SG120493G - N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof - Google Patents

N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof

Info

Publication number
SG120493G
SG120493G SG120493A SG120493A SG120493G SG 120493 G SG120493 G SG 120493G SG 120493 A SG120493 A SG 120493A SG 120493 A SG120493 A SG 120493A SG 120493 G SG120493 G SG 120493G
Authority
SG
Singapore
Prior art keywords
butyl
asparaginyl
decahydro
isoquinoline
carboxamide
Prior art date
Application number
SG120493A
Other languages
English (en)
Inventor
Joseph Armstrong Martin
Sally Redshaw
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB898927913A priority Critical patent/GB8927913D0/en
Priority to IN905MA1990 priority patent/IN172553B/en
Priority to EG68190A priority patent/EG19722A/xx
Priority to ZW174/90A priority patent/ZW17490A1/xx
Priority to MT1075A priority patent/MTP1075B/xx
Priority to MW88/90A priority patent/MW8890A1/xx
Priority to US07/615,534 priority patent/US5196438A/en
Priority to CA002030433A priority patent/CA2030433C/en
Priority to SK5765-90A priority patent/SK280249B6/sk
Priority to CS905765A priority patent/CZ280558B6/cs
Priority to FI973895A priority patent/FI973895A7/fi
Priority to MC902159A priority patent/MC2195A1/xx
Priority to RO146474A priority patent/RO107942B1/ro
Priority to ZA909743A priority patent/ZA909743B/xx
Priority to FI905983A priority patent/FI100883B/fi
Priority to IL9655090A priority patent/IL96550A/en
Priority to HU908076A priority patent/HU207298B/hu
Priority to MX023619A priority patent/MX173630B/es
Priority to KR90020078A priority patent/KR970005912B1/ko
Priority to IS3651A priority patent/IS1803B/is
Priority to AU67876/90A priority patent/AU634319B2/en
Priority to SI9012315A priority patent/SI9012315B/sl
Priority to PT96145A priority patent/PT96145B/pt
Priority to CN96107466A priority patent/CN1066329C/zh
Priority to NO905322A priority patent/NO176566C/no
Priority to DE1996175051 priority patent/DE19675051I2/de
Priority to BG093425A priority patent/BG51452A3/xx
Priority to DZ900221A priority patent/DZ1467A1/fr
Priority to AT90123697T priority patent/ATE122661T1/de
Priority to EP90123697A priority patent/EP0432695B1/en
Priority to IE445390A priority patent/IE67523B1/en
Priority to CN90109931A priority patent/CN1034805C/zh
Priority to ES90123697T priority patent/ES2072959T3/es
Priority to DE69019481T priority patent/DE69019481T2/de
Priority to CU90197A priority patent/CU22305A3/es
Priority to MA22289A priority patent/MA22014A1/fr
Priority to BR909006264A priority patent/BR9006264A/pt
Priority to DK90123697.6T priority patent/DK0432695T3/da
Priority to GB9026776A priority patent/GB2239016B/en
Priority to LU90014C priority patent/LU90014I2/fr
Priority to JP2409792A priority patent/JP2807093B2/ja
Priority to OA59914A priority patent/OA09334A/xx
Priority to PL90288201A priority patent/PL165225B1/pl
Priority to SU904831985A priority patent/RU2071470C1/ru
Priority to IDP14891A priority patent/ID1018B/id
Priority to HRP-2315/90A priority patent/HRP930341B1/xx
Priority to LTIP862A priority patent/LT3682B/lt
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to SG120493A priority patent/SG120493G/en
Priority to HK1290/93A priority patent/HK129093A/xx
Publication of SG120493G publication Critical patent/SG120493G/en
Priority to HU95P/P00230P priority patent/HU211342A9/hu
Priority to GR950402228T priority patent/GR3017114T3/el
Priority to LV960153A priority patent/LV5738B4/xx
Priority to NL970013C priority patent/NL970013I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measurement Of Force In General (AREA)
  • Confectionery (AREA)
  • Cleaning Or Clearing Of The Surface Of Open Water (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
SG120493A 1989-12-11 1993-11-02 N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof SG120493G (en)

Priority Applications (53)

