BR112012031580A2 - derivado de tetra-hidrocarbolina - Google Patents

derivado de tetra-hidrocarbolina

Info

Publication number
BR112012031580A2
BR112012031580A2 BR112012031580A BR112012031580A BR112012031580A2 BR 112012031580 A2 BR112012031580 A2 BR 112012031580A2 BR 112012031580 A BR112012031580 A BR 112012031580A BR 112012031580 A BR112012031580 A BR 112012031580A BR 112012031580 A2 BR112012031580 A2 BR 112012031580A2
Authority
BR
Brazil
Prior art keywords
drug
enpp2
inhibitory activity
present
excretion disorder
Prior art date
Application number
BR112012031580A
Other languages
English (en)
Inventor
Akira Ohata
Shingo Nakatani
Takashi Morimoto
Tetsuya Sugiyama
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of BR112012031580A2 publication Critical patent/BR112012031580A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

derivado de tetra-hidrocarbolina. um objetivo da presente invenção é fornecer um fármaco tendo a atividade inibitória de enpp2 que é um alvo diferente daquele entre o fármaco existente, como um medicamento útil em um paciente com transtorno de excreção uirinária para quem o fármaco existente tem o efeito insuficiente. a presente invenção fornece um composto represntado pela fórmula geral (i): em que a definição de cada grupo é definida na descrição tendo a atividade inibitória de enpp2, um sal do mesmo ou um solvato do mesmo ou um pró-fármaco do mesmo, e um agente para prevenir ou tratar o transtorno de excreção urinária e/ou melhorar os sintomas do mesmo, contendo o mesmo como um ingrediente ativo.
BR112012031580A 2010-07-06 2011-07-05 derivado de tetra-hidrocarbolina BR112012031580A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010154280 2010-07-06
JP2011060765 2011-03-18
PCT/JP2011/065312 WO2012005227A1 (ja) 2010-07-06 2011-07-05 テトラヒドロカルボリン誘導体

Publications (1)

Publication Number Publication Date
BR112012031580A2 true BR112012031580A2 (pt) 2016-11-08

Family

ID=45441206

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012031580A BR112012031580A2 (pt) 2010-07-06 2011-07-05 derivado de tetra-hidrocarbolina

Country Status (21)

Country Link
US (3) US9006246B2 (pt)
EP (2) EP2592081B1 (pt)
JP (2) JP5821848B2 (pt)
KR (1) KR101831005B1 (pt)
CN (1) CN102971318B (pt)
AU (1) AU2011274970C1 (pt)
BR (1) BR112012031580A2 (pt)
CA (1) CA2802216C (pt)
DK (1) DK2592081T3 (pt)
ES (2) ES2693247T3 (pt)
IL (1) IL223028A0 (pt)
MX (1) MX2012015279A (pt)
MY (1) MY161001A (pt)
NZ (1) NZ603575A (pt)
PL (1) PL2592081T3 (pt)
PT (1) PT2592081T (pt)
RU (1) RU2572818C2 (pt)
SG (1) SG186826A1 (pt)
TW (2) TWI586666B (pt)
WO (1) WO2012005227A1 (pt)
ZA (1) ZA201300032B (pt)

