DE69529172T2 - Zyklische hexapeptide mit antibiotischer aktivität - Google Patents

Zyklische hexapeptide mit antibiotischer aktivität

Info

Publication number
DE69529172T2
DE69529172T2 DE69529172T DE69529172T DE69529172T2 DE 69529172 T2 DE69529172 T2 DE 69529172T2 DE 69529172 T DE69529172 T DE 69529172T DE 69529172 T DE69529172 T DE 69529172T DE 69529172 T2 DE69529172 T2 DE 69529172T2
Authority
DE
Germany
Prior art keywords
antibiotic activity
cyclic hexapeptides
hexapeptides
cyclic
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69529172T
Other languages
English (en)
Other versions
DE69529172D1 (de
Inventor
Hidenori Ohki
Masaki Tomishima
Akira Yamada
Hisashi Takasugi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26305774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69529172(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB9420425A external-priority patent/GB9420425D0/en
Priority claimed from GBGB9508745.8A external-priority patent/GB9508745D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69529172D1 publication Critical patent/DE69529172D1/de
Application granted granted Critical
Publication of DE69529172T2 publication Critical patent/DE69529172T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69529172T 1994-10-07 1995-09-29 Zyklische hexapeptide mit antibiotischer aktivität Expired - Lifetime DE69529172T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9420425A GB9420425D0 (en) 1994-10-07 1994-10-07 New compound
GBGB9508745.8A GB9508745D0 (en) 1995-04-28 1995-04-28 New compound
PCT/JP1995/001983 WO1996011210A1 (en) 1994-10-07 1995-09-29 Cyclic hexapeptides having antibiotic activity

Publications (2)

Publication Number Publication Date
DE69529172D1 DE69529172D1 (de) 2003-01-23
DE69529172T2 true DE69529172T2 (de) 2003-04-17

Family

ID=26305774

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69529172T Expired - Lifetime DE69529172T2 (de) 1994-10-07 1995-09-29 Zyklische hexapeptide mit antibiotischer aktivität
DE122008000025C Active DE122008000025I2 (de) 1994-10-07 1995-09-29 Zyklische hexapeptide mit antibiotischer aktivität

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE122008000025C Active DE122008000025I2 (de) 1994-10-07 1995-09-29 Zyklische hexapeptide mit antibiotischer aktivität

Country Status (27)

Country Link
US (2) US6107458A (de)
EP (1) EP0788511B1 (de)
JP (2) JP2897427B2 (de)
KR (1) KR100353303B1 (de)
CN (1) CN1203089C (de)
AR (1) AR041770A1 (de)
AT (1) ATE229541T1 (de)
AU (1) AU696949B2 (de)
BR (2) BR9504791B1 (de)
CA (1) CA2202058C (de)
DE (2) DE69529172T2 (de)
DK (1) DK0788511T3 (de)
ES (1) ES2187575T3 (de)
FI (1) FI119988B (de)
FR (1) FR08C0028I2 (de)
HK (1) HK1004136A1 (de)
HU (1) HU228151B1 (de)
IL (1) IL115484A (de)
LU (1) LU91452I2 (de)
MX (1) MX9702531A (de)
NL (1) NL300352I2 (de)
NO (2) NO328483B1 (de)
OA (1) OA10475A (de)
PT (1) PT788511E (de)
RU (1) RU2165423C2 (de)
TR (1) TR199501229A2 (de)
WO (1) WO1996011210A1 (de)

