FR2511679A1 - Nouvelles imidazotetrazinones, leur preparation et les medicaments qui les contiennent - Google Patents

Nouvelles imidazotetrazinones, leur preparation et les medicaments qui les contiennent Download PDF

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Publication number
FR2511679A1
FR2511679A1 FR8214461A FR8214461A FR2511679A1 FR 2511679 A1 FR2511679 A1 FR 2511679A1 FR 8214461 A FR8214461 A FR 8214461A FR 8214461 A FR8214461 A FR 8214461A FR 2511679 A1 FR2511679 A1 FR 2511679A1
Authority
FR
France
Prior art keywords
general formula
carbon atoms
radicals
compound
imidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8214461A
Other languages
English (en)
French (fr)
Other versions
FR2511679B1 (ja
Inventor
Edward Lunt
Malcolm Francis Graham Stevens
Robert Stone
Kenneth Robert Harr Wooldridge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Publication of FR2511679A1 publication Critical patent/FR2511679A1/fr
Application granted granted Critical
Publication of FR2511679B1 publication Critical patent/FR2511679B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FR8214461A 1981-08-24 1982-08-23 Nouvelles imidazotetrazinones, leur preparation et les medicaments qui les contiennent Granted FR2511679A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8125791 1981-08-24

Publications (2)

Publication Number Publication Date
FR2511679A1 true FR2511679A1 (fr) 1983-02-25
FR2511679B1 FR2511679B1 (ja) 1985-02-01

Family

ID=10524141

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8214461A Granted FR2511679A1 (fr) 1981-08-24 1982-08-23 Nouvelles imidazotetrazinones, leur preparation et les medicaments qui les contiennent

Country Status (29)

Country Link
JP (1) JPS5843975A (ja)
KR (1) KR890000094B1 (ja)
AT (1) AT380256B (ja)
AU (1) AU571430B2 (ja)
BE (1) BE894175A (ja)
CA (1) CA1197247A (ja)
CH (1) CH655114A5 (ja)
DE (2) DE19975037I2 (ja)
DK (1) DK161147C (ja)
ES (1) ES8400438A1 (ja)
FI (1) FI73434C (ja)
FR (1) FR2511679A1 (ja)
GB (1) GB2104522B (ja)
GE (1) GEP19960641B (ja)
GR (1) GR76863B (ja)
HU (1) HU186107B (ja)
IE (1) IE53408B1 (ja)
IL (1) IL66606A (ja)
IT (1) IT1152505B (ja)
LT (1) LT2436B (ja)
LU (1) LU84347A1 (ja)
LV (2) LV5511A3 (ja)
NL (2) NL192739C (ja)
NZ (1) NZ201668A (ja)
OA (1) OA07174A (ja)
SE (1) SE448543B (ja)
SU (1) SU1447284A3 (ja)
UA (1) UA5971A1 (ja)
ZA (1) ZA826120B (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
WO2005063757A2 (en) * 2003-12-30 2005-07-14 Chemagis Ltd. Novel crystalline forms of temozolomide
WO2009077741A2 (en) * 2007-12-18 2009-06-25 Pharminox Limited 3-substituted-4-oxo-3,4-dihydro-imidazo-[5,1-d][1,2,3,5-tetrazine-8-carboxylic acid amides and their use
US9024018B2 (en) 2009-06-23 2015-05-05 Pharminox Limited 3-substituted-8-substituted-3H-imidazo[5,1-d][1,2,3,5]tetrazin-4-one compounds and their use

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531958B1 (fr) * 1982-08-17 1986-10-31 May & Baker Ltd Nouveaux derive
GB2125402B (en) * 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
US4517182A (en) * 1983-05-24 1985-05-14 Warner-Lambert Company 3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
MX2007008781A (es) 2005-01-21 2007-09-11 Astex Therapeutics Ltd Compuestos farmaceuticos.
PE20080695A1 (es) 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JPWO2009054332A1 (ja) 2007-10-23 2011-03-03 萬有製薬株式会社 ピリドン置換ジヒドロピラゾロピリミジノン誘導体
JP2012509868A (ja) * 2008-11-24 2012-04-26 リライアンス ライフ サイエンシズ ピーヴィーティー リミティッド テトラジン誘導体の製造方法
EP2403339B1 (en) 2009-03-06 2017-01-18 Merck Sharp & Dohme Corp. Combination cancer therapy with an akt inhibitor and other anticancer agents
RU2462466C1 (ru) * 2011-06-24 2012-09-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Замещенные азоло[1,2,4,5]тетразины - ингибиторы актинобактериальных серин-треониновых протеинкиназ
US20140271657A1 (en) 2011-10-12 2014-09-18 Children's Medical Center Corporation Combinatorial compositions and methods of treating hemoglobinopathies
MX2018011102A (es) 2016-03-15 2019-01-10 Oryzon Genomics Sa Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para uso en el tratamiento de tumores solidos.
KR101847342B1 (ko) * 2017-05-08 2018-04-11 (주)센텍코리아 웨어러블 체지방 연소량 측정기