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EP2592081B1 (en) 2010-07-06 2017-03-08 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
ES2587856T3 (es) * 2011-03-18 2016-10-27 Ono Pharmaceutical Co., Ltd. Derivado de tetrahidrocarbolina
WO2015002755A2 (en) * 2013-06-21 2015-01-08 The Broad Institute, Inc. Compounds for the treatment of malaria
WO2015163435A1 (ja) 2014-04-24 2015-10-29 田辺三菱製薬株式会社 新規２－アミノ－ピリジン及び２－アミノ－ピリミジン誘導体及びその医薬用途
TW201613917A (en) 2014-06-06 2016-04-16 Biogen Ma Inc ATX modulating agents
GB201501870D0 (en) 2015-02-04 2015-03-18 Cancer Rec Tech Ltd Autotaxin inhibitors
GB201502020D0 (en) 2015-02-06 2015-03-25 Cancer Rec Tech Ltd Autotaxin inhibitory compounds
US10118904B2 (en) 2015-06-05 2018-11-06 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of Demyelinating Diseases
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
CN110483424A (zh) * 2018-06-11 2019-11-22 上海睿升化工科技有限公司 一种1-h-1,2,3-三氮唑-4-羧酸叔丁酯的制备方法
BR112020027051A2 (pt) 2018-07-27 2021-03-30 Mitsubishi Tanabe Pharma Corporation Derivados de piridina 3,5-dissubstituída e piridazina 3,5-dissubstituída e uso farmacêutico dos mesmos
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers
CN111272918A (zh) * 2020-03-31 2020-06-12 广西-东盟食品检验检测中心 一种那非类医药中间体的高效液相色谱-质谱检测方法
CN111454260B (zh) * 2020-05-25 2023-02-28 贵州大学 一类含异丙醇胺亚结构的1，2，3，4-四氢-β-咔啉类化合物及其制备方法和应用
WO2024053650A1 (ja) * 2022-09-06 2024-03-14 小野薬品工業株式会社 ジアシルグリセロールキナーゼαおよび／またはζ阻害活性を有する化合物およびその医薬用途
CN115728428A (zh) * 2022-11-15 2023-03-03 山东省医药工业设计院有限公司 一种他达拉非中间体顺式四氢咔啉盐酸盐有关物质的测定方法

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CA2554150A1 (en) 2004-01-23 2005-08-04 Chiron Corporation Tetrahydrocarboline compounds as anticancer agents
BRPI0509660A (pt) 2004-04-09 2007-10-09 Millennium Pharm Inc compostos de beta-carbolina de utilidade no tratamento de doenças inflamatórias
ES2459742T3 (es) * 2004-12-22 2014-05-12 Ono Pharmaceutical Co., Ltd. Compuesto tricíclico y uso del mismo
JP2008297278A (ja) 2007-06-01 2008-12-11 Astellas Pharma Inc Ｌｐａ受容体アゴニスト
EP2592081B1 (en) 2010-07-06 2017-03-08 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
ES2587856T3 (es) 2011-03-18 2016-10-27 Ono Pharmaceutical Co., Ltd. Derivado de tetrahidrocarbolina

Also Published As

Publication number Publication date
RU2572818C2 (ru) 2016-01-20
US9636330B2 (en) 2017-05-02
KR20130098269A (ko) 2013-09-04
JP5821848B2 (ja) 2015-11-24
EP2592081A1 (en) 2013-05-15
TW201215611A (en) 2012-04-16
AU2011274970C1 (en) 2015-07-30
IL223028A0 (en) 2013-02-03
TWI525092B (zh) 2016-03-11
TWI586666B (zh) 2017-06-11
MX2012015279A (es) 2013-04-29
ES2693247T3 (es) 2018-12-10
US9974777B2 (en) 2018-05-22
US20150231118A1 (en) 2015-08-20
RU2013104866A (ru) 2014-08-20
CN102971318A (zh) 2013-03-13
JP6065052B2 (ja) 2017-01-25
KR101831005B1 (ko) 2018-02-21
CA2802216C (en) 2018-12-11
US20130109699A1 (en) 2013-05-02
ZA201300032B (en) 2013-09-25
MY161001A (en) 2017-03-31
PT2592081T (pt) 2017-05-03
CN102971318B (zh) 2015-11-25
NZ603575A (en) 2014-03-28
CA2802216A1 (en) 2012-01-12
TW201623306A (zh) 2016-07-01
DK2592081T3 (en) 2017-06-06
AU2011274970A1 (en) 2013-01-24
EP2592081B1 (en) 2017-03-08
PL2592081T3 (pl) 2017-07-31
WO2012005227A1 (ja) 2012-01-12
SG186826A1 (en) 2013-02-28
JPWO2012005227A1 (ja) 2013-09-02
EP2592081A4 (en) 2014-05-07
US9006246B2 (en) 2015-04-14
ES2623286T3 (es) 2017-07-10
JP2015214544A (ja) 2015-12-03
AU2011274970B2 (en) 2015-03-05
EP3002285B1 (en) 2018-08-29
EP3002285A1 (en) 2016-04-06
US20170189386A1 (en) 2017-07-06

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