HRP20160880T4 - Formulacija obložene tablete i postupak - Google Patents
Formulacija obložene tablete i postupak Download PDFInfo
- Publication number
- HRP20160880T4 HRP20160880T4 HRP20160880TT HRP20160880T HRP20160880T4 HR P20160880 T4 HRP20160880 T4 HR P20160880T4 HR P20160880T T HRP20160880T T HR P20160880TT HR P20160880 T HRP20160880 T HR P20160880T HR P20160880 T4 HRP20160880 T4 HR P20160880T4
- Authority
- HR
- Croatia
- Prior art keywords
- coating
- tablet
- coated tablet
- polymer
- coating layer
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 3
- 239000007916 tablet composition Substances 0.000 title 1
- 239000011247 coating layer Substances 0.000 claims 15
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 12
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 12
- 239000011248 coating agent Substances 0.000 claims 11
- 238000000576 coating method Methods 0.000 claims 11
- 229920001688 coating polymer Polymers 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 8
- 239000010410 layer Substances 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- QGJUIPDUBHWZPV-SGTAVMJGSA-N saxagliptin Chemical compound C1C(C2)CC(C3)CC2(O)CC13[C@H](N)C(=O)N1[C@H](C#N)C[C@@H]2C[C@@H]21 QGJUIPDUBHWZPV-SGTAVMJGSA-N 0.000 claims 7
- 229960004937 saxagliptin Drugs 0.000 claims 7
- 108010033693 saxagliptin Proteins 0.000 claims 7
- 238000009472 formulation Methods 0.000 claims 6
- 238000007789 sealing Methods 0.000 claims 5
- 238000001035 drying Methods 0.000 claims 3
- 239000011253 protective coating Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- -1 poly(ethylene glycol) Polymers 0.000 claims 2
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000008199 coating composition Substances 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 229960001021 lactose monohydrate Drugs 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 229940057948 magnesium stearate Drugs 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000011241 protective layer Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (16)
1. Obložena tableta naznačena time da sadrži jezgru tablete i
a) unutrašnji brtveni sloj premaza obložen oko jezgre tablete, koji sadrži formulaciju polimera za oblaganje koji sadrži polimer baziran na polivinilalkoholu (PVA);
b) drugi sloj premaza obložen oko unutrašnjeg brtvenog premaza jezgre tablete, te drugi sloj premaza sadrži saksagliptin
ili njegovu farmaceutski prihvatljivu sol, te formulacija polimera za oblaganje sadrži polimer baziran na PVA; i
c) vanjski zaštitni sloj premaza obložen oko drugog sloja premaza jezgre tablete, navedeni vanjski zaštitni sloj premaza sadrži formulaciju sloja premaza koja sadrži polimer baziran na PVA.
2. Obložena tableta kako je definirano u zahtjevu 1 naznačena time da navedeni drugi sloj premaza se sastoji od 0.1 do 70% težinski saksagliptina ili njegove farmaceutski prihvatljive soli i od 30 do 99.5% težinski polimera za oblaganje, u odnosu na težinu drugog sloja premaza.
3. Obložena tableta kako je definirano u zahtjevu 2 naznačena time da formulacija polimera za oblaganje u drugom sloju premaza je najmanje 2 mg s jezgrom tablete od 200 mg, i saksagliptin ili njegova farmaceutski prihvatljiva sol je najmanje 0.2 mg s tabletom od 200 mg.
4. Obložena tableta kako je definirano u zahtjevu 1 naznačena time da je polimer baziran na PVA u drugom sloju premaza isti kao polimer baziran na PVA u drugim slojevima premaza.
5. Obložena tableta kako je definirano u zahtjevu 1 naznačena time da se polimer baziran na PVA sastoji od polivinil alkohola.
6. Obložena tableta kako je definirano u zahtjevu 1 naznačena time da je u drugom sloju premaza saksagliptin ili njegova farmaceutski prihvatljiva sol prisutan u količini koja je u rasponu od 0.2 do 140 mg i polimer za oblaganje je prisutan u količini koja je u rasponu od 2 do 140 mg, i u svakom od unutrašnjem brtvećem sloju premaza i vanjskom zaštitnom sloju premaza, polimer za oblaganje je prisutan u količini koja je u rasponu od 1 do 100 mg.
7. Obložena tableta kako je definirano u zahtjevu 1 naznačena time da se jezgra tablete sastoji od jednog ili više punila, proizvoljno jednog ili više vezivnih sredstava, proizvoljno jednog ili više sredstava za razgradnju i proizvoljno jednog ili više lubrikanata za tabletiranje.
8. Obložena tableta kako je definirano u zahtjevu 7 naznačena time da se jezgra tablete sastoji od mikrokristalinične celuloze, laktoza monohidrata, kroskarmeloza natrija, te magnezijevog stearata.
