DE602005024245D1 - Tricyclische benzopyranverbindungen als antiarrhythmika - Google Patents

Tricyclische benzopyranverbindungen als antiarrhythmika

Info

Publication number
DE602005024245D1
DE602005024245D1 DE602005024245T DE602005024245T DE602005024245D1 DE 602005024245 D1 DE602005024245 D1 DE 602005024245D1 DE 602005024245 T DE602005024245 T DE 602005024245T DE 602005024245 T DE602005024245 T DE 602005024245T DE 602005024245 D1 DE602005024245 D1 DE 602005024245D1
Authority
DE
Germany
Prior art keywords
group
hydrogen atom
ring
atom
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005024245T
Other languages
English (en)
Inventor
Kazuhiko Ohrai
Yukihiro Shigeta
Osamu Uesugi
Takumi Okada
Tomoyuki Matsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Publication of DE602005024245D1 publication Critical patent/DE602005024245D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dental Preparations (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE602005024245T 2004-03-23 2005-03-23 Tricyclische benzopyranverbindungen als antiarrhythmika Active DE602005024245D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004084605 2004-03-23
PCT/JP2005/006004 WO2005090357A1 (en) 2004-03-23 2005-03-23 Tricyclic benzopyran compound as anti-arrhythmic agents

Publications (1)

Publication Number Publication Date
DE602005024245D1 true DE602005024245D1 (de) 2010-12-02

Family

ID=34962589

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005024245T Active DE602005024245D1 (de) 2004-03-23 2005-03-23 Tricyclische benzopyranverbindungen als antiarrhythmika

Country Status (31)

Country Link
US (2) US7652008B2 (de)
EP (1) EP1732929B1 (de)
JP (1) JP4840594B2 (de)
KR (2) KR101085979B1 (de)
CN (3) CN102190661B (de)
AT (1) ATE485299T1 (de)
AU (2) AU2005223612B2 (de)
BR (1) BRPI0508768A (de)
CA (1) CA2558139C (de)
CY (1) CY1111250T1 (de)
CZ (1) CZ2006598A3 (de)
DE (1) DE602005024245D1 (de)
DK (1) DK1732929T3 (de)
EG (1) EG27163A (de)
ES (1) ES2353021T3 (de)
HK (1) HK1099299A1 (de)
HR (1) HRP20110005T1 (de)
IL (1) IL177950A (de)
MX (1) MXPA06010880A (de)
NO (1) NO339495B1 (de)
NZ (2) NZ585606A (de)
PL (1) PL1732929T3 (de)
PT (1) PT1732929E (de)
RS (1) RS51742B (de)
RU (1) RU2380370C2 (de)
SI (1) SI1732929T1 (de)
SK (1) SK287994B6 (de)
TW (1) TWI352704B (de)
UA (1) UA91189C2 (de)
WO (1) WO2005090357A1 (de)
ZA (1) ZA200607388B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ585606A (en) * 2004-03-23 2011-11-25 Nissan Chemical Ind Ltd Tricyclic benzopyran compound as anti-arrhythmic agents
AU2007225765B2 (en) 2006-03-10 2012-05-24 Nissan Chemical Industries, Ltd. Process for producing optically active chromene oxide compound
WO2010018867A1 (ja) * 2008-08-14 2010-02-18 日産化学工業株式会社 ジ置換ベンゾピラン化合物
BRPI1007112A2 (pt) * 2009-04-30 2015-08-18 Nissan Chemical Ind Ltd Formas cristalinas a,b,e,f,g e h compostos triciclicos benzopirano e metodo para produçao das mesmas
PL2445502T5 (pl) 2009-06-25 2023-03-13 Alkermes Pharma Ireland Limited Związki heterocykliczne do leczenia zaburzeń neurologicznych i psychologicznych
JPWO2014051077A1 (ja) * 2012-09-27 2016-08-25 日産化学工業株式会社 高純度の含窒素複素環化合物の製造方法
CN104507948B (zh) * 2012-09-27 2017-05-03 日产化学工业株式会社 含氮杂环n‑氧化物化合物的制造方法
CN105377826A (zh) * 2013-07-25 2016-03-02 日产化学工业株式会社 杂环化合物的制造方法
CN110177796B (zh) * 2017-01-06 2022-04-08 阿斯克里斯有限公司 喹啉酮衍生物及其用于预防或治疗变应性疾病的药物组合物
CA3092335A1 (en) 2018-03-05 2019-09-12 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
CN108727261B (zh) * 2018-06-21 2021-09-24 济南大学 一种硝基取代喹那啶的制备方法
EP3903882A4 (de) * 2018-12-28 2022-09-21 Osaka University Therapeutisches mittel für vererbte bradyarrhythmie
RU2754610C1 (ru) * 2020-04-14 2021-09-03 Георгий Викторович ТЕЦ Препарат для лечения заболеваний, вызванных бактериями
JPWO2021261598A1 (de) * 2020-06-26 2021-12-30

