HRP20131235T1 - Produljeno vrijeme za napredovanje bolesti ili za preživljavanje uporabom pertuzumaba kod pacijenata koji boluju od raka jajnika - Google Patents
Produljeno vrijeme za napredovanje bolesti ili za preživljavanje uporabom pertuzumaba kod pacijenata koji boluju od raka jajnika Download PDFInfo
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- HRP20131235T1 HRP20131235T1 HRP20131235TT HRP20131235T HRP20131235T1 HR P20131235 T1 HRP20131235 T1 HR P20131235T1 HR P20131235T T HRP20131235T T HR P20131235TT HR P20131235 T HRP20131235 T HR P20131235T HR P20131235 T1 HRP20131235 T1 HR P20131235T1
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- Prior art keywords
- pertuzumab
- use according
- patient
- survival
- ttp
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- 229960002087 pertuzumab Drugs 0.000 title claims 23
- 230000004083 survival effect Effects 0.000 title claims 10
- 206010033128 Ovarian cancer Diseases 0.000 title claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 title claims 4
- 206010061818 Disease progression Diseases 0.000 title claims 3
- 230000005750 disease progression Effects 0.000 title claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 11
- 229940127089 cytotoxic agent Drugs 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 230000001399 anti-metabolic effect Effects 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- -1 COX-inhibitor Substances 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- 230000000750 progressive effect Effects 0.000 claims 2
- 230000002035 prolonged effect Effects 0.000 claims 2
- 229960000303 topotecan Drugs 0.000 claims 2
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 2
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 2
- NECZZOFFLFZNHL-XVGZVFJZSA-N (2s)-2-amino-5-[[(2r)-3-[2-[bis[bis(2-chloroethyl)amino]-oxidophosphaniumyl]oxyethylsulfonyl]-1-[[(r)-carboxy(phenyl)methyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;hydron;chloride Chemical compound Cl.ClCCN(CCCl)P(=O)(N(CCCl)CCCl)OCCS(=O)(=O)C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)N[C@@H](C(O)=O)C1=CC=CC=C1 NECZZOFFLFZNHL-XVGZVFJZSA-N 0.000 claims 1
- KAWIOCMUARENDQ-UHFFFAOYSA-N 2-(4-chlorophenyl)sulfanyl-n-(4-pyridin-2-yl-1,3-thiazol-2-yl)acetamide Chemical compound C1=CC(Cl)=CC=C1SCC(=O)NC1=NC(C=2N=CC=CC=2)=CS1 KAWIOCMUARENDQ-UHFFFAOYSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 229940124638 COX inhibitor Drugs 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 229940124226 Farnesyltransferase inhibitor Drugs 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 102100039064 Interleukin-3 Human genes 0.000 claims 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 229940078123 Ras inhibitor Drugs 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 206010038111 Recurrent cancer Diseases 0.000 claims 1
- 108700011582 TER 286 Proteins 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 230000003388 anti-hormonal effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 229950000772 canfosfamide Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
- 229960001433 erlotinib Drugs 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 1
- 231100000046 skin rash Toxicity 0.000 claims 1
- 238000002626 targeted therapy Methods 0.000 claims 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C07K2317/00—Immunoglobulins specific features
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Claims (18)
1. Pertuzumab, naznačen time, da se upotrebljava u postupku produljivanja vremena za napredovanje bolesti (TTP) ili za preživljavanje kod pacijenta koji boluje od raka, pri čemu taj postupak obuhvaća davanje pertuzumaba pacijentu u količini koja produljuje TTP ili preživljavanje pacijenta, dok je to pacijent koji boluje od raka jajnika.
2. Pertuzumab za uporabu prema zahtjevu 1, naznačen time, da je taj rak napredujući, otporan ili ponavljajući rak jajnika.
3. Pertuzumab za uporabu prema zahtjevu 1 ili zahtjevu 2, naznačen time, da se pertuzumab daje u postupku kao pojedinačno protutumorsko sredstvo.
4. Pertuzumab za uporabu prema zahtjevu 1 ili zahtjevu 2, naznačen time, da postupak obuhvaća davanje pacijentu drugog terapeutskog sredstva.
5. Pertuzumab za uporabu prema zahtjevu 4, naznačen time, da je drugo terapeutsko sredstvo odabrano iz skupine koju čine: kemoterapeutsko sredstvo, HER-protutijelo, protutijelo usmjereno protiv antigena povezanog s tumorom, antihormonalni spoj, kardioprotektant, citokin, EGFR-ciljani lijek, anti-angiogensko sredstvo, inhibitor tirozin kinaze, COX-inhibitor, nesteroidni protuupalni lijek, inhibitor transferaze farnesila, protutijelo koje veže onkofetalni protein CA 125, HER2-cjepivo, HER-ciljana terapija, Raf-inhibitor ili ras-inhibitor, liposomalni doksorubicin, topotekan, taksan, dvostruki inhibitor tirozin kinaze, TLK286, EMD-7200, lijek koji sprečava mučninu, lijek koji sprečava ili liječi kožni osip ili standardna terapija za akne, lijek koji liječi ili sprečava proljev, lijek koji smanjuje tjelesnu temperaturu i hematopoietični faktor rasta.
6. Pertuzumab za uporabu prema zahtjevu 5, naznačen time, da drugo terapeutsko sredstvo je kemoterapeutsko sredstvo.
7. Pertuzumab za uporabu prema zahtjevu 6, naznačen time, da kemoterapeutsko sredstvo je antimetaboličko kemoterapeutsko sredstvo.
8. Pertuzumab za uporabu prema zahtjevu 7, naznačen time, da antimetaboličko kemoterapeutsko sredstvo je gemcitabin.
9. Pertuzumab za uporabu prema zahtjevu 4, naznačen time, da drugo terapeutsko sredstvo je trastuzumab, erlotinib ili bevacizumab.
