FR2453148A1 - Nouveaux derives arylsulfinyle d'acide acetohydroxamique, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives arylsulfinyle d'acide acetohydroxamique, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2453148A1
FR2453148A1 FR8005644A FR8005644A FR2453148A1 FR 2453148 A1 FR2453148 A1 FR 2453148A1 FR 8005644 A FR8005644 A FR 8005644A FR 8005644 A FR8005644 A FR 8005644A FR 2453148 A1 FR2453148 A1 FR 2453148A1
Authority
FR
France
Prior art keywords
arylsulfinyl
derivatives
novel
preparation
acetohydroxamic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8005644A
Other languages
English (en)
Other versions
FR2453148B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of FR2453148A1 publication Critical patent/FR2453148A1/fr
Application granted granted Critical
Publication of FR2453148B1 publication Critical patent/FR2453148B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/56—Radicals substituted by sulfur atoms

Abstract

La présente invention concerne en tant que produits industriels nouveaux des dérivés arylsulfinyle d'acide acétohydroxamique de formule :
FR8005644A 1976-03-23 1980-03-13 Nouveaux derives arylsulfinyle d'acide acetohydroxamique, leur procede de preparation et leur application en therapeutique Granted FR2453148A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB11710/76A GB1574822A (en) 1976-03-23 1976-03-23 Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
GB629877 1977-02-15

Publications (2)

Publication Number Publication Date
FR2453148A1 true FR2453148A1 (fr) 1980-10-31
FR2453148B1 FR2453148B1 (fr) 1983-12-02

Family

ID=26240593

Family Applications (4)

Application Number Title Priority Date Filing Date
FR7706997A Granted FR2345430A1 (fr) 1976-03-23 1977-03-09 Nouveaux acides acetohydroxamiques
FR8005644A Granted FR2453148A1 (fr) 1976-03-23 1980-03-13 Nouveaux derives arylsulfinyle d'acide acetohydroxamique, leur procede de preparation et leur application en therapeutique
FR8005645A Granted FR2453133A1 (fr) 1976-03-23 1980-03-13 Nouveaux acides acetohydroxamiques, leur procede de preparation et leur application en therapeutique
FR8005646A Granted FR2453158A1 (fr) 1976-03-23 1980-03-13 Nouveaux acides benzimidazolyl-acetohydroxamiques, leur procede de preparation et leur application en therapeutique

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7706997A Granted FR2345430A1 (fr) 1976-03-23 1977-03-09 Nouveaux acides acetohydroxamiques

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR8005645A Granted FR2453133A1 (fr) 1976-03-23 1980-03-13 Nouveaux acides acetohydroxamiques, leur procede de preparation et leur application en therapeutique
FR8005646A Granted FR2453158A1 (fr) 1976-03-23 1980-03-13 Nouveaux acides benzimidazolyl-acetohydroxamiques, leur procede de preparation et leur application en therapeutique

Country Status (25)

Country Link
US (7) US4122186A (fr)
JP (1) JPS52144601A (fr)
AT (5) AT356078B (fr)
AU (1) AU516473B2 (fr)
BE (1) BE852738A (fr)
CA (2) CA1120928A (fr)
CH (1) CH620894A5 (fr)
CS (1) CS200511B2 (fr)
DD (1) DD129645A5 (fr)
DE (1) DE2711451A1 (fr)
DK (1) DK171197B1 (fr)
ES (1) ES457105A1 (fr)
FI (1) FI62821C (fr)
FR (4) FR2345430A1 (fr)
GB (1) GB1574822A (fr)
IE (1) IE44721B1 (fr)
IL (1) IL51705A (fr)
LU (1) LU76989A1 (fr)
NL (1) NL188801C (fr)
NO (4) NO144420C (fr)
NZ (1) NZ183616A (fr)
PH (1) PH16271A (fr)
PT (1) PT66300B (fr)
SE (4) SE432420B (fr)
SU (1) SU689617A3 (fr)

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Also Published As

Publication number Publication date
AT374191B (de) 1984-03-26
ES457105A1 (es) 1978-10-16
IL51705A0 (en) 1977-05-31
NO152972B (no) 1985-09-16
FR2453148B1 (fr) 1983-12-02
US4225617A (en) 1980-09-30
DK126677A (da) 1977-09-24
FR2453158B1 (fr) 1982-08-06
SE8302172L (sv) 1983-04-19
PH16271A (en) 1983-08-25
IE44721B1 (en) 1982-03-10
SE8302173D0 (sv) 1983-04-19
NL188801C (nl) 1992-10-01
SE458605B (sv) 1989-04-17
ATA501480A (de) 1983-08-15
JPS52144601A (en) 1977-12-02
CA1120928A (fr) 1982-03-30
DD129645A5 (de) 1978-02-01
AU516473B2 (en) 1981-06-04
ATA193077A (de) 1979-09-15
BE852738A (fr) 1977-09-22
SE456992B (sv) 1988-11-21
NO146431C (no) 1982-09-29
DE2711451A1 (de) 1977-10-06
ATA840078A (de) 1980-11-15
NL7703168A (nl) 1977-09-27
AU2334477A (en) 1978-09-21
US4183951A (en) 1980-01-15
NO146431B (no) 1982-06-21
FR2453158A1 (fr) 1980-10-31
AT356078B (de) 1980-04-10
FI770859A (fr) 1977-09-24
SE8302171D0 (sv) 1983-04-19
FR2453133B1 (fr) 1984-04-06
SE8302171L (sv) 1983-04-19
CS200511B2 (en) 1980-09-15
SE452155B (sv) 1987-11-16
FI62821C (fi) 1983-03-10
SE7703263L (sv) 1977-09-24
CA1130301A (fr) 1982-08-24
FR2345430B1 (fr) 1982-07-23
NO144420C (no) 1981-08-26
DK171197B1 (da) 1996-07-22
AT358556B (de) 1980-09-25
PT66300A (fr) 1977-04-01
SE432420B (sv) 1984-04-02
SU689617A3 (ru) 1979-09-30
GB1574822A (en) 1980-09-10
IL51705A (en) 1982-09-30
JPS628424B2 (fr) 1987-02-23
DE2711451C2 (fr) 1990-05-10
SE8302172D0 (sv) 1983-04-19
NO803336L (no) 1977-09-26
NO144420B (no) 1981-05-18
NZ183616A (en) 1979-03-28
AT361932B (de) 1981-04-10
AT362793B (de) 1981-06-10
ATA839878A (de) 1980-09-15
NO771006L (no) 1977-09-26
LU76989A1 (fr) 1977-07-18
IE44721L (en) 1977-09-23
NO152972C (no) 1985-12-27
CH620894A5 (fr) 1980-12-31
NO803337L (no) 1977-09-26
NO803338L (no) 1977-09-26
US4209524A (en) 1980-06-24
US4122186A (en) 1978-10-24
US4152458A (en) 1979-05-01
NO145881B (no) 1982-03-08
US4151300A (en) 1979-04-24
FR2345430A1 (fr) 1977-10-21
NO145881C (no) 1982-06-16
SE8302173L (sv) 1983-04-19
FI62821B (fi) 1982-11-30
PT66300B (pt) 1978-08-10
ATA839978A (de) 1980-02-15
FR2453133A1 (fr) 1980-10-31
US4209523A (en) 1980-06-24

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