ES2187575T3 - Hexapeptidos ciclicos dotados de actividad antibiotica. - Google Patents

Hexapeptidos ciclicos dotados de actividad antibiotica.

Info

Publication number
ES2187575T3
ES2187575T3 ES95932935T ES95932935T ES2187575T3 ES 2187575 T3 ES2187575 T3 ES 2187575T3 ES 95932935 T ES95932935 T ES 95932935T ES 95932935 T ES95932935 T ES 95932935T ES 2187575 T3 ES2187575 T3 ES 2187575T3
Authority
ES
Spain
Prior art keywords
hexapeptides
cycle
given
antibiotic activity
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95932935T
Other languages
English (en)
Inventor
Hidenori Ohki
Masaki Tomishima
Akira Yamada
Hisashi Takasugi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26305774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2187575(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB9420425A external-priority patent/GB9420425D0/en
Priority claimed from GBGB9508745.8A external-priority patent/GB9508745D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2187575T3 publication Critical patent/ES2187575T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

LA PRESENTE INVENCION, SE RELACIONA CON NUEVOS COMPUESTOS POLIPEPTIDICOS, REPRESENTADOS POR LA FORMULA (I), DONDE R{SUP,1} ES TAL Y COMO SE DEFINE EN LA DESCRIPCION, ASI COMO UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, LOS CUALES MUESTRAN ACTIVIDADES ANTIMICROBIANAS (ESPECIALMENTE ANTIFUNGICAS), ACTIVIDAD INHIBIDORA DE LA {BE}-1,3-GLUCANO SINTETASA. ASIMISMO, LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE LOS CITADOS COMPUESTOS, A UNA COMPOSICION FARMACEUTICA QUE LOS INCLUYE, Y A UN METODO DE TRATAMIENTO TERAPEUTICO Y/O PROFILACTICO DE ENFERMEDADES INFECCIOSAS, INCLUYENDO LA INFECCION POR PNEUMOCYSTIS CARINII (P.EJ. LA NEUMONIA CAUSADA POR PNEUMOCYSTIS CARINII), EN SERES HUMANOS O ANIMALES.
ES95932935T 1994-10-07 1995-09-29 Hexapeptidos ciclicos dotados de actividad antibiotica. Expired - Lifetime ES2187575T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9420425A GB9420425D0 (en) 1994-10-07 1994-10-07 New compound
GBGB9508745.8A GB9508745D0 (en) 1995-04-28 1995-04-28 New compound

Publications (1)

Publication Number Publication Date
ES2187575T3 true ES2187575T3 (es) 2003-06-16

Family

ID=26305774

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95932935T Expired - Lifetime ES2187575T3 (es) 1994-10-07 1995-09-29 Hexapeptidos ciclicos dotados de actividad antibiotica.

Country Status (27)

Country Link
US (2) US6107458A (es)
EP (1) EP0788511B1 (es)
JP (2) JP2897427B2 (es)
KR (1) KR100353303B1 (es)
CN (1) CN1203089C (es)
AR (1) AR041770A1 (es)
AT (1) ATE229541T1 (es)
AU (1) AU696949B2 (es)
BR (2) BRPI9504791B8 (es)
CA (1) CA2202058C (es)
DE (2) DE122008000025I2 (es)
DK (1) DK0788511T3 (es)
ES (1) ES2187575T3 (es)
FI (1) FI119988B (es)
FR (1) FR08C0028I2 (es)
HK (1) HK1004136A1 (es)
HU (1) HU228151B1 (es)
IL (1) IL115484A (es)
LU (1) LU91452I2 (es)
MX (1) MX9702531A (es)
NL (1) NL300352I2 (es)
NO (2) NO328483B1 (es)
OA (1) OA10475A (es)
PT (1) PT788511E (es)
RU (1) RU2165423C2 (es)
TR (1) TR199501229A2 (es)
WO (1) WO1996011210A1 (es)

