HRP20020910B1 - DERIVATI ß-KARBOLINA KORISNI KAO INHIBITORI FOSFODIESTERAZE - Google Patents

DERIVATI ß-KARBOLINA KORISNI KAO INHIBITORI FOSFODIESTERAZE

Info

Publication number
HRP20020910B1
HRP20020910B1 HR20020910A HRP20020910A HRP20020910B1 HR P20020910 B1 HRP20020910 B1 HR P20020910B1 HR 20020910 A HR20020910 A HR 20020910A HR P20020910 A HRP20020910 A HR P20020910A HR P20020910 B1 HRP20020910 B1 HR P20020910B1
Authority
HR
Croatia
Prior art keywords
c8alkyl
group
optionally substituted
nhra
heteroaryl
Prior art date
Application number
HR20020910A
Other languages
English (en)
Croatian (hr)
Inventor
Sui Zhihua
J. Macielag Mark
Original Assignee
Ortho-Mcneil Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical filed Critical Ortho-Mcneil Pharmaceutical
Publication of HRP20020910A2 publication Critical patent/HRP20020910A2/hr
Publication of HRP20020910B1 publication Critical patent/HRP20020910B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HR20020910A 2000-05-17 2001-05-03 DERIVATI ß-KARBOLINA KORISNI KAO INHIBITORI FOSFODIESTERAZE HRP20020910B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20466700P 2000-05-17 2000-05-17
PCT/US2001/014357 WO2001087038A2 (en) 2000-05-17 2001-05-03 β-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE

Publications (2)

Publication Number Publication Date
HRP20020910A2 HRP20020910A2 (en) 2004-12-31
HRP20020910B1 true HRP20020910B1 (hr) 2011-02-28

Family

ID=22758909

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020910A HRP20020910B1 (hr) 2000-05-17 2001-05-03 DERIVATI ß-KARBOLINA KORISNI KAO INHIBITORI FOSFODIESTERAZE

Country Status (31)

Country Link
US (2) US6492358B2 (cs)
EP (1) EP1289985B1 (cs)
JP (1) JP5014551B2 (cs)
KR (1) KR20030031482A (cs)
CN (1) CN1255403C (cs)
AR (1) AR028576A1 (cs)
AT (1) ATE256127T1 (cs)
AU (2) AU2001261167B2 (cs)
BG (1) BG66141B1 (cs)
CA (1) CA2409715C (cs)
CZ (1) CZ20023934A3 (cs)
DE (1) DE60101479T2 (cs)
DK (1) DK1289985T3 (cs)
ES (1) ES2211806T3 (cs)
GE (1) GEP20053511B (cs)
HR (1) HRP20020910B1 (cs)
HU (1) HUP0302412A3 (cs)
IL (2) IL152873A0 (cs)
MX (1) MXPA02011426A (cs)
MY (1) MY128479A (cs)
NO (1) NO324251B1 (cs)
NZ (1) NZ522731A (cs)
PL (1) PL205507B1 (cs)
PT (1) PT1289985E (cs)
RU (1) RU2271358C2 (cs)
SK (1) SK16972002A3 (cs)
TR (1) TR200302309T4 (cs)
TW (1) TWI286553B (cs)
UA (1) UA74826C2 (cs)
WO (1) WO2001087038A2 (cs)
ZA (1) ZA200210111B (cs)

