FI62821B - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara hydroxamsyror - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara hydroxamsyror Download PDF

Info

Publication number
FI62821B
FI62821B FI770859A FI770859A FI62821B FI 62821 B FI62821 B FI 62821B FI 770859 A FI770859 A FI 770859A FI 770859 A FI770859 A FI 770859A FI 62821 B FI62821 B FI 62821B
Authority
FI
Finland
Prior art keywords
crl
mice
solution
mol
compound
Prior art date
Application number
FI770859A
Other languages
English (en)
Finnish (fi)
Other versions
FI62821C (fi
FI770859A (sv
Inventor
Louis Lafon
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of FI770859A publication Critical patent/FI770859A/fi
Priority to FI821213A priority Critical patent/FI65236C/fi
Priority to FI821215A priority patent/FI71313C/fi
Priority to FI821214A priority patent/FI69624C/fi
Publication of FI62821B publication Critical patent/FI62821B/fi
Application granted granted Critical
Publication of FI62821C publication Critical patent/FI62821C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/56—Radicals substituted by sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Claims (2)

1. Menetelmä terapeuttisesti käyttökelpoisten hydroksaamihappo-jen valmistamiseksi, joiden kaava on I r2 R, -C-C^ I R3 ^ NHOH jossa R2 ja , jotka voivat olla samoja tai erilaisia, tarkoittavat vetyatomia tai (C-^-^^alkyyliryhmää, ja on N,N-disubstituoitu karbamoyyliryhmä, jonka kaava on Zl. ^N-CO- jossa Z·^ ja Z2/ jotka voivat olla samoja tai erilaisia, tarkoittavat (C^-Cg)-sykloalkyyliryhmää tai fenyyliryhmää ’ 3-hydantoinyyliryhmä, jonka kaava on X2 xi--f* HN N- T 0 jossa X^ on fenyyliryhmä, joka mahdollisesti on substituoitu halogee-niatomilla, ja X2 (C^-Cg)-alkyyliryhmä tai fenyyliryhmä, joka mahdollisesti on substituoitu halogeeniatomilla tai R^ on bentshydryylikar-boksamidoryhmä, jonka kaava on ! CH-CO-NH- €>x 62821 23 tunnettu siitä, että etikkahappojohdannainen, jonka kaava on II *2 Rj^-C-CO-Z II *3 jossa R·^, R£ ja tarkoittavat samaa kuin edellä ja Z on halogeeni-atomi tai (C^-C^)-alkoksiryhmää, saatetaan reagoimaan hydroksyyliamii-nin kanssa. 24 62821
1. Förfarande för framställning av terapeutiskt godtagbara hydroxaminsyror med formeIn I R,-C-C x * I R3 NIIOII väri R2 och , vilka kan vara lika ellei: olika, betecknar en väteatom eller en (C^-C2) -alkylgrupp, och R·^ är en N,Ν-disubstituerad karbamoyl-grupp med formeIn Zl"\ J^,N-CO- väri Z^ och Z2* vilka kan vara lika eller olika, betecknar en (C^-Cg)-cykloalkylgrupp eller en fenylgrupp en 3-hydanto.inylgrupp med forme In X2 / 0 v /? xi---f HN N- Y o väri är en fenylgrupp eventuellt substituerad halogenatom eller . är en benshydrylkarboxamidogrupp med formeln CH-CO-NH-
FI770859A 1976-03-23 1977-03-18 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara hydroxamsyror FI62821C (fi)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FI821213A FI65236C (fi) 1976-03-23 1982-04-06 Analogifoerfarande foer framstaellning av nya terapeutiskt anvaendbara arylsulfinylacetohydroxamsyror
FI821215A FI71313C (fi) 1976-03-23 1982-04-06 Analogifoerfarande foer framstaellning av terapeutiskt anvaendbar 2-(1-fenylbensimidazolyl)acetohydroxamsyra
FI821214A FI69624C (fi) 1976-03-23 1982-04-06 Analogifoerfarande foer framstaellning av nya terapeutiskt anvaendbara acetohydroxamsyror

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB11710/76A GB1574822A (en) 1976-03-23 1976-03-23 Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
GB1171076 1976-03-23
GB629877 1977-02-15
GB629877 1977-02-15

Publications (3)

Publication Number Publication Date
FI770859A FI770859A (sv) 1977-09-24
FI62821B true FI62821B (fi) 1982-11-30
FI62821C FI62821C (fi) 1983-03-10

Family

ID=26240593

Family Applications (1)

Application Number Title Priority Date Filing Date
FI770859A FI62821C (fi) 1976-03-23 1977-03-18 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara hydroxamsyror

Country Status (25)

