CY1113760T1 - Εμβολιο - Google Patents
ΕμβολιοInfo
- Publication number
- CY1113760T1 CY1113760T1 CY20121101065T CY121101065T CY1113760T1 CY 1113760 T1 CY1113760 T1 CY 1113760T1 CY 20121101065 T CY20121101065 T CY 20121101065T CY 121101065 T CY121101065 T CY 121101065T CY 1113760 T1 CY1113760 T1 CY 1113760T1
- Authority
- CY
- Cyprus
- Prior art keywords
- protein
- fusion
- self
- preparation
- helper
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 abstract 1
- 241000606768 Haemophilus influenzae Species 0.000 abstract 1
- 102000036673 PRAME Human genes 0.000 abstract 1
- 108060006580 PRAME Proteins 0.000 abstract 1
- 101710188053 Protein D Proteins 0.000 abstract 1
- 101710132893 Resolvase Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 208000037800 influenza D Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001189—PRAME
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με πρωτεΐνες σύντηξης που αποτελούνται από ένα αντιγόνο που προέρχεται από το επονομαζόμενο αντιγόνο απόρριψης όγκων PRAME (που είναι γνωστό κι ως DAGE) συνδεδεμένο με έναν ανοσολογικό συνεργό σύντηξης που παρέχει επιτόπους Τ βοηθητικών κυττάρων, όπως για παράδειγμα πρωτεΐνη D από Haemophilus influenzae Β, με πρωτεΐνες-συνεργούς σύντηξης που περιέχουν θραύσματα της πρωτεΐνης D, με μεθόδους παρασκευής των ιδίων και παρασκευής εμβολίων και με χρήση των ιδιών για θεραπεία μιας ποικιλίας καρκίνων.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0700760A GB0700760D0 (en) | 2007-01-15 | 2007-01-15 | Vaccine |
GB0701262A GB0701262D0 (en) | 2007-01-23 | 2007-01-23 | Vaccine |
EP08701434A EP2114993B1 (en) | 2007-01-15 | 2008-01-11 | Vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113760T1 true CY1113760T1 (el) | 2016-07-27 |
Family
ID=39300029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121101065T CY1113760T1 (el) | 2007-01-15 | 2012-11-09 | Εμβολιο |
Country Status (32)
Country | Link |
---|---|
US (1) | US20080187535A1 (el) |
EP (1) | EP2114993B1 (el) |
JP (1) | JP5391080B2 (el) |
KR (1) | KR20090101313A (el) |
CN (1) | CN101668770B (el) |
AR (1) | AR064862A1 (el) |
AU (1) | AU2008207025B2 (el) |
BR (1) | BRPI0806463A2 (el) |
CA (1) | CA2674552A1 (el) |
CL (1) | CL2008000104A1 (el) |
CO (1) | CO6210757A2 (el) |
CR (1) | CR10971A (el) |
CY (1) | CY1113760T1 (el) |
DK (1) | DK2114993T3 (el) |
DO (1) | DOP2009000167A (el) |
EA (1) | EA016326B1 (el) |
ES (1) | ES2393812T3 (el) |
HK (1) | HK1138853A1 (el) |
HR (1) | HRP20120828T1 (el) |
IL (1) | IL199663A0 (el) |
JO (1) | JO2840B1 (el) |
MA (1) | MA31093B1 (el) |
MX (1) | MX2009007571A (el) |
MY (1) | MY153679A (el) |
NZ (1) | NZ578285A (el) |
PE (2) | PE20081686A1 (el) |
PL (1) | PL2114993T3 (el) |
PT (1) | PT2114993E (el) |
SI (1) | SI2114993T1 (el) |
TW (1) | TWI434697B (el) |
WO (1) | WO2008087102A1 (el) |
ZA (1) | ZA200904923B (el) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2118128T3 (pl) * | 2007-01-15 | 2013-03-29 | Glaxosmithkline Biologicals Sa | Białka fuzyjne zawierające antygeny odrzucenia nowotworu NY-ESO-1 i LAGE-1 |
