GB2089339B - Novel cephalosporins processes for producing the same intermediates thereof and process for producing the intermediates - Google Patents

Novel cephalosporins processes for producing the same intermediates thereof and process for producing the intermediates

Info

Publication number
GB2089339B
GB2089339B GB8128011A GB8128011A GB2089339B GB 2089339 B GB2089339 B GB 2089339B GB 8128011 A GB8128011 A GB 8128011A GB 8128011 A GB8128011 A GB 8128011A GB 2089339 B GB2089339 B GB 2089339B
Authority
GB
United Kingdom
Prior art keywords
producing
intermediates
processes
same
novel cephalosporins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8128011A
Other languages
English (en)
Other versions
GB2089339A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55132253A external-priority patent/JPS5758689A/ja
Priority claimed from JP55158184A external-priority patent/JPS5782393A/ja
Priority claimed from JP55175263A external-priority patent/JPS6052755B2/ja
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of GB2089339A publication Critical patent/GB2089339A/en
Application granted granted Critical
Publication of GB2089339B publication Critical patent/GB2089339B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB8128011A 1980-09-25 1981-09-16 Novel cephalosporins processes for producing the same intermediates thereof and process for producing the intermediates Expired GB2089339B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP55132253A JPS5758689A (en) 1980-09-25 1980-09-25 Novel preparation of 7-substituted or unsubstituted amino-3-substituted methylcephem carboxylic acids
JP55158184A JPS5782393A (en) 1980-11-12 1980-11-12 7-amino-3-(2-(1,2,3,4-tetrazolyl)methyl)cephem-4-carboxylic acid
JP55175263A JPS6052755B2 (ja) 1980-12-13 1980-12-13 新規セファロスポリン類

Publications (2)

Publication Number Publication Date
GB2089339A GB2089339A (en) 1982-06-23
GB2089339B true GB2089339B (en) 1985-04-24

Family

ID=27316463

Family Applications (3)

Application Number Title Priority Date Filing Date
GB8128011A Expired GB2089339B (en) 1980-09-25 1981-09-16 Novel cephalosporins processes for producing the same intermediates thereof and process for producing the intermediates
GB08402250A Expired GB2136420B (en) 1980-09-25 1984-01-27 Cephalosporin derivatives
GB08402249A Expired GB2135304B (en) 1980-09-25 1984-01-27 7-amino-3-(triazolyl or tetrazolyl)methyl-.3-cephem-4-carboxylic acidss

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB08402250A Expired GB2136420B (en) 1980-09-25 1984-01-27 Cephalosporin derivatives
GB08402249A Expired GB2135304B (en) 1980-09-25 1984-01-27 7-amino-3-(triazolyl or tetrazolyl)methyl-.3-cephem-4-carboxylic acidss

Country Status (27)