Country Link
US (7) US4122186A (sv)
JP (1) JPS52144601A (sv)
AT (5) AT356078B (sv)
AU (1) AU516473B2 (sv)
BE (1) BE852738A (sv)
CA (2) CA1120928A (sv)
CH (1) CH620894A5 (sv)
CS (1) CS200511B2 (sv)
DD (1) DD129645A5 (sv)
DE (1) DE2711451A1 (sv)
DK (1) DK171197B1 (sv)
ES (1) ES457105A1 (sv)
FI (1) FI62821C (sv)
FR (4) FR2345430A1 (sv)
GB (1) GB1574822A (sv)
IE (1) IE44721B1 (sv)
IL (1) IL51705A (sv)
LU (1) LU76989A1 (sv)
NL (1) NL188801C (sv)
NO (4) NO144420C (sv)
NZ (1) NZ183616A (sv)
PH (1) PH16271A (sv)
PT (1) PT66300B (sv)
SE (4) SE432420B (sv)
SU (1) SU689617A3 (sv)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
US4405357A (en) 1980-06-02 1983-09-20 Fmc Corporation Herbicidal 3-isoxazolidinones and hydroxamic acids
FR2502617B1 (sv) * 1981-03-25 1984-04-27 Lafon Labor
FR2528041A1 (fr) * 1982-06-04 1983-12-09 Lafon Labor Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique
JPS59222454A (ja) * 1983-05-31 1984-12-14 Ajinomoto Co Inc アミノ酸の製造方法
US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
FR2584666B1 (fr) * 1985-07-10 1989-06-16 Champion Spark Plug Europ Bras moteur pour balai d'essuie-glace avec capuchon coulissant
FR2585699B1 (fr) * 1985-07-31 1988-03-11 Lafon Labor Derive d'acide acetohydroxamique, procede de preparation et utilisation en therapeutique
US5036157A (en) * 1986-03-11 1991-07-30 Burroughs Wellcome Co. Aryl derivatives
FR2601673B2 (fr) * 1986-07-21 1989-06-02 Lafon Labor Derives de l'acetamide et medicaments qui en contiennent
US4983567A (en) * 1987-03-16 1991-01-08 Biomeasure, Inc. Immunomodulators and methods of making same
ES2011588A6 (es) * 1989-05-29 1990-01-16 Vinas Lab Procedimiento para la preparacion de un nuevo derivado fenilacetico.
JPH0359402U (sv) * 1989-10-13 1991-06-12
US5283248A (en) * 1989-11-21 1994-02-01 Hoffmann-La Roche Inc. Amino substituted pyrimido[1,6-2]benzimidazoles
CA2028530A1 (en) * 1989-11-21 1991-05-22 Christian Hubschwerlen Substituted pyrimidobenzimidazole derivatives
US5378701A (en) * 1991-12-27 1995-01-03 Kyowa Hakko Kogyo Tricyclic compounds
US6060477A (en) * 1995-06-07 2000-05-09 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
DE69823019T2 (de) * 1997-02-27 2005-03-31 Wyeth Holdings Corp. N-hydroxy-2-(alkyl, aryl oder heteroaryl sulfanyl, sulfinyl oder sulfonyl)-3-substituierte alkyl-, aryl- oder heteroarylamide als matrixmetalloproteinaseinhibitoren
US6187924B1 (en) * 1997-11-12 2001-02-13 Darwin Discovery, Ltd. Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
PE20001566A1 (es) 1999-03-26 2001-02-05 Ucb Sa Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
US6686502B1 (en) 1999-03-26 2004-02-03 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
GB9911071D0 (en) * 1999-05-12 1999-07-14 Darwin Discovery Ltd Hydroxamic and carboxylic acid derivatives
EP1461308B1 (en) * 2001-12-04 2006-12-20 De Novo Pharmaceuticals Ltd. Bacterial enzyme inhibitors
DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin
EP1644323B1 (en) * 2003-07-07 2015-03-18 Georgetown University Histone deacetylase inhibitors and methods of use thereof
US7842835B2 (en) * 2003-07-07 2010-11-30 Georgetown University Histone deacetylase inhibitors and methods of use thereof
US7417040B2 (en) * 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7378426B2 (en) * 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
WO2007134169A2 (en) * 2006-05-10 2007-11-22 Nuada, Llc Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
US20090264384A1 (en) * 2004-11-01 2009-10-22 Nuada, Inc. Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
WO2007113644A2 (en) * 2006-04-05 2007-10-11 Orchid Research Laboratories Limited New hdac inhibitors
EP2041088B1 (en) 2006-06-28 2014-01-08 Amgen Inc. Glycine transporter-1 inhibitors
KR20090064400A (ko) * 2006-09-28 2009-06-18 머크 앤드 캄파니 인코포레이티드 Ｈｄａｃ 억제제 및 킬레이트화 가능한 금속 화합물 및 금속-ｈｄａｃ 억제제 킬레이트 착물의 약제학적 조성물
KR101312993B1 (ko) * 2006-10-28 2013-11-25 엔비보 파마슈티칼즈, 인코퍼레이티드 히스톤 데아세틸라아제의 억제제
WO2008094592A1 (en) * 2007-02-01 2008-08-07 Panthera Biopharna, Llc Hydroxamic acid derivatives of aniline useful as therapeutic agents for treating anthrax poisoning
FR2957492B1 (fr) 2010-03-18 2013-08-16 Rhodia Operations Nouvelles utilisations de composes de type esteramide
CN101982459A (zh) * 2010-10-21 2011-03-02 山东华尔康生物技术有限公司 乙酰氧肟酸的制备工艺
GB201509663D0 (en) * 2015-06-03 2015-07-15 Johnson Matthey Plc Benzo(h)quinoline ligands and complexes thereof
US11993575B1 (en) 2023-12-29 2024-05-28 King Faisal University Ethyl [4,4-bis(4-bromophenyl)-2,5-dioxoimidazolidin-1-yl]acetate as an antimicrobial compound
US11970462B1 (en) 2024-01-03 2024-04-30 King Faisal University Ethyl 3-[4,4-bis(4-chlorophenyl)-2,5-dioxoimidazolidin-1-yl]propanoate as an antimicrobial compound