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AUPO371596A0 (en) * 1996-11-19 1996-12-12 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound
US6291680B1 (en) * 1997-06-18 2001-09-18 Fujisawa Pharmaceutical Co., Ltd. Production process
US6232290B1 (en) * 1998-02-09 2001-05-15 Fujisawa Pharmaceutical Co., Ltd. Cyclic hexapeptides with antimicrobial activity
AU756792B2 (en) * 1998-02-09 2003-01-23 Fujisawa Pharmaceutical Co., Ltd. New compound
US7084279B1 (en) * 1999-02-11 2006-08-01 Emisphere Technologies Inc. Oxadiazole compounds and compositions for delivering active agents
DE60024414T2 (de) * 1999-02-11 2006-06-14 Emisphere Tech Inc Oxadiazolverbindungen und -zusammensetzungen zur abgabe von wirkstoffen
AUPP999799A0 (en) * 1999-04-27 1999-05-20 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPQ066399A0 (en) 1999-05-31 1999-06-24 Fujisawa Pharmaceutical Co., Ltd. Antifungal combination use
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
DE60040989D1 (de) * 1999-07-27 2009-01-15 Aventis Pharma Gmbh Cyclohexapeptide, deren herstellung und verwendung in pharmazeutische zusammensetzungen
AUPQ462399A0 (en) * 1999-12-13 2000-01-13 Fujisawa Pharmaceutical Co., Ltd. New use
TWI250992B (en) 2000-02-21 2006-03-11 Astellas Pharma Inc Polypeptide compounds for the prophylactic and/or therapeutic treatment of infectious diseases caused by pathogenic microorganisms
ES2191516B1 (es) * 2000-07-28 2005-01-01 Consejo Superior De Investigaciones Cientificas Antibioticos antifungicos de naturaleza peptidica inhibidores de la germinacion y el crecimiento de hongos fitopatogenos.
AUPQ938700A0 (en) * 2000-08-14 2000-09-07 Fujisawa Pharmaceutical Co., Ltd. Antifungal combination use
EP1356816B1 (en) 2001-01-29 2009-12-23 Shionogi & Co., Ltd. Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient
JP2005053782A (ja) * 2001-08-31 2005-03-03 Fujisawa Pharmaceut Co Ltd 環状リポペプチド化合物の新規結晶
KR20040088519A (ko) 2002-02-22 2004-10-16 뉴 리버 파마슈티칼스, 인크. 활성 제제 전달 시스템 및 활성 제제의 보호 및 투여 방법
WO2004014879A1 (en) * 2002-08-08 2004-02-19 Fujisawa Pharmaceutical Co., Ltd. New process
AU2003903205A0 (en) * 2003-06-23 2003-07-10 Fujisawa Pharmaceutical Co., Ltd. New compound
DE602004010915T2 (de) 2003-07-22 2008-12-11 Theravance, Inc., South San Francisco Verwendung eines antimykotischen echinocandin-mittels in kombination mit einem antibakteriellen glycopeptid-mittel
CN1845751A (zh) * 2003-09-05 2006-10-11 默克公司 固定相和利用该固定相的纯化方法
ATE547404T1 (de) * 2003-09-22 2012-03-15 Msd Kk Piperidinderivate
US7476673B2 (en) * 2003-12-30 2009-01-13 Allergan, Inc. Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors
US20080319175A1 (en) * 2004-05-20 2008-12-25 The Scripps Research Institute Transthyretin Stabilization
AR051090A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
AR051094A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
BRPI0515482A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seus usos como agentes terapêuticos
MX2007003325A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa.
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
EP1830837B1 (en) 2004-09-20 2013-09-04 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
SG156641A1 (en) * 2004-10-13 2009-11-26 Ptc Therapeutics Inc Compounds for nonsense suppression, and methods for their use
JP2009513563A (ja) 2005-06-03 2009-04-02 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトのステアロイル−ＣｏＡデサチュラーゼ阻害剤としてのアミノチアゾール誘導体
JPWO2007043401A1 (ja) * 2005-10-07 2009-04-16 キッセイ薬品工業株式会社 含窒素複素環化合物およびそれを含有する医薬組成物
CN101516387B (zh) * 2006-07-26 2014-06-04 桑多斯股份公司 卡泊芬净制剂
US8853392B2 (en) 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
BR122018001851B1 (pt) 2007-08-13 2019-08-20 Monsanto Technology Llc Método de controle de nematódeos parasitas de plantas
KR20100075892A (ko) * 2007-10-29 2010-07-05 아스테라스 세이야쿠 가부시키가이샤 폴리펩티드 화합물
US8034806B2 (en) 2007-11-02 2011-10-11 Vanderbilt University Bicyclic mGluR5 positive allosteric modulators and methods of making and using same
CN102076670B (zh) * 2008-06-24 2013-05-22 Irm责任有限公司 调节g蛋白偶联受体的化合物和方法
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
BR112013023531A2 (pt) * 2011-04-04 2016-12-06 Xellia Pharmaceuticals Aps processo de um único vaso para a fabricação de micafungina ou de um sal desta
HUE027806T2 (en) 2011-04-20 2016-11-28 Xellia Pharmaceuticals Aps A method for purifying micafungin
CN102775476B (zh) * 2011-05-12 2015-01-07 上海天伟生物制药有限公司 一种米卡芬净钠盐的制备方法
WO2012158844A1 (en) 2011-05-17 2012-11-22 Shionogi & Co., Ltd. Heterocyclic compounds
EP2763971B1 (en) * 2011-09-09 2016-06-08 Sandoz AG Preparation of micafungin intermediates
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN102627688B (zh) 2012-03-30 2014-12-31 上海天伟生物制药有限公司 一种高纯度环肽化合物及其制备方法和用途
CN102659930B (zh) 2012-03-30 2014-04-23 上海天伟生物制药有限公司 一种高纯度环肽类物质的晶体及其制备方法和用途
EP3150623B1 (en) * 2014-05-29 2019-04-03 Shanghai Techwell Biopharmaceutical Co., Ltd Solvate of cyclic peptide compound, preparation method for same, and uses thereof
WO2016056023A2 (en) * 2014-10-07 2016-04-14 Alaparthi Lakshmi Prasad Intermediates and processes to prepare micafungin
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
EP3485873A1 (en) 2017-11-17 2019-05-22 Cadila Healthcare Limited Stable pharmaceutical injectable compositions of micafungin
CN108752430B (zh) * 2018-05-31 2022-02-18 杭州中美华东制药有限公司 米卡芬净钠新晶型及其制备方法
WO2020013116A1 (ja) * 2018-07-10 2020-01-16 京都薬品工業株式会社 Ｐｔｐ－１ｂ阻害剤およびその用途
CN110734408A (zh) * 2019-10-22 2020-01-31 重庆康乐制药有限公司 一种米卡芬净类衍生物侧链中间体的制备方法

