FR2731617B1 - Compositions pharmaceutiques nouvelles contenant du propofol - Google Patents

Compositions pharmaceutiques nouvelles contenant du propofol

Info

Publication number
FR2731617B1
FR2731617B1 FR9503128A FR9503128A FR2731617B1 FR 2731617 B1 FR2731617 B1 FR 2731617B1 FR 9503128 A FR9503128 A FR 9503128A FR 9503128 A FR9503128 A FR 9503128A FR 2731617 B1 FR2731617 B1 FR 2731617B1
Authority
FR
France
Prior art keywords
pharmaceutical compositions
compositions containing
water
new pharmaceutical
opt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9503128A
Other languages
English (en)
Other versions
FR2731617A1 (fr
Inventor
Christopher Buchan Jones
John Henry Platt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48793621&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2731617(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to GB9405593A priority Critical patent/GB9405593D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Priority to CH01282/04A priority patent/CH694423A5/de
Priority to EP02009330A priority patent/EP1238677B1/fr
Priority to ES02009330T priority patent/ES2253469T3/es
Priority to EP95911412A priority patent/EP0814787B1/fr
Priority to NZ282005A priority patent/NZ282005A/xx
Priority to IL11302195A priority patent/IL113021A/en
Priority to CZ0290497A priority patent/CZ297549B6/cs
Priority to FR9503128A priority patent/FR2731617B1/fr
Priority to SK1247-97A priority patent/SK286375B6/sk
Priority to TW084102594A priority patent/TW458781B/zh
Priority to AT02009330T priority patent/ATE312625T1/de
Priority to DK95911412T priority patent/DK0814787T3/da
Priority to SI9530628T priority patent/SI0814787T1/xx
Priority to AT95911412T priority patent/ATE226817T1/de
Priority to ZA952239A priority patent/ZA952239B/xx
Priority to BR9510452A priority patent/BR9510452A/pt
Priority to PT95911412T priority patent/PT814787E/pt
Priority to AU18988/95A priority patent/AU710143B2/en
Priority to BE9500241A priority patent/BE1009198A5/fr
Priority to CH00393/03A priority patent/CH693762A5/de
Priority to DE19509828A priority patent/DE19509828A1/de
Priority to DE69528714T priority patent/DE69528714T2/de
Priority to ES95911412T priority patent/ES2183869T3/es
Priority to PL95322278A priority patent/PL186354B1/pl
Priority to RU97117100A priority patent/RU2147432C1/ru
Priority to NZ500588A priority patent/NZ500588A/en
Priority to CH02053/03A priority patent/CH694396A5/de
Priority to JP08528148A priority patent/JP3067806B2/ja
Priority to PCT/GB1995/000579 priority patent/WO1996029064A1/fr
Priority to GB9505405A priority patent/GB2298789B/en
Priority to DK02009330T priority patent/DK1238677T3/da
Priority to CH02011/97A priority patent/CH693764A5/de
Priority to CA002212794A priority patent/CA2212794C/fr
Priority to IT95MI000529A priority patent/IT1281193B1/it
Priority to MX9707005A priority patent/MX9707005A/es
Priority to HU9702180A priority patent/HU227951B1/hu
Priority to US08/408,707 priority patent/US5714520A/en
Publication of FR2731617A1 publication Critical patent/FR2731617A1/fr
Priority to US08/802,447 priority patent/US5731356A/en
Priority to US08/801,589 priority patent/US5731355A/en
Application granted granted Critical
Publication of FR2731617B1 publication Critical patent/FR2731617B1/fr
Priority to SE9703274A priority patent/SE523909C2/sv
Priority to LU90136A priority patent/LU90136B1/de
Priority to NO19974278A priority patent/NO320007B1/no
Priority to FI973702A priority patent/FI120640B/fi
Priority to DK106697A priority patent/DK106697A/da
Priority to US09/016,359 priority patent/US5908869A/en
Priority to HK98109677A priority patent/HK1008927A1/xx
Priority to JP00624199A priority patent/JP4012328B2/ja
Priority to SE0400115A priority patent/SE527123C2/sv
Priority to NO20041838A priority patent/NO334956B1/no
Priority to FI20085586A priority patent/FI120641B/fi
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Fats And Perfumes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FR9503128A 1994-03-22 1995-03-17 Compositions pharmaceutiques nouvelles contenant du propofol Expired - Lifetime FR2731617B1 (fr)

