FR13C0034I2 - Derives de styrylpyridine et leurs applications a la liaison et a l'imagerie de plaques amyloides - Google Patents

Derives de styrylpyridine et leurs applications a la liaison et a l'imagerie de plaques amyloides

Info

Publication number
FR13C0034I2
FR13C0034I2 FR13C0034C FR13C0034C FR13C0034I2 FR 13C0034 I2 FR13C0034 I2 FR 13C0034I2 FR 13C0034 C FR13C0034 C FR 13C0034C FR 13C0034 C FR13C0034 C FR 13C0034C FR 13C0034 I2 FR13C0034 I2 FR 13C0034I2
Authority
FR
France
Prior art keywords
imaging
applications
amyloid plaque
styrylpyridine
plaque binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR13C0034C
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English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of FR13C0034I1 publication Critical patent/FR13C0034I1/fr
Application granted granted Critical
Publication of FR13C0034I2 publication Critical patent/FR13C0034I2/fr
Active legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR13C0034C 2006-03-30 2013-06-26 Derives de styrylpyridine et leurs applications a la liaison et a l'imagerie de plaques amyloides Active FR13C0034I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78715606P 2006-03-30 2006-03-30
PCT/US2007/007400 WO2007126733A2 (en) 2006-03-30 2007-03-26 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

Publications (2)

Publication Number Publication Date
FR13C0034I1 FR13C0034I1 (pt) 2013-08-09
FR13C0034I2 true FR13C0034I2 (fr) 2014-03-07

Family

ID=38326579

Family Applications (1)

Application Number Title Priority Date Filing Date
FR13C0034C Active FR13C0034I2 (fr) 2006-03-30 2013-06-26 Derives de styrylpyridine et leurs applications a la liaison et a l'imagerie de plaques amyloides

Country Status (34)

Country Link
US (3) US7687052B2 (pt)
EP (3) EP2363391A1 (pt)
JP (1) JP5290954B2 (pt)
KR (1) KR101376807B1 (pt)
CN (1) CN101522624B (pt)
AT (1) ATE539060T1 (pt)
AU (1) AU2007243712B2 (pt)
BR (1) BRPI0710225B1 (pt)
CA (1) CA2644530C (pt)
CR (1) CR10329A (pt)
CY (3) CY1113048T1 (pt)
DK (2) DK1999109T3 (pt)
EA (1) EA017898B1 (pt)
EC (1) ECSP088783A (pt)
ES (2) ES2378785T3 (pt)
FR (1) FR13C0034I2 (pt)
GT (1) GT200800201A (pt)
HR (2) HRP20120135T1 (pt)
HU (2) HUE032660T2 (pt)
IL (1) IL193567A (pt)
LT (1) LT2363392T (pt)
LU (1) LU92232I2 (pt)
MX (1) MX2008012527A (pt)
NO (2) NO342090B1 (pt)
NZ (1) NZ570887A (pt)
PL (2) PL1999109T3 (pt)
PT (2) PT1999109E (pt)
RS (2) RS52222B (pt)
SG (1) SG173338A1 (pt)
SI (2) SI2363392T1 (pt)
TW (1) TWI399366B (pt)
UA (1) UA97802C2 (pt)
WO (1) WO2007126733A2 (pt)
ZA (1) ZA200807955B (pt)