Application Number Priority Date Filing Date Title
GB898927913A GB8927913D0 (en) 1989-12-11 1989-12-11 Amino acid derivatives
IN905MA1990 IN172553B (cs) 1989-12-11 1990-11-12
EG68190A EG19722A (en) 1989-12-11 1990-11-13 Process for preparing of amino acid derivatives
ZW174/90A ZW17490A1 (en) 1989-12-11 1990-11-14 Amino acid derivatives
MT1075A MTP1075B (en) 1989-12-11 1990-11-15 Amino acid derivatives
MW88/90A MW8890A1 (en) 1989-12-11 1990-11-19 Amino acid derivatives
US07/615,534 US5196438A (en) 1989-12-11 1990-11-19 Amino acid derivatives
CA002030433A CA2030433C (en) 1989-12-11 1990-11-21 New isoquinoline- carboxamide amino acid derivatives useful for treatment of viral diseases
SK5765-90A SK280249B6 (sk) 1989-12-11 1990-11-21 Deriváty aminokyselín, spôsob ich výroby, ich použ
CS905765A CZ280558B6 (cs) 1989-12-11 1990-11-21 Deriváty aminokyselin, způsob jejich výroby, jejich použití a léčiva na jejich bázi
FI973895A FI973895A7 (fi) 1989-12-11 1990-12-04 2-(3(S)-((L-asparaginyyli)amino)-2(R)-hydroksi-4-fenyylibutyyli)-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidijohdannaiset
MC902159A MC2195A1 (fr) 1989-12-11 1990-12-04 Derives d'acides amines
RO146474A RO107942B1 (ro) 1989-12-11 1990-12-04 2-[3(S)-[(L-ASPARANGINIL) AMINO]-2-(R)-HIDROXI-4-FENIL BUTIL]-N-TERT-BUTIL-DECAHIDRO-(4a S, 8 a S)- -IZOCHINOLIN-3-(S)-CARBOXAMIDE SI INTERMEDIARI
ZA909743A ZA909743B (en) 1989-12-11 1990-12-04 Amino acid derivatives
FI905983A FI100883B (fi) 1989-12-11 1990-12-04 Menetelmä 2-£3(S)-£(L-asparaginyyli)amino|-2(R)-hydroksi-4-fenyylibuty yli|-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidi johdannaisten valmistamiseksi
IL9655090A IL96550A (en) 1989-12-11 1990-12-05 Amino acid derivatives, their manufacture and pharmaceutical compositions containing them.
HU908076A HU207298B (en) 1989-12-11 1990-12-05 Process for producing perhydro-izoquinolin-amino-acid derivatives and pharmaceutical compositions containing them
MX023619A MX173630B (es) 1989-12-11 1990-12-06 Derivados de aminoacido, procedimiento para su preparacion y su preparacion y medicamento que los contiene
KR90020078A KR970005912B1 (en) 1989-12-11 1990-12-07 Amino acids derivatives
IS3651A IS1803B (is) 1989-12-11 1990-12-07 Amínósýruafleiður og aðferð til framleiðslu þeirra
AU67876/90A AU634319B2 (en) 1989-12-11 1990-12-07 Amino acid derivatives
SI9012315A SI9012315B (sl) 1989-12-11 1990-12-07 Derivati aminokislin
PT96145A PT96145B (pt) 1989-12-11 1990-12-10 Processo para a preparacao de novos derivados de aminoacidos e de composicoes farmaceuticas que os contem
CN96107466A CN1066329C (zh) 1989-12-11 1990-12-10 药物组合物的制备方法
NO905322A NO176566C (no) 1989-12-11 1990-12-10 Analogifremgangsmåte ved fremstilling av terapeutisk aktive aminosyrederivater
DE1996175051 DE19675051I2 (de) 1989-12-11 1990-12-10 Aminosaeurederivate
BG093425A BG51452A3 (bg) 1989-12-11 1990-12-10 Метод за получаване на производни на аминокиселини
DZ900221A DZ1467A1 (fr) 1989-12-11 1990-12-10 Dérivés d'acides amines.
AT90123697T ATE122661T1 (de) 1989-12-11 1990-12-10 Aminosäurederivate.
EP90123697A EP0432695B1 (en) 1989-12-11 1990-12-10 Amino acid derivatives
IE445390A IE67523B1 (en) 1989-12-11 1990-12-10 Amino acid derivatives
CN90109931A CN1034805C (zh) 1989-12-11 1990-12-10 氨基酸衍生物的制备方法
ES90123697T ES2072959T3 (es) 1989-12-11 1990-12-10 Derivados de aminoacido.
DE69019481T DE69019481T2 (de) 1989-12-11 1990-12-10 Aminosäurederivate.
CU90197A CU22305A3 (es) 1989-12-11 1990-12-10 Procedimiento para la preparacion de un derivado de aminoacidos
MA22289A MA22014A1 (fr) 1989-12-11 1990-12-10 Derives d'acides amines .
BR909006264A BR9006264A (pt) 1989-12-11 1990-12-10 Derivados de aminoacidos e processo para a sua producao,medicamentos,usos de um derivado de aminoacido e processo para tratamento ou prevencao de infeccoes viroticas
DK90123697.6T DK0432695T3 (da) 1989-12-11 1990-12-10 Aminosyrederivater
GB9026776A GB2239016B (en) 1989-12-11 1990-12-10 N-tert-butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl)isoquinoline-3-carbo xamide & asparaginyl derivatives thereof
LU90014C LU90014I2 (fr) 1989-12-11 1990-12-10 Invirase ou un de ses dérivés ou sels pharmaceutiquement acceptables Saquinavir
JP2409792A JP2807093B2 (ja) 1989-12-11 1990-12-10 アミノ酸誘導体
OA59914A OA09334A (fr) 1989-12-11 1990-12-11 "Dérivés d'acides aminés".
PL90288201A PL165225B1 (pl) 1989-12-11 1990-12-11 Sposób wytwarzania nowych pochodnych aminokwasów PL PL
SU904831985A RU2071470C1 (ru) 1989-12-11 1990-12-11 Производные аминокислот и их кислотно-аддитивные соли
IDP14891A ID1018B (id) 1989-12-11 1991-08-28 N-tersier-butil-dekahidro-2(3-amino-2-hidroksi-4-fenil-butil) isokinolin-3-karboksamida dan turunan-turunan asparaginil darinya
HRP-2315/90A HRP930341B1 (en) 1989-12-11 1993-03-12 Amino acid derivatives
LTIP862A LT3682B (en) 1989-12-11 1993-08-16 Method for preparing amino acid derivatives and pharmaceuthical compositions thereof
SG120493A SG120493G (en) 1989-12-11 1993-11-02 N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof
HK1290/93A HK129093A (en) 1989-12-11 1993-11-25 N-tert-butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl)isoquinoline-3-carboxamide & asparaginyl derivatives thereof
HU95P/P00230P HU211342A9 (en) 1989-12-11 1995-06-16 N-tert-butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl)isoquinoline-3-carboxamide and asparaginyl derivatives thereof
GR950402228T GR3017114T3 (en) 1989-12-11 1995-08-11 Amino acid derivatives.
LV960153A LV5738B4 (lv) 1989-12-11 1996-05-24 Aminoskabju atvasinajumi
NL970013C NL970013I2 (nl) 1989-12-11 1997-03-07 Aminozuurderivaten.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898927913A GB8927913D0 (en) 1989-12-11 1989-12-11 Amino acid derivatives
SG120493A SG120493G (en) 1989-12-11 1993-11-02 N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof