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IL98506A (en) * 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Peptides, of antibiotics, processes for their preparation and pharmaceutical preparations containing them
NZ512085A (en) * 1992-03-19 2003-08-29 Lilly Co Eli Methods employing cyclic peptide antifungal agents

Also Published As

Publication number Publication date
MX9702531A (es) 1997-06-28
AU696949B2 (en) 1998-09-24
HUT77736A (hu) 1998-07-28
TR199501229A2 (tr) 1996-07-21
EP0788511A1 (en) 1997-08-13
IL115484A0 (en) 1996-01-19
NO2010016I1 (no) 2010-08-16
CN1203089C (zh) 2005-05-25
BRPI9504791B8 (pt) 2019-12-31
AR041770A1 (es) 2005-06-01
AU3578095A (en) 1996-05-02
DE69529172T2 (de) 2003-04-17
BR9504791A (pt) 1996-10-22
NL300352I2 (nl) 2008-11-03
JP3518665B2 (ja) 2004-04-12
ATE229541T1 (de) 2002-12-15
DK0788511T3 (da) 2003-03-31
DE122008000025I1 (de) 2008-08-21
FR08C0028I1 (es) 2008-08-15
FR08C0028I2 (es) 2009-11-20
FI971397A (fi) 1997-05-27
OA10475A (en) 2002-04-08
WO1996011210A1 (en) 1996-04-18
JPH10324695A (ja) 1998-12-08
HU228151B1 (en) 2012-12-28
KR970707150A (ko) 1997-12-01
LU91452I2 (fr) 2008-08-04
JP2897427B2 (ja) 1999-05-31
KR100353303B1 (ko) 2003-01-15
US6107458A (en) 2000-08-22
EP0788511B1 (en) 2002-12-11
NO2010016I2 (no) 2011-10-17
HK1004136A1 (en) 1998-11-20
NL300352I1 (nl) 2008-08-01
PT788511E (pt) 2003-04-30
FI119988B (fi) 2009-05-29
NO971544D0 (no) 1997-04-04
RU2165423C2 (ru) 2001-04-20
NO328483B1 (no) 2010-03-01
CN1168675A (zh) 1997-12-24
JPH10507174A (ja) 1998-07-14
CA2202058C (en) 2007-11-06
FI971397A0 (fi) 1997-04-04
CA2202058A1 (en) 1996-04-18
IL115484A (en) 2000-07-16
NO971544L (no) 1997-06-04
DE69529172D1 (de) 2003-01-23
US6265536B1 (en) 2001-07-24
DE122008000025I2 (de) 2011-02-17
BR9504791B1 (pt) 2010-10-05

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