GB8419963D0 - Intermediate compound and method - Google Patents

Intermediate compound and method

Info

Publication number
GB8419963D0
GB8419963D0 GB848419963A GB8419963A GB8419963D0 GB 8419963 D0 GB8419963 D0 GB 8419963D0 GB 848419963 A GB848419963 A GB 848419963A GB 8419963 A GB8419963 A GB 8419963A GB 8419963 D0 GB8419963 D0 GB 8419963D0
Authority
GB
United Kingdom
Prior art keywords
preparation
intermediate compound
compounds
novel
dihydroisobenzufuran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB848419963A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10564974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB8419963(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Priority to GB848419963A priority Critical patent/GB8419963D0/en
Publication of GB8419963D0 publication Critical patent/GB8419963D0/en
Priority to NZ212541A priority patent/NZ212541A/en
Priority to IE1603/85A priority patent/IE57817B1/en
Priority to IL75690A priority patent/IL75690A/xx
Priority to ZA855026A priority patent/ZA855026B/xx
Priority to DE8585305168T priority patent/DE3566251D1/de
Priority to EP85305168A priority patent/EP0171943B1/en
Priority to AT85305168T priority patent/ATE38661T1/de
Priority to FI852902A priority patent/FI81338C/fi
Priority to GR851894A priority patent/GR851894B/el
Priority to US06/761,774 priority patent/US4650884A/en
Priority to PT80913A priority patent/PT80913B/pt
Priority to DK198503562A priority patent/DK172450B1/da
Priority to NO853091A priority patent/NO160364C/no
Priority to CA000488091A priority patent/CA1237147A/en
Priority to ES545885A priority patent/ES8606257A1/es
Priority to AU45776/85A priority patent/AU574819B2/en
Priority to JP60171937A priority patent/JPH0625099B2/ja
Priority to DK199500895A priority patent/DK172713B1/da
Priority to FI20031369A priority patent/FI115300B/fi
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Cosmetics (AREA)
  • Furan Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
GB848419963A 1984-08-06 1984-08-06 Intermediate compound and method Pending GB8419963D0 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GB848419963A GB8419963D0 (en) 1984-08-06 1984-08-06 Intermediate compound and method
NZ212541A NZ212541A (en) 1984-08-06 1985-06-25 4-(4-(dimethylamino)-1-(4'-fluorophenyl)-1- hydroxybutyl)-3- (hydroxymethyl)-benzonitrile
IE1603/85A IE57817B1 (en) 1984-08-06 1985-06-26 Novel intermediate and method for its preparation
IL75690A IL75690A (en) 1984-08-06 1985-07-01 4-(4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile and its preparation
ZA855026A ZA855026B (en) 1984-08-06 1985-07-03 Intermediate and method for its preparation
DE8585305168T DE3566251D1 (en) 1984-08-06 1985-07-19 Novel intermediate and method for its preparation
AT85305168T ATE38661T1 (de) 1984-08-06 1985-07-19 Zwischenprodukt und verfahren zu dessen herstellung.
EP85305168A EP0171943B1 (en) 1984-08-06 1985-07-19 Novel intermediate and method for its preparation
FI852902A FI81338C (fi) 1984-08-06 1985-07-25 4-/4-(dimetylamino)-1-(4'-fluorfenyl)- 1-hydroxibutyl/-3-(hydroximetyl)bensonitril foerfarande foer framstaellning av denna och dess anvaendning vid framstaellning av 1-(3-dimetylaminopropyl)-1-(4'-fluorfenyl)-1,3-dihydroisobensofuran-5- karbonitril.
GR851894A GR851894B (enExample) 1984-08-06 1985-08-01
US06/761,774 US4650884A (en) 1984-08-06 1985-08-02 Novel intermediate and method for its preparation
PT80913A PT80913B (pt) 1984-08-06 1985-08-05 Processo para a preparacao de novos compostos ciano-substituidos
AU45776/85A AU574819B2 (en) 1984-08-06 1985-08-05 Intermediate for the perparation of an anti-depressant drug
ES545885A ES8606257A1 (es) 1984-08-06 1985-08-05 Un metodo para preparar 4-(4-(dimetilamino)-1-(4'-fluoro- fenil)-1-hidroxibutil)-3-(hidroximetil)-benzonitrilo
DK198503562A DK172450B1 (da) 1984-08-06 1985-08-05 4-[4-(Dimethylamino)-1-(4'-fluorphenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitril, syreadditionssalte deraf, og fremgan
NO853091A NO160364C (no) 1984-08-06 1985-08-05 Nytt mellomprodukt og fremgangsmaate ved fremstilling derav
CA000488091A CA1237147A (en) 1984-08-06 1985-08-05 Intermediate 4-[4-(dimethylamino)-1- (4'-fluorophenyl)-1-hydroxybutyl]-3- (hydroxymethyl)-benzonitrile and method for its preparation
JP60171937A JPH0625099B2 (ja) 1984-08-06 1985-08-06 新規な中間生成物及びその製造方法
DK199500895A DK172713B1 (da) 1984-08-06 1995-08-10 Fremgangsmåde til fremstilling af 1-(3-dimethylaminopropyl)-1-(4'-fluorphenyl)-1,3-dihydroisobenzofuran-5-carbonnitril
FI20031369A FI115300B (fi) 1984-08-06 2003-09-23 4-[4-dimetyyliamino-1-(4'-fluorifenyyli)-1-hydroksibutyyli]-3-hydroksimetyyli-bentsonitriilin di-(p-toloyyli)viinihapon kanssa muodostama diastereomeerinen suola

