HRP20110005T1 - Spoj tricikličkog benzopirana kao anti-aritmijskog sredstva - Google Patents
Spoj tricikličkog benzopirana kao anti-aritmijskog sredstva Download PDFInfo
- Publication number
- HRP20110005T1 HRP20110005T1 HR20110005T HRP20110005T HRP20110005T1 HR P20110005 T1 HRP20110005 T1 HR P20110005T1 HR 20110005 T HR20110005 T HR 20110005T HR P20110005 T HRP20110005 T HR P20110005T HR P20110005 T1 HRP20110005 T1 HR P20110005T1
- Authority
- HR
- Croatia
- Prior art keywords
- group
- amino
- pyrano
- dihydro
- quinolin
- Prior art date
Links
- -1 benzopyran compound Chemical class 0.000 title claims 2
- 239000003416 antiarrhythmic agent Substances 0.000 title abstract 2
- 150000001562 benzopyrans Chemical class 0.000 claims abstract 20
- 150000003839 salts Chemical class 0.000 claims abstract 19
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 16
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 8
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims abstract 7
- 125000003277 amino group Chemical group 0.000 claims abstract 6
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 3
- 125000006553 (C3-C8) cycloalkenyl group Chemical group 0.000 claims abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims abstract 2
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 2
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 3
- CHIOVPNYOWEUJW-UHFFFAOYSA-N 2,2,7-trimethyl-4-(2-phenylethylamino)-3,4-dihydropyrano[2,3-g]quinolin-3-ol Chemical compound C12=CC3=NC(C)=CC=C3C=C2OC(C)(C)C(O)C1NCCC1=CC=CC=C1 CHIOVPNYOWEUJW-UHFFFAOYSA-N 0.000 claims 2
- ZZUSANGEAUESFL-UHFFFAOYSA-N 7-(hydroxymethyl)-2,2,9-trimethyl-4-(2-phenylethylamino)-3,4-dihydropyrano[2,3-g]quinolin-3-ol Chemical compound OC1C(C)(C)OC=2C=C3C(C)=CC(CO)=NC3=CC=2C1NCCC1=CC=CC=C1 ZZUSANGEAUESFL-UHFFFAOYSA-N 0.000 claims 2
- NGWVFMQMEXBFMD-UHFFFAOYSA-N 7-chloro-2,2,9-trimethyl-4-(2-phenylethylamino)-3,4-dihydropyrano[2,3-g]quinolin-3-ol Chemical compound OC1C(C)(C)OC=2C=C3C(C)=CC(Cl)=NC3=CC=2C1NCCC1=CC=CC=C1 NGWVFMQMEXBFMD-UHFFFAOYSA-N 0.000 claims 2
- UVSBPVGBBJBIPA-UHFFFAOYSA-N 7-chloro-2,2,9-trimethyl-4-(2-pyridin-3-ylethylamino)-3,4-dihydropyrano[2,3-g]quinolin-3-ol Chemical compound OC1C(C)(C)OC=2C=C3C(C)=CC(Cl)=NC3=CC=2C1NCCC1=CC=CN=C1 UVSBPVGBBJBIPA-UHFFFAOYSA-N 0.000 claims 2
- KCHOBYCFOXAKNM-UHFFFAOYSA-N 7-chloro-4-(2-cyclohexylethylamino)-2,2,9-trimethyl-3,4-dihydropyrano[2,3-g]quinolin-3-ol Chemical compound OC1C(C)(C)OC=2C=C3C(C)=CC(Cl)=NC3=CC=2C1NCCC1CCCCC1 KCHOBYCFOXAKNM-UHFFFAOYSA-N 0.000 claims 2