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EP2363391A1 (en) 2006-03-30 2011-09-07 The Trustees of The University of Pennsylvania Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
EP2172444A4 (en) * 2007-07-04 2010-12-22 Univ Tohoku PET SENSOR HAVING ALCOXY GROUP SUBSTITUTED BY FLUORIN ATOM AND HYDROXY GROUP
JP5603855B2 (ja) 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
DK2381967T3 (en) * 2008-12-31 2017-03-27 Avid Radiopharmaceuticals Inc Synthesis of 18F-radiolabelled styryl pyridines from tosylate precursors and stable pharmaceutical compositions thereof
CA2767475A1 (en) * 2009-07-10 2011-01-13 Bayer Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
ES2620177T3 (es) 2009-10-15 2017-06-27 Guerbet Agentes de formación de imágenes y su uso para el diagnóstico in vivo de enfermedades neurodegenerativas, particularmente la enfermedad de Alzheimer y enfermedades derivadas
EA022447B1 (ru) * 2009-12-23 2016-01-29 Пирамаль Имэджинг Са Композиции, приемлемые для рет-визуализации при помощи гидрофобных рет-агентов
WO2011141515A1 (en) 2010-05-14 2011-11-17 Bayer Pharma Aktiengesellschaft Diagnostic agents for amyloid beta imaging
BR112012030946A2 (pt) 2010-06-04 2016-11-01 Piramal Imaging Sa método para a produção de ligante para amiloide beta marcado com f-18
PL2579902T5 (pl) 2010-06-04 2020-08-10 Life Molecular Imaging Sa Sposób wytwarzania znakowanych F-18 ligandów amyloidu beta
WO2011151281A1 (en) * 2010-06-04 2011-12-08 Bayer Pharma Aktiengesellschaft Method for production of f-18 labeled amyloid beta ligands
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
CN101891674B (zh) * 2010-06-24 2012-11-14 山东大学 4-苯乙烯基吡啶类化合物及其制备方法与应用
EP2627361B1 (en) * 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
US20140079635A1 (en) * 2011-03-30 2014-03-20 Case Western Reserve University Molecular probes for detecting lipid composition
EP2699157B1 (en) * 2011-04-21 2018-03-14 The Regents of The University of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
BR112014009013A2 (pt) 2011-10-19 2017-05-02 Piramal Imaging Sa método melhorado para a produção de ligandos aß rotulados por f-18
ES2725314T3 (es) 2012-04-10 2019-09-23 Lantheus Medical Imaging Inc Métodos de síntesis radiofarmacéutica
JP6099045B2 (ja) * 2013-04-30 2017-03-22 国立大学法人京都大学 トリアゾロピリミジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
RS61810B1 (sr) 2014-05-13 2021-06-30 Hoffmann La Roche Deuterisana heterociklična jedinjenja i njihova upotreba kao sredstva za snimanje
KR20180052611A (ko) * 2015-08-18 2018-05-18 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 영상화 및 치료 용도를 위한 니트록사이드 함유 아밀로이드 결합 제제
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) * 2018-01-02 2018-07-20 北京师范大学 与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
CN114805190A (zh) * 2022-06-08 2022-07-29 吉林大学第一医院 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法
WO2024107620A1 (en) 2022-11-14 2024-05-23 Eli Lilly And Company Polymorphic forms of florbetapir precursor av-105

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WO1992000963A1 (en) * 1990-07-12 1992-01-23 Yoshitomi Pharmaceutical Industries, Ltd. Styryl compounds and use thereof as medicine
JPH0545875A (ja) * 1991-08-08 1993-02-26 Konica Corp 感光性組成物
US6020436A (en) * 1993-03-09 2000-02-01 The Chromaline Corporation Photosensitive resin composition
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
AU2001239544A1 (en) * 2000-03-22 2001-10-03 Bf Research Institute, Inc. Image diagnosis probe based on substituted azobenzene or analogue thereof for disease attributable to amyloid accumulation and composition for image diagnosis containing the same
US8007954B2 (en) 2000-11-09 2011-08-30 The Trustees Of The University Of Pennsylvania Use of sulfur-containing fuels for direct oxidation fuel cells
JP2002182254A (ja) 2000-12-18 2002-06-26 Fuji Photo Film Co Ltd 非線形光学材料とその製造方法
DK1432453T3 (da) * 2001-08-27 2013-11-18 Univ Pennsylvania Stilbenderivater og anvendelse heraf til binding og billeddannelse af amyloid-plaques
WO2003105252A2 (en) 2002-06-06 2003-12-18 The Trustees Of The University Of Pennsylvania Ceramic anodes and method of producing the same
WO2004016271A1 (en) * 2002-08-14 2004-02-26 Axxima Pharmaceuticals Ag Pyrimidones as antiviral agents
JP4482352B2 (ja) 2004-03-11 2010-06-16 本田技研工業株式会社 固体高分子型燃料電池
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use
WO2006066104A2 (en) * 2004-12-17 2006-06-22 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
AU2006261917A1 (en) * 2005-06-24 2007-01-04 The Trustees Of The University Of Pennsylvania Radiolabeled-pegylation of ligands for use as imaging agents
EP2363391A1 (en) * 2006-03-30 2011-09-07 The Trustees of The University of Pennsylvania Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques

Also Published As

Publication number Publication date
UA97802C2 (uk) 2012-03-26
TW200838852A (en) 2008-10-01
CN101522624B (zh) 2013-11-06
DK1999109T3 (da) 2012-04-02
EA200870389A1 (ru) 2009-04-28
PL2363392T3 (pl) 2017-10-31
LT2363392T (lt) 2017-07-25
LU92232I9 (pt) 2019-01-15
US20090123369A1 (en) 2009-05-14
WO2007126733A3 (en) 2008-03-06
KR20080106564A (ko) 2008-12-08
AU2007243712B2 (en) 2013-01-10
SG173338A1 (en) 2011-08-29
JP2009532349A (ja) 2009-09-10
HRP20170857T1 (hr) 2017-12-01
SI1999109T1 (sl) 2012-04-30
EA017898B1 (ru) 2013-04-30
RS56171B1 (sr) 2017-11-30
RS52222B (en) 2012-10-31
NZ570887A (en) 2011-05-27
IL193567A (en) 2014-03-31
IL193567A0 (en) 2009-05-04
EP1999109B1 (en) 2011-12-28
ES2378785T3 (es) 2012-04-17
BRPI0710225A2 (pt) 2011-08-02
CY2013024I1 (el) 2015-11-04
US20130129624A1 (en) 2013-05-23
BRPI0710225B1 (pt) 2021-07-13
TWI399366B (zh) 2013-06-21
WO2007126733A2 (en) 2007-11-08
AU2007243712A1 (en) 2007-11-08
CR10329A (es) 2008-10-29
HUS1300028I1 (hu) 2017-08-28
LU92232I2 (fr) 2013-08-26
EP1999109A2 (en) 2008-12-10
DK2363392T3 (en) 2017-07-03
CY2013024I2 (el) 2015-11-04
US20080038195A1 (en) 2008-02-14
EP2363392A1 (en) 2011-09-07
NO342090B1 (no) 2018-03-19
PT1999109E (pt) 2012-03-16
FR13C0034I1 (pt) 2013-08-09
CY1119048T1 (el) 2018-01-10
CA2644530C (en) 2015-05-19
PL1999109T3 (pl) 2012-05-31
PT2363392T (pt) 2017-06-15
US7687052B2 (en) 2010-03-30
MX2008012527A (es) 2008-10-14
ES2628882T3 (es) 2017-08-04
EP2363391A1 (en) 2011-09-07
CY1113048T1 (el) 2015-11-04
JP5290954B2 (ja) 2013-09-18
CA2644530A1 (en) 2007-11-08
NO20084590L (no) 2008-12-29
US8506929B2 (en) 2013-08-13
US8840866B2 (en) 2014-09-23
HUE032660T2 (en) 2017-10-30
EP2363392B1 (en) 2017-05-03
SI2363392T1 (sl) 2017-09-29
ZA200807955B (en) 2012-11-28
GT200800201A (es) 2009-08-20
CN101522624A (zh) 2009-09-02
ATE539060T1 (de) 2012-01-15
KR101376807B1 (ko) 2014-03-20
HRP20120135T1 (hr) 2012-03-31
ECSP088783A (es) 2008-10-31
NO2018030I1 (no) 2018-09-11

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