GB8828517D0 - Stable emulsions - Google Patents
Stable emulsionsInfo
- Publication number
- GB8828517D0 GB8828517D0 GB888828517A GB8828517A GB8828517D0 GB 8828517 D0 GB8828517 D0 GB 8828517D0 GB 888828517 A GB888828517 A GB 888828517A GB 8828517 A GB8828517 A GB 8828517A GB 8828517 D0 GB8828517 D0 GB 8828517D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- zeta potential
- fat emulsion
- doubly
- triply charged
- emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Fat emulsion for parenteral administration of the oil-in-water type with a phospholipid as emulsifier, on whose disperse phase a positive zeta potential of at least +7 mV has been conferred by a content of doubly and/or triply charged metal cations, in particular calcium, magnesium and triply charged iron ion, in physiologically acceptable concentration. This positively charged fat emulsion can be prepared by starting from phospholipids which have a low charge and which in dispersion produce a negative zeta potential not exceeding -20 mV, preferably from virtually uncharged phospholipids, and bringing about the change to the positive zeta potential by adding the doubly and/or triply charged cations before or after the preparation of the emulsion. The fat emulsion is distinguished by stability, especially towards added electrolytes, and can thus advantageously be employed as a basis for complete alimentation systems.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888828517A GB8828517D0 (en) | 1988-12-07 | 1988-12-07 | Stable emulsions |
AT89121784T ATE80551T1 (en) | 1988-12-07 | 1989-11-25 | STABLE FAT EMULSION FOR PARENTERAL ADMINISTRATION. |
DE8989121784T DE58902296D1 (en) | 1988-12-07 | 1989-11-25 | STABLE FAT EMULSION FOR PARENTERAL ADMINISTRATION. |
EP89121784A EP0372331B1 (en) | 1988-12-07 | 1989-11-25 | Stable fat emulsion for parenteral administration |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888828517A GB8828517D0 (en) | 1988-12-07 | 1988-12-07 | Stable emulsions |
Publications (1)
Publication Number | Publication Date |
---|---|
GB8828517D0 true GB8828517D0 (en) | 1989-01-11 |
Family
ID=10648081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB888828517A Pending GB8828517D0 (en) | 1988-12-07 | 1988-12-07 | Stable emulsions |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0372331B1 (en) |
AT (1) | ATE80551T1 (en) |
DE (1) | DE58902296D1 (en) |
GB (1) | GB8828517D0 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL101241A (en) * | 1992-03-16 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier |
US20020173547A1 (en) | 1994-03-22 | 2002-11-21 | Jones Christopher Buchan | Pharmaceuticals compositions |
US5731356A (en) * | 1994-03-22 | 1998-03-24 | Zeneca Limited | Pharmaceutical compositions of propofol and edetate |
GB9405593D0 (en) * | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL78929A0 (en) * | 1985-07-29 | 1986-09-30 | Abbott Lab | Microemulsion compositions for parenteral administration |
-
1988
- 1988-12-07 GB GB888828517A patent/GB8828517D0/en active Pending
-
1989
- 1989-11-25 AT AT89121784T patent/ATE80551T1/en not_active IP Right Cessation
- 1989-11-25 DE DE8989121784T patent/DE58902296D1/en not_active Expired - Fee Related
- 1989-11-25 EP EP89121784A patent/EP0372331B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE80551T1 (en) | 1992-10-15 |
EP0372331A1 (en) | 1990-06-13 |
EP0372331B1 (en) | 1992-09-16 |
DE58902296D1 (en) | 1992-10-22 |
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