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JP4223285B2 (ja) * 2001-02-12 2009-02-12 リリー アイコス リミテッド ライアビリティ カンパニー 化合物
JP4220779B2 (ja) * 2001-02-12 2009-02-04 リリー アイコス リミテッド ライアビリティ カンパニー 化学化合物
ES2278956T3 (es) * 2001-04-25 2007-08-16 Lilly Icos Llc Derivados de carbolina como inhibidores de fosfodiesterasa 5 (pde5) para el tratamiento de enfermedades cardiovasculares y de la disfuncion erectil.
WO2002098875A1 (en) * 2001-06-05 2002-12-12 Lilly Icos Llc Carboline derivatives as pde-5 inhibitors
WO2003000691A1 (en) * 2001-06-21 2003-01-03 Lilly Icos Llc Carboline derivatives as pdev inhibitors
WO2003042213A1 (en) 2001-11-14 2003-05-22 Ortho-Mcneil Pharmaceutical Corporation Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors
HRP20040793A2 (en) * 2002-02-07 2006-10-31 Gtx Inc. Treating benign prostate hyperplasia with sarms
AU2003243640A1 (en) * 2002-06-19 2004-01-06 Janssen Pharmaceutica, N.V. Substituted 2,4-dihydro-pyrrolo (3,4-b) -quinolin-9-one derivatives useful as phosphodiesterase inhibitors
US7872133B2 (en) * 2003-06-23 2011-01-18 Ono Pharmaceutical Co., Ltd. Tricyclic heterocycle compound
JP2007518822A (ja) 2004-01-23 2007-07-12 カイロン コーポレイション 抗癌剤としてのテトラヒドロカルボリン化合物
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
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AU2008276568A1 (en) * 2007-07-19 2009-01-22 Merck & Co., Inc. Beta carboline derivatives as antidiabetic compounds
JP2011505373A (ja) 2007-11-30 2011-02-24 ビオタ サイエンティフィック マネージメント ピーティーワイ リミテッド 抗菌剤としての２環式ｐｐａｔ阻害剤
CN101945872B (zh) 2008-01-11 2014-07-23 阿尔巴尼分子研究公司 作为mch拮抗剂的(1-吖嗪酮)-取代的吡啶并吲哚
US8338447B2 (en) 2008-03-24 2012-12-25 Medivation Technologies, Inc. Pyrido[3,4-B]indoles and methods of use
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WO2021046194A1 (en) * 2019-09-03 2021-03-11 The Regents Of The University Of Colorado A Body Corporate Tryptoline-based benzothiazoles and their use as antibiotics and antibiotic resistance-modifying agents
EP4011877A3 (en) * 2020-12-11 2023-01-11 Institut de Cardiologie de Montréal Method of treating elevated plasma cholesterol
JP2024502270A (ja) 2020-12-23 2024-01-18 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー エストロゲン受容体調節薬
CN119462646A (zh) * 2024-11-07 2025-02-18 江苏科技大学 一种取代的四氢-β-咔啉衍生物、其合成方法及其用途

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Also Published As

Publication number Publication date
BG66141B1 (bg) 2011-07-29
US6864253B2 (en) 2005-03-08
UA74826C2 (en) 2006-02-15
CA2409715A1 (en) 2001-11-22
JP5014551B2 (ja) 2012-08-29
HUP0302412A3 (en) 2007-02-28
US20020010189A1 (en) 2002-01-24
EP1289985B1 (en) 2003-12-10
BG107285A (bg) 2003-07-31
ES2211806T3 (es) 2004-07-16
CZ20023934A3 (cs) 2003-10-15
IL152873A0 (en) 2003-06-24
CA2409715C (en) 2010-09-14
DE60101479D1 (en) 2004-01-22
DK1289985T3 (da) 2004-04-05
JP2003533453A (ja) 2003-11-11
SK16972002A3 (sk) 2003-11-04
MY128479A (en) 2007-02-28
EP1289985A2 (en) 2003-03-12
NO20025527D0 (no) 2002-11-18
TR200302309T4 (tr) 2004-02-23
CN1446217A (zh) 2003-10-01
WO2001087038A2 (en) 2001-11-22
HUP0302412A2 (hu) 2003-11-28
TWI286553B (en) 2007-09-11
ATE256127T1 (de) 2003-12-15
NO20025527L (no) 2003-01-16
DE60101479T2 (de) 2005-04-28
HK1051368A1 (en) 2003-08-01
PL365445A1 (en) 2005-01-10
PT1289985E (pt) 2004-03-31
AR028576A1 (es) 2003-05-14
WO2001087038A3 (en) 2002-05-16
HRP20020910A2 (en) 2004-12-31
GEP20053511B (en) 2005-05-10
MXPA02011426A (es) 2004-09-06
CN1255403C (zh) 2006-05-10
US20030166641A1 (en) 2003-09-04
NZ522731A (en) 2004-09-24
ZA200210111B (en) 2004-03-12
AU6116701A (en) 2001-11-26
RU2271358C2 (ru) 2006-03-10
PL205507B1 (pl) 2010-04-30
KR20030031482A (ko) 2003-04-21
NO324251B1 (no) 2007-09-17
AU2001261167B2 (en) 2006-10-05
US6492358B2 (en) 2002-12-10
IL152873A (en) 2012-01-31

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