FI118768B - Menetelmä sientenvastaisten syklisten peptidien valmistamiseksi - Google Patents
Menetelmä sientenvastaisten syklisten peptidien valmistamiseksi Download PDFInfo
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- FI118768B FI118768B FI931202A FI931202A FI118768B FI 118768 B FI118768 B FI 118768B FI 931202 A FI931202 A FI 931202A FI 931202 A FI931202 A FI 931202A FI 118768 B FI118768 B FI 118768B
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- Finland
- Prior art keywords
- formula
- phenyl
- benzoyl
- compounds
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- 229940121375 antifungal agent Drugs 0.000 title description 25
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- 238000000034 method Methods 0.000 claims abstract description 28
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- WUPSJTQKGFMDON-FUMJLYDLSA-N N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-15-[(1R)-1-hydroxyethyl]-3-(hydroxymethyl)-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-18-yl]-12-methyltetradecanamide Chemical compound CCC(C)CCCCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@@H](C)CN2C(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)C(O)c1ccc(O)cc1 WUPSJTQKGFMDON-FUMJLYDLSA-N 0.000 claims description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/66—Gramicidins S, C; Tyrocidins A, B, C; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85411792A | 1992-03-19 | 1992-03-19 | |
| US85411792 | 1992-03-19 | ||
| US99239092A | 1992-12-16 | 1992-12-16 | |
| US99239092 | 1992-12-16 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI931202A0 FI931202A0 (fi) | 1993-03-18 |
| FI931202L FI931202L (fi) | 1993-09-20 |
| FI118768B true FI118768B (fi) | 2008-03-14 |
Family
ID=27127211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI931202A FI118768B (fi) | 1992-03-19 | 1993-03-18 | Menetelmä sientenvastaisten syklisten peptidien valmistamiseksi |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0561639B1 (cs) |
| JP (3) | JP3519754B2 (cs) |
| KR (1) | KR100256036B1 (cs) |
| CN (1) | CN1036715C (cs) |
| AT (1) | ATE217635T1 (cs) |
| AU (2) | AU3534193A (cs) |
| BR (1) | BR9301232A (cs) |
| CA (1) | CA2091663C (cs) |
| CZ (1) | CZ288974B6 (cs) |
| DE (2) | DE69331922T2 (cs) |
| DK (1) | DK0561639T3 (cs) |
| ES (1) | ES2174843T3 (cs) |
| FI (1) | FI118768B (cs) |
| HU (2) | HU225783B1 (cs) |
| IL (3) | IL105048A (cs) |
| LU (1) | LU91406I2 (cs) |
| MX (1) | MX9301457A (cs) |
| MY (1) | MY136593A (cs) |
| NL (1) | NL300334I2 (cs) |
| NO (1) | NO930948L (cs) |
| NZ (3) | NZ299314A (cs) |
| PT (1) | PT561639E (cs) |
| RU (1) | RU2129562C1 (cs) |
| TW (1) | TW264477B (cs) |
| YU (1) | YU49108B (cs) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5430018A (en) * | 1991-10-17 | 1995-07-04 | Merck & Co., Inc. | Cyclohexapeptide with basic nitrogen containing alkylamide groups |
| US6743777B1 (en) | 1992-03-19 | 2004-06-01 | Eli Lilly And Company | Cyclic peptide antifungal agents and process for preparation thereof |
| IL105048A (en) * | 1992-03-19 | 2001-06-14 | Eli Lilly And Company U S | Cyclic peptide antifungal agents and process for preparation thereof |
| US5378804A (en) * | 1993-03-16 | 1995-01-03 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| WO1994025045A1 (en) * | 1993-05-04 | 1994-11-10 | Merck & Co., Inc. | Cyclohexapeptidyl aminoalkyl ethers |
| US5948753A (en) * | 1993-05-04 | 1999-09-07 | Merck & Co., Inc. | Cyclohexapeptidyl propanolamine compounds |
| AU7874494A (en) * | 1993-09-22 | 1995-04-10 | Merck & Co., Inc. | Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use |
| US5516757A (en) * | 1994-09-16 | 1996-05-14 | Merck & Co., Inc. | Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use |
