HK1041262B - 吲衍生物 - Google Patents

吲衍生物 Download PDF

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Publication number
HK1041262B
HK1041262B HK02102830.8A HK02102830A HK1041262B HK 1041262 B HK1041262 B HK 1041262B HK 02102830 A HK02102830 A HK 02102830A HK 1041262 B HK1041262 B HK 1041262B
Authority
HK
Hong Kong
Prior art keywords
indol
palladium
ylmethyl
reaction
mixture
Prior art date
Application number
HK02102830.8A
Other languages
English (en)
Chinese (zh)
Other versions
HK1041262A1 (en
Inventor
Y. Chen Cheng
D. Larsen Robert
R. Verhoeven Thomas
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of HK1041262A1 publication Critical patent/HK1041262A1/xx
Publication of HK1041262B publication Critical patent/HK1041262B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Inorganic Insulating Materials (AREA)
HK02102830.8A 1994-05-24 2002-04-15 吲衍生物 HK1041262B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US248,288 1994-05-24
US08/248,288 US5567824A (en) 1994-05-24 1994-05-24 Palladium catalyzed ring closure of triazolyltryptamine

Publications (2)

Publication Number Publication Date
HK1041262A1 HK1041262A1 (en) 2002-07-05
HK1041262B true HK1041262B (zh) 2005-04-15

Family

ID=22938473

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02102830.8A HK1041262B (zh) 1994-05-24 2002-04-15 吲衍生物

Country Status (24)

Country Link
US (1) US5567824A (cg-RX-API-DMAC10.html)
EP (1) EP0763032B1 (cg-RX-API-DMAC10.html)
JP (1) JP3947216B2 (cg-RX-API-DMAC10.html)
KR (1) KR100385027B1 (cg-RX-API-DMAC10.html)
CN (2) CN1157390C (cg-RX-API-DMAC10.html)
AT (1) ATE252095T1 (cg-RX-API-DMAC10.html)
AU (1) AU688505B2 (cg-RX-API-DMAC10.html)
DE (1) DE69531939T2 (cg-RX-API-DMAC10.html)
DK (1) DK0763032T3 (cg-RX-API-DMAC10.html)
ES (1) ES2207648T3 (cg-RX-API-DMAC10.html)
FI (1) FI116899B (cg-RX-API-DMAC10.html)
HK (1) HK1041262B (cg-RX-API-DMAC10.html)
HR (1) HRP950304B1 (cg-RX-API-DMAC10.html)
HU (1) HU226460B1 (cg-RX-API-DMAC10.html)
MX (1) MX9605838A (cg-RX-API-DMAC10.html)
NZ (1) NZ285539A (cg-RX-API-DMAC10.html)
PT (1) PT763032E (cg-RX-API-DMAC10.html)
RO (1) RO118586B1 (cg-RX-API-DMAC10.html)
RU (1) RU2138496C1 (cg-RX-API-DMAC10.html)
SK (1) SK284495B6 (cg-RX-API-DMAC10.html)
TW (1) TW300221B (cg-RX-API-DMAC10.html)
UA (1) UA52586C2 (cg-RX-API-DMAC10.html)
WO (1) WO1995032197A1 (cg-RX-API-DMAC10.html)
YU (1) YU49345B (cg-RX-API-DMAC10.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA965837B (en) * 1995-07-11 1997-01-31 Merck & Co Inc A triazolylmethyl-indole ethylamine bisulfate salt
ES2163032T3 (es) * 1995-07-11 2002-01-16 Merck & Co Inc Sal bisulfato de triazolilmetil-indol etilamina.
CZ48299A3 (cs) * 1996-08-13 1999-07-14 Merck & Co., Inc. Způsob výroby indolových derivátů
US5877329A (en) * 1996-08-13 1999-03-02 Merck & Co., Inc. Palladium catalyzed indolization
US5811551A (en) * 1996-08-13 1998-09-22 Merck & Co., Inc. Palladium catalyzed indolization
US5808064A (en) * 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
JP2003503403A (ja) * 1999-06-28 2003-01-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 呼吸合胞体ウイルス複製阻害剤
ES2204303B2 (es) * 2002-08-07 2004-12-16 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
CA2552663A1 (en) 2004-01-09 2005-07-28 Ratiopharm Gmbh Crystalline forms of rizatriptan benzoate
ES2340861T3 (es) * 2004-01-28 2010-06-10 Ratiopharm Gmbh Procedimientos de sintesis e intermedios para la fabricacion de rizatriptan.
GT200500065A (es) * 2004-03-26 2005-10-24 Procedimientos para la preparacion de compuestos aminoarilos yodados
WO2006082598A2 (en) * 2005-02-01 2006-08-10 Natco Pharma Limited Novel crystalline forms of rizatriptan benzoate
WO2006137083A1 (en) * 2005-06-20 2006-12-28 Natco Pharma Limited Improved process for the preparation of rizatriptan benzoate
EP1951713A1 (en) * 2005-11-14 2008-08-06 Matrix Laboratories Ltd Process for the large scale production of rizatriptan benzoate
WO2007083320A2 (en) * 2006-01-19 2007-07-26 Matrix Laboratories Ltd Conversion of aromatic diazonium salt to aryl hydrazine
EP2160390A1 (en) * 2007-06-04 2010-03-10 Generics Ýuk¨Limited Novel process
CN108697637A (zh) 2016-01-27 2018-10-23 因斯塔尔科技股份公司 用于治疗性处理的口腔粘膜纳米纤维载体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
GB9215526D0 (en) * 1992-07-22 1992-09-02 Merck Sharp & Dohme Chemical process

Also Published As

Publication number Publication date
FI964669A0 (fi) 1996-11-22
MX9605838A (es) 1997-12-31
TW300221B (cg-RX-API-DMAC10.html) 1997-03-11
HU226460B1 (en) 2008-12-29
AU2467195A (en) 1995-12-18
RO118586B1 (ro) 2003-07-30
HUT76469A (en) 1997-09-29
CN1322725A (zh) 2001-11-21
SK149896A3 (en) 1997-09-10
EP0763032B1 (en) 2003-10-15
CN1152920A (zh) 1997-06-25
KR970703336A (ko) 1997-07-03
YU49345B (sh) 2005-07-19
DK0763032T3 (da) 2004-02-09
PT763032E (pt) 2004-02-27
HK1009045A1 (en) 1999-05-21
US5567824A (en) 1996-10-22
RU2138496C1 (ru) 1999-09-27
UA52586C2 (uk) 2003-01-15
NZ285539A (en) 1998-06-26
HRP950304B1 (en) 2004-12-31
CN1157390C (zh) 2004-07-14
ES2207648T3 (es) 2004-06-01
FI964669L (fi) 1996-11-22
EP0763032A1 (en) 1997-03-19
SK284495B6 (sk) 2005-05-05
CN1077104C (zh) 2002-01-02
DE69531939T2 (de) 2004-07-29
JP3947216B2 (ja) 2007-07-18
HU9603236D0 (en) 1997-01-28
KR100385027B1 (ko) 2003-08-14
YU33495A (sh) 1998-07-10
DE69531939D1 (de) 2003-11-20
JPH10500680A (ja) 1998-01-20
WO1995032197A1 (en) 1995-11-30
FI116899B (fi) 2006-03-31
HRP950304A2 (en) 1997-08-31
HK1041262A1 (en) 2002-07-05
ATE252095T1 (de) 2003-11-15
AU688505B2 (en) 1998-03-12

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20150518