Country Link
US (4) US4489072A (de)
KR (1) KR860000932B1 (de)
AR (1) AR240645A1 (de)
AT (4) AT375082B (de)
AU (3) AU550330B2 (de)
CA (2) CA1204735A (de)
CH (4) CH652128A5 (de)
DD (2) DD208351A5 (de)
DE (5) DE3137854A1 (de)
DK (1) DK163877C (de)
EG (1) EG17373A (de)
ES (4) ES8301998A1 (de)
FI (2) FI75575C (de)
FR (2) FR2509310B1 (de)
GB (3) GB2089339B (de)
HU (1) HU185850B (de)
IN (4) IN155375B (de)
IT (1) IT1172201B (de)
LU (1) LU83650A1 (de)
MX (1) MX155025A (de)
NL (1) NL8104386A (de)
NO (1) NO161117C (de)
NZ (1) NZ198350A (de)
PH (5) PH18072A (de)
PT (1) PT73727B (de)
RO (4) RO86823B (de)
SE (5) SE453090B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703046A (en) * 1978-09-08 1987-10-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
EP0061234A3 (de) * 1981-03-05 1983-11-16 Beecham Group Plc Cephalosporin derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
US4576938A (en) * 1981-12-08 1986-03-18 Tanabe Seiyaku Co., Ltd. Cephalosporin compound and process for preparing the same
DK521883A (da) * 1982-11-17 1984-05-18 Toyama Chemical Co Ltd Cephalosporinderivater, fremgangsmaade til fremstilling heraf og fremgangsmaade til fremstilling af mellemprodukter herfor
US4618606A (en) * 1982-11-17 1986-10-21 Toyama Chemical Co., Ltd. Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl) cephalosporins
JPS6064986A (ja) * 1983-09-20 1985-04-13 Toyama Chem Co Ltd セファロスポリン類の製造法
JPS60190783A (ja) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk セフエム系化合物
GB8406231D0 (en) * 1984-03-09 1984-04-11 Fujisawa Pharmaceutical Co Cephem compounds
GB2161476B (en) * 1984-05-25 1988-01-27 Toyama Chemical Co Ltd 2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins
AT397086B (de) * 1984-05-25 1994-01-25 Toyama Chemical Co Ltd Verfahren zur herstellung von neuen 2-(2-aminothiazol-4-4yl)-2-(syn)-alkoxyimino- acetamiden
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
DE3539901A1 (de) * 1985-11-11 1987-05-14 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
JPH064643B2 (ja) * 1985-12-20 1994-01-19 ファイザー製薬株式会社 セフアロスポリン化合物
US4692517A (en) * 1986-03-20 1987-09-08 American Home Products Corporation C-3' acylaminooxy-7-[(2-aminothiazol-4-yl)-α-(substituted-oximino)acetyl]cephalosporin derivatives
EP0265185A3 (de) * 1986-10-21 1990-03-28 Beecham Group Plc Cephalosporine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
ZA877987B (en) * 1986-11-12 1988-08-31 Ici Pharma Antibiotic compounds
DE3750673T2 (de) * 1986-11-21 1995-03-16 Ici Pharma Cephalosporine, Verfahren zu ihrer Herstellung und pharmazeutische Präparate.
EP0269298B1 (de) * 1986-11-21 1994-10-19 Ici Pharma Cephalosporine, Verfahren zu ihrer Herstellung und pharmazeutische Präparate
US4870168A (en) * 1987-02-26 1989-09-26 Bristol-Myers Company 3-Unsaturated alkyl cephems from 3-triflyl cephems
US5232918A (en) * 1987-07-23 1993-08-03 Imperial Chemical Industries Plc Cephalosporin derivatives
GB8816519D0 (en) * 1987-07-23 1988-08-17 Ici Plc Antibiotic compounds
GB8811056D0 (en) * 1988-05-10 1988-06-15 Ici Plc Antibiotic compounds
JPH0699443B2 (ja) * 1989-09-29 1994-12-07 ファイザー製薬株式会社 セファロスポリン化合物
US6800756B2 (en) * 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
EP1618114B1 (de) * 2003-04-16 2010-07-14 Sandoz AG Verfahren zur herstellung von cefepim
US7847093B2 (en) * 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
JP2007530589A (ja) * 2004-03-26 2007-11-01 アンフォラ ディスカバリー コーポレーション 特定のトリアゾールを基礎とする化合物、組成物、およびそれらの使用
US8198434B2 (en) 2008-05-07 2012-06-12 Idexx Laboratories, Inc. Process for preparing cefsulodin sodium
US20120329770A1 (en) * 2010-02-26 2012-12-27 Gary Igor Dmitrienko Cephalosporin derivatives useful as beta-lactamase inhibitors and compositions and methods of use thereof
CN102351886B (zh) * 2011-09-07 2013-10-16 山东罗欣药业股份有限公司 头孢特仑新戊酯晶体、其制备方法及含有该晶体的组合物片剂
MY184572A (en) * 2013-07-17 2021-04-05 Otsuka Pharma Co Ltd Cyanotriazole compounds
CN106046026B (zh) * 2016-06-30 2018-07-06 济南康和医药科技有限公司 一种头孢特仑新戊酯的制备方法