Priority Applications (51)

Application Number Priority Date Filing Date Title
GB9405593A GB9405593D0 (en) 1994-03-22 1994-03-22 Pharmaceutical compositions
CH01282/04A CH694423A5 (de) 1994-03-22 1995-03-17 Verwendung von Edetat zur Stabilisierung von pharmzeutischen Zusammensetzungen.
EP02009330A EP1238677B1 (fr) 1994-03-22 1995-03-17 Emulsions grasses parentérales, comprenant de l'EDTA comme conservateur
ES02009330T ES2253469T3 (es) 1994-03-22 1995-03-17 Emulsiones grasas parenterales que comprenden edetato como conservante.
EP95911412A EP0814787B1 (fr) 1994-03-22 1995-03-17 Emulsions huile dans l'eau contenant du propofol et de l'edetate disodique
NZ282005A NZ282005A (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol (2,6 diisopropylphenol) and edetate
IL11302195A IL113021A (en) 1994-03-22 1995-03-17 Oil in water emulsion compositions containing edetate
CZ0290497A CZ297549B6 (cs) 1994-03-22 1995-03-17 Sterilní farmaceutický prostredek pro parenterální podání, obsahující propofol a edetát
FR9503128A FR2731617B1 (fr) 1994-03-22 1995-03-17 Compositions pharmaceutiques nouvelles contenant du propofol
SK1247-97A SK286375B6 (sk) 1994-03-22 1995-03-17 Sterilná farmaceutická kompozícia na parenterálnepoužitie
TW084102594A TW458781B (en) 1994-03-22 1995-03-17 Sterile pharmaceutical compositions for parenteral administration and their uses
AT02009330T ATE312625T1 (de) 1994-03-22 1995-03-17 Parenterale fettemulsionen, die edta als konservierungsmittel enthalten
DK95911412T DK0814787T3 (da) 1994-03-22 1995-03-17 Olie-i-vand emulsioner indeholdende propofol og dinatrium-edetat
SI9530628T SI0814787T1 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and disodium edetate
AT95911412T ATE226817T1 (de) 1994-03-22 1995-03-17 Propofol und disodium edta enthaltende öl-in- wasser emulsionen
ZA952239A ZA952239B (en) 1994-03-22 1995-03-17 Pharmaceutical compositions
BR9510452A BR9510452A (pt) 1994-03-22 1995-03-17 Composição farmacêutica e aquosa estéril para a administração parenteral processos para limitar o potencial de crescimento microbiano em composição farmacêutica estéril para a administração parenteral para produzir anestesia em um animal de sangue quente e para aperfeiçoar o tempo de administração e/ou o tempo entre as trocas de conjuntos
PT95911412T PT814787E (pt) 1994-03-22 1995-03-17 Emulsoes de oleo em agua que contem propofol e edetato
AU18988/95A AU710143B2 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and edetate
BE9500241A BE1009198A5 (fr) 1994-03-22 1995-03-17 Compositions pharmaceutiques nouvelles contenant du propofol.
CH00393/03A CH693762A5 (de) 1994-03-22 1995-03-17 Wässrige Zusammensetzungen enthaltend eine Öl-in-Wasser-Emulsion
DE19509828A DE19509828A1 (de) 1994-03-22 1995-03-17 Pharmazeutische Zusammensetzungen
DE69528714T DE69528714T2 (de) 1994-03-22 1995-03-17 Propofol und disodium edta enthaltende öl-in-wasser emulsionen
ES95911412T ES2183869T3 (es) 1994-03-22 1995-03-17 Emulsiones de aceite en agua que contienen propofol y edetato.
PL95322278A PL186354B1 (pl) 1994-03-22 1995-03-17 Jałowe kompozycje farmaceutyczne oraz sposoby ograniczania potencjału wzrostowego drobnoustrojów i poprawiania czasu stosowania emulsji