MX2011009597A (es) | 2009-03-17 | 2012-05-29 | Glaxosmithkline Biolog Sa | Deteccion mejorada de la expresion del gen. |
WO2010141953A2 (en) * | 2009-06-05 | 2010-12-09 | The Ohio State University Research Foundation | Biomaterials, compositions, and methods |
GB0910046D0 (en) | 2009-06-10 | 2009-07-22 | Glaxosmithkline Biolog Sa | Novel compositions |
GB201008682D0 (en) * | 2010-05-25 | 2010-07-07 | Vib Vzw | Epitope tag for affinity based applications |
GB201101331D0 (en) * | 2011-01-26 | 2011-03-09 | Glaxosmithkline Biolog Sa | Compositions and uses |
WO2013014105A1 (en) | 2011-07-22 | 2013-01-31 | Glaxosmithkline Biologicals S.A. | Prame purification |
GB201114919D0 (en) * | 2011-08-30 | 2011-10-12 | Glaxosmithkline Biolog Sa | Method |
GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
RU2590701C2 (ru) * | 2013-04-29 | 2016-07-10 | Общество с ограниченной ответственностью "ГеноТехнология" | Антигенная композиция и ее терапевтическое применение для профилактики и лечения онкологических заболеваний, рекомбинантная плазмидная днк, обеспечивающая синтез гибридного белка, а также способ получения белка |
WO2015050158A1 (ja) | 2013-10-01 | 2015-04-09 | 国立大学法人三重大学 | 抗原提示を促進するエピトープ間配列を含むt細胞誘導ワクチン |
CN105254767A (zh) * | 2015-11-17 | 2016-01-20 | 重庆科润生物医药研发有限公司 | 一种Protein D与HER2融合蛋白及其制备方法和应用 |
EP3548623A4 (en) | 2016-11-30 | 2020-11-25 | Advaxis, Inc. | IMMUNOGENIC COMPOSITIONS TARGETING RECURRENT CANCER MUTATIONS AND THEIR USE PROCEDURES |
CN108264550B (zh) * | 2017-01-04 | 2021-04-23 | 香雪生命科学技术(广东)有限公司 | 一种识别源自于prame抗原短肽的tcr |
CN108948184B (zh) * | 2017-05-22 | 2021-04-23 | 香雪生命科学技术(广东)有限公司 | 一种识别衍生自prame抗原短肽的t细胞受体 |
CN109400697B (zh) * | 2017-08-17 | 2021-04-23 | 香雪生命科学技术(广东)有限公司 | 一种识别prame抗原短肽的tcr及其相关组合物 |
WO2019061297A1 (zh) * | 2017-09-29 | 2019-04-04 | 苏州工业园区唯可达生物科技有限公司 | 一种cd4辅助性t细胞表位融合肽及其疫苗 |
CN111655714A (zh) * | 2017-11-08 | 2020-09-11 | 阿德瓦希斯公司 | 来自癌症相关蛋白的免疫原性异变肽及其使用方法 |
CN109879957B (zh) * | 2017-12-06 | 2022-03-18 | 香雪生命科学技术(广东)有限公司 | 针对prame的高亲和力t细胞受体 |
WO2021243295A2 (en) * | 2020-05-29 | 2021-12-02 | Children's National Medical Center | Identification of hla-restricted prame peptide epitopes, prame-specific t cells suitable for "off-the-shelf" treatment of cancer expressing prame |
US20220372165A1 (en) | 2021-05-05 | 2022-11-24 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding prame |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE466259B (sv) * | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
DK0686030T3 (da) * | 1993-12-23 | 2001-06-25 | Rmf Dictagene Sa | Med antigen ladede mikropartikler og farmaceutiske sammensætninger, som indeholder disse mikropartikler |
US5830753A (en) | 1994-09-30 | 1998-11-03 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof. |
GB9717953D0 (en) * | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
