HRP20000415B1 - Kappa receptor opioid peptides - Google Patents

Kappa receptor opioid peptides

Info

Publication number
HRP20000415B1
HRP20000415B1 HR20000415A HRP20000415A HRP20000415B1 HR P20000415 B1 HRP20000415 B1 HR P20000415B1 HR 20000415 A HR20000415 A HR 20000415A HR P20000415 A HRP20000415 A HR P20000415A HR P20000415 B1 HRP20000415 B1 HR P20000415B1
Authority
HR
Croatia
Prior art keywords
opioid peptides
kappa receptor
receptor opioid
kappa
peptides
Prior art date
Application number
HR20000415A
Other languages
English (en)
Inventor
Junien Jean Louis
Pierre J M Riviere
Claudio D Schteingart
Javier Sueiras Diaz
Jerzy A Trojnar
Todd W Vanderah
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of HRP20000415A2 publication Critical patent/HRP20000415A2/hr
Publication of HRP20000415B1 publication Critical patent/HRP20000415B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20000415A 1997-12-23 2000-06-20 Kappa receptor opioid peptides HRP20000415B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides
PCT/US1998/027282 WO1999032510A1 (en) 1997-12-23 1998-12-22 Kappa receptor opioid peptides

Publications (2)

Publication Number Publication Date
HRP20000415A2 HRP20000415A2 (en) 2000-12-31
HRP20000415B1 true HRP20000415B1 (en) 2004-06-30

Family

ID=25543752

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000415A HRP20000415B1 (en) 1997-12-23 2000-06-20 Kappa receptor opioid peptides

Country Status (33)

Country Link
US (1) US5965701A (cs)
EP (1) EP1042359B1 (cs)
JP (1) JP4275852B2 (cs)
KR (1) KR100629548B1 (cs)
CN (1) CN1154655C (cs)
AR (1) AR014167A1 (cs)
AT (1) ATE301670T1 (cs)
AU (1) AU747806B2 (cs)
BR (2) BR9814499B1 (cs)
CA (1) CA2315878C (cs)
CR (1) CR5936A (cs)
CZ (1) CZ297281B6 (cs)
DE (1) DE69831176T2 (cs)
DK (1) DK1042359T3 (cs)
EE (1) EE04440B1 (cs)
ES (1) ES2247735T3 (cs)
HK (1) HK1029349A1 (cs)
HR (1) HRP20000415B1 (cs)
HU (1) HU227640B1 (cs)
IL (3) IL136742A0 (cs)
MY (1) MY117542A (cs)
NO (1) NO327080B1 (cs)
NZ (1) NZ505183A (cs)
PL (1) PL195842B1 (cs)
PT (1) PT1042359E (cs)
RU (1) RU2217437C2 (cs)
SK (1) SK286135B6 (cs)
TR (1) TR200001985T2 (cs)
TW (1) TW580502B (cs)
UA (1) UA68366C2 (cs)
UY (1) UY25327A1 (cs)
WO (1) WO1999032510A1 (cs)
ZA (1) ZA9811801B (cs)

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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
AU1623801A (en) * 1999-11-19 2001-05-30 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
DE10116978A1 (de) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
CA2451133C (en) * 2001-05-08 2012-09-18 Toray Industries, Inc. Therapeutic agent for sepsis
SI1494732T1 (sl) 2002-03-20 2008-08-31 Mannking Corp Inhalacijski aparat
JP5078014B2 (ja) 2004-08-20 2012-11-21 マンカインド コーポレイション ジケトピペラジン合成の触媒反応
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
EP1928423B1 (en) 2005-09-14 2015-12-09 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US20100029575A1 (en) * 2006-05-26 2010-02-04 Jean-Louis Junien N-Oxides of Kappa Receptor Peptides
CN101454017A (zh) * 2006-05-26 2009-06-10 卡拉治疗学股份有限公司 提升哺乳动物催乳素的方法
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
CN101627049B (zh) * 2006-11-10 2012-09-05 卡拉治疗学股份有限公司 合成酞酰胺
US7842662B2 (en) * 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
KR101558026B1 (ko) 2008-06-13 2015-10-06 맨카인드 코포레이션 건조 분말 흡입기 및 약물 투여 시스템
CA2728523C (en) 2008-06-20 2020-03-10 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
EP2440184B1 (en) 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazine microparticles with defined specific surface areas
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
CA2801936C (en) 2010-06-21 2021-06-01 Mannkind Corporation Dry powder drug delivery system and methods
KR101940832B1 (ko) 2011-04-01 2019-01-21 맨카인드 코포레이션 의약 카트리지용 블리스터 패키지
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2776053A1 (en) 2011-10-24 2014-09-17 MannKind Corporation Methods and compositions for treating pain
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
WO2014144895A1 (en) 2013-03-15 2014-09-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
RU2664545C2 (ru) * 2014-06-26 2018-08-20 Маруиси Фармасьютикал Ко., Лтд. Способ получения синтетического пентапептида
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2016181408A2 (en) 2015-05-11 2016-11-17 Cadila Healthcare Limited NOVEL SHORT-CHAIN PEPTIDES AS KAPPA (κ) OPIOID RECEPTORS (KOR) AGONIST
CN107098876B (zh) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
EP3521301B1 (en) * 2016-09-27 2024-03-06 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Polyamide compound and use thereof
MY200925A (en) * 2017-07-21 2024-01-24 Sichuan Haisco Pharmaceutical Co Ltd Peptide Amide Compound and Preparation Method and Medical use Thereof
MX2020005932A (es) 2017-12-06 2020-08-24 Jiangsu Hengrui Medicine Co Sal de derivado de fenilpropionamida y su metodo de preparacion.
CA3095966A1 (en) 2018-05-16 2019-11-21 Jiangsu Hengrui Medicine Co., Ltd. Pharmaceutical composition of kor receptor agonist
WO2021013086A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 氘代肽酰胺类化合物及其制备方法和在医药上的用途
CN114127085A (zh) * 2019-07-25 2022-03-01 四川海思科制药有限公司 一种肽酰胺盐及其制备方法和在医药上的用途
US20210040150A1 (en) * 2019-08-07 2021-02-11 Humanwell Pharmaceutical US Kappa opioid receptor peptide amide agonists
CA3180729A1 (en) 2020-06-25 2021-12-30 Subo Liao Peptides for treatment of medical disorders
TW202317533A (zh) 2021-07-02 2023-05-01 美商雅斯治療公司 奧沙奈坦(osanetant)之固體形式