RU97117100A RU2147432C1 (ru) 1994-03-22 1995-03-17 Эмульсии типа масло в воде, содержащие пропофол и эдетат
NZ500588A NZ500588A (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and edetate for producing anaesthesia
CH02053/03A CH694396A5 (de) 1994-03-22 1995-03-17 Pharmazeutische Zusammensetzung mit therapeutischem oder pharmazeutischem Mittel und Edetat.
JP08528148A JP3067806B2 (ja) 1994-03-22 1995-03-17 プロポフォールとエデテートとを含有する水中油滴エマルジョン
PCT/GB1995/000579 WO1996029064A1 (fr) 1994-03-22 1995-03-17 Emulsions huile dans eau contenant du propofol et de l'edetate
GB9505405A GB2298789B (en) 1994-03-22 1995-03-17 Pharmaceutical compositions
DK02009330T DK1238677T3 (da) 1994-03-22 1995-03-17 Parenterale fedtemulsioner, der omfatter edetat som konserveringsmiddel
CH02011/97A CH693764A5 (de) 1994-03-22 1995-03-17 Pharmazeutische Zusammensetzung enthaltend Propofol und Edetat.
CA002212794A CA2212794C (fr) 1994-03-22 1995-03-17 Emulsions huile dans eau contenant du propofol et de l'edetate
IT95MI000529A IT1281193B1 (it) 1994-03-22 1995-03-17 Composizioni farmaceutiche contenenti 2,6 diisopropilfenolo (propofol) e metodo per la loro preparazione
MX9707005A MX9707005A (es) 1994-03-22 1995-03-17 Composiciones farmaceuticas que contienen 2,6-diisopropilfenol (propofol).
HU9702180A HU227951B1 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and disodium edetate
US08/408,707 US5714520A (en) 1994-03-22 1995-03-22 Propofol compostion containing edetate
US08/802,447 US5731356A (en) 1994-03-22 1997-02-18 Pharmaceutical compositions of propofol and edetate
US08/801,589 US5731355A (en) 1994-03-22 1997-02-18 Pharmaceutical compositions of propofol and edetate
SE9703274A SE523909C2 (sv) 1994-03-22 1997-09-10 Olja-i-vattenemulsioner innehållande propofol och edetat
LU90136A LU90136B1 (de) 1994-03-22 1997-09-10 Oel-in-Wasser-Emulsionen die Propofol und Edetat enthalten
NO19974278A NO320007B1 (no) 1994-03-22 1997-09-16 Steril farmasoytisk blanding inneholdende propofol og edetat for parenteral administrering, fremgangsmate for a begrense potensialet for mikrobevekst i blandingen, samt anvendelse derav.
FI973702A FI120640B (fi) 1994-03-22 1997-09-16 Propofolia ja edetaattia sisältävät öljy-vedessä-emulsiot
DK106697A DK106697A (da) 1994-03-22 1997-09-17 Emulsioner af typen olie-i-vand indeholdende propofol og edetat
US09/016,359 US5908869A (en) 1994-03-22 1998-01-30 Propofol compositions containing edetate
HK98109677A HK1008927A1 (en) 1994-03-22 1998-08-04 Oil in water emulsions containing propofol and edetate
JP00624199A JP4012328B2 (ja) 1994-03-22 1999-01-13 エデテートを含有する水中油滴エマルジョン
SE0400115A SE527123C2 (sv) 1994-03-22 2004-01-21 Olja-I-vattenemulsioner innehållande propofol och edetat
NO20041838A NO334956B1 (no) 1994-03-22 2004-05-04 Sterilt, vandig propofolpreparat som omfatter en olje-i-vann-emulsjon og som videre omfatter en mengde av dinatriumedetat.
FI20085586A FI120641B (fi) 1994-03-22 2008-06-13 Ruuansulatuskanavan ulkopuolisesti annettavat rasvaemulsiot, jotka sisältävät edetaattia säilöntäaineena

