FI4005592T3 - Virionin kaltaisia kuljetuspartikkeleita itsereplikoituville rna-molekyyleille - Google Patents
Virionin kaltaisia kuljetuspartikkeleita itsereplikoituville rna-molekyyleille Download PDFInfo
- Publication number
- FI4005592T3 FI4005592T3 FIEP21204155.2T FI21204155T FI4005592T3 FI 4005592 T3 FI4005592 T3 FI 4005592T3 FI 21204155 T FI21204155 T FI 21204155T FI 4005592 T3 FI4005592 T3 FI 4005592T3
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- Prior art keywords
- composition according
- virus
- rna
- immunogen
- self
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- 239000002245 particle Substances 0.000 title claims 4
- 239000000203 mixture Substances 0.000 claims 13
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 10
- 230000002163 immunogen Effects 0.000 claims 7
- 150000002632 lipids Chemical class 0.000 claims 6
- 239000002502 liposome Substances 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000701022 Cytomegalovirus Species 0.000 claims 2
- 101710114810 Glycoprotein Proteins 0.000 claims 2
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 2
- 241000701041 Human betaherpesvirus 7 Species 0.000 claims 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 2
- 241001502974 Human gammaherpesvirus 8 Species 0.000 claims 2
- 241000701027 Human herpesvirus 6 Species 0.000 claims 2
- 241000711466 Murine hepatitis virus Species 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 101710167605 Spike glycoprotein Proteins 0.000 claims 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- OGHAROSJZRTIOK-KQYNXXCUSA-O 7-methylguanosine Chemical compound C1=2N=C(N)NC(=O)C=2[N+](C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OGHAROSJZRTIOK-KQYNXXCUSA-O 0.000 claims 1
- 241000710929 Alphavirus Species 0.000 claims 1
- 241000271566 Aves Species 0.000 claims 1
- 241000711573 Coronaviridae Species 0.000 claims 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 208000005577 Gastroenteritis Diseases 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 101000926057 Human herpesvirus 2 (strain G) Envelope glycoprotein C Proteins 0.000 claims 1
- 108060004795 Methyltransferase Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108700026244 Open Reading Frames Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- 108091028664 Ribonucleotide Proteins 0.000 claims 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 1
- 241000315672 SARS coronavirus Species 0.000 claims 1
- 241000711484 Transmissible gastroenteritis virus Species 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 210000000234 capsid Anatomy 0.000 claims 1
- 239000012876 carrier material Substances 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000763 evoking effect Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 208000037798 influenza B Diseases 0.000 claims 1
- 208000037799 influenza C Diseases 0.000 claims 1
- 108010026228 mRNA guanylyltransferase Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229940021993 prophylactic vaccine Drugs 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000002336 ribonucleotide Substances 0.000 claims 1
- 125000002652 ribonucleotide group Chemical group 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 210000002845 virion Anatomy 0.000 claims 1
Classifications
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36182810P | 2010-07-06 | 2010-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI4005592T3 true FI4005592T3 (fi) | 2023-01-13 |
Family
ID=44629863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP21204155.2T FI4005592T3 (fi) | 2010-07-06 | 2011-07-06 | Virionin kaltaisia kuljetuspartikkeleita itsereplikoituville rna-molekyyleille |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11291635B2 (enExample) |
| EP (4) | EP2590676B1 (enExample) |
| JP (1) | JP6061849B2 (enExample) |
| CN (2) | CN106421773A (enExample) |
| AU (1) | AU2011276232B2 (enExample) |
| BR (1) | BR112013000392B8 (enExample) |
| CA (1) | CA2804494A1 (enExample) |
| CY (1) | CY1118080T1 (enExample) |
| DK (1) | DK2590676T3 (enExample) |
| ES (2) | ES2600892T3 (enExample) |
| FI (1) | FI4005592T3 (enExample) |
| HR (2) | HRP20221522T1 (enExample) |
| HU (2) | HUE031485T2 (enExample) |
| LT (2) | LT4005592T (enExample) |
| MX (1) | MX342608B (enExample) |
| PL (2) | PL4005592T3 (enExample) |
| PT (2) | PT2590676T (enExample) |
