FR2453133A1 - Nouveaux acides acetohydroxamiques, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux acides acetohydroxamiques, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2453133A1
FR2453133A1 FR8005645A FR8005645A FR2453133A1 FR 2453133 A1 FR2453133 A1 FR 2453133A1 FR 8005645 A FR8005645 A FR 8005645A FR 8005645 A FR8005645 A FR 8005645A FR 2453133 A1 FR2453133 A1 FR 2453133A1
Authority
FR
France
Prior art keywords
novel
preparation process
therapeutic application
alkyl
acetohydroxamic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8005645A
Other languages
English (en)
Other versions
FR2453133B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of FR2453133A1 publication Critical patent/FR2453133A1/fr
Application granted granted Critical
Publication of FR2453133B1 publication Critical patent/FR2453133B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/56—Radicals substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

La présente invention concerne en tant que produits industriels nouveaux les acides acétohydroxamiques de formule R 1 R2 R3 C-CO-NHOH où R1 et R2 représentent chacun H ou un groupe alkyle en C1 -C6 , et R1 représente un groupe Z-A (où A représente- NH -, - N(alkyle en C1 -C 4 )-, -N(cycloalkyle en C5 -C6 )-, -NHCO-, N(alkyle en C1 -C 4 )CO-, -N(cycloalkyle en C5 -C6 )CO-, -CONH-, -CON(alkyle en C1 -C4 )-, -CON(cycloalkyle en C5 -C6 )-, NHCONH-, -N(C6 H5 )CONH-, - N(phényle substitué) CONH-,
FR8005645A 1976-03-23 1980-03-13 Nouveaux acides acetohydroxamiques, leur procede de preparation et leur application en therapeutique Granted FR2453133A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB11710/76A GB1574822A (en) 1976-03-23 1976-03-23 Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
GB629877 1977-02-15

Publications (2)

Publication Number Publication Date
FR2453133A1 true FR2453133A1 (fr) 1980-10-31
FR2453133B1 FR2453133B1 (fr) 1984-04-06

Family

ID=26240593

Family Applications (4)

Application Number Title Priority Date Filing Date
FR7706997A Granted FR2345430A1 (fr) 1976-03-23 1977-03-09 Nouveaux acides acetohydroxamiques
FR8005644A Granted FR2453148A1 (fr) 1976-03-23 1980-03-13 Nouveaux derives arylsulfinyle d'acide acetohydroxamique, leur procede de preparation et leur application en therapeutique
FR8005645A Granted FR2453133A1 (fr) 1976-03-23 1980-03-13 Nouveaux acides acetohydroxamiques, leur procede de preparation et leur application en therapeutique
FR8005646A Granted FR2453158A1 (fr) 1976-03-23 1980-03-13 Nouveaux acides benzimidazolyl-acetohydroxamiques, leur procede de preparation et leur application en therapeutique

Family Applications Before (2)

Application Number Title Priority Date Filing Date
FR7706997A Granted FR2345430A1 (fr) 1976-03-23 1977-03-09 Nouveaux acides acetohydroxamiques
FR8005644A Granted FR2453148A1 (fr) 1976-03-23 1980-03-13 Nouveaux derives arylsulfinyle d'acide acetohydroxamique, leur procede de preparation et leur application en therapeutique

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8005646A Granted FR2453158A1 (fr) 1976-03-23 1980-03-13 Nouveaux acides benzimidazolyl-acetohydroxamiques, leur procede de preparation et leur application en therapeutique

Country Status (25)