10. Pertuzumab za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time, da se produljuje TTP.
11. Pertuzumab za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time, da se produljuje preživljavanje.
12. Pertuzumab za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time, da se u postupku primjene pertuzumaba produljuje TTP ili preživljavanje barem 20% više nego što je TTP ili preživljavanje postignuto primjenom jednog odobrenog antitumorskog sredstva na pacijentu koji boluje od raka.
13. Pertuzumab, naznačen time, da se upotrebljava u postupku produljivanja vremena za napredovanje bolesti (TTP) ili za preživljavanje pacijenta koji boluje od raka jajnika, pri čemu taj postupak obuhvaća davanje pertuzumaba pacijentu u količini koja produljuje TTP ili preživljavanje pacijenta, dok rak od kojega boluje pacijent pokazuje aktiviranje HER2.
14. Pertuzumab za uporabu prema zahtjevu 13, naznačen time, da pacijent boluje od napredujućeg, otpornog ili ponavljajućeg raka.
15. Pertuzumab za uporabu prema zahtjevu 13 ili zahtjevu 14, naznačen time, da se postupkom davanja pertuzumaba pacijentu produljuje TTP ili preživljavanje barem 20% više nego što je TTP ili preživljavanje postignuto primjenom topotekana ili liposomalnog doksorubicina kod pacijenta.
16. Pertuzumab za uporabu prema bilo kojem od zahtjeva 13 do 15, naznačen time, da postupak nadalje obuhvaća davanje pacijentu kemoterapeutskog sredstva.
17. Pertuzumab za uporabu prema zahtjevu 16, naznačen time, da kemoterapeutsko sredstvo je antimetaboličko kemoterapeutsko sredstvo.
18. Pertuzumab za uporabu prema zahtjevu 17, naznačen time, da antimetaboličko kemoterapeutsko sredstvo je gemcitabin.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65527705P | 2005-02-23 | 2005-02-23 | |
PCT/US2006/006334 WO2006091693A2 (en) | 2005-02-23 | 2006-02-21 | Extending time to disease progression or survival in cancer patients using a her dimerization inhibitor |
Publications (1)
Publication Number | Publication Date |
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HRP20131235T1 true HRP20131235T1 (hr) | 2014-02-14 |
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Application Number | Title | Priority Date | Filing Date |
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HRP20131235TT HRP20131235T1 (hr) | 2005-02-23 | 2013-12-30 | Produljeno vrijeme za napredovanje bolesti ili za preživljavanje uporabom pertuzumaba kod pacijenata koji boluju od raka jajnika |
Country Status (32)
Country | Link |
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US (6) | US20060188509A1 (hr) |
EP (3) | EP1850874B1 (hr) |
JP (6) | JP2008531576A (hr) |
KR (1) | KR101253576B1 (hr) |
CN (2) | CN101163503B (hr) |
AR (1) | AR054426A1 (hr) |
AU (1) | AU2006216732C1 (hr) |
BR (1) | BRPI0606542A8 (hr) |
CA (1) | CA2596133C (hr) |
CL (1) | CL2015000428A1 (hr) |
CR (1) | CR9312A (hr) |
DK (1) | DK1850874T3 (hr) |
DO (1) | DOP2006000052A (hr) |
ES (1) | ES2440481T3 (hr) |
GT (1) | GT200600092A (hr) |
HK (1) | HK1112588A1 (hr) |
HR (1) | HRP20131235T1 (hr) |
IL (2) | IL184884A (hr) |
MA (1) | MA29331B1 (hr) |
MX (1) | MX2007009889A (hr) |
MY (1) | MY152164A (hr) |
NO (1) | NO20074824L (hr) |
NZ (1) | NZ590431A (hr) |
PL (1) | PL1850874T3 (hr) |
PT (1) | PT1850874E (hr) |
RS (1) | RS53128B (hr) |
RU (1) | RU2404806C2 (hr) |
SI (1) | SI1850874T1 (hr) |
TW (2) | TWI435730B (hr) |
UA (1) | UA95902C2 (hr) |
WO (1) | WO2006091693A2 (hr) |
ZA (1) | ZA200707078B (hr) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
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ZA9811162B (en) * | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
ATE441433T1 (de) * | 2000-05-19 | 2009-09-15 | Genentech Inc | Gennachweisverfahren zur verbesserung der wahrscheinlichkeit einer wirkungsvollen antwort auf eine krebstherapie mit einem erbb- antagonisten |
SV2006002143A (es) * | 2004-06-16 | 2006-01-26 | Genentech Inc | Uso de un anticuerpo para el tratamiento del cancer resistente al platino |
KR20070038557A (ko) * | 2004-07-22 | 2007-04-10 | 제넨테크, 인크. | Her2 항체 조성물 |
JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
JP2008523073A (ja) * | 2004-12-07 | 2008-07-03 | ジェネンテック・インコーポレーテッド | Her阻害剤を用いた治療のための患者の選択 |
ZA200706017B (en) * | 2005-01-21 | 2008-12-31 | Genentech Inc | Fixed dosing of her antibodies |
EP1850874B1 (en) * | 2005-02-23 | 2013-10-16 | Genentech, Inc. | Extending time to disease progression or survival in ovarian cancer patients using pertuzumab |
PE20070207A1 (es) * | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
EP2468899B1 (en) | 2006-01-05 | 2015-03-11 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis of stomach cancers |
DK2132229T3 (en) | 2007-03-01 | 2016-06-20 | Symphogen As | Recombinant anti-epidermal growth factor receptor-ANTIBODY COMPOSITIONS |
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