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2862020A (en) * 1958-11-25 Derivatives of a-amino-p-hydroxy
US2279560A (en) * 1940-05-08 1942-04-14 Du Pont Viscous hydrocarbon oil
US2397508A (en) * 1943-05-29 1946-04-02 Standard Oil Co Hydroxamic acids
GB894119A (en) * 1959-11-02 1962-04-18 Ici Ltd Pivalic acid derivative
US3275643A (en) * 1963-07-19 1966-09-27 Irwin I Lubowe Allantoin-pantothenate compounds
US3634509A (en) * 1966-06-08 1972-01-11 Shell Oil Co 2 6-dinitroanilinoacetamides
NL6715600A (sv) * 1966-12-02 1968-06-04
US3927092A (en) * 1968-06-24 1975-12-16 Merck & Co Inc Amides of 2-{8 halophenoxy (or halophenylthio){9 -alkanoic acids
DE1805548A1 (de) * 1968-10-26 1970-10-08 Agfa Gevaert Ag Benzimidazol-Derivate und ihre photographische Verwendung
FR2036953A1 (en) * 1969-04-23 1970-12-31 Pluripharm Diphenylhydantoin derivs
US4092430A (en) * 1970-09-09 1978-05-30 Ciba-Geigy Corporation Antiphlogistic phenylacetohydroxamic acid compositions
US3728380A (en) * 1971-05-17 1973-04-17 Morton Norwich Products Inc P-chlorobenzamidoacetohydroxamic acid
US3839580A (en) * 1972-08-14 1974-10-01 Morton Norwich Products Inc 2-p-(nitrobenzamido)acetohydroxamic for treating urinary tract infections
SE7411007L (sv) * 1973-10-10 1975-04-11 Ciba Geigy Ag
JPS51102636A (en) * 1974-04-03 1976-09-10 Fuji Photo Film Co Ltd Karaashashingazo no keiseihoho
FR2285867A1 (fr) * 1974-09-30 1976-04-23 Lafon Labor Derives du diphenylsulfoxyde
CH593954A5 (sv) * 1975-07-21 1977-12-30 Ciba Geigy Ag
US4029812A (en) * 1976-02-18 1977-06-14 The Dow Chemical Company Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides