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
GB9405593A GB9405593D0 (en) 1994-03-22 1994-03-22 Pharmaceutical compositions
NZ282005A NZ282005A (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol (2,6 diisopropylphenol) and edetate
PL95322278A PL186354B1 (pl) 1994-03-22 1995-03-17 Jałowe kompozycje farmaceutyczne oraz sposoby ograniczania potencjału wzrostowego drobnoustrojów i poprawiania czasu stosowania emulsji
PCT/GB1995/000579 WO1996029064A1 (fr) 1994-03-22 1995-03-17 Emulsions huile dans eau contenant du propofol et de l'edetate
CH02011/97A CH693764A5 (de) 1994-03-22 1995-03-17 Pharmazeutische Zusammensetzung enthaltend Propofol und Edetat.
CH01282/04A CH694423A5 (de) 1994-03-22 1995-03-17 Verwendung von Edetat zur Stabilisierung von pharmzeutischen Zusammensetzungen.
ZA952239A ZA952239B (en) 1994-03-22 1995-03-17 Pharmaceutical compositions
NZ500588A NZ500588A (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and edetate for producing anaesthesia
EP95911412A EP0814787B1 (fr) 1994-03-22 1995-03-17 Emulsions huile dans l'eau contenant du propofol et de l'edetate disodique
BR9510452A BR9510452A (pt) 1994-03-22 1995-03-17 Composição farmacêutica e aquosa estéril para a administração parenteral processos para limitar o potencial de crescimento microbiano em composição farmacêutica estéril para a administração parenteral para produzir anestesia em um animal de sangue quente e para aperfeiçoar o tempo de administração e/ou o tempo entre as trocas de conjuntos
BE9500241A BE1009198A5 (fr) 1994-03-22 1995-03-17 Compositions pharmaceutiques nouvelles contenant du propofol.
CH00393/03A CH693762A5 (de) 1994-03-22 1995-03-17 Wässrige Zusammensetzungen enthaltend eine Öl-in-Wasser-Emulsion
CA002212794A CA2212794C (fr) 1994-03-22 1995-03-17 Emulsions huile dans eau contenant du propofol et de l'edetate
HU9702180A HU227951B1 (en) 1994-03-22 1995-03-17 Oil in water emulsions containing propofol and disodium edetate
FR9503128A FR2731617B1 (fr) 1994-03-22 1995-03-17 Compositions pharmaceutiques nouvelles contenant du propofol
DE19509828A DE19509828A1 (de) 1994-03-22 1995-03-17 Pharmazeutische Zusammensetzungen
NO19974278A NO320007B1 (no) 1994-03-22 1997-09-16 Steril farmasoytisk blanding inneholdende propofol og edetat for parenteral administrering, fremgangsmate for a begrense potensialet for mikrobevekst i blandingen, samt anvendelse derav.
JP00624199A JP4012328B2 (ja) 1994-03-22 1999-01-13 エデテートを含有する水中油滴エマルジョン
FI20085586A FI120641B (fi) 1994-03-22 2008-06-13 Ruuansulatuskanavan ulkopuolisesti annettavat rasvaemulsiot, jotka sisältävät edetaattia säilöntäaineena

