GB2199829B - Peptide derivatives - Google Patents

Peptide derivatives

Info

Publication number
GB2199829B
GB2199829B GB8723737A GB8723737A GB2199829B GB 2199829 B GB2199829 B GB 2199829B GB 8723737 A GB8723737 A GB 8723737A GB 8723737 A GB8723737 A GB 8723737A GB 2199829 B GB2199829 B GB 2199829B
Authority
GB
United Kingdom
Prior art keywords
peptide derivatives
peptide
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8723737A
Other languages
English (en)
Other versions
GB2199829A (en
GB8723737D0 (en
Inventor
Rainer Albert
Wilfired Bauer
Francois Cardinaux
Monika Mergler
Janos Pless
Walter Prikoszovich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB8723737D0 publication Critical patent/GB8723737D0/en
Publication of GB2199829A publication Critical patent/GB2199829A/en
Priority to GB9011637A priority Critical patent/GB2233652B/en
Application granted granted Critical
Publication of GB2199829B publication Critical patent/GB2199829B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
GB8723737A 1986-10-13 1987-10-09 Peptide derivatives Expired - Lifetime GB2199829B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9011637A GB2233652B (en) 1986-10-13 1990-05-24 Solid phase synthesis of peptide alcohols

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE3634797 1986-10-13
DE3634826 1986-10-13
DE3634825 1986-10-13
DE3712626 1987-04-14
CH315387 1987-08-17

Publications (3)

Publication Number Publication Date
GB8723737D0 GB8723737D0 (en) 1987-11-11
GB2199829A GB2199829A (en) 1988-07-20
GB2199829B true GB2199829B (en) 1991-04-17

Family

ID=27509117

Family Applications (2)

Application Number Title Priority Date Filing Date
GB8723737A Expired - Lifetime GB2199829B (en) 1986-10-13 1987-10-09 Peptide derivatives
GB8800537A Expired - Lifetime GB2199831B (en) 1986-10-13 1988-01-12 Peptide derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB8800537A Expired - Lifetime GB2199831B (en) 1986-10-13 1988-01-12 Peptide derivatives

Country Status (23)

Country Link
US (1) US5656721A (cg-RX-API-DMAC7.html)
JP (2) JPH0645639B2 (cg-RX-API-DMAC7.html)
KR (1) KR960016861B1 (cg-RX-API-DMAC7.html)
AU (2) AU617986B2 (cg-RX-API-DMAC7.html)
BE (1) BE1003752A4 (cg-RX-API-DMAC7.html)
CA (1) CA1340985C (cg-RX-API-DMAC7.html)
CH (2) CH682632A5 (cg-RX-API-DMAC7.html)
DE (1) DE3790635T1 (cg-RX-API-DMAC7.html)
DK (1) DK174337B1 (cg-RX-API-DMAC7.html)
ES (1) ES2007418A6 (cg-RX-API-DMAC7.html)
FI (1) FI874495L (cg-RX-API-DMAC7.html)
FR (1) FR2609991A1 (cg-RX-API-DMAC7.html)
GB (2) GB2199829B (cg-RX-API-DMAC7.html)
GR (1) GR871567B (cg-RX-API-DMAC7.html)
HU (3) HU906340D0 (cg-RX-API-DMAC7.html)
IE (1) IE912442A1 (cg-RX-API-DMAC7.html)
LU (1) LU87014A1 (cg-RX-API-DMAC7.html)
NL (1) NL194729C (cg-RX-API-DMAC7.html)
NZ (1) NZ222133A (cg-RX-API-DMAC7.html)
PL (1) PL157156B1 (cg-RX-API-DMAC7.html)
PT (1) PT85904B (cg-RX-API-DMAC7.html)
SE (2) SE8703938L (cg-RX-API-DMAC7.html)
WO (1) WO1988002756A2 (cg-RX-API-DMAC7.html)