Publications (1)

Publication Number Publication Date
SG120493G true SG120493G (en) 1994-01-21

Family

ID=26296345

Family Applications (1)

Application Number Title Priority Date Filing Date
SG120493A SG120493G (en) 1989-12-11 1993-11-02 N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof

Country Status (48)

Country Link
US (1) US5196438A (cs)
EP (1) EP0432695B1 (cs)
JP (1) JP2807093B2 (cs)
KR (1) KR970005912B1 (cs)
CN (2) CN1034805C (cs)
AT (1) ATE122661T1 (cs)
AU (1) AU634319B2 (cs)
BG (1) BG51452A3 (cs)
BR (1) BR9006264A (cs)
CA (1) CA2030433C (cs)
CU (1) CU22305A3 (cs)
CZ (1) CZ280558B6 (cs)
DE (2) DE69019481T2 (cs)
DK (1) DK0432695T3 (cs)
DZ (1) DZ1467A1 (cs)
EG (1) EG19722A (cs)
ES (1) ES2072959T3 (cs)
FI (2) FI973895A7 (cs)
GB (2) GB8927913D0 (cs)
GR (1) GR3017114T3 (cs)
HK (1) HK129093A (cs)
HR (1) HRP930341B1 (cs)
HU (2) HU207298B (cs)
ID (1) ID1018B (cs)
IE (1) IE67523B1 (cs)
IL (1) IL96550A (cs)
IN (1) IN172553B (cs)
IS (1) IS1803B (cs)
LT (1) LT3682B (cs)
LU (1) LU90014I2 (cs)
LV (1) LV5738B4 (cs)
MA (1) MA22014A1 (cs)
MC (1) MC2195A1 (cs)
MT (1) MTP1075B (cs)
MW (1) MW8890A1 (cs)
MX (1) MX173630B (cs)
NL (1) NL970013I2 (cs)
NO (1) NO176566C (cs)
OA (1) OA09334A (cs)
PL (1) PL165225B1 (cs)
PT (1) PT96145B (cs)
RO (1) RO107942B1 (cs)
RU (1) RU2071470C1 (cs)
SG (1) SG120493G (cs)
SI (1) SI9012315B (cs)
SK (1) SK280249B6 (cs)
ZA (1) ZA909743B (cs)
ZW (1) ZW17490A1 (cs)

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US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
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US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
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EP0641325B1 (en) * 1992-05-21 2001-03-07 Monsanto Company Retroviral protease inhibitors
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
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US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
US5783701A (en) * 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
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US5733906A (en) * 1993-10-12 1998-03-31 Eli Lilly And Company Inhibitors of HIV Protease useful for the treatment of Aids
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