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848419963A GB8419963D0 (en) 1984-08-06 1984-08-06 Intermediate compound and method

Publications (1)

Publication Number Publication Date
GB8419963D0 true GB8419963D0 (en) 1984-09-12

Family

ID=10564974

Family Applications (1)

Application Number Title Priority Date Filing Date
GB848419963A Pending GB8419963D0 (en) 1984-08-06 1984-08-06 Intermediate compound and method

Country Status (18)

Country Link
US (1) US4650884A (enExample)
EP (1) EP0171943B1 (enExample)
JP (1) JPH0625099B2 (enExample)
AT (1) ATE38661T1 (enExample)
AU (1) AU574819B2 (enExample)
CA (1) CA1237147A (enExample)
DE (1) DE3566251D1 (enExample)
DK (2) DK172450B1 (enExample)
ES (1) ES8606257A1 (enExample)
FI (2) FI81338C (enExample)
GB (1) GB8419963D0 (enExample)
GR (1) GR851894B (enExample)
IE (1) IE57817B1 (enExample)
IL (1) IL75690A (enExample)
NO (1) NO160364C (enExample)
NZ (1) NZ212541A (enExample)
PT (1) PT80913B (enExample)
ZA (1) ZA855026B (enExample)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JPH0675987U (ja) * 1993-04-09 1994-10-25 日立造船株式会社 貨物輸送船におけるバラストタンクへのアクセス用トランク構造
US5607939A (en) * 1994-04-28 1997-03-04 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
DE69801764T2 (de) 1997-07-08 2002-07-04 H. Lundbeck A/S, Kobenhavn-Valby Verfahren zur herstellung von citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
WO1998019512A2 (en) 1997-11-11 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
HU228576B1 (en) 1998-10-20 2013-04-29 Lundbeck & Co As H Method for the preparation of citalopram
NZ512073A (en) 1998-12-23 2003-10-31 H Method for the preparation of 5-cyanophthalide and citalopram
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PT1173431E (pt) 1999-04-14 2003-09-30 Lundbeck & Co As H Metodo de preparacao do citalopram
US6245782B1 (en) 1999-05-17 2001-06-12 Heartdrug Research L.L.C. Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
HRP20020344B1 (hr) 1999-10-25 2010-10-31 H. Lundbeck A/S Način priprave citaloprama
WO2000012044A2 (en) * 1999-10-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
MXPA02006503A (es) 1999-12-28 2002-12-09 Lundbeck & Co As H Metodo para la preparacion de citalopram.
WO2001049672A1 (en) * 1999-12-30 2001-07-12 H. Lundbeck A/S Method for the preparation of citalopram
AU2006201612B2 (en) * 2000-01-14 2008-03-13 H Lundbeck A/S Method for the preparation of 5-cyanophthalide
KR100660802B1 (ko) * 2000-01-14 2006-12-26 하. 룬트벡 아크티에 셀스카브 5-시아노프탈리드의 제조 방법
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
WO2001068629A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
CA2402388A1 (en) 2000-03-13 2001-09-20 Hans Petersen Method for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
AU2001239213A1 (en) 2000-03-14 2001-09-24 H Lundbeck A/S Method for the preparation of citalopram
SK14812002A3 (sk) * 2000-03-16 2003-02-04 H. Lundbeck A/S Spôsob prípravy 5-kyano-1-(4-fluórfenyl)-1,3-dihydrobenzofuránov a antidepresívny farmaceutický prostriedok
US6494503B1 (en) * 2000-03-25 2002-12-17 Non Metallic Resources, Inc. Pipe joint assembly and method for using same
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
BG64901B1 (bg) * 2000-05-29 2006-08-31 H. Lundbeck A/S Метод за получаване на циталопрам
IES20010693A2 (en) * 2000-08-10 2002-07-10 Lundbeck & Co As H Pharmaceutical composition containing citalopram
GB2376233B (en) * 2000-08-10 2003-09-10 Lundbeck & Co As H Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns
IL144816A (en) * 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
HK1048812B (zh) 2000-12-22 2007-06-01 H‧隆德贝克有限公司 制备纯西酞普兰的方法
AU3920201A (en) * 2000-12-28 2001-07-09 H. Lundbeck A/S Process for the preparation of pure citalopram
CA2435925A1 (en) 2001-01-30 2002-08-08 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
US20050066373A1 (en) * 2001-02-02 2005-03-24 Matthew Rabinowitz Position location using broadcast digital television signals
YU85303A (sh) * 2001-05-01 2006-05-25 H. Lundbeck A/S Upotreba enantiomerno čistog escitaloprama