9. Obložena tableta kako je definirano u zahtjevu 1; naznačena time da svaki sloj premaza sadrži sredstvo za plastificiranje.
10. Obložena tableta kako je definirano u zahtjevu 9, naznačena time da sredstvo za plastificiranje je poli(etilen glikol).
11. Obložena tableta kako je definirano u zahtjevu 1, naznačena time da se početna tableta koristi umjesto jezgre tablete.
12. Obložena tableta kako je definirano u zahtjevu 11, naznačena time da početna tableta je tableta drugog lijeka.
13. Obložena tableta kako je definirano u zahtjevu 1 naznačena time da ima slijedeći sastav:
14. Obložena tableta kako je definirano u zahtjevu 1 naznačena time da se za 5 mg potencije drugi sloj premaza sastoji od 5 mg saksagliptina ili njegove farmaceutski prihvatljive soli i 5 mg premaza na bazi polimera i za 2.5 mg potencije drugi sloj premaza se sastoji od 2.5 mg saksagliptina ili njegove farmaceutski prihvatljive soli i 20 mg premaza na bazi polimera.
15. Postupak za pripremanje obložene tablete kako je definirano u zahtjevu 1 naznačen time da sadrži:
a) osiguravanje jezgre tablete;
b) prevlačenje tablete s formulacijom unutrašnjeg brtvenog sloja premaza koja sadrži najmanje jedan polimer za prevlačenje koji je baziran na PVA;
c) sušenje obložene tablete da se na njoj stvori unutrašnji brtveni premaz;
d) oblaganje tako obložene tablete sa formulacijom drugog sloja premaza koja sadrži medikament koji je saksagliptin ili njegova farmaceutski prihvatljiva sol i najmanje jedan polimer za prevlačenje baziran na PVA;
e) sušenje tako obložene tablete da se na njoj stvori drugi sloj premaza; i
f) oblaganje tako obložene tablete sa formulacijom trećeg vanjskog zaštitnog sloja premaza koja sadrži najmanje jedan polimer za prevlačenje baziran na PVA; i
g) sušenje tako obložene tablete da se oblikuje obložena tablete prema izumu.
16. Postupak kako je definirano u zahtjevu 15 naznačen time da se slojevi premaza primjenjuju kao suspenzija od najmanje jednog polimera za prevlačenje koji je baziran na PVA.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57531904P | 2004-05-28 | 2004-05-28 | |
| EP05756474.2A EP1753406B2 (en) | 2004-05-28 | 2005-05-26 | Coated tablet formulation and method |
| PCT/US2005/018692 WO2005117841A1 (en) | 2004-05-28 | 2005-05-26 | Coated tablet formulation and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20160880T1 HRP20160880T1 (hr) | 2016-09-23 |
| HRP20160880T4 true HRP20160880T4 (hr) | 2020-01-10 |
Family
ID=34971747
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160880TT HRP20160880T4 (hr) | 2004-05-28 | 2016-07-15 | Formulacija obložene tablete i postupak |
| HRP20161210TT HRP20161210T4 (hr) | 2004-05-28 | 2016-09-21 | Formulacija obložene tablete i postupak |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161210TT HRP20161210T4 (hr) | 2004-05-28 | 2016-09-21 | Formulacija obložene tablete i postupak |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US7951400B2 (hr) |
| EP (3) | EP1753406B2 (hr) |
| JP (1) | JP4901727B2 (hr) |
| KR (2) | KR101290925B1 (hr) |
| CN (2) | CN102895208B (hr) |
| AR (2) | AR049062A1 (hr) |
| AU (1) | AU2005249467B2 (hr) |
| BR (1) | BRPI0510419B8 (hr) |
| CA (1) | CA2568391C (hr) |
| CY (2) | CY1117813T1 (hr) |
| DK (2) | DK2298288T4 (hr) |
| ES (3) | ES2754573T3 (hr) |
| GE (1) | GEP20094639B (hr) |
| HK (2) | HK1094951A1 (hr) |
| HR (2) | HRP20160880T4 (hr) |
| HU (2) | HUE029446T2 (hr) |
| IL (2) | IL179454A (hr) |
| LT (1) | LT2298288T (hr) |
| ME (2) | ME02516B (hr) |
| MX (1) | MXPA06013711A (hr) |
| MY (1) | MY147639A (hr) |
| NO (1) | NO343907B1 (hr) |
| NZ (1) | NZ551591A (hr) |
| PE (1) | PE20060425A1 (hr) |
| PL (2) | PL1753406T5 (hr) |
| PT (2) | PT1753406E (hr) |
| RS (2) | RS55174B2 (hr) |