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US5367053A (en) * 1993-05-19 1994-11-22 Houghten Pharmaceuticals, Inc. Opioid peptide inhibitors
US5610271A (en) * 1995-06-07 1997-03-11 Torrey Pines Institute For Molecular Studies Kappa receptor selective opioid peptides

Also Published As

Publication number Publication date
KR100629548B1 (ko) 2006-09-27
EE04440B1 (et) 2005-02-15
UA68366C2 (en) 2004-08-16
NZ505183A (en) 2001-09-28
DE69831176T2 (de) 2006-04-20
CZ297281B6 (cs) 2006-10-11
SK9602000A3 (en) 2001-01-18
SK286135B6 (sk) 2008-04-07
DE69831176D1 (de) 2005-09-15
PL341308A1 (en) 2001-04-09
CN1283201A (zh) 2001-02-07
KR20010033450A (ko) 2001-04-25
RU2217437C2 (ru) 2003-11-27
ZA9811801B (en) 1999-06-22
HUP0100626A2 (hu) 2001-08-28
PT1042359E (pt) 2005-11-30
DK1042359T3 (da) 2005-11-28
EP1042359A1 (en) 2000-10-11
NO20003245D0 (no) 2000-06-21
ATE301670T1 (de) 2005-08-15
UY25327A1 (es) 2000-12-29
EP1042359B1 (en) 2005-08-10
BRPI9814499A (pt) 2000-10-10
WO1999032510A1 (en) 1999-07-01
BR9814499B1 (pt) 2014-10-21
JP2001526295A (ja) 2001-12-18
ES2247735T3 (es) 2006-03-01
CR5936A (es) 2006-08-18
PL195842B1 (pl) 2007-10-31
IL136742A (en) 2006-12-31
MY117542A (en) 2004-07-31
CA2315878C (en) 2010-11-16
CA2315878A1 (en) 1999-07-01
EE200000370A (et) 2001-10-15
TW580502B (en) 2004-03-21
CZ20002382A3 (cs) 2000-12-13
US5965701A (en) 1999-10-12
HU227640B1 (en) 2011-10-28
AU747806B2 (en) 2002-05-23
BR9814499A (pt) 2000-10-10
HRP20000415A2 (en) 2000-12-31
JP4275852B2 (ja) 2009-06-10
IL136742A0 (en) 2001-06-14
AR014167A1 (es) 2001-02-07
HK1029349A1 (en) 2001-03-30
WO1999032510A9 (en) 1999-09-23
NO20003245L (no) 2000-08-23
HUP0100626A3 (en) 2001-12-28
CN1154655C (zh) 2004-06-23
BRPI9814499B1 (pt) 2014-10-21
BRPI9814499B8 (pt) 2021-11-09
AU1940299A (en) 1999-07-12
IL178471A0 (en) 2007-02-11
NO327080B1 (no) 2009-04-20
TR200001985T2 (tr) 2000-11-21

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B1PR Patent granted
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Owner name: CARA THERAPEUTICS, INC., US

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Payment date: 20111213

Year of fee payment: 14

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Effective date: 20121223