FI973895L - 2-(3(S)-((L-asparaginyyli)amino)-2(R)-hydroksi-4-fenyylibutyyli)-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidijohdannaiset - Google Patents

2-(3(S)-((L-asparaginyyli)amino)-2(R)-hydroksi-4-fenyylibutyyli)-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidijohdannaiset Download PDF

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Publication number
FI973895L
FI973895L FI973895A FI973895A FI973895L FI 973895 L FI973895 L FI 973895L FI 973895 A FI973895 A FI 973895A FI 973895 A FI973895 A FI 973895A FI 973895 L FI973895 L FI 973895L
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FI
Finland
Prior art keywords
butyldecahydro
asparaginyl
phenylbutyl
isoquinoline
tert
Prior art date
Application number
FI973895A
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English (en)
Finnish (fi)
Swedish (sv)
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FI973895A7 (fi
FI973895A0 (fi
Inventor
Joseph Armstrong Martin
Sally Redshaw
Original Assignee
Hoffmann La Roche
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to FI973895A priority Critical patent/FI973895L/fi
Publication of FI973895A7 publication Critical patent/FI973895A7/fi
Publication of FI973895A0 publication Critical patent/FI973895A0/fi
Publication of FI973895L publication Critical patent/FI973895L/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Confectionery (AREA)
  • Cleaning Or Clearing Of The Surface Of Open Water (AREA)
  • Measurement Of Force In General (AREA)
FI973895A 1989-12-11 1990-12-04 2-(3(S)-((L-asparaginyyli)amino)-2(R)-hydroksi-4-fenyylibutyyli)-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidijohdannaiset FI973895L (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI973895A FI973895L (fi) 1989-12-11 1990-12-04 2-(3(S)-((L-asparaginyyli)amino)-2(R)-hydroksi-4-fenyylibutyyli)-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidijohdannaiset

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898927913A GB8927913D0 (en) 1989-12-11 1989-12-11 Amino acid derivatives
FI905983A FI100883B (fi) 1989-12-11 1990-12-04 Menetelmä 2-£3(S)-£(L-asparaginyyli)amino|-2(R)-hydroksi-4-fenyylibuty yli|-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidi johdannaisten valmistamiseksi
FI973895A FI973895L (fi) 1989-12-11 1990-12-04 2-(3(S)-((L-asparaginyyli)amino)-2(R)-hydroksi-4-fenyylibutyyli)-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidijohdannaiset
SG120493A SG120493G (en) 1989-12-11 1993-11-02 N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof

Publications (3)

Publication Number Publication Date
FI973895A7 FI973895A7 (fi) 1997-10-06
FI973895A0 FI973895A0 (fi) 1997-10-06
FI973895L true FI973895L (fi) 1997-10-06

Family

ID=26296345

Family Applications (2)

Application Number Title Priority Date Filing Date
FI973895A FI973895L (fi) 1989-12-11 1990-12-04 2-(3(S)-((L-asparaginyyli)amino)-2(R)-hydroksi-4-fenyylibutyyli)-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidijohdannaiset
FI905983A FI100883B (fi) 1989-12-11 1990-12-04 Menetelmä 2-£3(S)-£(L-asparaginyyli)amino|-2(R)-hydroksi-4-fenyylibuty yli|-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidi johdannaisten valmistamiseksi

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI905983A FI100883B (fi) 1989-12-11 1990-12-04 Menetelmä 2-£3(S)-£(L-asparaginyyli)amino|-2(R)-hydroksi-4-fenyylibuty yli|-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidi johdannaisten valmistamiseksi

Country Status (48)

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US (1) US5196438A (cs)
EP (1) EP0432695B1 (cs)
JP (1) JP2807093B2 (cs)
KR (1) KR970005912B1 (cs)
CN (2) CN1066329C (cs)
AT (1) ATE122661T1 (cs)
AU (1) AU634319B2 (cs)
BG (1) BG51452A3 (cs)
BR (1) BR9006264A (cs)
CA (1) CA2030433C (cs)
CU (1) CU22305A3 (cs)
CZ (1) CZ280558B6 (cs)
DE (2) DE69019481T2 (cs)
DK (1) DK0432695T3 (cs)
DZ (1) DZ1467A1 (cs)
EG (1) EG19722A (cs)
ES (1) ES2072959T3 (cs)
FI (2) FI973895L (cs)
GB (2) GB8927913D0 (cs)
GR (1) GR3017114T3 (cs)
HK (1) HK129093A (cs)
HR (1) HRP930341B1 (cs)
HU (2) HU207298B (cs)
ID (1) ID1018B (cs)
IE (1) IE67523B1 (cs)
IL (1) IL96550A (cs)
IN (1) IN172553B (cs)
IS (1) IS1803B (cs)
LT (1) LT3682B (cs)
LU (1) LU90014I2 (cs)
LV (1) LV5738B4 (cs)
MA (1) MA22014A1 (cs)
MC (1) MC2195A1 (cs)
MT (1) MTP1075B (cs)
MW (1) MW8890A1 (cs)
MX (1) MX173630B (cs)
NL (1) NL970013I2 (cs)
NO (1) NO176566C (cs)
OA (1) OA09334A (cs)
PL (1) PL165225B1 (cs)
PT (1) PT96145B (cs)
RO (1) RO107942B1 (cs)
RU (1) RU2071470C1 (cs)
SG (1) SG120493G (cs)
SI (1) SI9012315B (cs)
SK (1) SK280249B6 (cs)
ZA (1) ZA909743B (cs)
ZW (1) ZW17490A1 (cs)

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ZA909743B (en) 1991-08-28
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FI100883B (fi) 1998-03-13
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