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZM7682A1 (en) 1981-09-25 1983-05-23 Beecham Group Plc Active compounds
JPS5867683U (ja) 1981-10-28 1983-05-09 株式会社ナムコ 歩行ロボツト
JPH0699439B2 (ja) 1988-02-03 1994-12-07 日産化学工業株式会社 ピラノベンゾオキサジアゾール誘導体
JP2658198B2 (ja) 1988-06-23 1997-09-30 日産化学工業株式会社 ピラノベンゾトリアゾール誘導体
JP2876712B2 (ja) * 1989-07-17 1999-03-31 日産化学工業株式会社 光学活性ピラノベンゾオキサジアゾール誘導体
US5097037A (en) * 1989-07-17 1992-03-17 Nissan Chemical Industries, Ltd. Process for the optical resolution of pyranobenzoxadiazole compounds
US5164509A (en) * 1990-11-26 1992-11-17 E. R. Squibb & Sons, Inc. Benzodiazolo analogs
JPH07300414A (ja) * 1993-04-02 1995-11-14 Nissan Chem Ind Ltd 心不全治療薬
KR960700713A (ko) 1993-04-02 1996-02-24 도쿠시마 슈이치 심부전증 치료약(medicines for cardiac insufficiency)
JP2734457B2 (ja) 1994-02-23 1998-03-30 日産化学工業株式会社 不斉エポキシ化反応
US5843989A (en) 1994-06-10 1998-12-01 Smithkline Beecham P.L.C. C4 -amide substituted compounds and their use as therapeutic agents
ES2218617T3 (es) * 1996-05-15 2004-11-16 Aventis Pharma Deutschland Gmbh Cromanos sustituidos con sulfonamida, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico, asi como medicamentos que los contienen.
DE69921815T2 (de) 1998-06-03 2005-11-10 Nissan Chemical Industries, Ltd. Indanderivate
AU5444499A (en) 1998-09-01 2000-03-21 Nissan Chemical Industries Ltd. Benzoxazine derivatives
AU2830800A (en) 1999-03-25 2000-10-16 Nissan Chemical Industries Ltd. Chroman derivatives
EP1212314B1 (de) 1999-09-17 2005-11-30 Nissan Chemical Industries, Ltd. Benzopyran derivate
US6555574B1 (en) 1999-09-24 2003-04-29 Nissan Chemical Industries, Ltd. 4-oxybenzopyran derivative
EP1218367A1 (de) 1999-10-05 2002-07-03 Nissan Chemical Industries, Ltd. 4-oxobenzopyranderivate
TW589305B (en) 2001-02-14 2004-06-01 Nissan Chemical Ind Ltd 4-aminobenzopyran derivatives
DE60206505T2 (de) 2001-06-25 2006-07-06 Nissan Chemical Industries, Ltd. Substituierte benzopyranderivate gegen arrhytmie
WO2003014113A1 (en) 2001-08-06 2003-02-20 Glenmark Pharmaceuticals Limited Novel benzopyran compounds and process for their preparation and use
NZ585606A (en) * 2004-03-23 2011-11-25 Nissan Chemical Ind Ltd Tricyclic benzopyran compound as anti-arrhythmic agents

Also Published As

Publication number Publication date
PL1732929T3 (pl) 2011-04-29
UA91189C2 (en) 2010-07-12
CN101429200A (zh) 2009-05-13
MXPA06010880A (es) 2006-12-15
HK1099299A1 (en) 2007-08-10
IL177950A0 (en) 2006-12-31
SK287994B6 (sk) 2012-09-03
KR20070009638A (ko) 2007-01-18
JP4840594B2 (ja) 2011-12-21
US7964623B2 (en) 2011-06-21
SK50792006A3 (sk) 2007-09-06
AU2010202900A1 (en) 2010-07-29
EG27163A (en) 2015-08-24
CY1111250T1 (el) 2015-06-11
HRP20110005T1 (hr) 2011-02-28
US20100069374A1 (en) 2010-03-18
CN1934116B (zh) 2012-10-10
RS51742B (en) 2011-10-31
EP1732929B1 (de) 2010-10-20
NZ549570A (en) 2010-08-27
CA2558139A1 (en) 2005-09-29
TW200600509A (en) 2006-01-01
NZ585606A (en) 2011-11-25
CN102190661B (zh) 2013-07-31
KR101019402B1 (ko) 2011-03-07
KR20100130249A (ko) 2010-12-10
NO20064819L (no) 2006-10-23
JP2007530436A (ja) 2007-11-01
RU2006137284A (ru) 2008-04-27
RU2380370C2 (ru) 2010-01-27
AU2010202900B2 (en) 2011-10-27
NO339495B1 (no) 2016-12-19
TWI352704B (en) 2011-11-21
CN1934116A (zh) 2007-03-21
AU2005223612A1 (en) 2005-09-29
CN101429200B (zh) 2012-05-30
CZ2006598A3 (cs) 2006-11-15
ZA200607388B (en) 2008-07-30
CN102190661A (zh) 2011-09-21
WO2005090357A1 (en) 2005-09-29
AU2005223612B2 (en) 2010-06-24
ATE485299T1 (de) 2010-11-15
US20080004262A1 (en) 2008-01-03
KR101085979B1 (ko) 2011-11-22
CA2558139C (en) 2012-01-17
IL177950A (en) 2013-04-30
US7652008B2 (en) 2010-01-26
BRPI0508768A (pt) 2007-02-27
ES2353021T3 (es) 2011-02-24
PT1732929E (pt) 2010-12-21
EP1732929A1 (de) 2006-12-20
DK1732929T3 (da) 2010-12-20
SI1732929T1 (sl) 2010-12-31

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