AP9901532A0 - 2-Methoxyphenylpiperazine derivatives. - Google Patents

2-Methoxyphenylpiperazine derivatives.

Info

Publication number
AP9901532A0
AP9901532A0 APAP/P/1999/001532A AP9901532A AP9901532A0 AP 9901532 A0 AP9901532 A0 AP 9901532A0 AP 9901532 A AP9901532 A AP 9901532A AP 9901532 A0 AP9901532 A0 AP 9901532A0
Authority
AP
ARIPO
Prior art keywords
compounds
imidazo
relates
formula
disorders
Prior art date
Application number
APAP/P/1999/001532A
Inventor
Istvan Laszlovszky
Gyorgy Domany
Tibor Acs
Gyorgy Ferenczy
Csaba Szantay
Eszter Thuroczyne Kalman
Erzsebet Lapis
Ferenc Trischler
Bela Hegedus
Ferenc Auth
Monika Csejtei
Egon Karpati
Bela Kiss
Judit Laszy
Margit Pellioniszne Paroczai
Adam Sarkadi
Sandor SZAABO
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of AP9901532A0 publication Critical patent/AP9901532A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to novel fused heterocyclic compounds with ring junction nitrogen atom of formula (i), wherein q stands for 2-in-dolizinyl, 2-imidazo[1,2-a]pyridinyl, 2-imidazo[1,2-a]pyrimidinyl, 6-(2,3-dihydroimidazo[2,1-b]thiazol)-yl or 6-imidazo[2,1-b]thiazolyl group; and nis an integer ffom 2 to 4, as well as their therapeutically useful salts thereof. The invention further relates to pharmaceutical compositions containing these compounds as well as a process for the preparation of the above compounds and compositions. The novel compounds of formula (i)exhibit mainly antipsychotic effects so the invention relates also to a method of treatment of schizophrenia, organic mental disorders, affective disorders, anxiety and personality disorders.
APAP/P/1999/001532A 1996-10-30 1997-10-22 2-Methoxyphenylpiperazine derivatives. AP9901532A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9603001A HUP9603001A3 (en) 1996-10-30 1996-10-30 Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
PCT/HU1997/000069 WO1998018797A1 (en) 1996-10-30 1997-10-22 2-methoxyphenylpiperazine derivatives

Publications (1)

Publication Number Publication Date
AP9901532A0 true AP9901532A0 (en) 1999-06-30

Family

ID=89994394

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1999/001532A AP9901532A0 (en) 1996-10-30 1997-10-22 2-Methoxyphenylpiperazine derivatives.

Country Status (25)

Country Link
US (1) US6103724A (en)
EP (1) EP0935599A1 (en)
JP (1) JP2001503048A (en)
KR (1) KR20000052872A (en)
CN (1) CN1235606A (en)
AP (1) AP9901532A0 (en)
AR (1) AR010260A1 (en)
AU (1) AU4962097A (en)
BG (1) BG103370A (en)
BR (1) BR9712588A (en)
CA (1) CA2269814A1 (en)
CZ (1) CZ132099A3 (en)
EA (1) EA199900433A1 (en)
EE (1) EE9900182A (en)
HU (1) HUP9603001A3 (en)
IL (1) IL129418A0 (en)
IS (1) IS5026A (en)
NO (1) NO992059L (en)
OA (1) OA11041A (en)
PL (1) PL333076A1 (en)
SK (1) SK49499A3 (en)
TR (1) TR199900946T2 (en)
TW (1) TW406083B (en)
WO (1) WO1998018797A1 (en)
ZA (1) ZA979617B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7253165B2 (en) * 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
CA2383340C (en) * 1999-09-14 2010-06-15 Aventis Pharmaceuticals Inc. Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists
ATE254620T1 (en) * 1999-09-14 2003-12-15 Aventis Pharma Inc UNSUBSTITUTED ETHYL AND PROPYL DERIVATIVES OF PHENOXYTHIENOISOXAZOLES AS D4 ANTAGONISTS
US6908929B2 (en) 2000-03-31 2005-06-21 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
TW200811175A (en) * 2006-06-21 2008-03-01 Nihon Mediphysics Co Ltd Novel compound with affinity with amyloid
US20100249418A1 (en) * 2007-10-24 2010-09-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
TW200918101A (en) * 2007-10-26 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
US7964605B2 (en) * 2008-05-29 2011-06-21 Sk Holdings Co., Ltd. Phenyl piperazine compounds, pharmaceutical composition comprising the same, and use thereof
US7985752B2 (en) * 2008-05-29 2011-07-26 Sk Holdings Co., Ltd. Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof
CN106187873B (en) * 2016-07-25 2019-11-05 宜春学院 A kind of aryl amine alkyl oxygen class compound and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880824A (en) * 1987-09-21 1989-11-14 Ortho Pharmaceutical Corporation Phenyl and benzoyl substituted imidazo-fused heterocyclic calcium channel blockers
ES2126573T3 (en) * 1991-04-22 1999-04-01 Otsuka Pharma Co Ltd DERIVATIVE OF PYRAZOLE (1,5-A) PIRIMIDINE AND ANTI-INFLAMMATORY AGENT CONTAINING THIS DERIVATIVE.
US5486517A (en) * 1994-05-10 1996-01-23 Warner-Lambert Company Benzimidazoles and imidazopyridines as central nervous system agents
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases

Also Published As

Publication number Publication date
JP2001503048A (en) 2001-03-06
CA2269814A1 (en) 1998-05-07
TR199900946T2 (en) 1999-07-21
WO1998018797A1 (en) 1998-05-07
CN1235606A (en) 1999-11-17
IL129418A0 (en) 2000-02-17
HUP9603001A2 (en) 1998-07-28
PL333076A1 (en) 1999-11-08
CZ132099A3 (en) 1999-08-11
EP0935599A1 (en) 1999-08-18
EE9900182A (en) 1999-12-15
OA11041A (en) 2003-03-07
AR010260A1 (en) 2000-06-07
SK49499A3 (en) 2000-03-13
IS5026A (en) 1999-04-15
HUP9603001A3 (en) 1999-07-28
AU4962097A (en) 1998-05-22
EA199900433A1 (en) 1999-10-28
BG103370A (en) 2000-05-31
NO992059D0 (en) 1999-04-29
KR20000052872A (en) 2000-08-25
HU9603001D0 (en) 1996-12-30
US6103724A (en) 2000-08-15
BR9712588A (en) 1999-10-26
TW406083B (en) 2000-09-21
ZA979617B (en) 1998-05-21
NO992059L (en) 1999-04-29

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