3 ili 5, prehrambeni dodatak kao što je definiran u zahtjevu 4 ili 5 ili prehrana za životinje, prehrambeni proizvod, dijetetski dodatak, ili aditiv za hranu kao što je definiran u zahtjevu 6 ili 7 naznačen time da je za upotrebu u smanjenju ekspresije jednog ili više proupalnih gena u stanici ili stanicama subjekta, proizvoljno pri čemu se navedeni proupalni geni biraju iz skupine koja se sastoji od IL1-β, IL6, IL8, IL10 i njihovih kombinacija, i/ili pri čemu navedena stanica je stanica probavnog kanala (kao što je stanica ulaznog dijela debelog crijeva), ili epitelne stanice (kao što je crijevna epitelna stanica).
15. Bacteroides thetaiotaomicron kao što je definiran u zahtjevu 1, pripravak kao što je definiran u zahtjevu 2 ili 5, farmaceutski pripravak kao što je definiran u zahtjevu 3 ili 5, prehrambeni dodatak kao što je definiran u zahtjevu 4 ili 5 ili prehrana za životinje, hranjivi proizvod, dijetetski dodatak, ili aditiv za hranu kao što je definiran u zahtjevu 6 ili 7 naznačen time da je za upotrebu u povećanju postotka regulacijskih T stanica (Treg-a) u alimentarnom kanalu ili dijelu probavnog kanala, proizvoljno pri čemu je navedeni dio probavnog kanala lamina propria tankog crijeva.
16. Postupak za dobivanje farmaceutskog pripravka prema zahtjevu 3 ili 5, naznačen time da navedeni postupak sadrži miješanje navedenog Bacteroides thetaiotaomicron s farmaceutski prihvatljivim pomoćnim sredstvom, nosačem ili otapalom.
17. Postupak za dobivanje prehrambenog dodatka prema zahtjevu 4 ili 5, naznačen time da navedeni postupak sadrži miješanje navedenog Bacteroides thetaiotaomicron s pomoćnim sredstvom, nosačem ili otapalom koje je prihvatljivo za upotrebu u prehrani.
18. Postupak za dobivanje prehrane za životinje, prehrambenog proizvoda, dijetetskog dodatka, ili aditiva za hranu prema zahtjevu 6 ili 7, naznačen time da navedeni postupak sadrži miješanje navedenog Bacteroides thetaiotaomicron s prehranom za životinje, prehrambenim proizvodom, dijetetskim dodatkom, aditivom za hranu ili njihovim sastojkom.
19. Postupak prema zahtjevu 16, 17 ili 18, naznačen time da je Bacteroides thetaiotaomicron inkapsuliran u navedenom postupku.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201423084 | 2014-12-23 | ||
EP15817513.3A EP3065748B1 (en) | 2014-12-23 | 2015-12-22 | A bacteroides thetaiotaomicron strain and its use in reducing inflammation |
PCT/GB2015/054112 WO2016102950A1 (en) | 2014-12-23 | 2015-12-22 | Immune modulation |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20180123T1 true HRP20180123T1 (hr) | 2018-05-04 |
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