- HZUJFGLZSGYMQT-UHFFFAOYSA-N 8-hydroxy-7,7-dimethyl-9-(2-phenylethylamino)-8,9-dihydro-1h-pyrano[3,2-g][1,4]benzoxazin-2-one Chemical compound OC1C(C)(C)OC2=CC=3OCC(=O)NC=3C=C2C1NCCC1=CC=CC=C1 HZUJFGLZSGYMQT-UHFFFAOYSA-N 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- LMVGPQNBHMECBB-UHFFFAOYSA-N 2,2,7,9-tetramethyl-4-(2-phenylethylamino)-3,4-dihydropyrano[2,3-g]quinolin-3-ol Chemical compound C12=CC3=NC(C)=CC(C)=C3C=C2OC(C)(C)C(O)C1NCCC1=CC=CC=C1 LMVGPQNBHMECBB-UHFFFAOYSA-N 0.000 claims 1
- IDLTUNKJYAGSFN-UHFFFAOYSA-N 2,2-dimethyl-4-(2-phenylethylamino)-3,4-dihydropyrano[2,3-g]quinolin-3-ol Chemical compound OC1C(C)(C)OC2=CC3=CC=CN=C3C=C2C1NCCC1=CC=CC=C1 IDLTUNKJYAGSFN-UHFFFAOYSA-N 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- XEQQREZFQJPKEY-UHFFFAOYSA-N 3,3-dimethyl-1-(2-phenylethylamino)-1,2-dihydropyrano[3,2-f]quinolin-2-ol Chemical compound OC1C(C)(C)OC2=CC=C3N=CC=CC3=C2C1NCCC1=CC=CC=C1 XEQQREZFQJPKEY-UHFFFAOYSA-N 0.000 claims 1
- OWYYYCYHGORREH-UHFFFAOYSA-N 3-hydroxy-2,2,9-trimethyl-4-(2-phenylethylamino)-3,4-dihydropyrano[2,3-g]quinoline-7-carbonitrile Chemical compound OC1C(C)(C)OC=2C=C3C(C)=CC(C#N)=NC3=CC=2C1NCCC1=CC=CC=C1 OWYYYCYHGORREH-UHFFFAOYSA-N 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- ACZVHCBJCSMHIL-UHFFFAOYSA-N 7-chloro-2,2,9-trimethyl-4-(pentylamino)-3,4-dihydropyrano[2,3-g]quinolin-3-ol Chemical compound C1=C(Cl)N=C2C=C3C(NCCCCC)C(O)C(C)(C)OC3=CC2=C1C ACZVHCBJCSMHIL-UHFFFAOYSA-N 0.000 claims 1
- ODTMNOQRTBPFTK-UHFFFAOYSA-N 7-chloro-4-[2-(4-chlorophenyl)ethylamino]-2,2,9-trimethyl-3,4-dihydropyrano[2,3-g]quinolin-3-ol Chemical compound OC1C(C)(C)OC=2C=C3C(C)=CC(Cl)=NC3=CC=2C1NCCC1=CC=C(Cl)C=C1 ODTMNOQRTBPFTK-UHFFFAOYSA-N 0.000 claims 1
- SJROYWSEXZWKAM-UHFFFAOYSA-N 7-chloro-4-[2-(4-fluorophenyl)ethylamino]-2,2,9-trimethyl-3,4-dihydropyrano[2,3-g]quinolin-3-ol Chemical compound OC1C(C)(C)OC=2C=C3C(C)=CC(Cl)=NC3=CC=2C1NCCC1=CC=C(F)C=C1 SJROYWSEXZWKAM-UHFFFAOYSA-N 0.000 claims 1
- NFWWZVHIWDPWEY-UHFFFAOYSA-N 7-chloro-4-[2-(cyclopenten-1-yl)ethylamino]-2,2,9-trimethyl-3,4-dihydropyrano[2,3-g]quinolin-3-ol Chemical compound OC1C(C)(C)OC=2C=C3C(C)=CC(Cl)=NC3=CC=2C1NCCC1=CCCC1 NFWWZVHIWDPWEY-UHFFFAOYSA-N 0.000 claims 1
- KOCXCSREADKFMD-UHFFFAOYSA-N 8-hydroxy-7,7-dimethyl-9-(2-phenylethylamino)-8,9-dihydro-4h-pyrano[2,3-g][1,4]benzoxazin-3-one Chemical compound OC1C(C)(C)OC2=CC=3NC(=O)COC=3C=C2C1NCCC1=CC=CC=C1 KOCXCSREADKFMD-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- IQQDNMHUOLMLNJ-UHFFFAOYSA-N quinolin-3-ol Chemical compound C1=CC=CC2=CC(O)=CN=C21 IQQDNMHUOLMLNJ-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004084605 | 2004-03-23 | ||
PCT/JP2005/006004 WO2005090357A1 (en) | 2004-03-23 | 2005-03-23 | Tricyclic benzopyran compound as anti-arrhythmic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110005T1 true HRP20110005T1 (hr) | 2011-02-28 |