| RU (1) | RU2372894C2 (hr) |
| SI (3) | SI2298288T2 (hr) |
| TW (2) | TWI415635B (hr) |
| UA (1) | UA88168C2 (hr) |
| WO (1) | WO2005117841A1 (hr) |
| ZA (1) | ZA200609541B (hr) |
Families Citing this family (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0487425A (ja) * | 1990-07-31 | 1992-03-19 | Fujitsu Ltd | 回線切り替え装置 |
| CN100408579C (zh) * | 2001-02-24 | 2008-08-06 | 贝林格尔英格海姆法玛两合公司 | 黄嘌呤衍生物,其制法及其作为药物组合物的用途 |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| AU2005210285B2 (en) | 2004-02-05 | 2008-01-24 | Kyorin Pharmaceutical Co., Ltd. | Bicycloester derivative |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| TW200534879A (en) * | 2004-03-25 | 2005-11-01 | Bristol Myers Squibb Co | Coated tablet formulation and method |
| US7829720B2 (en) * | 2004-05-04 | 2010-11-09 | Bristol-Myers Squibb Company | Process for preparing atazanavir bisulfate and novel forms |
| US20050256314A1 (en) * | 2004-05-04 | 2005-11-17 | Soojin Kim | Process employing controlled crystallization in forming crystals of a pharmaceutical |
| TWI415635B (zh) | 2004-05-28 | 2013-11-21 | 必治妥施貴寶公司 | 加衣錠片調製物及製備彼之方法 |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| GB0526291D0 (en) * | 2005-12-23 | 2006-02-01 | Prosidion Ltd | Therapeutic method |
| SI1818057T1 (sl) * | 2006-02-09 | 2010-08-31 | Teva Pharma | Stabilne farmacevtske formulacije montelukast natrija |
| JP5101489B2 (ja) * | 2006-03-08 | 2012-12-19 | 杏林製薬株式会社 | アミノアセチルピロリジンカルボニトリル誘導体の製造方法およびその製造中間体 |
| EP1852108A1 (en) * | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| NO347644B1 (no) | 2006-05-04 | 2024-02-12 | Boehringer Ingelheim Int | Polymorfer |
| US20080064701A1 (en) * | 2007-04-24 | 2008-03-13 | Ramesh Sesha | Anti-diabetic combinations |
| US20070172525A1 (en) * | 2007-03-15 | 2007-07-26 | Ramesh Sesha | Anti-diabetic combinations |
| JPWO2008114857A1 (ja) * | 2007-03-22 | 2010-07-08 | 杏林製薬株式会社 | アミノアセチルピロリジンカルボニトリル誘導体の製造方法 |
| PE20090185A1 (es) | 2007-03-22 | 2009-02-28 | Bristol Myers Squibb Co | Formulaciones farmaceuticas que contienen un inhibidor sglt2 |
| PE20090696A1 (es) * | 2007-04-20 | 2009-06-20 | Bristol Myers Squibb Co | Formas cristalinas de saxagliptina y procesos para preparar las mismas |
| EP2178512B1 (en) * | 2007-06-22 | 2011-03-09 | Bristol-Myers Squibb Company | Tableted compositions containing atazanavir |
| PT2170292E (pt) * | 2007-06-22 | 2014-03-06 | Bristol Myers Squibb Holdings Ireland | Composições de comprimido contendo atazanavir |
| SI2178513T1 (sl) * | 2007-06-22 | 2011-05-31 | Bristol Myers Squibb Co | Tabletni sestavki vsebujoäśi atazanavir |
| DE602008005316D1 (de) * | 2007-06-22 | 2011-04-14 | Bristol Myers Squibb Co | Tablettierte atazanavirhaltige zusammensetzungen |
| CN101772304B (zh) * | 2007-07-31 | 2014-07-09 | 卡吉尔公司 | 直接可压缩的右旋糖 |
| BRPI0815387B8 (pt) * | 2007-08-13 | 2021-05-25 | Abuse Deterrent Pharmaceutical Llc | composição farmacêutica, método para fazer uma composição farmacêutica e uso da composição farmacêutica |
| CL2008002427A1 (es) | 2007-08-16 | 2009-09-11 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2. |
| US8551524B2 (en) * | 2008-03-14 | 2013-10-08 | Iycus, Llc | Anti-diabetic combinations |
| AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
| IT1393244B1 (it) * | 2008-07-18 | 2012-04-12 | Universita' Degli Studi Di Milano | Sistema per il rilascio al colon di farmaci suscettibili di degradazione enzimatica e/o scarsamente assorbiti nel tratto gastrointestinale |
| KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
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- 2005-05-26 CN CN2005800245879A patent/CN1988891B/zh active Active
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