Country Link
US (7) US4122186A (fr)
JP (1) JPS52144601A (fr)
AT (5) AT356078B (fr)
AU (1) AU516473B2 (fr)
BE (1) BE852738A (fr)
CA (2) CA1120928A (fr)
CH (1) CH620894A5 (fr)
CS (1) CS200511B2 (fr)
DD (1) DD129645A5 (fr)
DE (1) DE2711451A1 (fr)
DK (1) DK171197B1 (fr)
ES (1) ES457105A1 (fr)
FI (1) FI62821C (fr)
FR (4) FR2345430A1 (fr)
GB (1) GB1574822A (fr)
IE (1) IE44721B1 (fr)
IL (1) IL51705A (fr)
LU (1) LU76989A1 (fr)
NL (1) NL188801C (fr)
NO (4) NO144420C (fr)
NZ (1) NZ183616A (fr)
PH (1) PH16271A (fr)
PT (1) PT66300B (fr)
SE (4) SE432420B (fr)
SU (1) SU689617A3 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
US4405357A (en) 1980-06-02 1983-09-20 Fmc Corporation Herbicidal 3-isoxazolidinones and hydroxamic acids
FR2502617B1 (fr) * 1981-03-25 1984-04-27 Lafon Labor
FR2528041A1 (fr) * 1982-06-04 1983-12-09 Lafon Labor Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique
JPS59222454A (ja) * 1983-05-31 1984-12-14 Ajinomoto Co Inc アミノ酸の製造方法
US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
FR2584666B1 (fr) * 1985-07-10 1989-06-16 Champion Spark Plug Europ Bras moteur pour balai d'essuie-glace avec capuchon coulissant
FR2585699B1 (fr) * 1985-07-31 1988-03-11 Lafon Labor Derive d'acide acetohydroxamique, procede de preparation et utilisation en therapeutique
US5036157A (en) * 1986-03-11 1991-07-30 Burroughs Wellcome Co. Aryl derivatives
FR2601673B2 (fr) * 1986-07-21 1989-06-02 Lafon Labor Derives de l'acetamide et medicaments qui en contiennent
US4983567A (en) * 1987-03-16 1991-01-08 Biomeasure, Inc. Immunomodulators and methods of making same
ES2011588A6 (es) * 1989-05-29 1990-01-16 Vinas Lab Procedimiento para la preparacion de un nuevo derivado fenilacetico.
JPH0359402U (fr) * 1989-10-13 1991-06-12
CA2028530A1 (fr) * 1989-11-21 1991-05-22 Christian Hubschwerlen Derives substitues du pyrimidobenzimidazole
US5283248A (en) * 1989-11-21 1994-02-01 Hoffmann-La Roche Inc. Amino substituted pyrimido[1,6-2]benzimidazoles
US5378701A (en) * 1991-12-27 1995-01-03 Kyowa Hakko Kogyo Tricyclic compounds
US6060477A (en) * 1995-06-07 2000-05-09 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
JP2001513771A (ja) * 1997-02-27 2001-09-04 アメリカン・サイアナミド・カンパニー マトリクス金属プロテイナーゼ阻害薬としてのｎ−ヒドロキシ−２−（アルキル、アリール、またはヘテロアリールスルファニル、スルフィニルまたはスルホニル）−３−置換アルキル、アリールまたはヘテロアリールアミド
US6187924B1 (en) * 1997-11-12 2001-02-13 Darwin Discovery, Ltd. Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
US6686502B1 (en) 1999-03-26 2004-02-03 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
PE20001566A1 (es) 1999-03-26 2001-02-05 Ucb Sa Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
GB9911071D0 (en) * 1999-05-12 1999-07-14 Darwin Discovery Ltd Hydroxamic and carboxylic acid derivatives
WO2003048114A2 (fr) * 2001-12-04 2003-06-12 De Novo Pharmaceuticals Limited Inhibiteurs d'enzymes bacteriennes
DE10320453A1 (de) * 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin
US7842835B2 (en) * 2003-07-07 2010-11-30 Georgetown University Histone deacetylase inhibitors and methods of use thereof
EP1644323B1 (fr) * 2003-07-07 2015-03-18 Georgetown University Inhibiteurs d'histone desacetylase et leurs procedes d'utilisation
US7417040B2 (en) * 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7378426B2 (en) * 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US20090264384A1 (en) * 2004-11-01 2009-10-22 Nuada, Inc. Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
WO2007134169A2 (fr) * 2006-05-10 2007-11-22 Nuada, Llc Composés d'acide indole, benzimidazole et benzolactame boronique, analogues de ces composés et méthodes d'utilisation correspondantes
WO2007113644A2 (fr) * 2006-04-05 2007-10-11 Orchid Research Laboratories Limited Nouveaux inhibiteurs d'hdac
EP2565183A1 (fr) 2006-06-28 2013-03-06 Amgen Inc. Inhibiteurs du transporteur 1 de la glycine
AU2007300532A1 (en) * 2006-09-28 2008-04-03 Merck Sharp & Dohme Corp. Pharmaceutical compositions of HDAC inhibitors and chelatable metal compounds, and metal-HDAC inhibitor chelate complexes
CL2007003108A1 (es) * 2006-10-28 2008-07-18 Methylgene Inc Envivo Pharmace Compuestos derivados de n-hidroxiamida sustituida con heterociclos, inhibidores de histona desacetilasa; composicion farmaceutica que comprende a dichos compuestos; y uso para tratar una enfermedad del grupo que consiste en enfermedad de huntington,
US8242174B2 (en) 2007-02-01 2012-08-14 Panthera Biopharma Llc Hydroxamic acid derivatives of aniline useful as therapeutic agents for treating anthrax poisoning
FR2957492B1 (fr) * 2010-03-18 2013-08-16 Rhodia Operations Nouvelles utilisations de composes de type esteramide
CN101982459A (zh) * 2010-10-21 2011-03-02 山东华尔康生物技术有限公司 乙酰氧肟酸的制备工艺
GB201509663D0 (en) * 2015-06-03 2015-07-15 Johnson Matthey Plc Benzo(h)quinoline ligands and complexes thereof
US11970462B1 (en) 2024-01-03 2024-04-30 King Faisal University Ethyl 3-[4,4-bis(4-chlorophenyl)-2,5-dioxoimidazolidin-1-yl]propanoate as an antimicrobial compound