Family
ID=34962589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110005T HRP20110005T1 (hr) | 2004-03-23 | 2011-01-05 | Spoj tricikličkog benzopirana kao anti-aritmijskog sredstva |
Country Status (31)
Country | Link |
---|---|
US (2) | US7652008B2 (ko) |
EP (1) | EP1732929B1 (ko) |
JP (1) | JP4840594B2 (ko) |
KR (2) | KR101019402B1 (ko) |
CN (3) | CN101429200B (ko) |
AT (1) | ATE485299T1 (ko) |
AU (2) | AU2005223612B2 (ko) |
BR (1) | BRPI0508768A (ko) |
CA (1) | CA2558139C (ko) |
CY (1) | CY1111250T1 (ko) |
CZ (1) | CZ2006598A3 (ko) |
DE (1) | DE602005024245D1 (ko) |
DK (1) | DK1732929T3 (ko) |
EG (1) | EG27163A (ko) |
ES (1) | ES2353021T3 (ko) |
HK (1) | HK1099299A1 (ko) |
HR (1) | HRP20110005T1 (ko) |
IL (1) | IL177950A (ko) |
MX (1) | MXPA06010880A (ko) |
NO (1) | NO339495B1 (ko) |
NZ (2) | NZ549570A (ko) |
PL (1) | PL1732929T3 (ko) |
PT (1) | PT1732929E (ko) |
RS (1) | RS51742B (ko) |
RU (1) | RU2380370C2 (ko) |
SI (1) | SI1732929T1 (ko) |
SK (1) | SK287994B6 (ko) |
TW (1) | TWI352704B (ko) |
UA (1) | UA91189C2 (ko) |
WO (1) | WO2005090357A1 (ko) |
ZA (1) | ZA200607388B (ko) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2380370C2 (ru) * | 2004-03-23 | 2010-01-27 | Ниссан Кемикал Индастриз, Лтд. | Трициклические соединения бензопирана в качестве противоаритмических агентов |
CA2645683A1 (en) | 2006-03-10 | 2007-09-20 | Nissan Chemical Industries, Ltd. | Process for producing optically active chromene oxide compound |
JPWO2010018867A1 (ja) * | 2008-08-14 | 2012-01-26 | 日産化学工業株式会社 | ジ置換ベンゾピラン化合物 |
WO2010126138A1 (ja) * | 2009-04-30 | 2010-11-04 | 日産化学工業株式会社 | 3環性ベンゾピラン化合物の新規な結晶形態及びその製造方法 |
WO2010151689A1 (en) | 2009-06-25 | 2010-12-29 | Alkermes, Inc. | Heterocyclic compounds for the treatment of neurological and psychological disorders |
WO2014050613A1 (ja) * | 2012-09-27 | 2014-04-03 | 日産化学工業株式会社 | 含窒素複素環n-オキシド化合物の製造方法 |
US9464095B2 (en) | 2012-09-27 | 2016-10-11 | Nissan Chemical Industries, Ltd. | Production method of high-purity nitrogen-containing heterocyclic compound |
CN105377826A (zh) * | 2013-07-25 | 2016-03-02 | 日产化学工业株式会社 | 杂环化合物的制造方法 |
US11168094B2 (en) | 2017-01-06 | 2021-11-09 | Azcuris Co., Ltd. | Quinolinone derivative and pharmaceutical composition for preventing or treating allergic diseases such as asthma or atopic dermatitis including the quinolinone derivative as active ingredient |
WO2019173230A1 (en) | 2018-03-05 | 2019-09-12 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
CN108727261B (zh) * | 2018-06-21 | 2021-09-24 | 济南大学 | 一种硝基取代喹那啶的制备方法 |
EP3903882A4 (en) * | 2018-12-28 | 2022-09-21 | Osaka University | THERAPEUTIC AGENT FOR INHERITED BRADYARRHYTHMIA |