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AUPO371596A0 (en) * 1996-11-19 1996-12-12 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound
EP0994101A4 (de) * 1997-06-18 2002-05-02 Fujisawa Pharmaceutical Co Neues herstellungsverfahren
AU756792B2 (en) * 1998-02-09 2003-01-23 Fujisawa Pharmaceutical Co., Ltd. New compound
WO1999040108A1 (en) * 1998-02-09 1999-08-12 Fujisawa Pharmaceutical Co., Ltd. New compound
AU3492100A (en) * 1999-02-11 2000-08-29 Emisphere Technologies, Inc. Oxadiazole compounds and compositions for delivering active agents
US7084279B1 (en) * 1999-02-11 2006-08-01 Emisphere Technologies Inc. Oxadiazole compounds and compositions for delivering active agents
AUPP999799A0 (en) * 1999-04-27 1999-05-20 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPQ066399A0 (en) 1999-05-31 1999-06-24 Fujisawa Pharmaceutical Co., Ltd. Antifungal combination use
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
ATE416189T1 (de) * 1999-07-27 2008-12-15 Aventis Pharma Gmbh Cyclohexapeptide, deren herstellung und verwendung in pharmazeutische zusammensetzungen
AUPQ462399A0 (en) * 1999-12-13 2000-01-13 Fujisawa Pharmaceutical Co., Ltd. New use
TWI250992B (en) * 2000-02-21 2006-03-11 Astellas Pharma Inc Polypeptide compounds for the prophylactic and/or therapeutic treatment of infectious diseases caused by pathogenic microorganisms
ES2191516B1 (es) * 2000-07-28 2005-01-01 Consejo Superior De Investigaciones Cientificas Antibioticos antifungicos de naturaleza peptidica inhibidores de la germinacion y el crecimiento de hongos fitopatogenos.
AUPQ938700A0 (en) * 2000-08-14 2000-09-07 Fujisawa Pharmaceutical Co., Ltd. Antifungal combination use
EP1356816B1 (de) 2001-01-29 2009-12-23 Shionogi & Co., Ltd. Arzneipräparat, das als wirkstoff 5-methyl-1-phenyl-2-(1h)-pyridon enthält
JP2005053782A (ja) * 2001-08-31 2005-03-03 Fujisawa Pharmaceut Co Ltd 環状リポペプチド化合物の新規結晶
EP2266590A3 (de) 2002-02-22 2011-04-20 Shire LLC Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen
WO2004014879A1 (en) * 2002-08-08 2004-02-19 Fujisawa Pharmaceutical Co., Ltd. New process
AU2003903205A0 (en) * 2003-06-23 2003-07-10 Fujisawa Pharmaceutical Co., Ltd. New compound
JP4664912B2 (ja) * 2003-07-22 2011-04-06 セラヴァンス， インコーポレーテッド グリコペプチド抗菌剤と組み合わせたエキノカンジン抗真菌剤の使用
JP2007504460A (ja) * 2003-09-05 2007-03-01 メルク　エンド　カムパニー　インコーポレーテッド 固定相及び該固定相を用いた精製プロセス
CA2551037A1 (en) * 2003-09-22 2005-03-31 Banyu Pharmaceutical Co., Ltd. Novel piperidine derivative
US7476673B2 (en) * 2003-12-30 2009-01-13 Allergan, Inc. Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors
WO2005112913A1 (en) * 2004-05-20 2005-12-01 The Scripps Research Institute Transthyretin stabilization
AR051202A1 (es) 2004-09-20 2006-12-27 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
CN101083994A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其用作硬脂酰CoA去饱和酶抑制剂的用途
MX2007003321A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
CA2580845A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
AU2005329423A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
WO2006034315A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
US7951805B2 (en) 2004-09-20 2011-05-31 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
BRPI0516110A (pt) * 2004-10-13 2008-08-26 Ptc Therapeutics Inc compostos para supressão sem sentido e métodos para seu uso
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
JPWO2007043401A1 (ja) * 2005-10-07 2009-04-16 キッセイ薬品工業株式会社 含窒素複素環化合物およびそれを含有する医薬組成物
CN101516387B (zh) * 2006-07-26 2014-06-04 桑多斯股份公司 卡泊芬净制剂
US8853392B2 (en) 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
AR068193A1 (es) 2007-08-13 2009-11-11 Divergence Inc Composiciones y metodos para controlar nematodos
RU2470939C2 (ru) * 2007-10-29 2012-12-27 Астеллас Фарма Инк. Полипептидное соединение
US8034806B2 (en) 2007-11-02 2011-10-11 Vanderbilt University Bicyclic mGluR5 positive allosteric modulators and methods of making and using same
WO2010008831A2 (en) * 2008-06-24 2010-01-21 Irm Llc Compounds and methods for modulating g protein-coupled receptors
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
BR112013023531A2 (pt) * 2011-04-04 2016-12-06 Xellia Pharmaceuticals Aps processo de um único vaso para a fabricação de micafungina ou de um sal desta
AU2012244435B2 (en) 2011-04-20 2017-06-15 Xellia Pharmaceuticals Aps Method for purification of Micafungin
CN102775476B (zh) 2011-05-12 2015-01-07 上海天伟生物制药有限公司 一种米卡芬净钠盐的制备方法
EP2709609B1 (de) 2011-05-17 2017-10-04 Shionogi & Co., Ltd. Heterozyklische verbindungen
DK2763971T3 (en) 2011-09-09 2016-07-18 Sandoz Ag Preparation of micafungin intermediates
CN102627688B (zh) 2012-03-30 2014-12-31 上海天伟生物制药有限公司 一种高纯度环肽化合物及其制备方法和用途
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN102659930B (zh) 2012-03-30 2014-04-23 上海天伟生物制药有限公司 一种高纯度环肽类物质的晶体及其制备方法和用途
EP3150623B1 (de) * 2014-05-29 2019-04-03 Shanghai Techwell Biopharmaceutical Co., Ltd Solvat einer cyclischen peptidverbindung, herstellungsverfahren und verwendungen davon
EP3226885A4 (de) * 2014-10-07 2018-07-18 Alaparthi, Lakshmi Prasad Zwischenprodukte und verfahren zur herstellung von micafungin
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
EP3485873A1 (de) 2017-11-17 2019-05-22 Cadila Healthcare Limited Stabile pharmazeutische injizierbare zusammensetzungen von micafungin
CN113087775B (zh) * 2018-05-31 2022-07-08 杭州中美华东制药有限公司 米卡芬净钠新晶型ii及其制备方法
WO2020013116A1 (ja) * 2018-07-10 2020-01-16 京都薬品工業株式会社 Ｐｔｐ－１ｂ阻害剤およびその用途
CN110734408A (zh) * 2019-10-22 2020-01-31 重庆康乐制药有限公司 一种米卡芬净类衍生物侧链中间体的制备方法