| RS (2) | RS63817B1 (enExample) |
| RU (1) | RU2013104890A (enExample) |
| SI (2) | SI4005592T1 (enExample) |
| SM (2) | SMT202200500T1 (enExample) |
| WO (1) | WO2012006376A2 (enExample) |
Families Citing this family (205)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3243526T1 (sl) | 2010-07-06 | 2020-02-28 | Glaxosmithkline Biologicals S.A. | Dostava RNA za sprožitev večih imunskih poti |
| HUE026646T2 (en) | 2010-07-06 | 2016-07-28 | Glaxosmithkline Biologicals Sa | Preferred liposomes containing lipids of PKA value for delivery of RNA |
| EP3449910A1 (en) | 2010-07-06 | 2019-03-06 | GlaxoSmithKline Biologicals S.A. | Cationic oil-in-water emulsions |
| PL2591114T3 (pl) | 2010-07-06 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Immunizacja dużych ssaków małymi dawkami rna |
| EP2590676B1 (en) | 2010-07-06 | 2016-08-17 | GlaxoSmithKline Biologicals SA | Virion-like delivery particles for self-replicating rna molecules |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| DK4008357T3 (da) * | 2010-08-31 | 2023-02-20 | Glaxosmithkline Biologicals Sa | Små liposomer til afgivelse af immunogen-kodende RNA |
| RS63329B1 (sr) | 2010-08-31 | 2022-07-29 | Glaxosmithkline Biologicals Sa | Pegilovani lipozomi za isporuku rnk koja kodira imunogen |
| HUE069586T2 (hu) | 2010-10-01 | 2025-03-28 | Modernatx Inc | Módosított nukleozidok, nukleotidok és nukleinsavak, valamint ezek felhasználása |
| CN103269713B (zh) * | 2010-10-11 | 2016-01-20 | 诺华有限公司 | 抗原递送平台 |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
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| HUE026646T2 (en) | 2010-07-06 | 2016-07-28 | Glaxosmithkline Biologicals Sa | Preferred liposomes containing lipids of PKA value for delivery of RNA |
| SI3243526T1 (sl) | 2010-07-06 | 2020-02-28 | Glaxosmithkline Biologicals S.A. | Dostava RNA za sprožitev večih imunskih poti |
| EP3449910A1 (en) | 2010-07-06 | 2019-03-06 | GlaxoSmithKline Biologicals S.A. | Cationic oil-in-water emulsions |
| US9770463B2 (en) | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
| EP2590676B1 (en) | 2010-07-06 | 2016-08-17 | GlaxoSmithKline Biologicals SA | Virion-like delivery particles for self-replicating rna molecules |
| DK4008357T3 (da) * | 2010-08-31 | 2023-02-20 | Glaxosmithkline Biologicals Sa | Små liposomer til afgivelse af immunogen-kodende RNA |
| AU2011295938B2 (en) | 2010-08-31 | 2016-01-14 | Glaxosmithkline Biologicals S.A. | Lipids suitable for liposomal delivery of protein-coding RNA |
| RS63329B1 (sr) | 2010-08-31 | 2022-07-29 | Glaxosmithkline Biologicals Sa | Pegilovani lipozomi za isporuku rnk koja kodira imunogen |
| JP2014520806A (ja) | 2011-07-06 | 2014-08-25 | ノバルティス アーゲー | Ｒｎａ分子の送達のための有用なｎ：ｐ比を有するリポソーム |
| HUE041800T2 (hu) | 2011-08-31 | 2019-05-28 | Glaxosmithkline Biologicals Sa | Pegilált liposzómák immunogént kódoló RNS bejuttatására |
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2011
- 2011-07-06 EP EP11741348.4A patent/EP2590676B1/en not_active Revoked
- 2011-07-06 PL PL21204155.2T patent/PL4005592T3/pl unknown
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- 2011-07-06 RS RS20221148A patent/RS63817B1/sr unknown
- 2011-07-06 SI SI201132073T patent/SI4005592T1/sl unknown
- 2011-07-06 WO PCT/US2011/043103 patent/WO2012006376A2/en not_active Ceased
- 2011-07-06 CA CA2804494A patent/CA2804494A1/en active Pending
- 2011-07-06 PT PT212041552T patent/PT4005592T/pt unknown
- 2011-07-06 FI FIEP21204155.2T patent/FI4005592T3/fi active
- 2011-07-06 US US13/808,089 patent/US11291635B2/en active Active
- 2011-07-06 LT LTEP11741348.4T patent/LT2590676T/lt unknown
- 2011-07-06 EP EP22200367.5A patent/EP4180057A1/en active Pending
- 2011-07-06 SM SM20220500T patent/SMT202200500T1/it unknown
- 2011-07-06 DK DK11741348.4T patent/DK2590676T3/en active
- 2011-07-06 SI SI201130994A patent/SI2590676T1/sl unknown
- 2011-07-06 CN CN201610906410.1A patent/CN106421773A/zh active Pending
- 2011-07-06 EP EP16184271.1A patent/EP3115061A1/en not_active Withdrawn
- 2011-07-06 HR HRP20221522TT patent/HRP20221522T1/hr unknown
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- 2011-07-06 ES ES11741348.4T patent/ES2600892T3/es active Active
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2016
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2022
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