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2862020A (en) * 1958-11-25 Derivatives of a-amino-p-hydroxy
US2279560A (en) * 1940-05-08 1942-04-14 Du Pont Viscous hydrocarbon oil
US2397508A (en) * 1943-05-29 1946-04-02 Standard Oil Co Hydroxamic acids
GB894119A (en) * 1959-11-02 1962-04-18 Ici Ltd Pivalic acid derivative
US3275643A (en) * 1963-07-19 1966-09-27 Irwin I Lubowe Allantoin-pantothenate compounds
US3634509A (en) * 1966-06-08 1972-01-11 Shell Oil Co 2 6-dinitroanilinoacetamides
NL6715600A (fr) * 1966-12-02 1968-06-04
US3927092A (en) * 1968-06-24 1975-12-16 Merck & Co Inc Amides of 2-{8 halophenoxy (or halophenylthio){9 -alkanoic acids
DE1805548A1 (de) * 1968-10-26 1970-10-08 Agfa Gevaert Ag Benzimidazol-Derivate und ihre photographische Verwendung
FR2036953A1 (en) * 1969-04-23 1970-12-31 Pluripharm Diphenylhydantoin derivs
US4092430A (en) * 1970-09-09 1978-05-30 Ciba-Geigy Corporation Antiphlogistic phenylacetohydroxamic acid compositions
US3728380A (en) * 1971-05-17 1973-04-17 Morton Norwich Products Inc P-chlorobenzamidoacetohydroxamic acid
US3839580A (en) * 1972-08-14 1974-10-01 Morton Norwich Products Inc 2-p-(nitrobenzamido)acetohydroxamic for treating urinary tract infections
SE7411007L (fr) * 1973-10-10 1975-04-11 Ciba Geigy Ag
JPS51102636A (en) * 1974-04-03 1976-09-10 Fuji Photo Film Co Ltd Karaashashingazo no keiseihoho
FR2285859A1 (fr) * 1974-09-30 1976-04-23 Lafon Labor Phenylsulfinyl-amidines et derives
CH593954A5 (fr) * 1975-07-21 1977-12-30 Ciba Geigy Ag
US4029812A (en) * 1976-02-18 1977-06-14 The Dow Chemical Company Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 55, no. 17, 21 août 1961, colonne 16662, a-; et subject index , page 182s, COLUMBUS, OHIO (US)& IGIENA 9, 319 - 26 (1960), A. ICHIM et al.: Chemical and bacteriological study of hydroxamic acids *
JOURNAL OF THE CHEMICAL SOCIETY, 1958, lONDRES (GB), A.L. Green et al.. 'The reactivity of some active nucleophilic reagents with organophosphorus anticholinesterases', pages 1583 - 1587 *

