HK1020677A1 - Aqueous formulations of lhrh-related peptide compounds, methods for their preparation and uses thereof - Google Patents

Aqueous formulations of lhrh-related peptide compounds, methods for their preparation and uses thereof

Info

Publication number
HK1020677A1
HK1020677A1 HK99105751A HK99105751A HK1020677A1 HK 1020677 A1 HK1020677 A1 HK 1020677A1 HK 99105751 A HK99105751 A HK 99105751A HK 99105751 A HK99105751 A HK 99105751A HK 1020677 A1 HK1020677 A1 HK 1020677A1
Authority
HK
Hong Kong
Prior art keywords
lhrh
preparation
methods
related peptide
peptide compounds
Prior art date
Application number
HK99105751A
Other languages
English (en)
Inventor
James B Eckenhoff
Cynthia L Stevenson
Sally A Tao
Steven J Prestrelski
Jeremy C Wright
Joe Leonard
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of HK1020677A1 publication Critical patent/HK1020677A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/09Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
HK99105751A 1996-07-03 1999-12-09 Aqueous formulations of lhrh-related peptide compounds, methods for their preparation and uses thereof HK1020677A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2119996P 1996-07-03 1996-07-03
PCT/US1997/010816 WO1998000157A1 (en) 1996-07-03 1997-07-01 Aqueous formulations of peptides

Publications (1)

Publication Number Publication Date
HK1020677A1 true HK1020677A1 (en) 2000-05-19

Family

ID=21802912

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99105751A HK1020677A1 (en) 1996-07-03 1999-12-09 Aqueous formulations of lhrh-related peptide compounds, methods for their preparation and uses thereof

Country Status (27)