CN112645842B (zh) * 2020-12-25 2022-08-19 复旦大学 一种氰乙酸叔丁酯的连续流制备方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB912541A (en) * 1958-03-17 1962-12-12 Nat Res Dev Cephalosporin c compounds
DE1795484U (de) 1959-04-21 1959-09-10 Richard Langer Quertraeger fuer laengsdraehte zum abstuetzen von pflanzen, insbesondere weinreben.
GB1032641A (en) 1962-02-16 1966-06-15 Edward Penley Abraham Cephalosporins
GB1057883A (en) * 1962-07-11 1967-02-08 Glaxo Lab Ltd Improvements in or relating to antibiotics
US3226384A (en) 1963-01-25 1965-12-28 Nat Res Dev Cephalosporin ca derivatives
BE634644A (de) * 1963-07-10
US3821206A (en) * 1966-12-15 1974-06-28 Glaxo Lab Ltd Cephalosporins having a polyazole substituent
GB1211694A (en) * 1966-12-15 1970-11-11 Glaxo Lab Ltd Derivatives of 7-aminocephalosporanic acid
GB1360860A (en) * 1970-07-08 1974-07-24 Ciba Geigy Ag Cepham compounds process for their manufacture and compositions containing them
US3932465A (en) * 1970-07-08 1976-01-13 Ciba-Geigy Corporation 3-R-methyl-7-amino-ceph-em-4-carboxylic acid compounds
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
US4343937A (en) * 1971-06-02 1982-08-10 Merck & Co., Inc. 3-Substituted-7-methoxy-7-amino-3-cephem-4-carboxylic acids
SU589918A3 (ru) * 1971-07-14 1978-01-25 Мерк Энд Ко Инк (Фирма) Способ получени сложного эфира 3-замещенной метил-7-ациломидо-7-метокси-2-цефем -4- карбоноаой кислоты
JPS5653557B2 (de) * 1973-10-15 1981-12-19
CH605997A5 (de) * 1974-08-30 1978-10-13 Ciba Geigy Ag
NO760358L (de) * 1975-02-04 1976-08-05 Fujisawa Pharmaceutical Co
GB1547165A (en) * 1975-08-15 1979-06-06 Beecham Group Ltd 3-carbamoylbenzyl and 3-(carbamoylpyridylmethyl)-cephems
GB1575803A (en) * 1976-03-09 1980-10-01 Fujisawa Pharmaceutical Co 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof
US4165430A (en) * 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
JPS5946237B2 (ja) * 1976-04-02 1984-11-10 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
GB1565941A (en) * 1977-02-08 1980-04-23 Toyama Chemical Co Ltd Process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids
ES467601A1 (es) * 1977-03-12 1979-06-16 Hoechst Ag Procedimiento para la preparacion de derivados de cefem.
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US4148997A (en) * 1977-11-07 1979-04-10 Yeda Research And Development Co., Ltd. 7-[Sulfomethyl)phenyl]acetamidocephalosporin derivatives
DE2822861A1 (de) * 1978-05-26 1979-11-29 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
JPS6027677B2 (ja) 1978-07-06 1985-06-29 富山化学工業株式会社 ７−置換又は非置換アミノ−３−置換チオメチルセフエムカルボン酸類の新規製造法
ES485439A1 (es) * 1978-10-27 1980-07-01 Glaxo Group Ltd Un procedimiento para la preparacion de antibioticos de ce- falosporina
SE7909401L (sv) * 1978-11-15 1980-05-16 Glaxo Group Ltd Cefalosporinantibiotika
ES8103104A1 (es) * 1979-02-23 1981-02-16 Glaxo Group Ltd Un procedimiento para la preparacion de un antibiotico de cefalosporina.
JPS55139387A (en) 1979-04-19 1980-10-31 Yamanouchi Pharmaceut Co Ltd Novel synthetic method of 7-amino-3-heterocyclic thiomethyl-delta3-carboxylic acids
JPS55153790A (en) 1979-05-17 1980-11-29 Yamanouchi Pharmaceut Co Ltd Preparation of 7-amino-3-heterocyclic thiomethyl-delta3- cephem-4-carboxylic acid
FR2461713A1 (fr) * 1979-07-19 1981-02-06 Roussel Uclaf Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
EP0061234A3 (de) * 1981-03-05 1983-11-16 Beecham Group Plc Cephalosporin derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
DK163925C (da) * 1981-09-10 1992-09-14 Takeda Chemical Industries Ltd Fremgangsmaade til fremstilling af cephalosporinforbindelser
JPS6064986A (ja) * 1983-09-20 1985-04-13 Toyama Chem Co Ltd セファロスポリン類の製造法
GB2161476B (en) * 1984-05-25 1988-01-27 Toyama Chemical Co Ltd 2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins
CA1293719C (en) * 1986-09-22 1991-12-31 Takao Takaya Cephem compounds and processes for preparation thereof