| US5514651A (en) * | 1994-09-16 | 1996-05-07 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| AU692308B2 (en) * | 1994-09-16 | 1998-06-04 | Merck Sharp & Dohme Corp. | Aza cyclohexapeptide compounds |
| HU228151B1 (en) * | 1994-10-07 | 2012-12-28 | Astellas Pharma Inc | Cyclic hexapeptides |
| US5516756A (en) * | 1994-10-31 | 1996-05-14 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| DK0805685T3 (da) * | 1995-01-26 | 2001-11-19 | Merck & Co Inc | Hidtil ukendte antifungale cyclohexapeptider |
| US5646111A (en) * | 1995-04-07 | 1997-07-08 | Eli Lilly And Company | Cyclic peptide antifungal Agents |
| US5786325A (en) * | 1995-05-26 | 1998-07-28 | Eli Lilly And Company | Cyclic peptide antifungal agents and methods of making and using |
| US5652213A (en) * | 1995-05-26 | 1997-07-29 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5629290A (en) * | 1995-05-26 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5618787A (en) * | 1995-05-26 | 1997-04-08 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5629289A (en) * | 1995-07-25 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5693611A (en) * | 1996-02-01 | 1997-12-02 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| JP2001503015A (ja) * | 1996-02-01 | 2001-03-06 | イーライ・リリー・アンド・カンパニー | 環状ペプチド抗真菌剤 |
| JPH09227422A (ja) * | 1996-02-12 | 1997-09-02 | Rolic Ag | シクロペンチル誘導体 |
| US5696084A (en) * | 1996-08-16 | 1997-12-09 | Abbott Laboratories | Amino-lipopetide antifungal agents |
| AUPO381496A0 (en) * | 1996-11-25 | 1996-12-19 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| UA72200C2 (uk) * | 1997-12-10 | 2005-02-15 | Авентіс Фарма С.А. | Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція |
| FR2784993B1 (fr) * | 1998-10-26 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides |
| AU2003200556B2 (en) * | 1997-12-10 | 2005-12-01 | Novexel | Echinocandin derivative and their preparation method |
| AUPP172898A0 (en) * | 1998-02-09 | 1998-03-05 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| EP1064299A1 (en) * | 1998-03-16 | 2001-01-03 | Fujisawa Pharmaceutical Co., Ltd. | Cyclohexapeptide wf14573 or its salt, production thereof and use thereof |
| US6653281B1 (en) | 1998-08-20 | 2003-11-25 | Eli Lilly And Company | Ring modified cyclic peptide analogs |
| DE69933046T2 (de) | 1998-12-09 | 2007-09-13 | Eli Lilly And Co., Indianapolis | Reinigung von echinocandin cyclopeptiden |
| DE19907904A1 (de) | 1999-02-24 | 2000-08-31 | Clariant Gmbh | Verfahren zur Herstellung von [1,1':4',1"]-Terphenylverbindungen |
| AU771727B2 (en) | 1999-03-03 | 2004-04-01 | Eli Lilly And Company | Processes for making pharmaceutical oral ECB formulations and compositions |
| CN1345333A (zh) | 1999-03-03 | 2002-04-17 | 伊莱利利公司 | 棘白菌素/糖类复合物 |
| ATE338060T1 (de) | 1999-03-03 | 2006-09-15 | Lilly Co Eli | Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b |
| DK1582204T3 (da) | 1999-03-03 | 2013-11-04 | Lilly Co Eli | Echinocandin-farmaceutiske formuleringer, der indeholder miceldannende overfladeaktive stoffer |
| ATE302184T1 (de) * | 2000-02-18 | 2005-09-15 | Meiji Seika Kaisha | Phenoxyalkylaminderivate als agonisten des opioid-delta rezeptors |
| FR2833596B1 (fr) * | 2001-12-14 | 2005-02-18 | Aventis Pharma Sa | Procede de preparation de derives d'echinocandine |
| US6991800B2 (en) | 2002-06-13 | 2006-01-31 | Vicuron Pharmaceuticals Inc. | Antifungal parenteral products |
| EP1620422A2 (en) * | 2003-04-30 | 2006-02-01 | The Institutes for Pharmaceutical Discovery, LLC | Phenyl substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b |
| KR101551207B1 (ko) * | 2008-09-04 | 2015-09-08 | 롬엔드하스전자재료코리아유한회사 | 신규한 유기 발광 화합물 및 이를 발광재료로서 채용하고 있는 유기 발광 소자 |
| CN102464704B (zh) * | 2010-11-05 | 2013-12-11 | 上海医药工业研究院 | 一种化合物及其制备方法和用途 |
| SI3677252T1 (sl) * | 2012-03-19 | 2024-02-29 | Cidara Therapeutics, Inc. | Sheme odmerjanja za spojine iz razreda ehinokandinov |