CZ298347B6 (cs) | 1998-02-05 | 2007-09-05 | Glaxosmithkline Biologicals S.A. | Fúzní protein z rodiny MAGE, kódová sekvence nukleové kyseliny, vektor, hostitelská bunka, vakcina a použití fúzního proteinu pro výrobu vakciny |
JP2002537354A (ja) * | 1999-02-25 | 2002-11-05 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ペプチド、及びH.influenzaeのプロテインD由来の担体を含む免疫原 |
ATE306938T1 (de) * | 1999-06-29 | 2005-11-15 | Glaxosmithkline Biolog Sa | Verwendung von cpg als adjuvans für hivimpstoff |
CA2378097A1 (en) * | 1999-07-08 | 2001-01-18 | Stressgen Biotechnologies Corporation | Induction of a th1-like response in vitro |
-
2008
- 2008-01-11 SI SI200830787T patent/SI2114993T1/sl unknown
- 2008-01-11 AR ARP080100127A patent/AR064862A1/es active IP Right Grant
- 2008-01-11 MY MYPI20092932A patent/MY153679A/en unknown
- 2008-01-11 MX MX2009007571A patent/MX2009007571A/es active IP Right Grant
- 2008-01-11 PL PL08701434T patent/PL2114993T3/pl unknown
- 2008-01-11 DK DK08701434.6T patent/DK2114993T3/da active
- 2008-01-11 PE PE2008000124A patent/PE20081686A1/es not_active Application Discontinuation
- 2008-01-11 EA EA200900795A patent/EA016326B1/ru not_active IP Right Cessation
- 2008-01-11 TW TW097101177A patent/TWI434697B/zh not_active IP Right Cessation
- 2008-01-11 NZ NZ578285A patent/NZ578285A/en not_active IP Right Cessation
- 2008-01-11 AU AU2008207025A patent/AU2008207025B2/en not_active Ceased
- 2008-01-11 CN CN2008800078884A patent/CN101668770B/zh not_active Expired - Fee Related
- 2008-01-11 CA CA002674552A patent/CA2674552A1/en not_active Abandoned
- 2008-01-11 PE PE2012001372A patent/PE20130324A1/es not_active Application Discontinuation
- 2008-01-11 ES ES08701434T patent/ES2393812T3/es active Active
- 2008-01-11 WO PCT/EP2008/050290 patent/WO2008087102A1/en active Application Filing
- 2008-01-11 PT PT08701434T patent/PT2114993E/pt unknown
- 2008-01-11 JP JP2009545186A patent/JP5391080B2/ja not_active Expired - Fee Related
- 2008-01-11 BR BRPI0806463-6A patent/BRPI0806463A2/pt not_active IP Right Cessation
- 2008-01-11 US US12/013,011 patent/US20080187535A1/en not_active Abandoned
- 2008-01-11 EP EP08701434A patent/EP2114993B1/en not_active Not-in-force
- 2008-01-11 KR KR1020097017027A patent/KR20090101313A/ko not_active Application Discontinuation
- 2008-01-13 JO JO200815A patent/JO2840B1/en active
- 2008-01-14 CL CL200800104A patent/CL2008000104A1/es unknown
-
2009
- 2009-07-02 DO DO2009000167A patent/DOP2009000167A/es unknown
- 2009-07-02 IL IL199663A patent/IL199663A0/en unknown
- 2009-07-10 MA MA32087A patent/MA31093B1/fr unknown
- 2009-07-14 ZA ZA2009/04923A patent/ZA200904923B/en unknown
- 2009-07-15 CO CO09073705A patent/CO6210757A2/es not_active Application Discontinuation
- 2009-08-07 CR CR10971A patent/CR10971A/es unknown
-
2010
- 2010-05-03 HK HK10104329.2A patent/HK1138853A1/xx not_active IP Right Cessation
-
2012
- 2012-10-15 HR HRP20120828AT patent/HRP20120828T1/hr unknown
- 2012-11-09 CY CY20121101065T patent/CY1113760T1/el unknown
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