Also Published As

Publication number Publication date
DE3152935C2 (de) 1992-07-16
AU4986185A (en) 1986-03-20
FR2509310B1 (fr) 1985-08-02
PT73727B (en) 1982-12-30
AU568033B2 (en) 1987-12-10
US5144027A (en) 1992-09-01
FR2511377A1 (fr) 1983-02-18
DK163877B (da) 1992-04-13
FI75575B (fi) 1988-03-31
IT8149348A0 (it) 1981-09-23
CH652130A5 (de) 1985-10-31
AT378961B (de) 1985-10-25
AT378193B (de) 1985-06-25
GB2136420B (en) 1985-05-01
DE3152934C2 (de) 1990-01-18
US4879381A (en) 1989-11-07
PH18484A (en) 1985-08-02
CA1204735A (en) 1986-05-20
GB8402250D0 (en) 1984-02-29
RO86823A (ro) 1985-05-20
IN155375B (de) 1985-01-19
RO86825A (ro) 1985-05-20
RO82689B (ro) 1983-10-30
SE8600192L (sv) 1986-01-16
SE8600194D0 (sv) 1986-01-16
RO86824A (ro) 1985-05-20
GB2136420A (en) 1984-09-19
ATA410981A (de) 1983-11-15
AT375082B (de) 1984-06-25
RO86825B (ro) 1985-05-31
FR2511377B1 (fr) 1985-12-13
IN158589B (de) 1986-12-13
NO161117C (no) 1989-07-05
NO161117B (no) 1989-03-28
HU185850B (en) 1985-04-28
US4673738A (en) 1987-06-16
FR2509310A1 (fr) 1983-01-14
FI75575C (fi) 1988-07-11
FI870153A0 (fi) 1987-01-15
FI812980L (fi) 1982-03-26
FI870153A (fi) 1987-01-15
AU550330B2 (en) 1986-03-20
ATA55583A (de) 1985-03-15
SE468476B (sv) 1993-01-25
EG17373A (en) 1990-12-30
US4489072A (en) 1984-12-18
KR860000932B1 (ko) 1986-07-19
NZ198350A (en) 1985-02-28
MX155025A (es) 1988-01-20
SE468477B (sv) 1993-01-25
RO82689A (ro) 1983-11-01
PH20221A (en) 1986-10-23
NO813252L (no) 1982-03-26
CH652129A5 (de) 1985-10-31
DD208351A5 (de) 1984-05-02
IT1172201B (it) 1987-06-18
ES505760A0 (es) 1983-01-01
GB2089339A (en) 1982-06-23
ATA55483A (de) 1985-03-15
PH19147A (en) 1986-01-15
RO86823B (ro) 1985-05-31
SE8105658L (sv) 1982-05-05
ES514669A0 (es) 1983-05-01
SE8600195D0 (sv) 1986-01-16
AU558649B2 (en) 1987-02-05
DE3152931C2 (de) 1989-10-05
ES8301998A1 (es) 1983-01-01
ES514670A0 (es) 1983-05-01
DE3152932C2 (de) 1990-02-08
ES8306155A1 (es) 1983-05-01
DE3137854C2 (de) 1987-06-19
GB2135304A (en) 1984-08-30
AR240645A1 (es) 1990-07-31
SE8600193D0 (sv) 1986-01-16
FI80041C (fi) 1990-04-10
AU4986285A (en) 1986-04-24
PH18072A (en) 1985-03-18
SE8600195L (sv) 1986-01-16
IN159126B (de) 1987-03-28
DK163877C (da) 1992-09-14
IN158590B (de) 1986-12-13
SE8600192D0 (sv) 1986-01-16
SE8600193L (sv) 1986-01-16
SE468478B (sv) 1993-01-25
ES514671A0 (es) 1983-05-01
ES8306157A1 (es) 1983-05-01
FI80041B (fi) 1989-12-29
SE453090B (sv) 1988-01-11
ES8306156A1 (es) 1983-05-01
DD202436A5 (de) 1983-09-14
DK421881A (da) 1982-04-15
CH651837A5 (de) 1985-10-15
SE8600194L (sv) 1986-01-16
LU83650A1 (fr) 1982-01-21
PH19251A (en) 1986-02-17
DE3137854A1 (de) 1982-04-15
RO86824B (ro) 1985-05-31
NL8104386A (nl) 1982-04-16
PT73727A (en) 1981-10-01
CH652128A5 (de) 1985-10-31
GB2135304B (en) 1985-03-27
AU7543881A (en) 1982-04-01
SE468479B (sv) 1993-01-25
ATA55683A (de) 1984-11-15
AT378962B (de) 1985-10-25
GB8402249D0 (en) 1984-02-29
CA1200541A (en) 1986-02-11

