FR2385693A1 - Derives d'acetamide utiles notamment en therapeutique - Google Patents

Derives d'acetamide utiles notamment en therapeutique

Info

Publication number
FR2385693A1
FR2385693A1 FR7805590A FR7805590A FR2385693A1 FR 2385693 A1 FR2385693 A1 FR 2385693A1 FR 7805590 A FR7805590 A FR 7805590A FR 7805590 A FR7805590 A FR 7805590A FR 2385693 A1 FR2385693 A1 FR 2385693A1
Authority
FR
France
Prior art keywords
therapeutics
derivatives useful
acetamide derivatives
useful particularly
acetamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7805590A
Other languages
English (en)
Other versions
FR2385693B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of FR2385693A1 publication Critical patent/FR2385693A1/fr
Application granted granted Critical
Publication of FR2385693B1 publication Critical patent/FR2385693B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides

Abstract

La présente invention concerne en tant que produits industriels nouveaux les dérivés d'acétamide de formule:
FR7805590A 1977-03-31 1978-02-27 Derives d'acetamide utiles notamment en therapeutique Granted FR2385693A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB13579/77A GB1584462A (en) 1977-03-31 1977-03-31 N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
FR2385693A1 true FR2385693A1 (fr) 1978-10-27
FR2385693B1 FR2385693B1 (fr) 1980-04-11

Family

ID=10025527

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7805590A Granted FR2385693A1 (fr) 1977-03-31 1978-02-27 Derives d'acetamide utiles notamment en therapeutique

Country Status (14)

Country Link
US (1) US4177290A (fr)
JP (1) JPS53121724A (fr)
BE (1) BE865468A (fr)
CA (1) CA1091679A (fr)
CH (1) CH628026A5 (fr)
DE (2) DE19875010I2 (fr)
DK (1) DK152207C (fr)
ES (1) ES468378A1 (fr)
FR (1) FR2385693A1 (fr)
GB (1) GB1584462A (fr)
IE (1) IE46566B1 (fr)
IT (1) IT1094041B (fr)
LU (2) LU79335A1 (fr)
NL (2) NL188692C (fr)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528038A2 (fr) * 1982-06-04 1983-12-09 Lafon Labor Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique
EP0097072A1 (fr) * 1982-06-04 1983-12-28 LABORATOIRE L. LAFON Société anonyme dite: Nouveaux dérivés de benzylsulfinylacétamide, utilisation en thérapeutique et procédé de préparation
US4489095A (en) * 1982-06-04 1984-12-18 Laboratoire L. Lafon Halogenobenzhydrylsulfinylacetohydroxamic acids
FR2561646A1 (fr) * 1984-03-23 1985-09-27 Lafon Labor Derives d'acide (a-(alkylaminomethyl)-benzyl)-thioacetique, procede de preparation et utilisation en therapeutique
FR2584666A1 (fr) * 1985-07-10 1987-01-16 Champion Spark Plug Europ Bras moteur pour balai d'essuie-glace avec capuchon coulissant
FR2593809A1 (fr) * 1986-01-31 1987-08-07 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
EP0258134A1 (fr) * 1986-08-13 1988-03-02 Laboratoire L. Lafon Compsitions thérapeutiques contenant des dérivés du benzhydrylthiométhane
FR2611709A1 (fr) * 1987-02-26 1988-09-09 Lafon Labor 2-(benzhydrylsulfonyl)acetamide, son procede de preparation et son application en therapeutique
EP0462004A2 (fr) 1990-06-14 1991-12-18 Laboratoire L. Lafon Nouvelle utilisation du modafinil
FR2684875A1 (fr) * 1991-12-13 1993-06-18 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament ayant un effet anti-ischemique.
EP0594507A1 (fr) 1992-10-23 1994-04-27 Laboratoire L. Lafon Utilisation du modafinil pour le traitement de l'incontinence urinaire et fécale
FR2706767A1 (fr) * 1993-06-22 1994-12-30 Lafon Labor
WO1995001333A1 (fr) * 1993-06-30 1995-01-12 Laboratoire L. Lafon Derives d'acetamide et leur utilisation comme modificateurs du comportement de prise alimentaire
WO1995001171A1 (fr) * 1993-06-30 1995-01-12 Laboratoire L. Lafon Utilisation de derives d'acetamide pour modifier le comportement alimentaire
WO2001012170A2 (fr) * 1999-08-16 2001-02-22 Cephalon, Inc. Compositions a base de modafinil destinees au traitement du trouble deficitaire de l'attention avec hyperactivite et de la fatigue associee a la sclerose en plaques
WO2001054648A2 (fr) * 2000-01-31 2001-08-02 Laboratoire L. Lafon Traitement des troubles de la vigilance associes aux myopathies
US7297817B2 (en) 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7772237B2 (en) 2004-04-13 2010-08-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US8071604B2 (en) 2004-04-13 2011-12-06 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US8563014B2 (en) 2004-07-29 2013-10-22 Teva Sante Modafinil oral lyophilizate
US8580308B2 (en) 2002-07-12 2013-11-12 Cephalon, Inc. Modafinil pharmaceutical compositions