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
EP1522539B1 (en) * 2001-07-31 2007-01-24 H. Lundbeck A/S Crystalline composition containing escitalopram
PT1281707E (pt) * 2001-08-02 2005-04-29 Infosint Sa Processo para a preparacao de isobenzofuranos 5-substituidos
EP1288211A1 (en) * 2001-08-28 2003-03-05 Sekhsaria Chemicals Ltd. Improved process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
AU2003207774A1 (en) * 2002-01-30 2003-09-02 Montana State University Pestalotiopsis microsporia isolates and compounds derived therefrom
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
CA2381341A1 (en) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Process and intermediates for preparing escitalopram
BG65515B1 (bg) * 2002-07-26 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
BG65516B1 (bg) * 2002-07-31 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
AU2002330730A1 (en) * 2002-08-14 2004-03-03 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
NZ540653A (en) 2002-12-23 2008-02-29 Lundbeck & Co As H A process for the preparation of racemic citalopram diol and/or S- or R- citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram
ATE388947T1 (de) * 2002-12-23 2008-03-15 Lundbeck & Co As H Escitalopramhydrobromid und ein verfahren zu dessen herstellung
AU2003242990A1 (en) * 2003-01-17 2004-08-13 Pulla Reddy Muddasani Processes for the preparation of escitalopram and its precursor
EP1611118A2 (en) * 2003-03-21 2006-01-04 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
CA2537402C (en) 2003-09-12 2009-05-05 Pfizer Inc. Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
EP1506963B1 (en) * 2003-10-28 2005-04-13 Adorkem Technology SpA Method for the preparation of citalopram
EP1678122A4 (en) * 2003-10-28 2007-05-23 Wockhardt Ltd IMPROVED PROCESS FOR THE PREPARATION OF CITALOPRAM HYDROBROMIDE
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2005070914A1 (en) * 2004-01-23 2005-08-04 Jubilant Organosys Limited A method for the preparation of citalopram acid addition salts
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EP1723133A1 (en) * 2004-02-16 2006-11-22 Jubilant Organosys Limited One pot synthesis of citalopram from 5-cyanophthalide
JP2005247710A (ja) * 2004-03-01 2005-09-15 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
JP2005263741A (ja) * 2004-03-19 2005-09-29 Sumitomo Chemical Co Ltd シタロプラムの製造方法ならびにその中間体およびその製造方法
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
ES2285972T1 (es) * 2004-08-23 2007-12-01 Sun Pharmaceutical Industries Limited Procedimiento de fabricacion de citalopram y enantiomeros.
ITMI20041872A1 (it) 2004-10-01 2005-01-01 Adorkem Technology Spa Processo per la preparazione di citalopram e di scitalopram
US7939680B2 (en) * 2005-07-27 2011-05-10 Aurobindo Pharma Ltd. Process for the preparation of Escitalopram
EP1777221A1 (en) * 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
US20080312318A1 (en) * 2007-06-14 2008-12-18 Protia, Llc Deuterium-enriched escitalopram
EP2017271A1 (en) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Process for the preparation of escitalopram
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
CN100548974C (zh) * 2007-10-11 2009-10-14 浙江大学 西酞普兰中间体的萃取分离方法
CN101560199B (zh) * 2008-04-16 2013-09-18 北京德众万全药物技术开发有限公司 一种依地普仑的制备方法
CN101265215B (zh) * 2008-04-18 2011-03-16 浙江奥托康制药集团股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法
US20110092719A1 (en) * 2008-06-16 2011-04-21 Shodhana Laboratories Limited Preparation of Escitalopram, Its Salts and Intermediates
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
CN102190600B (zh) * 2010-03-13 2015-04-15 浙江华海药业股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法
WO2016197320A1 (zh) * 2015-06-09 2016-12-15 浙江华海药业股份有限公司 一种西酞普兰二醇中间体的制备方法
CN105294496A (zh) * 2015-09-28 2016-02-03 中山大学 一种西酞普兰中间体的制备方法
KR102134179B1 (ko) * 2018-09-17 2020-07-16 (주)유케이케미팜 카보네이트를 이용한 시탈로프람 및 에스시탈로프람의 새로운 제조 방법
CN112409212B (zh) * 2020-11-30 2023-03-14 四川新迪医药化工有限公司 西酞普兰二醇中间体氢溴酸盐的制备方法及西酞普兰二醇中间体氢溴酸盐、西酞普兰