| ES2694561T3 (es) | 2015-02-23 | 2018-12-21 | Selectchemie Ag | Composición de anidulafungina |
| JP6866583B2 (ja) * | 2016-07-05 | 2021-04-28 | Dic株式会社 | 液晶化合物 |
| CN116903706B (zh) * | 2023-06-13 | 2024-05-17 | 深圳市祥根生物有限公司 | 一种棘白菌素类药物及其制备方法和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE886576A (fr) * | 1979-12-13 | 1981-06-10 | Lilly Co Eli | Derives de noyaux peptidiques cycliques, leur preparation et leur utilisation comme agents antifongiques |
| BE886575A (fr) * | 1979-12-13 | 1981-06-10 | Lilly Co Eli | Derives de noyaux peptidiques cycliques, leur preparation et leur utilisation comme agents antifongiques |
| CA2037957A1 (en) * | 1990-03-12 | 1991-09-13 | Merck & Co., Inc. | N-acylated cyclohexapeptide compounds |
| GB2241956A (en) * | 1990-03-16 | 1991-09-18 | Merck & Co Inc | N-acylated cyclohexapeptide compounds |
| US5330973A (en) * | 1990-03-19 | 1994-07-19 | Merck & Co., Inc. | Lipopeptide derivatives |
| US5310726A (en) * | 1990-03-19 | 1994-05-10 | Merck & Co., Inc. | Lipopeptide compounds |
| IL97347A0 (en) * | 1990-03-19 | 1992-05-25 | Merck & Co Inc | Lipopeptide derivatives and antimicrobial compositions containing them |
| IL105048A (en) * | 1992-03-19 | 2001-06-14 | Eli Lilly And Company U S | Cyclic peptide antifungal agents and process for preparation thereof |
-
1993
- 1993-03-15 IL IL10504893A patent/IL105048A/en active Protection Beyond IP Right Term
- 1993-03-15 TW TW082101890A patent/TW264477B/zh not_active IP Right Cessation
- 1993-03-15 NZ NZ299314A patent/NZ299314A/en not_active IP Right Cessation
- 1993-03-15 IL IL12231593A patent/IL122315A/en not_active IP Right Cessation
- 1993-03-15 NZ NZ247149A patent/NZ247149A/en not_active IP Right Cessation
- 1993-03-15 MY MYPI93000458A patent/MY136593A/en unknown
- 1993-03-15 NZ NZ512085A patent/NZ512085A/en not_active IP Right Cessation
- 1993-03-15 CA CA002091663A patent/CA2091663C/en not_active Expired - Lifetime
- 1993-03-15 CZ CZ1993416A patent/CZ288974B6/cs not_active IP Right Cessation
- 1993-03-16 NO NO93930948A patent/NO930948L/no not_active Application Discontinuation
- 1993-03-16 MX MX9301457A patent/MX9301457A/es unknown
- 1993-03-17 KR KR1019930004076A patent/KR100256036B1/ko not_active Expired - Lifetime
- 1993-03-18 DK DK93302064T patent/DK0561639T3/da active
- 1993-03-18 CN CN93103587A patent/CN1036715C/zh not_active Expired - Lifetime
- 1993-03-18 YU YU18593A patent/YU49108B/sh unknown
- 1993-03-18 ES ES93302064T patent/ES2174843T3/es not_active Expired - Lifetime
- 1993-03-18 FI FI931202A patent/FI118768B/fi not_active IP Right Cessation
- 1993-03-18 DE DE69331922T patent/DE69331922T2/de not_active Expired - Lifetime
- 1993-03-18 RU RU93004787A patent/RU2129562C1/ru active
- 1993-03-18 PT PT93302064T patent/PT561639E/pt unknown
- 1993-03-18 JP JP05852993A patent/JP3519754B2/ja not_active Expired - Lifetime
- 1993-03-18 EP EP93302064A patent/EP0561639B1/en not_active Expired - Lifetime
- 1993-03-18 BR BR9301232A patent/BR9301232A/pt not_active Application Discontinuation
- 1993-03-18 HU HU9300785A patent/HU225783B1/hu unknown
- 1993-03-18 AT AT93302064T patent/ATE217635T1/de active
- 1993-03-18 DE DE200812000006 patent/DE122008000006I2/de active Active
- 1993-03-19 AU AU35341/93A patent/AU3534193A/en not_active Abandoned
-
1995
- 1995-06-22 HU HU95P/P00378P patent/HU211562A9/hu active Protection Beyond IP Right Term
-
1996
- 1996-09-09 AU AU65529/96A patent/AU689391B2/en not_active Expired
-
1997
- 1997-11-27 IL IL12231597A patent/IL122315A0/xx unknown
-
2002
- 2002-01-10 JP JP2002003969A patent/JP3520071B2/ja not_active Expired - Lifetime
-
2003
- 2003-12-10 JP JP2003412638A patent/JP2004115540A/ja active Pending
-
2008
- 2008-01-09 LU LU91406C patent/LU91406I2/fr unknown
- 2008-01-21 NL NL300334C patent/NL300334I2/nl unknown
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