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US4393026A (en) * 1980-06-19 1983-07-12 Petrolite Corporation Compounds containing sulfur and amino groups
US4539404A (en) * 1980-06-19 1985-09-03 Petrolite Corporation Pyrimidines containing sulfur and amino groups as corrosion inhibitors
US4332967A (en) * 1980-06-19 1982-06-01 Petrolite Corporation Compounds containing sulfur and amino groups
US4616085A (en) * 1980-06-19 1986-10-07 Petrolite Corporation Thioethers of imidazolines
US4450137A (en) * 1981-11-10 1984-05-22 Petrolite Corporation Processes for inhibiting corrosion using compounds containing sulfur and amino groups
US4684507A (en) * 1981-11-10 1987-08-04 Petrolite Corporation Process of corrosion inhibition using compounds containing sulfur and amino groups
US4450138A (en) * 1981-11-10 1984-05-22 Petrolite Corporation Processes for inhibiting corrosion using compounds containing sulfur and amino groups
JPH0421903U (fr) * 1990-06-18 1992-02-24
US5618845A (en) * 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
FR2771004B1 (fr) * 1997-11-19 2000-02-18 Inst Curie Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse
US6455588B1 (en) 1999-08-20 2002-09-24 Cephalon, Inc. Compositions including modafinil for treatment of eating disorders and for appetite stimulation
CN1249932A (zh) 1999-09-29 2000-04-12 付俊昌 一种莫达芬尼及其光学对映体l及d异构体的新用途
US6492396B2 (en) * 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
US6670358B2 (en) * 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
KR100729298B1 (ko) * 2000-07-27 2007-06-18 테바 파마슈티컬 인더스트리즈 리미티드 결정질의 순수한 모다피닐 및 이의 제조 방법
US7749540B2 (en) 2000-10-11 2010-07-06 Cephalon, Inc. Compositions comprising modafinil compounds
US6489363B2 (en) 2000-10-11 2002-12-03 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
US6919378B2 (en) * 2000-10-11 2005-07-19 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
US7141555B2 (en) 2000-12-19 2006-11-28 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
US7704975B2 (en) * 2000-12-19 2010-04-27 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
IL143106A (en) 2001-05-13 2005-11-20 Chemagis Ltd Process for the preparation of diphenylmethylthioacetamide
ATE357228T1 (de) * 2001-05-25 2007-04-15 Cephalon Inc Feste pharmazeutische formulierung enthaltend modafinil
US20080058424A1 (en) * 2002-05-23 2008-03-06 Cephalon, Inc. Novel pharmaceutical formulations of modafinil
ITMI20020991A1 (it) * 2002-05-10 2003-11-10 Dinamite Dipharma S P A In For Procedimento per la sintesi del modafinil
US6875893B2 (en) * 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
US7229644B2 (en) * 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
US6992219B2 (en) 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
TW200413296A (en) * 2002-08-09 2004-08-01 Cephalon France Modafinil polymorphic forms
US20040116532A1 (en) * 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
CN1305842C (zh) * 2002-12-31 2007-03-21 中国人民解放军军事医学科学院放射与辐射医学研究所 取代亚砜基乙酰胺的制备方法
EP1437345A1 (fr) * 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Procédé pour la préparation de 2-diphénylméthylsulfinylacétate de méthyl
CA2514900A1 (fr) * 2003-01-31 2004-09-10 Alembic Limited Procede de preparation de 2-[(diphenylmethyl)thioacetamide
