SE432420B - Forfarande for framstellning av terapeutiskt verksamma hydroxamsyror - Google Patents

Forfarande for framstellning av terapeutiskt verksamma hydroxamsyror

Info

Publication number
SE432420B
SE432420B SE7703263A SE7703263A SE432420B SE 432420 B SE432420 B SE 432420B SE 7703263 A SE7703263 A SE 7703263A SE 7703263 A SE7703263 A SE 7703263A SE 432420 B SE432420 B SE 432420B
Authority
SE
Sweden
Prior art keywords
procedure
preparation
therapeutically effective
hydroxamic acids
hydroxamic
Prior art date
Application number
SE7703263A
Other languages
English (en)
Other versions
SE7703263L (sv
Inventor
L Lafon
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of SE7703263L publication Critical patent/SE7703263L/sv
Publication of SE432420B publication Critical patent/SE432420B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/56—Radicals substituted by sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
SE7703263A 1976-03-23 1977-03-22 Forfarande for framstellning av terapeutiskt verksamma hydroxamsyror SE432420B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB11710/76A GB1574822A (en) 1976-03-23 1976-03-23 Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
GB629877 1977-02-15

Publications (2)

Publication Number Publication Date
SE7703263L SE7703263L (sv) 1977-09-24
SE432420B true SE432420B (sv) 1984-04-02

Family

ID=26240593

Family Applications (4)

Application Number Title Priority Date Filing Date
SE7703263A SE432420B (sv) 1976-03-23 1977-03-22 Forfarande for framstellning av terapeutiskt verksamma hydroxamsyror
SE8302171A SE452155B (sv) 1976-03-23 1983-04-19 Analogiforfarande for framstellning av terapeutiskt verksamma arylsulfinylacetohydroxamsyraderivat
SE8302172A SE458605B (sv) 1976-03-23 1983-04-19 Foerfarande foer framstaellning av acetohydroxamsyror
SE8302173A SE456992B (sv) 1976-03-23 1983-04-19 Foerfarande foer framstaellning av 2-(1-fenyl-bensimidazolyl)-acetohydroxamsyra

Family Applications After (3)

Application Number Title Priority Date Filing Date
SE8302171A SE452155B (sv) 1976-03-23 1983-04-19 Analogiforfarande for framstellning av terapeutiskt verksamma arylsulfinylacetohydroxamsyraderivat
SE8302172A SE458605B (sv) 1976-03-23 1983-04-19 Foerfarande foer framstaellning av acetohydroxamsyror
SE8302173A SE456992B (sv) 1976-03-23 1983-04-19 Foerfarande foer framstaellning av 2-(1-fenyl-bensimidazolyl)-acetohydroxamsyra

Country Status (25)

Country Link
US (7) US4122186A (sv)
JP (1) JPS52144601A (sv)
AT (5) AT356078B (sv)
AU (1) AU516473B2 (sv)
BE (1) BE852738A (sv)
CA (2) CA1120928A (sv)
CH (1) CH620894A5 (sv)
CS (1) CS200511B2 (sv)
DD (1) DD129645A5 (sv)
DE (1) DE2711451A1 (sv)
DK (1) DK171197B1 (sv)
ES (1) ES457105A1 (sv)
FI (1) FI62821C (sv)
FR (4) FR2345430A1 (sv)
GB (1) GB1574822A (sv)
IE (1) IE44721B1 (sv)
IL (1) IL51705A (sv)
LU (1) LU76989A1 (sv)
NL (1) NL188801C (sv)
NO (4) NO144420C (sv)
NZ (1) NZ183616A (sv)
PH (1) PH16271A (sv)
PT (1) PT66300B (sv)
SE (4) SE432420B (sv)
SU (1) SU689617A3 (sv)

