IT1094041B - Derivati d'acetammide impiegabili segnatamente in terapia,e procedimento per produrli - Google Patents

Derivati d'acetammide impiegabili segnatamente in terapia,e procedimento per produrli

Info

Publication number
IT1094041B
IT1094041B IT21872/78A IT2187278A IT1094041B IT 1094041 B IT1094041 B IT 1094041B IT 21872/78 A IT21872/78 A IT 21872/78A IT 2187278 A IT2187278 A IT 2187278A IT 1094041 B IT1094041 B IT 1094041B
Authority
IT
Italy
Prior art keywords
signally
therapy
procedure
produce
acetamide derivatives
Prior art date
Application number
IT21872/78A
Other languages
English (en)
Other versions
IT7821872A0 (it
Inventor
Louis Lafon
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of IT7821872A0 publication Critical patent/IT7821872A0/it
Application granted granted Critical
Publication of IT1094041B publication Critical patent/IT1094041B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT21872/78A 1977-03-31 1978-03-31 Derivati d'acetammide impiegabili segnatamente in terapia,e procedimento per produrli IT1094041B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB13579/77A GB1584462A (en) 1977-03-31 1977-03-31 N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
IT7821872A0 IT7821872A0 (it) 1978-03-31
IT1094041B true IT1094041B (it) 1985-07-26

Family

ID=10025527

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21872/78A IT1094041B (it) 1977-03-31 1978-03-31 Derivati d'acetammide impiegabili segnatamente in terapia,e procedimento per produrli

Country Status (14)