CN1753867A (zh) * 2003-02-24 2006-03-29 马林克罗特公司 制备二苯甲基硫代乙酰胺的方法
CA2420180A1 (fr) * 2003-02-28 2004-08-28 Bernard Charles Sherman Comprimes contenant du modafinil
US20070066996A1 (en) * 2003-03-17 2007-03-22 Katzman Daniel E Modafinil-based neurorehabilitation of impaired neurological function associated with brian injury
US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
DE60329167D1 (de) * 2003-05-16 2009-10-22 Cephalon France Verfahren zur Herstellung von Modafinil
ITMI20031298A1 (it) * 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).
WO2005046854A2 (fr) * 2003-09-12 2005-05-26 Sun Pharmaceutical Industries Limited Procede pour preparer des derives de diphenylmethylsulfinyle
EP1516869A1 (fr) * 2003-09-19 2005-03-23 Cephalon France Procédé de synthèse énantiosélective d' énantiomères uniques du modafinil par oxidation asymétrique
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
DE602004017036D1 (de) * 2003-10-23 2008-11-20 Mallinckrodt Inc Verbessertes verfahren zur herstellung von benzhydrylthioacetamid.
US20050137264A1 (en) * 2003-12-22 2005-06-23 Patel Ashish A. Modafinil compositions
CN1980888B (zh) * 2004-02-06 2011-04-13 赛福伦公司 莫达芬尼组合物
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
US7423176B2 (en) * 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
EP1586559A1 (fr) * 2004-04-13 2005-10-19 Cephalon, Inc. Dérivés biarylméthanesulfides, -sulfinyles et -sulfonyles
EP1586561A1 (fr) * 2004-04-13 2005-10-19 Cephalon, Inc. Dérivés bicycliques aromatiques de sulfinyle
US7314875B2 (en) * 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
US20060086667A1 (en) * 2004-09-13 2006-04-27 Cephalon, Inc., U.S. Corporation Methods for the separation of enantiomeric sulfinylacetamides
CN100393699C (zh) * 2005-03-10 2008-06-11 浙江工业大学 2-（二苯基甲基亚硫酰基）乙酰胺的合成方法
EP1702915A1 (fr) * 2005-03-14 2006-09-20 Cephalon France Procédé de synthèse énantiosélective d' énantiomères uniques de dérivés arylméthanesulfanyles thio-substitués par oxidation asymétrique
CN1321978C (zh) * 2005-04-29 2007-06-20 浙江工业大学 一种2－（二苯基甲基亚硫酰基）乙酰胺的合成方法
US20090123545A1 (en) * 2005-07-21 2009-05-14 Ron Eyal S Rapid Onset and Short Term Modafinil Compositions and Methods of Use Thereof
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EP2238973A1 (fr) 2009-04-07 2010-10-13 Cephalon France Préparations lyophilisées d'inhibiteurs du protéasome
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US9862679B2 (en) 2013-03-08 2018-01-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
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EP3391886A1 (fr) 2017-04-19 2018-10-24 Novartis AG Utilisation d'un agoniste inverse h3r pour le traitement de trouble du travail par équipes
WO2019094856A1 (fr) 2017-11-13 2019-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibiteurs atypiques de transporteurs de monoamine ; leur procédé de production et d'utilisation
KR102126389B1 (ko) 2018-09-14 2020-06-25 셀라이온바이오메드 주식회사 벤즈히드릴티오 아세트아미드 화합물을 유효성분으로 포함하는 간 질환의 예방 또는 치료용 조성물
MX2021004085A (es) 2018-10-11 2021-06-04 Novartis Ag El uso de un agonista inverso de h3r para el tratamiento de la somnolencia diurna excesiva asociada con la enfermedad de parkinson (ep).
KR102277739B1 (ko) 2019-12-11 2021-07-15 셀라이온바이오메드 주식회사 벤즈히드릴 티오 아세트아미드 화합물을 유효성분으로 포함하는 섬유화 질환의 치료용 조성물