Family Cites Families (3)

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GB1143703A (enExample) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
NL8105170A (nl) * 1980-12-10 1982-07-01 Thomae Gmbh Dr K Nieuwe fenylalkylaminen, werkwijze ter bereiding daarvan en de toepassing daarvan als geneesmiddelen.

Also Published As

Publication number Publication date
FI20031369A7 (fi) 2003-09-23
DK172450B1 (da) 1998-08-10
ATE38661T1 (de) 1988-12-15
ES8606257A1 (es) 1986-04-01
US4650884A (en) 1987-03-17
NO160364C (no) 1989-04-12
JPH0625099B2 (ja) 1994-04-06
DE3566251D1 (en) 1988-12-22
IL75690A (en) 1988-10-31
EP0171943B1 (en) 1988-11-17
AU574819B2 (en) 1988-07-14
NO160364B (no) 1989-01-02
CA1237147A (en) 1988-05-24
NO853091L (no) 1986-02-07
FI81338C (fi) 1990-10-10
FI81338B (fi) 1990-06-29
EP0171943A1 (en) 1986-02-19
PT80913A (en) 1985-09-01
PT80913B (pt) 1987-09-30
NZ212541A (en) 1988-05-30
FI115300B (fi) 2005-04-15
ES545885A0 (es) 1986-04-01
DK172713B1 (da) 1999-06-14
ZA855026B (en) 1986-06-25
IE57817B1 (en) 1993-04-21
DK356285A (da) 1986-02-07
AU4577685A (en) 1986-02-13
FI852902A0 (fi) 1985-07-25
FI852902L (fi) 1986-02-07
DK356285D0 (da) 1985-08-05
DK89595A (da) 1995-08-10
GR851894B (enExample) 1985-12-03
IE851603L (en) 1986-02-06
JPS6187654A (ja) 1986-05-06

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