AT361932B - Verfahren zur herstellung von neuen piperazin-1 -yl-acethydroxamsaeuren und deren salzen - Google Patents

Verfahren zur herstellung von neuen piperazin-1 -yl-acethydroxamsaeuren und deren salzen

Info

Publication number
AT361932B
AT361932B AT839878A AT839878A AT361932B AT 361932 B AT361932 B AT 361932B AT 839878 A AT839878 A AT 839878A AT 839878 A AT839878 A AT 839878A AT 361932 B AT361932 B AT 361932B
Authority
AT
Austria
Prior art keywords
acethydroxamic
salts
acids
producing new
new piperazine
Prior art date
Application number
AT839878A
Other languages
English (en)
Other versions
ATA839878A (de
Inventor
Louis Lafon
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of ATA839878A publication Critical patent/ATA839878A/de
Application granted granted Critical
Publication of AT361932B publication Critical patent/AT361932B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/56—Radicals substituted by sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT839878A 1976-03-23 1978-11-24 Verfahren zur herstellung von neuen piperazin-1 -yl-acethydroxamsaeuren und deren salzen AT361932B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB11710/76A GB1574822A (en) 1976-03-23 1976-03-23 Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
GB629877 1977-02-15

Publications (2)

Publication Number Publication Date
ATA839878A ATA839878A (de) 1980-09-15
AT361932B true AT361932B (de) 1981-04-10

Family

ID=26240593

Family Applications (5)

Application Number Title Priority Date Filing Date
AT193077A AT356078B (de) 1976-03-23 1977-03-21 Verfahren zur herstellung neuer acetohydroxam- saeuren und deren salze
AT839978A AT358556B (de) 1976-03-23 1978-11-24 Verfahren zur herstellung neuer aralkylsul- finyl-acetohydroxamsaeuren und deren salzen
AT0840078A AT362793B (de) 1976-03-23 1978-11-24 Verfahren zur herstellung neuer ureido-acetohydroxamsaeuren und deren metallsalzen
AT839878A AT361932B (de) 1976-03-23 1978-11-24 Verfahren zur herstellung von neuen piperazin-1 -yl-acethydroxamsaeuren und deren salzen
AT0501480A AT374191B (de) 1976-03-23 1980-10-09 Verfahren zur herstellung von neuen substituierten acethydroxamsaeuren und deren salzen

Family Applications Before (3)

Application Number Title Priority Date Filing Date
AT193077A AT356078B (de) 1976-03-23 1977-03-21 Verfahren zur herstellung neuer acetohydroxam- saeuren und deren salze
AT839978A AT358556B (de) 1976-03-23 1978-11-24 Verfahren zur herstellung neuer aralkylsul- finyl-acetohydroxamsaeuren und deren salzen
AT0840078A AT362793B (de) 1976-03-23 1978-11-24 Verfahren zur herstellung neuer ureido-acetohydroxamsaeuren und deren metallsalzen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT0501480A AT374191B (de) 1976-03-23 1980-10-09 Verfahren zur herstellung von neuen substituierten acethydroxamsaeuren und deren salzen

Country Status (25)

Country Link
US (7) US4122186A (de)
JP (1) JPS52144601A (de)
AT (5) AT356078B (de)
AU (1) AU516473B2 (de)
BE (1) BE852738A (de)
CA (2) CA1120928A (de)
CH (1) CH620894A5 (de)
CS (1) CS200511B2 (de)
DD (1) DD129645A5 (de)
DE (1) DE2711451A1 (de)
DK (1) DK171197B1 (de)
ES (1) ES457105A1 (de)
FI (1) FI62821C (de)
FR (4) FR2345430A1 (de)
GB (1) GB1574822A (de)
IE (1) IE44721B1 (de)
IL (1) IL51705A (de)
LU (1) LU76989A1 (de)
NL (1) NL188801C (de)
NO (4) NO144420C (de)
NZ (1) NZ183616A (de)
PH (1) PH16271A (de)
PT (1) PT66300B (de)
SE (4) SE432420B (de)
SU (1) SU689617A3 (de)