Country Link
US (2) US5916582A (pl)
EP (1) EP0909177B1 (pl)
JP (2) JP2001504442A (pl)
CN (1) CN1256146C (pl)
AR (1) AR007715A1 (pl)
AT (1) ATE259241T1 (pl)
AU (1) AU3574897A (pl)
BR (1) BR9710131A (pl)
CA (1) CA2259505A1 (pl)
CO (1) CO4890855A1 (pl)
CZ (1) CZ298464B6 (pl)
DE (1) DE69727572T2 (pl)
ES (1) ES2213828T3 (pl)
HK (1) HK1020677A1 (pl)
HU (1) HU225691B1 (pl)
ID (1) ID19305A (pl)
IL (1) IL127770A (pl)
MY (1) MY125556A (pl)
NO (1) NO323296B1 (pl)
NZ (1) NZ333579A (pl)
PL (1) PL189403B1 (pl)
RO (1) RO120611B1 (pl)
RU (1) RU2201248C2 (pl)
SK (1) SK284283B6 (pl)
TW (1) TW586932B (pl)
WO (1) WO1998000157A1 (pl)
ZA (1) ZA975943B (pl)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7193521B2 (en) 1998-10-29 2007-03-20 Medtronic Minimed, Inc. Method and apparatus for detecting errors, fluid pressure, and occlusions in an ambulatory infusion pump
US6248093B1 (en) 1998-10-29 2001-06-19 Minimed Inc. Compact pump drive system
US6800071B1 (en) 1998-10-29 2004-10-05 Medtronic Minimed, Inc. Fluid reservoir piston
US20020173748A1 (en) 1998-10-29 2002-11-21 Mcconnell Susan Reservoir connector
EP2204203A3 (en) 1998-10-29 2016-07-13 Medtronic MiniMed, Inc. Compact pump drive system
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US7063684B2 (en) 1999-10-28 2006-06-20 Medtronic Minimed, Inc. Drive system seal
US7884071B2 (en) * 2002-09-27 2011-02-08 Zentaris Gmbh Administration form for pharmaceutically active peptides with sustained release and method for the production thereof
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
US20060039949A1 (en) * 2004-08-20 2006-02-23 Nycz Jeffrey H Acetabular cup with controlled release of an osteoinductive formulation
US20060045902A1 (en) * 2004-09-01 2006-03-02 Serbousek Jon C Polymeric wrap for in vivo delivery of osteoinductive formulations
US20060057184A1 (en) * 2004-09-16 2006-03-16 Nycz Jeffrey H Process to treat avascular necrosis (AVN) with osteoinductive materials
CA2593112A1 (en) * 2005-01-21 2006-07-27 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion
US8137664B2 (en) * 2005-02-02 2012-03-20 Sdgi Holdings, Inc. Method and kit for repairing a defect in bone
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US20080200383A1 (en) * 2005-04-08 2008-08-21 Amylin Pharmaceuticals, Inc. Pharmaceutical Formulations Comprising Incretin Peptide and Aprotic Polar Solvent
CN100336557C (zh) * 2005-05-11 2007-09-12 北京双鹭药业股份有限公司 一种生长抑素的水溶液制剂、其制备方法及应用
US20060293243A1 (en) * 2005-06-17 2006-12-28 Navneet Puri Stable, buffered, pharmaceutical compositions including motilin-like peptides
US20060287243A1 (en) * 2005-06-17 2006-12-21 Navneet Puri Stable pharmaceutical compositions including motilin-like peptides
MX2008012678A (es) * 2006-04-07 2008-12-17 Merrion Res Iii Ltd Forma de dosis oral solida que contiene un mejorador.
KR101106510B1 (ko) 2006-05-30 2012-01-20 인타르시아 세라퓨틱스 인코포레이티드 투피스, 내부채널 삼투압 전달 시스템 유동 조절기
AU2007284759B2 (en) 2006-08-09 2010-10-28 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
RU2440097C2 (ru) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления
CA2691531C (en) 2007-06-22 2016-11-01 Board Of Regents,The University Of Texas System Formation of stable submicron peptide or protein particles by thin film freezing
AU2008297551A1 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a defensin peptide as a therapeutic agent
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
KR20110007242A (ko) * 2008-05-07 2011-01-21 메리온 리서치 Ⅲ 리미티드 펩티드 조성물 및 그의 제조 방법
RS60101B1 (sr) 2008-08-15 2020-05-29 Ironwood Pharmaceuticals Inc Formulacije koje sadrže linaklotid za oralnu primenu
EP2376522A4 (en) 2008-11-16 2013-12-25 Univ Texas LOW VISCOSIS HIGHLY CONCENTRATED SUSPENSIONS
US20100215743A1 (en) * 2009-02-25 2010-08-26 Leonard Thomas W Composition and drug delivery of bisphosphonates
EP2246063A1 (en) 2009-04-29 2010-11-03 Ipsen Pharma S.A.S. Sustained release formulations comprising GnRH analogues
JP2013501071A (ja) 2009-08-06 2013-01-10 アイロンウッド ファーマシューティカルズ, インコーポレイテッド リナクロチドを含む処方物
EP3735944A1 (en) 2009-09-28 2020-11-11 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
EA201290799A1 (ru) 2010-02-17 2013-03-29 Айронвуд Фармасьютикалз, Инк. Лечение желудочно-кишечных расстройств
US9089484B2 (en) * 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
LT2603232T (lt) 2010-08-11 2020-01-27 Ironwood Pharmaceuticals, Inc. Stabilios linaklotido vaisto formos
CN103476419A (zh) 2011-01-07 2013-12-25 梅里翁第三研究有限公司 口服投药的含铁药物组合物
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
PL2776055T3 (pl) 2011-08-17 2017-06-30 Ironwood Pharmaceuticals, Inc. Sposoby leczenia zaburzeń żołądkowo-jelitowych
US10112987B2 (en) 2012-01-09 2018-10-30 Icb International, Inc. Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
US20140271923A1 (en) 2013-03-14 2014-09-18 Christopher Brian Reid Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
EP2832361A1 (en) * 2013-07-29 2015-02-04 Ipsen Pharma S.A.S. Aqueous sustained release compositions of LHRH analogs
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
ES2975708T3 (es) 2015-01-29 2024-07-12 Novo Nordisk As Comprimidos que comprenden agonista del GLP-1 y recubrimiento entérico
MA44390A (fr) 2015-06-03 2019-01-23 Intarcia Therapeutics Inc Systèmes de mise en place et de retrait d'implant
CN105749245A (zh) * 2016-03-02 2016-07-13 张光泉 抗癌药醋酸地加瑞克注射液及其制备方法
WO2017200943A1 (en) 2016-05-16 2017-11-23 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
IL267736B2 (en) 2017-01-03 2024-03-01 Intarcia Therapeutics Inc Methods involving continuous administration of a GLP-1 receptor agonist and co-administration of a drug

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914412A (en) * 1973-10-11 1975-10-21 Abbott Lab {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
US4248864A (en) * 1979-08-30 1981-02-03 American Home Products Corporation Reproduction control
DE3371281D1 (en) * 1982-12-10 1987-06-11 Syntex Inc Lhrh preparations for intranasal administration
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
US4661472A (en) * 1985-05-09 1987-04-28 The Salk Institute For Biological Studies GnRH antagonists IX
US4851385A (en) * 1987-07-15 1989-07-25 Indiana University Foundation LHRH antagonist analogs having low histamine-release activity
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
DD273980B5 (de) * 1988-07-12 1994-04-14 Berlin Chemie Ag Verfahren zur Herstellung von Insulin-Pr{paraten zur rektalen Anwendung
US5110596A (en) * 1988-12-13 1992-05-05 Alza Corporation Delivery system comprising means for delivering agent to livestock
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
DE4117507A1 (de) * 1991-05-24 1992-11-26 Schering Ag Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
US5446025A (en) * 1992-06-12 1995-08-29 Abbott Laboratories Formulations and method of the percutaneous administration of leuprolide
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
RU2143889C1 (ru) * 1993-02-23 2000-01-10 Генентек, Инк. Способ стабилизации полипептида, способы получения композиций полипептида и композиции
DE4320201A1 (de) * 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
PT708657E (pt) * 1993-06-29 2001-11-30 Ferring Bv Composicoes para administracao nasal de desmopressina
US5482931A (en) * 1993-06-29 1996-01-09 Ferring Ab Stabilized pharmaceutical peptide compositions
US5413990A (en) * 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
US5595760A (en) * 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
PT877599E (pt) * 1996-02-02 2003-08-29 Alza Corp Administracao continua de leuprolido utilizando um sistema implantavel