Similar Documents

Publication Publication Date Title
GB2089339B (en) Novel cephalosporins processes for producing the same intermediates thereof and process for producing the intermediates
DE3166724D1 (en) Process for the manufacture of 1-4-butanediol and tetrahydrofuran
GB2102024B (en) Process for the production of monascus-pigment
ZA811158B (en) Process for 3-iodomethyl cephalosporins
DE3160132D1 (en) Process for the production of coatings
GB2116182B (en) Intermediates for the production of picropodphyllin and picrosikkimotoxin
YU92481A (en) Process for the manufacture of substituted dibenzo-oxepines
GB2084612B (en) Method for the production of shaped objects
YU213181A (en) Process for obtaining certain cephalosporins
ZA825858B (en) Process for the production of 2- -d-ribofuranosylthiazole-4-carboxamide
PH21357A (en) Method for the production of ferrochromium
DE3171693D1 (en) Process for the production of polyethylene
IL60160A0 (en) Novel cephalosporins and process for producing the same
PT75561A (en) Process for the manufacture of novel polycyclic polyazaheterocycles
GB2080294B (en) Method for the production of n-cyclohexylbenzothiazole-2-sulfenamide
PT73594A (en) Process for the production of urea
DE3276582D1 (en) Novel endo-deoxyribonuclease and process for the production thereof
GB2074574B (en) Process for the production of ureas
DE3168356D1 (en) Process for the carbazolation of anthrimides
GB2071127B (en) Process for the purification of glucosaninoglucans
EP0047449A3 (en) Process for the production of colour-photographic images
ZA816576B (en) Cephalosporins,processes for producing same,intermediates thereof and process for producing the intermediates
DE3066758D1 (en) Process for the production of nitro-amino-benzenes
ZA821491B (en) Novel n-acyl-polypeptides and processes for the production thereof
GB2083814B (en) Method for the production of 2-isopropyl-4-methyl-6-hydroxypyrimidine

Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 20010915