Also Published As

Publication number Publication date
IE44721B1 (en) 1982-03-10
IL51705A0 (en) 1977-05-31
ES457105A1 (es) 1978-10-16
SE8302172D0 (sv) 1983-04-19
CA1130301A (fr) 1982-08-24
FI770859A (fr) 1977-09-24
NO771006L (no) 1977-09-26
US4209524A (en) 1980-06-24
US4209523A (en) 1980-06-24
US4225617A (en) 1980-09-30
JPS628424B2 (fr) 1987-02-23
SE432420B (sv) 1984-04-02
ATA501480A (de) 1983-08-15
CA1120928A (fr) 1982-03-30
AT361932B (de) 1981-04-10
LU76989A1 (fr) 1977-07-18
SE8302172L (sv) 1983-04-19
FR2345430A1 (fr) 1977-10-21
BE852738A (fr) 1977-09-22
AU516473B2 (en) 1981-06-04
FI62821B (fi) 1982-11-30
SE458605B (sv) 1989-04-17
PT66300A (fr) 1977-04-01
DE2711451A1 (de) 1977-10-06
FR2345430B1 (fr) 1982-07-23
DK126677A (da) 1977-09-24
NO152972B (no) 1985-09-16
CH620894A5 (fr) 1980-12-31
ATA839878A (de) 1980-09-15
FR2453148B1 (fr) 1983-12-02
NL188801C (nl) 1992-10-01
ATA840078A (de) 1980-11-15
FR2453133B1 (fr) 1984-04-06
NO803338L (no) 1977-09-26
SE8302173D0 (sv) 1983-04-19
SE8302173L (sv) 1983-04-19
DK171197B1 (da) 1996-07-22
PH16271A (en) 1983-08-25
FR2453148A1 (fr) 1980-10-31
FR2453158B1 (fr) 1982-08-06
FI62821C (fi) 1983-03-10
US4183951A (en) 1980-01-15
DD129645A5 (de) 1978-02-01
NO803337L (no) 1977-09-26
NO803336L (no) 1977-09-26
ATA839978A (de) 1980-02-15
PT66300B (pt) 1978-08-10
IE44721L (en) 1977-09-23
AU2334477A (en) 1978-09-21
NZ183616A (en) 1979-03-28
IL51705A (en) 1982-09-30
ATA193077A (de) 1979-09-15
NO146431B (no) 1982-06-21
AT374191B (de) 1984-03-26
NO145881B (no) 1982-03-08
SE7703263L (sv) 1977-09-24
FR2453158A1 (fr) 1980-10-31
DE2711451C2 (fr) 1990-05-10
AT362793B (de) 1981-06-10
AT358556B (de) 1980-09-25
SU689617A3 (ru) 1979-09-30
SE456992B (sv) 1988-11-21
CS200511B2 (en) 1980-09-15
JPS52144601A (en) 1977-12-02
US4152458A (en) 1979-05-01
NO144420B (no) 1981-05-18
NO152972C (no) 1985-12-27
GB1574822A (en) 1980-09-10
SE8302171D0 (sv) 1983-04-19
AT356078B (de) 1980-04-10
US4122186A (en) 1978-10-24
NO145881C (no) 1982-06-16
NO146431C (no) 1982-09-29
NO144420C (no) 1981-08-26
NL7703168A (nl) 1977-09-27
SE8302171L (sv) 1983-04-19
SE452155B (sv) 1987-11-16
US4151300A (en) 1979-04-24

Similar Documents

Publication Publication Date Title
FR2453133A1 (fr) Nouveaux acides acetohydroxamiques, leur procede de preparation et leur application en therapeutique
YU47159B (sh) Postupak za dobijanje derivata saharoze
ES2044836T3 (es) Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene.
ATE150462T1 (de) Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung
FR2364206A1 (fr) Nouveaux derives d'acides phenoxyvaleriques et compositions herbicides les contenant
HUT59676A (en) Process for producing piperazinyl-alkyl-carbonyl derivatives of condensed heterocyclic compounds and pharmaceutical compositions containing them
FR2416889A1 (fr) Derives esters de l'acide dihydro-1,4-pyridine-dicarboxylique-3,5, medicaments a base de ces derives et leur procede de production
HU913436D0 (en) Process for the production of amino-cumarane-derivatives and medical preparations containing them
ATE48602T1 (de) Beta-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
ATE60579T1 (de) Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten.
ES2130111T3 (es) Derivados de ciclohexano, preparaciones que los contienen y su utilizacion.
FR2364219A1 (fr) Derives de thiazolidine, leur procede de preparation et leur application en therapeutique
DE3777544D1 (de) Glutaminsaeure-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische formulierungen.
IS3452A7 (is) Efni afleidd af acyl og aðferð til framleiðslu þeirra
PT83104B (en) Novel guanidinomethylbenzoic acid derivatives
ATE4642T1 (de) 2-hydroxyalkyl-3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
FR2403330A1 (fr) Nouveaux derives de benzoyl-2-chloro-4-glycinanilides substitues, leur procede de preparation et leur application en tant que medicaments
ES2012507A6 (es) Un procedimiento para la preparacion de derivados de b-lactama.
FR2450820A1 (fr) Nouveaux derives d'acides 1- (o-mercaptoacyl) -4,5-dihydropyrazole-5-carboxyliques, utiles notamment comme agents hypotenseurs, et leur procede de preparation
FR2660657B1 (fr) Nouveaux derives du 3-aminochromane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
PH20421A (en) Derivatives of piperidinedione for protecting the myocardium presenting an anti-arrythmic activity and pharmaceutical compositions containing them
FR2386547A1 (fr) Nouveaux derives de la pyrido-(2,3-b)benzothiazepine-(1,5) substitues en position 5, leur procede de preparation et leur application pharmaceutique
DE3280255D1 (de) Herstellung von substituierten gamma-butyrolactonen, verwendbar als zwischenprodukte zur herstellung von fungiziden imidazolen und triazolen.
FR2433522A1 (fr) Nouveau derive de tetrahydrofurannol, son procede de preparation et parfum le contenant
FR2609603B1 (fr) Agents edulcorants derives des acides guanidinoacetique et ethanamidinoacetique, procede pour edulcorer des produits divers, et compositions contenant de tels agents edulcorants