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DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
WO1989007109A1 (en) * 1988-02-01 1989-08-10 The Upjohn Company Renin inhibiting peptides with polar end groups
DK163689A (da) * 1988-04-08 1989-10-30 Sandoz Ag Peptidderivater
DE3910667A1 (de) * 1988-04-11 1989-10-19 Sandoz Ag Peptidderivate
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
FR2638968B1 (fr) * 1988-11-11 1994-10-07 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
IT1229514B (it) * 1989-01-30 1991-09-03 Farmhispania S A A Montme Glicoconiugati anfifilici sintetici per impiego neurologico.
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
IT1260156B (it) * 1992-08-03 1996-03-28 Fidia Spa Derivati dell'acido neuraminico
TW263437B (cg-RX-API-DMAC7.html) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5710244A (en) * 1992-12-31 1998-01-20 Labroo; Virender M. Derivatized calcitonins
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
KR100325972B1 (ko) * 1993-08-09 2002-07-27 바이오메져 인코퍼레이티드 치료성펩타이드유도체
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
JP3896430B2 (ja) * 1996-07-15 2007-03-22 アークレイ株式会社 糖化アミノ化合物の製造方法
IL119029A0 (en) 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
US7026289B2 (en) 1997-05-13 2006-04-11 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Method and compositions for treating hyperlipidemia and other conditions
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US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
WO1999040928A1 (en) * 1998-02-13 1999-08-19 Amylin Pharmaceuticals, Inc. Novel mixed amylin activity compounds
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US20050037490A1 (en) * 1999-10-29 2005-02-17 Lawrence Rosenberg Medium for preparing dedifferentiated cells
DE60231801D1 (de) * 2001-04-23 2009-05-14 Mallinckrodt Inc Tc und re markierte radioaktive glycosylierte octreotid-derivate
NZ530007A (en) 2001-06-08 2006-02-24 Sod Conseils Rech Applic Somatostatin-dopamine chimeric analogues that retain both somatostatin and dopamine activity in vivo and display enhanced biological activity
AU2003211011A1 (en) * 2002-02-27 2003-09-09 Ferring Bv Intermediates and methods for making heptapeptide oxytocin analogues
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
AU2006282799B2 (en) * 2005-08-26 2012-11-29 Healthpartners Research & Education Methods for treatment of headaches by administration of oxytocin
PT1787658E (pt) 2005-11-10 2012-06-22 Chemi Spa Formulações de libertação sustentada de análogos de somatostatina inibidores da hormona do crescimento
WO2008011168A2 (en) * 2006-07-21 2008-01-24 Amgen Inc. Glycosylated peptide antagonists of the bradykinin b1 receptor
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CA2682174C (en) 2007-03-28 2021-04-06 President And Fellows Of Harvard College Stitched polypeptides
AU2008303584C1 (en) 2007-09-25 2013-10-10 Glycom A/S Glycoproteins and glycosylated cells and a method for the preparation of the same
WO2009062200A1 (en) * 2007-11-09 2009-05-14 University Of Tennessee Research Foundation Anti-inflammatory quinic acid derivatives for oral administration
KR101642363B1 (ko) 2008-06-12 2016-07-25 입센 바이오이노베이션 리미티드 신경내분비계 질환의 억제
CN107446053A (zh) 2008-06-12 2017-12-08 益普生生物创新有限公司 癌症的抑制
US8377891B2 (en) 2008-11-07 2013-02-19 Usv, Ltd. Process for synthesis of cyclic octapeptide
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
WO2012021875A1 (en) 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with triazole linkers
EP2752424B1 (en) 2011-09-04 2019-09-11 Glytech, Inc. Glycosylated somatostatin and drug composition containing it
CA2847336C (en) 2011-09-04 2021-09-07 Glytech, Inc. Glycosylated polypeptide and drug composition containing said polypeptide
CN108929375A (zh) 2011-10-18 2018-12-04 爱勒让治疗公司 拟肽大环化合物
CN112500466B (zh) 2012-02-15 2022-05-03 艾瑞朗医疗公司 拟肽大环化合物
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CN104812384B (zh) 2012-11-01 2020-09-18 爱勒让治疗公司 二取代的氨基酸及其制备和使用方法
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EP4541348A3 (en) 2016-04-12 2025-06-04 Tonix Pharma Limited Magnesium-containing oxytocin formulations and methods of use
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US12466851B2 (en) 2019-04-16 2025-11-11 Bachem Holding Ag Manufacture of disulfide bonded peptides
US20230399373A1 (en) * 2020-10-22 2023-12-14 The Trustees Of Indiana University Molecular designs of glucose-responsive and glucose-cleavable insulin analogues
WO2025229200A1 (en) 2024-05-03 2025-11-06 Bachem Holding Ag Manufacture of disulfide bonded peptides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4280953A (en) * 1979-11-08 1981-07-28 The Salk Institute For Biological Studies Glycosylated analogs of somatostatin