Country Link
US (1) US4177290A (it)
JP (1) JPS53121724A (it)
BE (1) BE865468A (it)
CA (1) CA1091679A (it)
CH (1) CH628026A5 (it)
DE (2) DE19875010I2 (it)
DK (1) DK152207C (it)
ES (1) ES468378A1 (it)
FR (1) FR2385693A1 (it)
GB (1) GB1584462A (it)
IE (1) IE46566B1 (it)
IT (1) IT1094041B (it)
LU (2) LU79335A1 (it)
NL (2) NL188692C (it)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
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US4539404A (en) * 1980-06-19 1985-09-03 Petrolite Corporation Pyrimidines containing sulfur and amino groups as corrosion inhibitors
US4393026A (en) * 1980-06-19 1983-07-12 Petrolite Corporation Compounds containing sulfur and amino groups
US4616085A (en) * 1980-06-19 1986-10-07 Petrolite Corporation Thioethers of imidazolines
US4332967A (en) * 1980-06-19 1982-06-01 Petrolite Corporation Compounds containing sulfur and amino groups
US4450137A (en) * 1981-11-10 1984-05-22 Petrolite Corporation Processes for inhibiting corrosion using compounds containing sulfur and amino groups
US4450138A (en) * 1981-11-10 1984-05-22 Petrolite Corporation Processes for inhibiting corrosion using compounds containing sulfur and amino groups
US4684507A (en) * 1981-11-10 1987-08-04 Petrolite Corporation Process of corrosion inhibition using compounds containing sulfur and amino groups
FR2528041A1 (fr) * 1982-06-04 1983-12-09 Lafon Labor Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique
FR2528038B2 (fr) * 1982-06-04 1985-08-09 Lafon Labor Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique
FR2528039A1 (fr) * 1982-06-04 1983-12-09 Lafon Labor Nouveaux derives de benzylsulfinylacetamide, utilisation en therapeutique et procede de preparation
FR2561646B1 (fr) * 1984-03-23 1987-10-09 Lafon Labor Derives d'acide (a-(alkylaminomethyl)-benzyl)-thioacetique, procede de preparation et utilisation en therapeutique
FR2584666B1 (fr) * 1985-07-10 1989-06-16 Champion Spark Plug Europ Bras moteur pour balai d'essuie-glace avec capuchon coulissant
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
FR2606015B1 (fr) * 1986-08-13 1989-05-19 Lafon Labor Derives du benzhydrylthiomethane, leurs procedes de preparation et leurs applications en therapeutique
FR2611709B1 (fr) * 1987-02-26 1989-06-09 Lafon Labor 2-(benzhydrylsulfonyl)acetamide, son procede de preparation et son application en therapeutique
FR2663225B1 (fr) * 1990-06-14 1994-11-04 Lafon Labor Nouvelle utilisation du modafinil.
JPH0421903U (it) * 1990-06-18 1992-02-24
FR2684875B1 (fr) * 1991-12-13 1995-05-24 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament ayant un effet anti-ischemique.
FR2697162B1 (fr) * 1992-10-23 1995-01-13 Lafon Labor Utilisation du modafinil pour la fabrication d'un médicament pour le traitement de l'incontinence urinaire et des troubles sphinctériens urétro vésicaux.
FR2706767B1 (it) * 1993-06-22 1995-09-08 Lafon Labor
FR2707637B1 (fr) * 1993-06-30 1995-10-06 Lafon Labor Nouveaux dérivés d'acétamide, leur procédé de préparation et leur utilisation en thérapeutique.
FR2708201B1 (fr) * 1993-06-30 1995-10-20 Lafon Labor Utilisation de dérivés d'acétamide pour la fabrication de médicaments.
US5618845A (en) * 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
FR2771004B1 (fr) * 1997-11-19 2000-02-18 Inst Curie Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse
US6346548B1 (en) * 1999-08-16 2002-02-12 Cephalon, Inc. Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
US6455588B1 (en) 1999-08-20 2002-09-24 Cephalon, Inc. Compositions including modafinil for treatment of eating disorders and for appetite stimulation
CN1249932A (zh) 1999-09-29 2000-04-12 付俊昌 一种莫达芬尼及其光学对映体l及d异构体的新用途
FR2804322B1 (fr) * 2000-01-31 2002-04-19 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament destine a corriger les troubles de la vigilance associes aux myopathies
US6670358B2 (en) * 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
US6492396B2 (en) * 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
CZ2003529A3 (cs) * 2000-07-27 2003-09-17 Teva Pharmaceutical Industries Ltd. Krystalický a čistý modafinil a postup jeho přípravy
US6919378B2 (en) * 2000-10-11 2005-07-19 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
US6489363B2 (en) 2000-10-11 2002-12-03 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
HU229409B1 (en) 2000-10-11 2013-12-30 Cephalon Compositions comprising modafinil compounds
US7704975B2 (en) * 2000-12-19 2010-04-27 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
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IL143106A (en) * 2001-05-13 2005-11-20 Chemagis Ltd Process for the preparation of diphenylmethylthioacetamide
US20080058424A1 (en) * 2002-05-23 2008-03-06 Cephalon, Inc. Novel pharmaceutical formulations of modafinil
IL158959A (en) * 2001-05-25 2010-06-30 Cephalon Inc Solid pharmaceutical formulations comprising modafinil
ITMI20020991A1 (it) * 2002-05-10 2003-11-10 Dinamite Dipharma S P A In For Procedimento per la sintesi del modafinil
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US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
TW200413296A (en) * 2002-08-09 2004-08-01 Cephalon France Modafinil polymorphic forms
US6992219B2 (en) 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
US20040116532A1 (en) * 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
FR2849029B1 (fr) * 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
CN1305842C (zh) * 2002-12-31 2007-03-21 中国人民解放军军事医学科学院放射与辐射医学研究所 取代亚砜基乙酰胺的制备方法
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JP2006518754A (ja) * 2003-02-24 2006-08-17 マリンクロッド・インコーポレイテッド ベンズヒドリルチオアセトアミドの改良製法
CA2420180A1 (en) * 2003-02-28 2004-08-28 Bernard Charles Sherman Tablets comprising modafinil
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ITMI20031298A1 (it) * 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).
WO2005046854A2 (en) * 2003-09-12 2005-05-26 Sun Pharmaceutical Industries Limited A process for the preparation of diphenylmethylsulfinyl derivatives
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
ATE410410T1 (de) * 2003-10-23 2008-10-15 Mallinckrodt Inc Verbessertes verfahren zur herstellung von benzhydrylthioacetamid.
US20050137264A1 (en) * 2003-12-22 2005-06-23 Patel Ashish A. Modafinil compositions
CN1980888B (zh) * 2004-02-06 2011-04-13 赛福伦公司 莫达芬尼组合物
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US9289403B2 (en) * 2007-03-09 2016-03-22 The Board of Trustees of the University of Arizona Use of modafinil to treat spasticity
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US8173169B2 (en) * 2007-07-11 2012-05-08 Hikma Pharmaceuticals Formulation and process for the preparation of modafinil
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US20090082461A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched modafinil
US20090325999A1 (en) * 2008-06-27 2009-12-31 Jie Du Personalized pharmaceutical kits, packaging and compositions for the treatment of allergic conditions
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CN102976985A (zh) * 2011-09-07 2013-03-20 大连大学 一锅法合成二苯甲基亚磺酰基乙酰胺及其类似物的方法
AU2014225550C1 (en) * 2013-03-08 2017-08-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
CN104341327A (zh) * 2013-08-08 2015-02-11 中国人民解放军63975部队 多卤素取代2-(二苯甲基亚硫酰基)乙酰胺类化合物及其立体异构体
CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
CN104672118A (zh) * 2014-12-12 2015-06-03 上海泓海荣通医药技术有限公司 一种莫达非尼多晶体的合成方法
EP3391886A1 (en) 2017-04-19 2018-10-24 Novartis AG The use of a h3r inverse agonist for the treatment of shift work disorder
WO2019094856A1 (en) 2017-11-13 2019-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Atypical inhibitors of monoamine transporters; method of making; and use thereof
KR102126389B1 (ko) 2018-09-14 2020-06-25 셀라이온바이오메드 주식회사 벤즈히드릴티오 아세트아미드 화합물을 유효성분으로 포함하는 간 질환의 예방 또는 치료용 조성물
EP3863619A1 (en) 2018-10-11 2021-08-18 Novartis AG The use of a h3r inverse agonist for the treatment of excessive daytime sleepiness associated with parkinson's disease (pd)
KR102277739B1 (ko) 2019-12-11 2021-07-15 셀라이온바이오메드 주식회사 벤즈히드릴 티오 아세트아미드 화합물을 유효성분으로 포함하는 섬유화 질환의 치료용 조성물