Also Published As

Publication number Publication date
ATA839978A (de) 1980-02-15
FI62821C (fi) 1983-03-10
NO146431B (no) 1982-06-21
IL51705A (en) 1982-09-30
FR2453133B1 (sv) 1984-04-06
FI770859A (sv) 1977-09-24
JPS52144601A (en) 1977-12-02
NO145881C (no) 1982-06-16
CA1130301A (en) 1982-08-24
FR2453158A1 (fr) 1980-10-31
CA1120928A (en) 1982-03-30
SE458605B (sv) 1989-04-17
AT361932B (de) 1981-04-10
AU516473B2 (en) 1981-06-04
PT66300B (pt) 1978-08-10
FR2345430A1 (fr) 1977-10-21
NL188801C (nl) 1992-10-01
SE8302172L (sv) 1983-04-19
US4151300A (en) 1979-04-24
DK126677A (da) 1977-09-24
FR2453148A1 (fr) 1980-10-31
FR2453158B1 (sv) 1982-08-06
SE432420B (sv) 1984-04-02
NZ183616A (en) 1979-03-28
FR2345430B1 (sv) 1982-07-23
NO152972B (no) 1985-09-16
FR2453148B1 (sv) 1983-12-02
CH620894A5 (sv) 1980-12-31
IE44721B1 (en) 1982-03-10
SE452155B (sv) 1987-11-16
AT362793B (de) 1981-06-10
SE456992B (sv) 1988-11-21
AT356078B (de) 1980-04-10
SE8302171L (sv) 1983-04-19
ATA840078A (de) 1980-11-15
SE8302171D0 (sv) 1983-04-19
SE7703263L (sv) 1977-09-24
SU689617A3 (ru) 1979-09-30
DE2711451A1 (de) 1977-10-06
US4122186A (en) 1978-10-24
PT66300A (fr) 1977-04-01
DE2711451C2 (sv) 1990-05-10
NO146431C (no) 1982-09-29
CS200511B2 (en) 1980-09-15
US4209523A (en) 1980-06-24
ATA193077A (de) 1979-09-15
NO803336L (no) 1977-09-26
US4152458A (en) 1979-05-01
AT374191B (de) 1984-03-26
ATA501480A (de) 1983-08-15
LU76989A1 (sv) 1977-07-18
DK171197B1 (da) 1996-07-22
NO144420C (no) 1981-08-26
PH16271A (en) 1983-08-25
AU2334477A (en) 1978-09-21
SE8302173D0 (sv) 1983-04-19
NL7703168A (nl) 1977-09-27
IL51705A0 (en) 1977-05-31
US4209524A (en) 1980-06-24
DD129645A5 (de) 1978-02-01
BE852738A (fr) 1977-09-22
ATA839878A (de) 1980-09-15
NO152972C (no) 1985-12-27
FR2453133A1 (fr) 1980-10-31
ES457105A1 (es) 1978-10-16
GB1574822A (en) 1980-09-10
NO803338L (no) 1977-09-26
SE8302173L (sv) 1983-04-19
US4183951A (en) 1980-01-15
NO803337L (no) 1977-09-26
NO144420B (no) 1981-05-18
JPS628424B2 (sv) 1987-02-23
US4225617A (en) 1980-09-30
AT358556B (de) 1980-09-25
NO771006L (no) 1977-09-26
SE8302172D0 (sv) 1983-04-19
NO145881B (no) 1982-03-08
IE44721L (en) 1977-09-23

Similar Documents

Publication Publication Date Title
FI62821B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara hydroxamsyror
JP2771328B2 (ja) Ｎ―フェニルアルキル置換α―アミノカルボキシアミド誘導体およびその製造方法
FI62282C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara cyliska aminosyror
DE3885889T2 (de) (r)5-pentylamino-5-oxopentanesäure-derivate mit anticholecystokininwirkung.
US4400394A (en) Benzylidene derivatives
KR101922949B1 (ko) 중추신경계 질환 및 질병 치료에 유효한 신규 화합물
JP5128959B2 (ja) 新規ヒスチジン誘導体
CS266593B2 (en) Method of 2-(2-hydroxy-3-phenosypropylamine) ethoxyphenolh's derivativesprodduction
JPH04270255A (ja) 酸化窒素生合成の抑制剤
HU215437B (hu) Gyulladáscsökkentő és vérlemezke-aggregációt gátló salétromsav-észterek és eljárás előállításukra
HU183652B (en) Process for preparing bicyclic compounds
DK162985B (da) Pyridazinderivater, som i 3-stillingen er substitueret med amino, og som indvirker paa centralnervesystemet, fremgangsmaade til fremstilling heraf og laegemidler med indhold heraf
NO141756B (no) Analogifremgangsmaate for fremstilling av antiparasittisk aktive salicylanilidderivater
WO1997033861A1 (en) Anticonvulsant enantiomeric amino acid derivatives
FI72967B (fi) Foerfarande foer framtaellning av farmaceutiskt aktiva 2-amino-3-bensoylfenylacetamidderivat.
WO2010032771A1 (ja) アミノ酸誘導体
US5451606A (en) Anthraquinone compounds useful to treat osteoarticular conditions, pharmaceutical compositions and method of treatment
DE69402004T2 (de) Beta-mercapto-propanamidderivate verwendbar zur Behandlung kardiovaskularer Krankheiten oder Erkrankungen
PT1043332E (pt) Dipeptídeos contendo ciclopentano-beta-aminoácidos
SK17302002A3 (sk) Zlúčeniny vhodné na prípravu liekov s inhibičnou aktivitou proti fosfodiesteráze IV
EP0053017A1 (en) Amide derivatives
HU190710B (en) Process for preparing 2-/4-piperazinyl/-4-phenyl-quinazoline derivatives
JPS59108758A (ja) 硫黄含有ベンジリデン誘導体
JP5121018B2 (ja) 新規ヒスチジン誘導体
FR2526793A1 (fr) Nouveaux a-(n-pyrrolyl)-acides et leurs sels et esters, utiles comme medicaments et procede de la preparation de tels composes

Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: LABORATORIE L. LAFON