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US4254023A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Synthesis of peptide alcohols by the solid phase method
ATE2512T1 (de) * 1979-11-27 1983-03-15 Sandoz Ag Polypeptide, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen, die diese polypeptide enthalten, und ihre verwendung.
FR2522967B1 (fr) * 1982-03-15 1986-03-07 Anvar Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
US4483792A (en) * 1982-11-17 1984-11-20 Kim Wan S Glycosylated insulin derivatives
FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2548673B1 (fr) * 1983-07-05 1985-10-04 Essilor Int Polymeres supports de produits actifs relargables et leur procede de preparation
LU85269A1 (fr) * 1984-03-26 1985-10-14 Techland S A Composes nouveaux de somatostatine,procede pour leur synthese,preparation a usage veterinaire contenant lesdits composes et procede pour le traitement d'animaux
US4564998A (en) * 1984-10-19 1986-01-21 Westinghouse Electric Corp. Coil winding methods and apparatus
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin
EP0192611A3 (de) * 1985-02-20 1988-05-11 Ciba-Geigy Ag Acylierte Hexosederivate und Verfahren zu ihrer Herstellung
JPS61264260A (ja) * 1985-05-17 1986-11-22 Rikagaku Kenkyusho アルデヒド化多孔性高分子材料によるタンパク質の除去方法
AU597909B2 (en) * 1985-10-09 1990-06-14 Procter & Gamble Company, The Granular detergent compositions having improved solubility
SE8506094D0 (sv) * 1985-12-20 1985-12-20 Astra Laekemedel Ab New antibacterial agents and intermediates therefor
JPS63165411A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製法
JPS63165410A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製造方法
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis
CH679045A5 (cg-RX-API-DMAC7.html) * 1987-06-29 1991-12-13 Sandoz Ag

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US4280953A (en) * 1979-11-08 1981-07-28 The Salk Institute For Biological Studies Glycosylated analogs of somatostatin

Also Published As

Publication number Publication date
PL268173A1 (en) 1988-09-01
SE8703938L (sv) 1988-04-14
IE912442L (en) 1988-04-13
KR960016861B1 (ko) 1996-12-23
SE8703938D0 (sv) 1987-10-12
NL8702345A (nl) 1988-05-02
FI874495A7 (fi) 1988-04-14
NZ222133A (en) 1993-02-25
HU206890B (en) 1993-01-28
SE9301172L (cg-RX-API-DMAC7.html) 1900-01-01
FR2609991B1 (cg-RX-API-DMAC7.html) 1995-03-10
DK532787D0 (da) 1987-10-12
KR880005153A (ko) 1988-06-28
DK532787A (da) 1988-04-14
IE912442A1 (en) 1992-02-12
SE518630C2 (sv) 2002-11-05
BE1003752A4 (fr) 1992-06-09
HUT46710A (en) 1988-11-28
SE9301172D0 (sv) 1993-04-07
AU7956487A (en) 1988-04-14
JPS63101399A (ja) 1988-05-06
GB2199831A (en) 1988-07-20
FI874495A0 (fi) 1987-10-12
CH682632A5 (de) 1993-10-29
FR2609991A1 (fr) 1988-07-29
WO1988002756A3 (en) 1988-07-14
NL194729B (nl) 2002-09-02
GB2199829A (en) 1988-07-20
CA1340985C (en) 2000-05-09
HU906341D0 (en) 1991-04-29
WO1988002756A2 (en) 1988-04-21
PT85904A (en) 1987-11-01
GB2199831B (en) 1991-04-17
NL194729C (nl) 2003-01-07
FI874495L (fi) 1988-04-14
ES2007418A6 (es) 1989-06-16
GB8800537D0 (en) 1988-02-10
AU8015091A (en) 1991-10-31
CH680512A5 (cg-RX-API-DMAC7.html) 1992-09-15
AU617986B2 (en) 1991-12-12
GB8723737D0 (en) 1987-11-11
LU87014A1 (fr) 1988-05-03
DE3790635T1 (cg-RX-API-DMAC7.html) 1988-10-06
DK174337B1 (da) 2002-12-16
PT85904B (pt) 1990-08-31
JP2744910B2 (ja) 1998-04-28
AU634664B2 (en) 1993-02-25
HU906340D0 (en) 1991-04-29
JPH0314599A (ja) 1991-01-23
GR871567B (en) 1988-02-16
PL157156B1 (pl) 1992-05-29
JPH0645639B2 (ja) 1994-06-15
US5656721A (en) 1997-08-12

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19941009