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
IE912046A1 (en) * 1990-06-18 1991-12-18 Fujisawa Pharmaceutical Co New polypeptide compound and a process for preparation¹thereof
TW264477B (de) * 1992-03-19 1995-12-01 Lilly Co Eli

Also Published As

Publication number Publication date
AU3578095A (en) 1996-05-02
HK1004136A1 (en) 1998-11-20
OA10475A (en) 2002-04-08
ATE229541T1 (de) 2002-12-15
US6265536B1 (en) 2001-07-24
BR9504791B1 (pt) 2010-10-05
IL115484A0 (en) 1996-01-19
JP3518665B2 (ja) 2004-04-12
HU228151B1 (en) 2012-12-28
DE69529172D1 (de) 2003-01-23
WO1996011210A1 (en) 1996-04-18
BRPI9504791B8 (pt) 2019-12-31
FI971397A (fi) 1997-05-27
DK0788511T3 (da) 2003-03-31
NO971544L (no) 1997-06-04
RU2165423C2 (ru) 2001-04-20
DE122008000025I1 (de) 2008-08-21
AU696949B2 (en) 1998-09-24
US6107458A (en) 2000-08-22
BR9504791A (pt) 1996-10-22
EP0788511A1 (de) 1997-08-13
EP0788511B1 (de) 2002-12-11
NO971544D0 (no) 1997-04-04
IL115484A (en) 2000-07-16
CN1168675A (zh) 1997-12-24
FI971397A0 (fi) 1997-04-04
FR08C0028I1 (de) 2008-08-15
NO328483B1 (no) 2010-03-01
MX9702531A (es) 1997-06-28
DE122008000025I2 (de) 2011-02-17
NO2010016I1 (no) 2010-08-16
CA2202058C (en) 2007-11-06
KR970707150A (ko) 1997-12-01
JPH10507174A (ja) 1998-07-14
PT788511E (pt) 2003-04-30
HUT77736A (hu) 1998-07-28
CA2202058A1 (en) 1996-04-18
LU91452I2 (fr) 2008-08-04
ES2187575T3 (es) 2003-06-16
CN1203089C (zh) 2005-05-25
FI119988B (fi) 2009-05-29
AR041770A1 (es) 2005-06-01
NO2010016I2 (no) 2011-10-17
JPH10324695A (ja) 1998-12-08
FR08C0028I2 (de) 2009-11-20
NL300352I1 (nl) 2008-08-01
NL300352I2 (nl) 2008-11-03
KR100353303B1 (ko) 2003-01-15
TR199501229A2 (tr) 1996-07-21
JP2897427B2 (ja) 1999-05-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP

V448 Application of spc

Free format text: PRODUCT NAME: MYCAMINE-MICAFUNGIN; REGISTRATION NO/DATE: EU/1/08/448/001, EU/1/08/448/002; 20080425

Spc suppl protection certif: 12 2008 000 025

Filing date: 20080523

Free format text: PRODUCT NAME: MICAFUNGIN UND PHARMAZEUTISCH VERTRAEGLICHE SALZE DAVON, INSBESONDERE MICAFUNGINNATRIUM; REGISTRATION NO/DATE: EU/1/08/448/001, EU/1/08/448/002; 20080425

Spc suppl protection certif: 12 2008 000 025

Filing date: 20080523

V484 Delivery of the decision of grant

Free format text: PRODUCT NAME: MICAFUNGIN UND PHARMAZEUTISCH VERTRAEGLICHE SALZE DAVON; REGISTRATION NO/DATE: EU/1/08/448/001, EU/1/08/448/002; 20080425

Spc suppl protection certif: 12 2008 000 025

Filing date: 20080523

V457 Spc granted

Free format text: PRODUCT NAME: MICAFUNGIN UND PHARMAZEUTISCH VERTRAEGLICHE SALZE DAVON; REGISTRATION NO/DATE: EU/1/08/448/001, EU/1/08/448/002; 20080425

Spc suppl protection certif: 12 2008 000 025

Filing date: 20080523