HK1048817B - Hiv replication inhibiting pyrimidines - Google Patents

Hiv replication inhibiting pyrimidines Download PDF

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Publication number
HK1048817B
HK1048817B HK03101063.7A HK03101063A HK1048817B HK 1048817 B HK1048817 B HK 1048817B HK 03101063 A HK03101063 A HK 03101063A HK 1048817 B HK1048817 B HK 1048817B
Authority
HK
Hong Kong
Prior art keywords
alkyl
amino
substituted
cyano
formula
Prior art date
Application number
HK03101063.7A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1048817A1 (en
Inventor
Bart De Cort
Marc Rene De Jonge
Jan Heeres
Chih Yung Ho
Paul Andriaan Jan Janssen
Robert W. Kavash
Lucien Maria Henricus Koymans
Michael Joseph Kukla
Donald William Ludovici
Koen Jeanne Alfons Van Aken
Koenraad Jozef Lodewijk Marcel Andries
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26805159&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1048817(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1048817A1 publication Critical patent/HK1048817A1/en
Publication of HK1048817B publication Critical patent/HK1048817B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK03101063.7A 1998-11-10 2003-02-14 Hiv replication inhibiting pyrimidines HK1048817B (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10779298P 1998-11-10 1998-11-10
US107792P 1998-11-10
US14396299P 1999-07-15 1999-07-15
US143962P 1999-07-15
WOPCT/EP99/07417 1999-09-24
PCT/EP1999/007417 WO2000027825A1 (en) 1998-11-10 1999-09-24 Hiv replication inhibiting pyrimidines

Publications (2)

Publication Number Publication Date
HK1048817A1 HK1048817A1 (en) 2003-04-17
HK1048817B true HK1048817B (en) 2010-04-09

Family

ID=26805159

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03101063.7A HK1048817B (en) 1998-11-10 2003-02-14 Hiv replication inhibiting pyrimidines

Country Status (41)

Country Link
US (5) US6878717B2 (enExample)
EP (2) EP1002795B1 (enExample)
JP (1) JP3635238B2 (enExample)
KR (1) KR100658489B1 (enExample)
CN (1) CN1214013C (enExample)
AP (1) AP1683A (enExample)
AR (1) AR024227A1 (enExample)
AT (2) ATE455107T1 (enExample)
AU (2) AU762523C (enExample)
BG (1) BG65103B1 (enExample)
BR (1) BRPI9915552B8 (enExample)
CA (1) CA2350801C (enExample)
CY (1) CY2008021I2 (enExample)
CZ (1) CZ301367B6 (enExample)
DE (3) DE69941934D1 (enExample)
DK (1) DK1002795T3 (enExample)
EA (1) EA004049B1 (enExample)
EE (1) EE05086B1 (enExample)
ES (2) ES2193664T3 (enExample)
FR (1) FR09C0004I2 (enExample)
HK (1) HK1048817B (enExample)
HR (2) HRP20080359B1 (enExample)
HU (2) HU227453B1 (enExample)
ID (1) ID28376A (enExample)
IL (2) IL143023A0 (enExample)
LT (1) LTC1002795I2 (enExample)
LU (1) LU91528I2 (enExample)
MY (1) MY121108A (enExample)
NL (1) NL300373I2 (enExample)
NO (3) NO318801B1 (enExample)
NZ (1) NZ511116A (enExample)
OA (1) OA11674A (enExample)
PL (1) PL204427B1 (enExample)
PT (1) PT1002795E (enExample)
SI (1) SI1002795T1 (enExample)
SK (2) SK287269B6 (enExample)
TR (1) TR200101306T2 (enExample)
TW (1) TWI238161B (enExample)
UA (1) UA70966C2 (enExample)
WO (1) WO2000027825A1 (enExample)
ZA (1) ZA200103769B (enExample)

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