RU2754610C1 (ru) * | 2020-04-14 | 2021-09-03 | Георгий Викторович ТЕЦ | Препарат для лечения заболеваний, вызванных бактериями |
TW202214582A (zh) * | 2020-06-26 | 2022-04-16 | 國立大學法人大阪大學 | 藥劑誘發性心律過慢及心律過慢性心律不整治療藥 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZM7682A1 (en) | 1981-09-25 | 1983-05-23 | Beecham Group Plc | Active compounds |
JPS5867683U (ja) | 1981-10-28 | 1983-05-09 | 株式会社ナムコ | 歩行ロボツト |
JPH0699439B2 (ja) * | 1988-02-03 | 1994-12-07 | 日産化学工業株式会社 | ピラノベンゾオキサジアゾール誘導体 |
JP2658198B2 (ja) * | 1988-06-23 | 1997-09-30 | 日産化学工業株式会社 | ピラノベンゾトリアゾール誘導体 |
US5097037A (en) * | 1989-07-17 | 1992-03-17 | Nissan Chemical Industries, Ltd. | Process for the optical resolution of pyranobenzoxadiazole compounds |
JP2876712B2 (ja) * | 1989-07-17 | 1999-03-31 | 日産化学工業株式会社 | 光学活性ピラノベンゾオキサジアゾール誘導体 |
US5164509A (en) * | 1990-11-26 | 1992-11-17 | E. R. Squibb & Sons, Inc. | Benzodiazolo analogs |
JPH07300414A (ja) * | 1993-04-02 | 1995-11-14 | Nissan Chem Ind Ltd | 心不全治療薬 |
UA27973C2 (uk) * | 1993-04-02 | 2000-10-16 | Ніссан Кемікал Індастріз Лтд | Лікарський засіб для лікування серцевої недостатності |
JP2734457B2 (ja) | 1994-02-23 | 1998-03-30 | 日産化学工業株式会社 | 不斉エポキシ化反応 |
EP0764159B1 (en) * | 1994-06-10 | 2000-08-09 | Smithkline Beecham Plc | C -4 amide substituted compounds and their use as therapeutic agents |
NZ314800A (en) * | 1996-05-15 | 1999-02-25 | Hoechst Ag | Sulphonamide-substituted chroman derivatives and their use as a medicament or a diagnostic |
EP1085009B1 (en) | 1998-06-03 | 2004-11-10 | Nissan Chemical Industries, Ltd. | Indan derivatives |
WO2000012492A1 (en) | 1998-09-01 | 2000-03-09 | Nissan Chemical Industries, Ltd. | Benzoxazine derivatives |
WO2000058300A1 (fr) | 1999-03-25 | 2000-10-05 | Nissan Chemical Industries, Ltd. | Derives du chroman |
CA2383583C (en) | 1999-09-17 | 2009-04-07 | Nissan Chemical Industries, Ltd. | Benzopyran derivative |
AU7319800A (en) | 1999-09-24 | 2001-04-24 | Nissan Chemical Industries Ltd. | 4-oxybenzopyran derivative |
AU7453900A (en) | 1999-10-05 | 2001-05-10 | Nissan Chemical Industries Ltd. | 4-oxybenzopyran derivative |
TW589305B (en) | 2001-02-14 | 2004-06-01 | Nissan Chemical Ind Ltd | 4-aminobenzopyran derivatives |
SK15782003A3 (sk) | 2001-06-25 | 2004-05-04 | Nissan Chemical Industries, Ltd. | Substituované benzopyránové deriváty proti arytmiám |
WO2003014113A1 (en) | 2001-08-06 | 2003-02-20 | Glenmark Pharmaceuticals Limited | Novel benzopyran compounds and process for their preparation and use |
RU2380370C2 (ru) * | 2004-03-23 | 2010-01-27 | Ниссан Кемикал Индастриз, Лтд. | Трициклические соединения бензопирана в качестве противоаритмических агентов |
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2005