Also Published As

Publication number Publication date
MY125556A (en) 2006-08-30
HUP0000589A2 (hu) 2000-09-28
AR007715A1 (es) 1999-11-10
JP2008291037A (ja) 2008-12-04
EP0909177A1 (en) 1999-04-21
ZA975943B (en) 1998-04-16
ID19305A (id) 1998-07-02
WO1998000157A1 (en) 1998-01-08
DE69727572D1 (de) 2004-03-18
CZ433998A3 (cs) 1999-04-14
RU2201248C2 (ru) 2003-03-27
PL189403B1 (pl) 2005-08-31
CN1224357A (zh) 1999-07-28
NO986208L (no) 1998-12-30
ATE259241T1 (de) 2004-02-15
CA2259505A1 (en) 1998-01-08
RO120611B1 (ro) 2006-05-30
NO986208D0 (no) 1998-12-30
CO4890855A1 (es) 2000-02-28
NO323296B1 (no) 2007-03-05
CN1256146C (zh) 2006-05-17
BR9710131A (pt) 1999-08-10
CZ298464B6 (cs) 2007-10-10
SK284283B6 (sk) 2005-01-03
EP0909177B1 (en) 2004-02-11
ES2213828T3 (es) 2004-09-01
JP2001504442A (ja) 2001-04-03
HUP0000589A3 (en) 2001-04-28
US6068850A (en) 2000-05-30
US5916582A (en) 1999-06-29
TW586932B (en) 2004-05-11
PL330903A1 (en) 1999-06-07
NZ333579A (en) 2000-06-23
DE69727572T2 (de) 2004-12-16
IL127770A (en) 2006-10-31
HU225691B1 (en) 2007-06-28
SK179898A3 (en) 1999-06-11
IL127770A0 (en) 1999-10-28
AU3574897A (en) 1998-01-21

Similar Documents

Publication Publication Date Title
HK1020677A1 (en) Aqueous formulations of lhrh-related peptide compounds, methods for their preparation and uses thereof
HUP0003972A3 (en) Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
HUP0101545A3 (en) Pharmaceutical compositions for prolonged peptide release and preparation method
AU2091499A (en) Permeable compositions and methods for their preparation
HUP0003631A3 (en) Preparation of 3,3-dimethylbutyraldehyde by oyidation of 3,3-dimethylbutanol
HUP0000426A3 (en) Novel benzonaphthyridines, pharmaceutical compositions and use thereof and process for their preparation
AU1245297A (en) Preparation of 1,1,1,3,3-pentachlorobutane and 1,1,1,3,3-pentafluorobutane
IL129089A0 (en) New derivatives from piperidine-keto acid their preparation and use
HUP0002404A3 (en) Amino acid derivatives, pharmaceutical compositions comprising thereof, process for preparation them and their use
AU2548097A (en) Formulations of ob protein
IL123647A0 (en) Substituted amino compounds their preparation and use
GB9813725D0 (en) Depilatory compositions, methods for their preparation and their use
AU4944997A (en) Deodorizing preparations
EP0907644A4 (en) PHARMACEUTICAL PREPARATION
ZA976857B (en) Insecticidal aerosol composition and insecticidal composition for preparation of same.
HUP9902963A3 (en) Process for the preparation of amino alcohols and derivatives thereof
HUP0001773A3 (en) Substituted tetrahydropyridin derivatives, method of preparation and pharmaceutical compositions containing them
PL328763A1 (en) Misolastin containing pharmaceutical preparations of prolonged action
CY2590B2 (en) Preparation of 1-butyl-4-piperidinylmethylamine
IL127133A (en) 7 -(3' - o - acyl- 5' - c - substituted - 4 '- o - alkyl - ?? - l - lyxopyranosyloxy) - 4 - hydroxy - 3 -substituted - 2h -1 - benzopyran - 2 - one derivatives, preparation process and pharmaceutical compositions containing them
NZ329271A (en) 4-benzyl-piperidin-4-ol derivatives, preparation and pharmaceutical compositions thereof
AU5219798A (en) Gpi-ceruloplasmin, analogs thereof, and methods of use
IL136635A0 (en) Pharmaceutical formulations and processes for their preparation
HUP0000342A3 (en) Preparation of [1s-[1a,2b,3b,4a(s
AU5263596A (en) Pharmaceutical formulations of (rhizophora mangle l)

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120701