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2932305A1 (de) * 1979-08-09 1981-02-26 Basf Ag Azolo- eckige klammer auf 5,1-d eckige klammer zu - eckige klammer auf 1,2,3,5 eckige klammer zu -tetrazin-4-one und verfahren zur herstellung dieser verbindungen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2932305A1 (de) * 1979-08-09 1981-02-26 Basf Ag Azolo- eckige klammer auf 5,1-d eckige klammer zu - eckige klammer auf 1,2,3,5 eckige klammer zu -tetrazin-4-one und verfahren zur herstellung dieser verbindungen

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
WO2005063757A2 (en) * 2003-12-30 2005-07-14 Chemagis Ltd. Novel crystalline forms of temozolomide
WO2005063757A3 (en) * 2003-12-30 2005-09-09 Chemagis Ltd Novel crystalline forms of temozolomide
US7615632B2 (en) 2003-12-30 2009-11-10 Chemagis Ltd. Crystalline forms of temozolomide
EP2275425A1 (en) * 2003-12-30 2011-01-19 Chemagis Ltd. Novel crystalline forms of temozolomide
WO2009077741A2 (en) * 2007-12-18 2009-06-25 Pharminox Limited 3-substituted-4-oxo-3,4-dihydro-imidazo-[5,1-d][1,2,3,5-tetrazine-8-carboxylic acid amides and their use
WO2009077741A3 (en) * 2007-12-18 2009-12-03 Pharminox Limited 3-substituted-4-0x0-3, 4-dihydro-imidazo- [5, 1-d] [1,2,3,5] -tetrazine-8-carboxylic acid amides as anticancer agents
US8450479B2 (en) 2007-12-18 2013-05-28 Pharminox Limited 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5-tetrazine-8-carboxylic acid amides and their use
US9024018B2 (en) 2009-06-23 2015-05-05 Pharminox Limited 3-substituted-8-substituted-3H-imidazo[5,1-d][1,2,3,5]tetrazin-4-one compounds and their use

Also Published As

Publication number Publication date
NZ201668A (en) 1985-08-16
DE3231255A1 (de) 1983-03-03
KR840001175A (ko) 1984-03-28
NL192739C (nl) 1998-01-06
CA1197247A (fr) 1985-11-26
CH655114A5 (fr) 1986-03-27
AT380256B (de) 1986-05-12
FI73434C (fi) 1987-10-09
GR76863B (ja) 1984-09-04
AU8749382A (en) 1983-03-03
GEP19960641B (en) 1996-11-15
IL66606A0 (en) 1982-12-31
SU1447284A3 (ru) 1988-12-23
DE3231255C2 (ja) 1992-02-27
OA07174A (fr) 1984-04-30
IL66606A (en) 1987-07-31
ES515176A0 (es) 1983-11-01
DE19975037I2 (de) 2001-06-13
SE8204817D0 (sv) 1982-08-23
NL990010I2 (nl) 1999-09-01
LV5511A3 (lv) 1994-03-10
BE894175A (fr) 1983-02-23
LU84347A1 (fr) 1983-06-07
LT2436B (lt) 1994-02-15
IE822026L (en) 1983-02-24
DK377882A (da) 1983-02-25
GB2104522B (en) 1985-06-12
FI73434B (fi) 1987-06-30
DK161147B (da) 1991-06-03
SE448543B (sv) 1987-03-02
HU186107B (en) 1985-06-28
IT8222938A0 (it) 1982-08-23
IT1152505B (it) 1987-01-07
JPS5843975A (ja) 1983-03-14
LV5621A3 (lv) 1994-05-10
FI822921L (fi) 1983-02-25
NL192739B (nl) 1997-09-01
ATA319182A (de) 1985-09-15
ZA826120B (en) 1983-07-27
NL990010I1 (nl) 1999-07-01
AU571430B2 (en) 1988-04-21
GB2104522A (en) 1983-03-09
IE53408B1 (en) 1988-11-09
NL8203286A (nl) 1983-03-16
DK161147C (da) 1991-11-18
FR2511679B1 (ja) 1985-02-01
SE8204817L (sv) 1983-02-25
KR890000094B1 (ko) 1989-03-07
ES8400438A1 (es) 1983-11-01
JPH045029B2 (ja) 1992-01-30
FI822921A0 (fi) 1982-08-23
UA5971A1 (uk) 1994-12-29

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Legal Events

Date Code Title Description
CD Change of name or company name
TP Transmission of property
CP Supplementary protection certificate (spc) filed

Free format text: PRODUCT NAME: TEMOZOLOMIDE; NAT. REGISTRATION NO/DATE: EU/1/98/096/005 19990126; FIRST REGISTRATION: FR - EU/1/98/096/005 19990126

Spc suppl protection certif: 99C0015

Filing date: 19990504

CR Request for supplementary protection certificate laid open to the public (eec regulation of 18 june 1992)

Free format text: 99C0015, 990504

CP Supplementary protection certificate (spc) filed
CY Supplementary certificate of protection granted (eec regulation of 18 june 1992)

Free format text: 99C0015, 19990504, EXPIRES: 20070822