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Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528038A2 (fr) * 1982-06-04 1983-12-09 Lafon Labor Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique
EP0097072A1 (fr) * 1982-06-04 1983-12-28 LABORATOIRE L. LAFON Société anonyme dite: Nouveaux dérivés de benzylsulfinylacétamide, utilisation en thérapeutique et procédé de préparation
EP0097071A1 (fr) * 1982-06-04 1983-12-28 LABORATOIRE L. LAFON Société anonyme dite: Dérivés de benzhydrylsulfinylacétamide et leur utilisation en thérapeutique
US4489095A (en) * 1982-06-04 1984-12-18 Laboratoire L. Lafon Halogenobenzhydrylsulfinylacetohydroxamic acids
FR2561646A1 (fr) * 1984-03-23 1985-09-27 Lafon Labor Derives d'acide (a-(alkylaminomethyl)-benzyl)-thioacetique, procede de preparation et utilisation en therapeutique
EP0158545A1 (fr) * 1984-03-23 1985-10-16 LABORATOIRE L. LAFON Société anonyme dite: Dérivés d'acide [alpha-(alkylaminométhyl)-benzylthio]-acétique, procédé de préparation et utilisation en thérapeutique
FR2584666A1 (fr) * 1985-07-10 1987-01-16 Champion Spark Plug Europ Bras moteur pour balai d'essuie-glace avec capuchon coulissant
FR2593809A1 (fr) * 1986-01-31 1987-08-07 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
EP0233106A1 (fr) * 1986-01-31 1987-08-19 Laboratoire L. Lafon (-)-Benzhydrylsulfinylacétamide, procédé de préparation et utilisation en thérapeutique
FR2606015A1 (fr) * 1986-08-13 1988-05-06 Lafon Labor Derives du benzhydrylthiomethane, leurs procedes de preparation et leurs applications en therapeutique
EP0258134A1 (fr) * 1986-08-13 1988-03-02 Laboratoire L. Lafon Compsitions thérapeutiques contenant des dérivés du benzhydrylthiométhane
FR2611709A1 (fr) * 1987-02-26 1988-09-09 Lafon Labor 2-(benzhydrylsulfonyl)acetamide, son procede de preparation et son application en therapeutique
EP0283362A1 (fr) * 1987-02-26 1988-09-21 Laboratoire L. Lafon 2-(benzhydrylsulfonyl) acétamide, son procédé de préparation et son application en thérapeutique
EP0462004A2 (fr) 1990-06-14 1991-12-18 Laboratoire L. Lafon Nouvelle utilisation du modafinil
FR2663225A1 (fr) * 1990-06-14 1991-12-20 Lafon Labor Nouvelle utilisation du modafinil.
EP0462004A3 (en) * 1990-06-14 1992-01-22 Laboratoire L. Lafon New use of modafinil
US5391576A (en) * 1991-12-13 1995-02-21 Laboratoire L. Lafon Method for treating and protecting the cerebral tissue against repercussions of cerebral ischaemia and cerebral infarctions
FR2684875A1 (fr) * 1991-12-13 1993-06-18 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament ayant un effet anti-ischemique.
EP0594507A1 (fr) 1992-10-23 1994-04-27 Laboratoire L. Lafon Utilisation du modafinil pour le traitement de l'incontinence urinaire et fécale
FR2697162A1 (fr) * 1992-10-23 1994-04-29 Lafon Labor Utilisation du modafinil pour la fabrication d'un médicament pour le traitement de l'incontinence urinaire et des troubles sphinctériens urétro vésicaux.
US5401776A (en) * 1992-10-23 1995-03-28 Laboratoire L. Lafon Use of modafinil for the treatment of urinary and fecal incontinence
WO1995000132A1 (fr) * 1993-06-22 1995-01-05 Laboratoire L. Lafon Utilisation du modafinil pour le traitement des apnees du sommeil et troubles ventilatoires d'origine centrale
FR2706767A1 (fr) * 1993-06-22 1994-12-30 Lafon Labor
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FR2708201A1 (fr) * 1993-06-30 1995-02-03 Lafon Labor Utilisation de dérivés d'acétamide pour la fabrication de médicaments.
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WO2001012170A3 (fr) * 1999-08-16 2002-09-06 Cephalon Inc Compositions a base de modafinil destinees au traitement du trouble deficitaire de l'attention avec hyperactivite et de la fatigue associee a la sclerose en plaques
WO2001012170A2 (fr) * 1999-08-16 2001-02-22 Cephalon, Inc. Compositions a base de modafinil destinees au traitement du trouble deficitaire de l'attention avec hyperactivite et de la fatigue associee a la sclerose en plaques
WO2001054648A2 (fr) * 2000-01-31 2001-08-02 Laboratoire L. Lafon Traitement des troubles de la vigilance associes aux myopathies
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US6462089B1 (en) 2000-01-31 2002-10-08 Laboratoire L. Lafon Method for correcting the vigilance disorders associated with myopathies
US8580308B2 (en) 2002-07-12 2013-11-12 Cephalon, Inc. Modafinil pharmaceutical compositions
US7297817B2 (en) 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7772237B2 (en) 2004-04-13 2010-08-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US8071604B2 (en) 2004-04-13 2011-12-06 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US8563014B2 (en) 2004-07-29 2013-10-22 Teva Sante Modafinil oral lyophilizate

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NL7803432A (nl) 1978-10-03
CA1091679A (fr) 1980-12-16
NL980003I1 (nl) 1998-03-02
IT7821872A0 (it) 1978-03-31
DK140878A (da) 1978-10-01
ES468378A1 (es) 1978-12-16
DE19875010I2 (de) 2001-06-13
LU90153I2 (fr) 1998-02-16
NL188692C (nl) 1992-09-01
IT1094041B (it) 1985-07-26
FR2385693B1 (fr) 1980-04-11
US4177290A (en) 1979-12-04
GB1584462A (en) 1981-02-11
DK152207C (da) 1988-07-11
LU79335A1 (fr) 1978-09-28
DK152207B (da) 1988-02-08
IE46566B1 (en) 1983-07-27
JPS53121724A (en) 1978-10-24
BE865468A (fr) 1978-10-02
DE2809625A1 (de) 1978-10-05
JPS629103B2 (fr) 1987-02-26
CH628026A5 (fr) 1982-02-15
DE2809625C2 (de) 1985-05-09
IE780433L (en) 1978-09-30
NL980003I2 (nl) 1998-05-06

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