Publications (2)

Publication Number Publication Date
FR2731617A1 FR2731617A1 (fr) 1996-09-20
FR2731617B1 true FR2731617B1 (fr) 1997-05-30

Family

ID=48793621

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9503128A Expired - Lifetime FR2731617B1 (fr) 1994-03-22 1995-03-17 Compositions pharmaceutiques nouvelles contenant du propofol

Country Status (33)

Country Link
US (1) US5714520A (fr)
EP (2) EP0814787B1 (fr)
JP (2) JP3067806B2 (fr)
AT (2) ATE312625T1 (fr)
AU (1) AU710143B2 (fr)
BE (1) BE1009198A5 (fr)
BR (1) BR9510452A (fr)
CA (1) CA2212794C (fr)
CH (4) CH694423A5 (fr)
CZ (1) CZ297549B6 (fr)
DE (2) DE69528714T2 (fr)
DK (3) DK1238677T3 (fr)
ES (2) ES2253469T3 (fr)
FI (2) FI120640B (fr)
FR (1) FR2731617B1 (fr)
GB (2) GB9405593D0 (fr)
HK (1) HK1008927A1 (fr)
HU (1) HU227951B1 (fr)
IL (1) IL113021A (fr)
IT (1) IT1281193B1 (fr)
LU (1) LU90136B1 (fr)
MX (1) MX9707005A (fr)
NO (2) NO320007B1 (fr)
NZ (2) NZ282005A (fr)
PL (1) PL186354B1 (fr)
PT (1) PT814787E (fr)
RU (1) RU2147432C1 (fr)
SE (2) SE523909C2 (fr)
SI (1) SI0814787T1 (fr)
SK (1) SK286375B6 (fr)
TW (1) TW458781B (fr)
WO (1) WO1996029064A1 (fr)
ZA (1) ZA952239B (fr)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
GB9405593D0 (en) * 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
MY113046A (en) * 1994-03-22 2001-11-30 Astrazeneca Uk Ltd Pharmaceutical compositions
US20020173547A1 (en) 1994-03-22 2002-11-21 Jones Christopher Buchan Pharmaceuticals compositions
US5637625A (en) * 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations
KR19980025601A (ko) * 1996-10-04 1998-07-15 우동일 혈관주사제용 프로포폴 유탁액의 제조방법
CH692322A5 (it) 1997-05-26 2002-05-15 Westy Ag Formulazione iniettabile limpida di Propofol.
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
DE19757224A1 (de) 1997-12-22 1999-07-01 Bayer Ag Verfahren und Vorrichtung zur in-situ-Formulierung einer Arzneistofflösung zur parenteralen Applikation
BR9907832A (pt) 1998-02-10 2000-10-31 Sicor Inc Composição de propofol contendo sulfito
US6254853B1 (en) 1998-05-08 2001-07-03 Vyrex Corporation Water soluble pro-drugs of propofol
ATE252889T1 (de) * 1998-08-19 2003-11-15 Skyepharma Canada Inc Injizierbare wässerige propofoldispersionen
US6150423A (en) 1998-10-15 2000-11-21 Phoenix Scientific, Inc. Propofol-based anesthetic and method of making same
US6028108A (en) * 1998-10-22 2000-02-22 America Home Products Corporation Propofol composition comprising pentetate
US6140373A (en) * 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
US6140374A (en) * 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
US6682758B1 (en) 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
ES2232195T3 (es) * 1999-01-28 2005-05-16 Dinesh Shantilal Patel Solucion parenteral de propofol (2,6-diisopropilfenol) y 2,5-di-o-metil-1,4;3,6-dianhidro-d-glucitol como solvente.
US6177477B1 (en) * 1999-03-24 2001-01-23 American Home Products Corporation Propofol formulation containing TRIS
US6100302A (en) * 1999-04-05 2000-08-08 Baxter International Inc. Propofol formulation with enhanced microbial characteristics
ES2261210T3 (es) * 1999-06-21 2006-11-16 Kuhnil Pharmaceutical Co., Ltd. Comoposicion anestesica para inyeccion intravenosa que comprende propofol.
GB2359747B (en) 2000-02-29 2002-04-24 Maelor Pharmaceuticals Ltd Anaesthetic formulations
SE0001865D0 (sv) * 2000-05-19 2000-05-19 Astrazeneca Ab Management of septic shock
GB0012597D0 (en) * 2000-05-25 2000-07-12 Astrazeneca Ab Formulation
AU2001258592A1 (en) * 2000-05-25 2001-12-03 Astrazeneca Ab Pharmaceutical composition comprising a free-radical scavenging sedative agent and a metal ion chelating agent
WO2001097779A2 (fr) * 2000-06-16 2001-12-27 Rtp Pharma Inc. Dispersions injectables de propofol ameliorees
IN188917B (fr) * 2000-12-07 2002-11-23 Bharat Surums & Vaccines Ltd
EP1386606B1 (fr) 2001-05-11 2015-08-19 Mitsubishi Tanabe Pharma Corporation Produit d'injection stable à des concentrations élevées contenant un dérive de pyrazolone
JP4127757B2 (ja) * 2001-08-21 2008-07-30 株式会社エヌ・ティ・ティ・ドコモ 無線通信システム、通信端末装置、及びバースト信号送信方法
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
US8541472B2 (en) 2001-12-05 2013-09-24 Aseptica, Inc. Antiseptic compositions, methods and systems
CA2474262C (fr) 2002-01-25 2011-03-15 Theravance, Inc. Agents hypnotiques sedatifs a action courte pour l'anesthesie et la sedation
AU2003230691A1 (en) * 2002-03-20 2003-10-08 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
US20080220075A1 (en) * 2002-03-20 2008-09-11 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