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US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
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EP1644323B1 (de) * 2003-07-07 2015-03-18 Georgetown University Histondeacetylaseinhibitoren und verfahren zu deren anwendung
US7842835B2 (en) * 2003-07-07 2010-11-30 Georgetown University Histone deacetylase inhibitors and methods of use thereof
US7417040B2 (en) * 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7378426B2 (en) * 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
WO2007134169A2 (en) * 2006-05-10 2007-11-22 Nuada, Llc Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
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KR101312993B1 (ko) * 2006-10-28 2013-11-25 엔비보 파마슈티칼즈, 인코퍼레이티드 히스톤 데아세틸라아제의 억제제
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FR2957492B1 (fr) 2010-03-18 2013-08-16 Rhodia Operations Nouvelles utilisations de composes de type esteramide
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Also Published As

Publication number Publication date
FI62821B (fi) 1982-11-30
ATA839978A (de) 1980-02-15
FI62821C (fi) 1983-03-10
NO146431B (no) 1982-06-21
IL51705A (en) 1982-09-30
FR2453133B1 (de) 1984-04-06
FI770859A (de) 1977-09-24
JPS52144601A (en) 1977-12-02
NO145881C (no) 1982-06-16
CA1130301A (en) 1982-08-24
FR2453158A1 (fr) 1980-10-31
CA1120928A (en) 1982-03-30
SE458605B (sv) 1989-04-17
AU516473B2 (en) 1981-06-04
PT66300B (pt) 1978-08-10
FR2345430A1 (fr) 1977-10-21
NL188801C (nl) 1992-10-01
SE8302172L (sv) 1983-04-19
US4151300A (en) 1979-04-24
DK126677A (da) 1977-09-24
FR2453148A1 (fr) 1980-10-31
FR2453158B1 (de) 1982-08-06
SE432420B (sv) 1984-04-02
NZ183616A (en) 1979-03-28
FR2345430B1 (de) 1982-07-23
NO152972B (no) 1985-09-16
FR2453148B1 (de) 1983-12-02
CH620894A5 (de) 1980-12-31
IE44721B1 (en) 1982-03-10
SE452155B (sv) 1987-11-16
AT362793B (de) 1981-06-10
SE456992B (sv) 1988-11-21
AT356078B (de) 1980-04-10
SE8302171L (sv) 1983-04-19
ATA840078A (de) 1980-11-15
SE8302171D0 (sv) 1983-04-19
SE7703263L (sv) 1977-09-24
SU689617A3 (ru) 1979-09-30
DE2711451A1 (de) 1977-10-06
US4122186A (en) 1978-10-24
PT66300A (fr) 1977-04-01
DE2711451C2 (de) 1990-05-10
NO146431C (no) 1982-09-29
CS200511B2 (en) 1980-09-15
US4209523A (en) 1980-06-24
ATA193077A (de) 1979-09-15
NO803336L (no) 1977-09-26
US4152458A (en) 1979-05-01
AT374191B (de) 1984-03-26
ATA501480A (de) 1983-08-15
LU76989A1 (de) 1977-07-18
DK171197B1 (da) 1996-07-22
NO144420C (no) 1981-08-26
PH16271A (en) 1983-08-25
AU2334477A (en) 1978-09-21
SE8302173D0 (sv) 1983-04-19
NL7703168A (nl) 1977-09-27
IL51705A0 (en) 1977-05-31
US4209524A (en) 1980-06-24
DD129645A5 (de) 1978-02-01
BE852738A (fr) 1977-09-22
ATA839878A (de) 1980-09-15
NO152972C (no) 1985-12-27
FR2453133A1 (fr) 1980-10-31
ES457105A1 (es) 1978-10-16
GB1574822A (en) 1980-09-10
NO803338L (no) 1977-09-26
SE8302173L (sv) 1983-04-19
US4183951A (en) 1980-01-15
NO803337L (no) 1977-09-26
NO144420B (no) 1981-05-18
JPS628424B2 (de) 1987-02-23
US4225617A (en) 1980-09-30
AT358556B (de) 1980-09-25
NO771006L (no) 1977-09-26
SE8302172D0 (sv) 1983-04-19
NO145881B (no) 1982-03-08
IE44721L (en) 1977-09-23

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