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DE2546319C2 (de) * 1975-10-16 1986-02-27 Dr. Karl Thomae Gmbh, 7950 Biberach Cyclohexylphenyl-Derivate, Verfahren zu deren Herstellung und diese enthaltende Mittel
GB1574822A (en) * 1976-03-23 1980-09-10 Lafon Labor Acetohydroxamic acid derivatives and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
DK152207B (da) 1988-02-08
LU90153I2 (fr) 1998-02-16
DE2809625C2 (de) 1985-05-09
IE780433L (en) 1978-09-30
NL980003I2 (nl) 1998-05-06
DE19875010I2 (de) 2001-06-13
FR2385693A1 (fr) 1978-10-27
JPS629103B2 (it) 1987-02-26
BE865468A (fr) 1978-10-02
CH628026A5 (fr) 1982-02-15
NL7803432A (nl) 1978-10-03
CA1091679A (en) 1980-12-16
FR2385693B1 (it) 1980-04-11
JPS53121724A (en) 1978-10-24
DK152207C (da) 1988-07-11
GB1584462A (en) 1981-02-11
DE2809625A1 (de) 1978-10-05
IE46566B1 (en) 1983-07-27
ES468378A1 (es) 1978-12-16
LU79335A1 (fr) 1978-09-28
NL980003I1 (nl) 1998-03-02
NL188692C (nl) 1992-09-01
IT7821872A0 (it) 1978-03-31
DK140878A (da) 1978-10-01
US4177290A (en) 1979-12-04

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Legal Events

Date Code Title Description
MEDB Supplementary protection certificate for pharmaceutical products: suspended

Free format text: CCP 615, 19980325; LABORATOIRE L. LAFON S.A.

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950331