PL373850A1 (en) * 2002-04-08 2005-09-19 Guilford Pharmaceuticals, Inc. Pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering same
AU2003261274C1 (en) 2002-07-29 2009-02-12 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
US7550155B2 (en) 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
JP2006504771A (ja) * 2002-10-29 2006-02-09 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド システインを伴うプロポフォール
EP3470084A1 (fr) 2002-12-09 2019-04-17 Abraxis BioScience, LLC Compositions comprenant des nanoparticules d'albumine et méthodes pour la libération de principes actifs
US20040225022A1 (en) * 2003-05-09 2004-11-11 Desai Neil P. Propofol formulation containing reduced oil and surfactants
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
PL1648413T3 (pl) * 2003-07-23 2010-03-31 Theravance Inc Kompozycje farmaceutyczne zawierające jako składnik czynny krótko działający środek uspokajający i usypiający
US8546453B2 (en) 2003-08-14 2013-10-01 Rensheng Zhang Propofol compositions and methods for reducing pain associated with propofol injection
AU2004286814A1 (en) * 2003-10-24 2005-05-19 Auspex Pharmaceuticals, Inc. pH sensitive prodrugs of 2,6-diisopropylphenol
CA2556185C (fr) 2004-02-13 2010-09-21 Bioavailability, Inc. Preparation de micro-emulsion a forte teneur en propofol a des fins anesthesiques
KR20070058608A (ko) * 2004-09-13 2007-06-08 바라트 쎄럼스 앤드 백신스 리미티드 항미생물 방부 효능을 갖는 정맥 내 투여를 위한 안정한에멀젼 조성물
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
WO2007000662A2 (fr) * 2005-02-03 2007-01-04 Taro Pharmaceuticals U.S.A., Inc. Nouvelle composition de propofol comprenant de l'acide ascorbique ou des sels pharmaceutiquement acceptables de ce dernier
CA2598159A1 (fr) 2005-02-18 2006-08-24 Abraxis Bioscience, Inc. Compositions, procedes d'utilisation et de preparation de 2,6-diisopropylphenol et d'analogues de ce dernier pour traiter une liaison ischemique
WO2006128088A1 (fr) * 2005-05-27 2006-11-30 Sandhya Goyal Nouvelle composition de propofol contenant un sel de formaldehyde sulfoxylate pharmaceutiquement acceptable
WO2007052288A2 (fr) 2005-08-05 2007-05-10 Bharat Serums & Vaccines Ltd. Compositions d'emulsion de propofol pour administration intraveineuse presentant une efficacite de conservation
WO2007052295A2 (fr) * 2005-08-12 2007-05-10 Bharat Serums & Vaccines Ltd. Compositions aqueuses anesthesiques comprenant du propofol
WO2007022437A2 (fr) * 2005-08-18 2007-02-22 Auspex Pharmaceuticals, Inc. Nouveaux agents thérapeutiques pour le traitement de cancers, de maladies métaboliques et de troubles cutanés
RU2451510C2 (ru) * 2005-08-31 2012-05-27 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Композиции и способы получения слаборастворимых в воде лекарственных средств с увеличенной стабильностью
KR101643416B1 (ko) * 2005-08-31 2016-07-27 아브락시스 바이오사이언스, 엘엘씨 증가된 안정성을 가진 수 난용성 약물의 조성물 및 제조방법
US7589239B2 (en) * 2005-09-02 2009-09-15 Auspex Pharmaceuticals Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
TWI376239B (en) * 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
CN1903187B (zh) * 2006-03-21 2012-05-30 沈阳药科大学 含有局麻药的复方异丙酚注射剂及制备工艺
CA2685813A1 (fr) 2007-05-09 2008-11-20 Pharmacofore, Inc. Composes therapeutiques
NZ580752A (en) 2007-05-09 2012-03-30 Pharmacofore Inc Stereoisomers propofol therapeutic compounds
KR20080102010A (ko) * 2007-05-17 2008-11-24 대원제약주식회사 프로포폴을 포함하는 주사제용 조성물 및 이의 제조 방법
AU2009276560B2 (en) 2008-08-01 2015-04-16 Chiesi Farmaceutici S.P.A. Pharmaceutical compositions and methods for producing low impurity concentrations of the same
US9132090B2 (en) 2009-01-13 2015-09-15 Chetan Majmudar Propofol based anesthetic with preservative
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
ES2539861T5 (es) * 2010-10-12 2018-11-16 Chiesi Farmaceutici S.P.A. Formulaciones en emulsión de clevidipina que contienen agentes antimicrobianos
CN102407986B (zh) * 2011-11-03 2013-11-27 南通四方冷链装备股份有限公司 隔料装置
CN102525921B (zh) * 2012-02-06 2013-08-07 西安力邦制药有限公司 2,2’,6,6’-四异丙基-4,4’-二联苯酚脂微球制剂及其制备方法
CN102579555A (zh) * 2012-03-01 2012-07-18 四川大学华西医院 注射用脂肪乳在作为拮抗全身麻醉用药作用的药物制备中的应用
MX2014013826A (es) 2012-05-16 2018-04-24 Singh Mewa Composiciones farmaceuticas para la entrega de farmacos sustancialmente solubles en agua.
WO2017031261A1 (fr) 2015-08-20 2017-02-23 Mewa Singh Polymère polyphénolique qui permettent que des molécules insolubles dans l'eau deviennent solubles dans l'eau
EP3612229A4 (fr) 2017-04-19 2020-04-29 Mayo Foundation for Medical Education and Research Mélange de kétamine et de propofol

