CY1118080T1 - Σωματιδια απελευθερωσης που ομοιαζουν με ιικα σωματιδια για αυτοαντιγραφικα rna μορια - Google Patents

Σωματιδια απελευθερωσης που ομοιαζουν με ιικα σωματιδια για αυτοαντιγραφικα rna μορια

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Publication number
CY1118080T1
CY1118080T1 CY20161101007T CY161101007T CY1118080T1 CY 1118080 T1 CY1118080 T1 CY 1118080T1 CY 20161101007 T CY20161101007 T CY 20161101007T CY 161101007 T CY161101007 T CY 161101007T CY 1118080 T1 CY1118080 T1 CY 1118080T1
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CY
Cyprus
Prior art keywords
release
rna
self
particles
particle
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CY20161101007T
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English (en)
Inventor
Andrew Geall
Christian Mandl
Derek O'hagan
Manmohan Singh
Original Assignee
Glaxosmithkline Biologicals S.A.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44629863&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1118080(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of CY1118080T1 publication Critical patent/CY1118080T1/el

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Abstract

Η ανοσοποίηση νουκλεϊνικού οξέος επιτυγχάνεται με απελευθέρωση αυτο-αντιγραφικού RNA ενθυλακωμένου εντός μικρού σωματιδίου. Το RNA κωδικοποιεί ανοσογόνο που ενδιαφέρει και το σωματίδιο μπορεί να απελευθερώσει αυτό το RNA μιμούμενο την λειτουργία απελευθέρωσης φυσικού RNA ιού. Έτσι η εφεύρεση παρέχει μη-ιικό σωματίδιο για in vivo απελευθέρωση RNA σε κύτταρο σπονδυλωτού, όπου το σωματίδιο περιλαμβάνει υλικό απελευθέρωσης που ενθυλακώνει μόριο αυτο-αντιγραφικού RNA που κωδικοποιεί ανοσογόνο. Αυτά τα σωματίδια είναι χρήσιμα ως συστατικά σε φαρμακευτικές συνθέσεις για ανοσοποίηση υποκειμένων έναντι διαφόρων ασθενειών.
CY20161101007T 2010-07-06 2016-10-10 Σωματιδια απελευθερωσης που ομοιαζουν με ιικα σωματιδια για αυτοαντιγραφικα rna μορια CY1118080T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36182810P 2010-07-06 2010-07-06
PCT/US2011/043103 WO2012006376A2 (en) 2010-07-06 2011-07-06 Virion-like delivery particles for self-replicating rna molecules

Publications (1)

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CY1118080T1 true CY1118080T1 (el) 2017-06-28

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CY20161101007T CY1118080T1 (el) 2010-07-06 2016-10-10 Σωματιδια απελευθερωσης που ομοιαζουν με ιικα σωματιδια για αυτοαντιγραφικα rna μορια

Country Status (22)

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US (2) US11291635B2 (el)
EP (4) EP4005592B1 (el)
JP (1) JP6061849B2 (el)
CN (2) CN103052400B (el)
AU (1) AU2011276232B2 (el)
BR (1) BR112013000392B8 (el)
CA (1) CA2804494A1 (el)
CY (1) CY1118080T1 (el)
DK (1) DK2590676T3 (el)
ES (2) ES2600892T3 (el)
FI (1) FI4005592T3 (el)
HR (2) HRP20221522T1 (el)
HU (2) HUE031485T2 (el)
LT (2) LT4005592T (el)
MX (1) MX342608B (el)
PL (2) PL4005592T3 (el)
PT (2) PT2590676T (el)
RS (2) RS55260B1 (el)
RU (1) RU2013104890A (el)
SI (2) SI4005592T1 (el)
SM (1) SMT201600386B (el)
WO (1) WO2012006376A2 (el)

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