- 2005-03-23 RU RU2006137284/04A patent/RU2380370C2/ru not_active IP Right Cessation
- 2005-03-23 CN CN2008101707921A patent/CN101429200B/zh not_active Expired - Fee Related
- 2005-03-23 SK SK5079-2006A patent/SK287994B6/sk not_active IP Right Cessation
- 2005-03-23 DE DE602005024245T patent/DE602005024245D1/de active Active
- 2005-03-23 ES ES05727581T patent/ES2353021T3/es active Active
- 2005-03-23 UA UAA200611101A patent/UA91189C2/ru unknown
- 2005-03-23 AU AU2005223612A patent/AU2005223612B2/en not_active Ceased
- 2005-03-23 PT PT05727581T patent/PT1732929E/pt unknown
- 2005-03-23 JP JP2006530022A patent/JP4840594B2/ja active Active
- 2005-03-23 US US10/590,975 patent/US7652008B2/en active Active
- 2005-03-23 NZ NZ549570A patent/NZ549570A/en unknown
- 2005-03-23 TW TW094108962A patent/TWI352704B/zh active
- 2005-03-23 ZA ZA200607388A patent/ZA200607388B/en unknown
- 2005-03-23 DK DK05727581.0T patent/DK1732929T3/da active
- 2005-03-23 PL PL05727581T patent/PL1732929T3/pl unknown
- 2005-03-23 CA CA2558139A patent/CA2558139C/en not_active Expired - Fee Related
- 2005-03-23 BR BRPI0508768-6A patent/BRPI0508768A/pt not_active Application Discontinuation
- 2005-03-23 WO PCT/JP2005/006004 patent/WO2005090357A1/en active Application Filing
- 2005-03-23 AT AT05727581T patent/ATE485299T1/de active
- 2005-03-23 CN CN2005800090295A patent/CN1934116B/zh active Active
- 2005-03-23 RS RS20110028A patent/RS51742B/en unknown
- 2005-03-23 CZ CZ20060598A patent/CZ2006598A3/cs unknown
- 2005-03-23 KR KR1020067021988A patent/KR101019402B1/ko active IP Right Grant
- 2005-03-23 KR KR1020107027058A patent/KR101085979B1/ko active IP Right Grant
- 2005-03-23 MX MXPA06010880A patent/MXPA06010880A/es active IP Right Grant
- 2005-03-23 SI SI200531171T patent/SI1732929T1/sl unknown
- 2005-03-23 CN CN2011100751168A patent/CN102190661B/zh not_active Expired - Fee Related
- 2005-03-23 NZ NZ585606A patent/NZ585606A/en unknown
- 2005-03-23 EP EP05727581A patent/EP1732929B1/en active Active
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2006
- 2006-09-02 EG EGNA2006000900 patent/EG27163A/xx active
- 2006-09-07 IL IL177950A patent/IL177950A/en not_active IP Right Cessation
- 2006-10-23 NO NO20064819A patent/NO339495B1/no not_active IP Right Cessation
-
2007
- 2007-06-15 HK HK07106502.1A patent/HK1099299A1/xx unknown
-
2009
- 2009-11-17 US US12/591,353 patent/US7964623B2/en not_active Expired - Fee Related
-
2010
- 2010-07-08 AU AU2010202900A patent/AU2010202900B2/en not_active Ceased
-
2011
- 2011-01-05 HR HR20110005T patent/HRP20110005T1/hr unknown
- 2011-01-19 CY CY20111100060T patent/CY1111250T1/el unknown
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