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US4405357A (en) 1980-06-02 1983-09-20 Fmc Corporation Herbicidal 3-isoxazolidinones and hydroxamic acids
FR2502617B1 (sv) * 1981-03-25 1984-04-27 Lafon Labor
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BR9807803A (pt) * 1997-02-27 2000-02-22 American Cyanamid Co N-hidróxi-2-(alquil, aril ou heteroaril sulfanil, sulfinil ou sulfonil) -alquila, arila ou heteroarilamidas 3-substituìdas como inibidores da metaloproteinase matricial
US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6187924B1 (en) * 1997-11-12 2001-02-13 Darwin Discovery, Ltd. Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
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DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin
US7842835B2 (en) * 2003-07-07 2010-11-30 Georgetown University Histone deacetylase inhibitors and methods of use thereof
EP1644323B1 (en) * 2003-07-07 2015-03-18 Georgetown University Histone deacetylase inhibitors and methods of use thereof
US7417040B2 (en) * 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7378426B2 (en) * 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US20090264384A1 (en) * 2004-11-01 2009-10-22 Nuada, Inc. Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
WO2007134169A2 (en) * 2006-05-10 2007-11-22 Nuada, Llc Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
WO2007113644A2 (en) * 2006-04-05 2007-10-11 Orchid Research Laboratories Limited New hdac inhibitors
KR101288781B1 (ko) 2006-06-28 2013-07-22 암젠 인크 글리신 수송자-1 억제제
MX2009003405A (es) * 2006-09-28 2009-04-09 Merck & Co Inc Composiciones farmaceuticas de inhibidores de la histona desacetilasa y compuestos quelantes de metal, y complejos de quelato de metal-inhibidor de histona desacetilasa.
BRPI0718089A2 (pt) * 2006-10-28 2013-11-05 Methylgene Inc Composto, uso do composto, composição, e, métodos para inibir histona desacetilase e para tratar uma doença de expansão da poliglutamina
US8242174B2 (en) 2007-02-01 2012-08-14 Panthera Biopharma Llc Hydroxamic acid derivatives of aniline useful as therapeutic agents for treating anthrax poisoning
FR2957492B1 (fr) * 2010-03-18 2013-08-16 Rhodia Operations Nouvelles utilisations de composes de type esteramide
CN101982459A (zh) * 2010-10-21 2011-03-02 山东华尔康生物技术有限公司 乙酰氧肟酸的制备工艺
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US11993575B1 (en) 2023-12-29 2024-05-28 King Faisal University Ethyl [4,4-bis(4-bromophenyl)-2,5-dioxoimidazolidin-1-yl]acetate as an antimicrobial compound
US11970462B1 (en) 2024-01-03 2024-04-30 King Faisal University Ethyl 3-[4,4-bis(4-chlorophenyl)-2,5-dioxoimidazolidin-1-yl]propanoate as an antimicrobial compound

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Also Published As

Publication number Publication date
AT361932B (de) 1981-04-10
ATA839878A (de) 1980-09-15
NO146431B (no) 1982-06-21
FR2453158A1 (fr) 1980-10-31
NZ183616A (en) 1979-03-28
NO803336L (no) 1977-09-26
US4209523A (en) 1980-06-24
ATA501480A (de) 1983-08-15
SE8302171L (sv) 1983-04-19
US4183951A (en) 1980-01-15
NO771006L (no) 1977-09-26
US4151300A (en) 1979-04-24
US4152458A (en) 1979-05-01
JPS52144601A (en) 1977-12-02
IL51705A (en) 1982-09-30
FI770859A (sv) 1977-09-24
FI62821C (fi) 1983-03-10
SE458605B (sv) 1989-04-17
ES457105A1 (es) 1978-10-16
AT356078B (de) 1980-04-10
IE44721B1 (en) 1982-03-10
IL51705A0 (en) 1977-05-31
DD129645A5 (de) 1978-02-01
ATA193077A (de) 1979-09-15
NO144420B (no) 1981-05-18
US4225617A (en) 1980-09-30
NL188801C (nl) 1992-10-01
FI62821B (fi) 1982-11-30
SE7703263L (sv) 1977-09-24
US4122186A (en) 1978-10-24
DE2711451A1 (de) 1977-10-06
FR2453148B1 (sv) 1983-12-02
BE852738A (fr) 1977-09-22
AU516473B2 (en) 1981-06-04
CA1120928A (en) 1982-03-30
CA1130301A (en) 1982-08-24
GB1574822A (en) 1980-09-10
SU689617A3 (ru) 1979-09-30
PH16271A (en) 1983-08-25
NO152972C (no) 1985-12-27
NL7703168A (nl) 1977-09-27
SE8302173D0 (sv) 1983-04-19
ATA840078A (de) 1980-11-15
AT374191B (de) 1984-03-26
FR2345430B1 (sv) 1982-07-23
IE44721L (en) 1977-09-23
DK171197B1 (da) 1996-07-22
DK126677A (da) 1977-09-24
SE8302173L (sv) 1983-04-19
NO803338L (no) 1977-09-26
AT362793B (de) 1981-06-10
ATA839978A (de) 1980-02-15
NO145881C (no) 1982-06-16
AU2334477A (en) 1978-09-21
DE2711451C2 (sv) 1990-05-10
NO146431C (no) 1982-09-29
FR2453133A1 (fr) 1980-10-31
NO145881B (no) 1982-03-08
SE8302172D0 (sv) 1983-04-19
FR2453133B1 (sv) 1984-04-06
NO144420C (no) 1981-08-26
PT66300A (fr) 1977-04-01
US4209524A (en) 1980-06-24
LU76989A1 (sv) 1977-07-18
FR2345430A1 (fr) 1977-10-21
SE452155B (sv) 1987-11-16
SE8302171D0 (sv) 1983-04-19
NO152972B (no) 1985-09-16
SE456992B (sv) 1988-11-21
CS200511B2 (en) 1980-09-15
SE8302172L (sv) 1983-04-19
NO803337L (no) 1977-09-26
PT66300B (pt) 1978-08-10
FR2453148A1 (fr) 1980-10-31
FR2453158B1 (sv) 1982-08-06
JPS628424B2 (sv) 1987-02-23
CH620894A5 (sv) 1980-12-31
AT358556B (de) 1980-09-25

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