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3384545A (en) * 1965-03-09 1968-05-21 Hoffmann La Roche Injectable aqueous emulsions of fat soluble vitamins
US3230143A (en) * 1965-05-14 1966-01-18 Merck & Co Inc Antihypertensive injection methods using acid addition salts of alkyl esters of alpha-methyl-3, 4-dihy-droxyphenylalanine
DE1792410B2 (de) * 1967-09-01 1980-03-13 Apoteksvarucentralen Vitrum Apotekareaktiebolaget, Stockholm Arzneimittelzubereitung zur intravenösen Injektion
GB1472793A (en) * 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
US4798846A (en) * 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions
US4328213A (en) * 1979-11-28 1982-05-04 Schering Corporation Stable injectable labetalol formulation
DE3225706C2 (de) * 1982-07-09 1984-04-26 A. Nattermann & Cie GmbH, 5000 Köln Flüssige Wirkstofformulierungen in Form von Konzentraten für Mikroemulsionen
JPS5916818A (ja) * 1982-07-20 1984-01-28 Shimizu Seiyaku Kk 経静脈投与用輸液剤
SE8505047L (sv) * 1985-10-25 1987-04-26 Nutritional Int Res Inst Fettemulsion
IL83086A (en) * 1987-07-06 1991-03-10 Teva Pharma Stable,injectable solutions of vincristine salts
US4868169A (en) * 1987-11-13 1989-09-19 E. R. Squibb & Sons, Inc. Steroid cream formulation
JPH075456B2 (ja) * 1988-10-01 1995-01-25 参天製薬株式会社 点眼液
JPH03503171A (ja) * 1988-11-29 1991-07-18 ユニリーバー・ナームローゼ・ベンノートシヤープ 抗菌薬及びその使用
GB8828517D0 (en) * 1988-12-07 1989-01-11 Leopold & Co Ag Stable emulsions
US5079003A (en) * 1990-03-14 1992-01-07 Adelia Scaffidi Skin lotions and creams
JP3308555B2 (ja) * 1991-03-08 2002-07-29 カネボウ株式会社 微細化エマルション組成物の製造方法
JP2811036B2 (ja) * 1992-05-26 1998-10-15 参天製薬株式会社 ビタミンｅ点眼剤
GB9405593D0 (en) * 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions

Also Published As

Publication number Publication date
AU1898895A (en) 1996-10-08
US5714520A (en) 1998-02-03
NO320007B1 (no) 2005-10-10
IT1281193B1 (it) 1998-02-17
CZ290497A3 (en) 1997-12-17
EP1238677A3 (fr) 2003-01-22
EP1238677A2 (fr) 2002-09-11
NO974278D0 (no) 1997-09-16
JPH11263725A (ja) 1999-09-28
GB2298789A (en) 1996-09-18
EP1238677B1 (fr) 2005-12-14
EP0814787B1 (fr) 2002-10-30
LU90136B1 (de) 1997-11-27
CA2212794C (fr) 2000-09-12
IL113021A (en) 2001-04-30
ATE226817T1 (de) 2002-11-15
AU710143B2 (en) 1999-09-16
EP0814787A1 (fr) 1998-01-07
DE19509828A1 (de) 1996-09-19
SE523909C2 (sv) 2004-06-01
RU2147432C1 (ru) 2000-04-20
CZ297549B6 (cs) 2007-02-07
PL322278A1 (en) 1998-01-19
DK106697A (da) 1997-09-17
CA2212794A1 (fr) 1996-09-26
HK1008927A1 (en) 1999-07-16
ITMI950529A0 (it) 1995-03-17
IL113021A0 (en) 1995-12-08
FI973702A0 (fi) 1997-09-16
NO974278L (no) 1997-09-16
JP4012328B2 (ja) 2007-11-21
JPH11500737A (ja) 1999-01-19
DE69528714D1 (de) 2002-12-05
SK286375B6 (sk) 2008-08-05
MX9707005A (es) 1997-11-29
BE1009198A5 (fr) 1996-12-03
SE527123C2 (sv) 2005-12-27
SE0400115L (sv) 2004-01-21
FI120640B (fi) 2010-01-15
FI20085586A (fi) 2008-06-13
JP3067806B2 (ja) 2000-07-24
CH693764A5 (de) 2004-01-30
HUT77358A (hu) 1998-03-30
SE9703274L (sv) 1997-09-10
PL186354B1 (pl) 2003-12-31
ZA952239B (en) 1996-09-17
ES2183869T3 (es) 2003-04-01
ATE312625T1 (de) 2005-12-15
SE0400115D0 (sv) 2004-01-21
WO1996029064A1 (fr) 1996-09-26
PT814787E (pt) 2003-02-28
NZ500588A (en) 2001-04-27
NO334956B1 (no) 2014-08-04
ITMI950529A1 (it) 1996-09-17
GB9505405D0 (en) 1995-05-03
GB9405593D0 (en) 1994-05-11
BR9510452A (pt) 1998-05-19
DK0814787T3 (da) 2003-01-06
DE69528714T2 (de) 2003-06-12
SE9703274D0 (sv) 1997-09-10
TW458781B (en) 2001-10-11
CH694396A5 (de) 2004-12-31
NZ282005A (en) 2000-01-28
CH694423A5 (de) 2005-01-14
FR2731617A1 (fr) 1996-09-20
FI973702A (fi) 1997-09-16
ES2253469T3 (es) 2006-06-01
HU227951B1 (en) 2012-07-30
FI120641B (fi) 2010-01-15
NO20041838L (no) 1997-09-16
SK124797A3 (en) 1998-01-14
SI0814787T1 (en) 2003-04-30
GB2298789B (en) 1999-12-08
CH693762A5 (de) 2004-01-30
DK1238677T3 (da) 2006-03-06

Similar Documents

Publication Publication Date Title
FR2731617B1 (fr) Compositions pharmaceutiques nouvelles contenant du propofol
CA2194226A1 (fr) Emulsions stables huile-dans-eau incorporant une taxine (taxol) et procede de preparation
DE69016749D1 (de) Emulsion.
KR870002835A (ko) 이온화성 소수성약제의 약제학적 제조방법
GR3024405T3 (en) Preparations comprising a fluorocarbon and a lipophilic/fluorophilic organic compound, and their use
ATE110563T1 (de) Arzneiemulsionen.
NO20025629L (no) Formulering
NO952521L (no) Fluorkarbonemulsjoner
DE50212331D1 (de) O/w-emulsionen mit unpolaren wirkstoffen
SE8705064L (sv) Emulsion foer parenteral administrering
TR200102995T2 (tr) PIT-emülsiyonların fermantasyon işlemlerinde kullanımı
BR0111094A (pt) Composição farmacêutica, uso de uma composição farmacêutica estéril, e, método para melhorar a sobrevida em um paciente criticamente doente
FR2681247B1 (fr) Composition pharmaceutique pour application topique contenant du dithranol et procede de preparation.
KR890011887A (ko) 이미다조벤조디아제핀에 의한 공포상태의 예방 및 중지방법
FR2692164B1 (fr) Procédé d'ultrafiltration d'émulsions stabilisées.
KR950702942A (ko) 암의 간전이 억제용 의약 조성물 및 간암 치료용 의약 조성물(pharmaceutical compositions for preventing liver metastasis of cancer and pharmaceutical composition for the treatment of liver cancer)

Legal Events

Date Code Title Description
TP Transmission of property
CD Change of name or company name
TP Transmission of property