DE69529172D1 - Zyklische hexapeptide mit antibiotischer aktivität - Google Patents

Zyklische hexapeptide mit antibiotischer aktivität

Info

Publication number
DE69529172D1
DE69529172D1 DE69529172T DE69529172T DE69529172D1 DE 69529172 D1 DE69529172 D1 DE 69529172D1 DE 69529172 T DE69529172 T DE 69529172T DE 69529172 T DE69529172 T DE 69529172T DE 69529172 D1 DE69529172 D1 DE 69529172D1
Authority
DE
Germany
Prior art keywords
antibiotic activity
cyclic hexapeptides
hexapeptides
cyclic
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69529172T
Other languages
English (en)
Other versions
DE69529172T2 (de
Inventor
Hidenori Ohki
Masaki Tomishima
Akira Yamada
Hisashi Takasugi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26305774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69529172(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB9420425A external-priority patent/GB9420425D0/en
Priority claimed from GBGB9508745.8A external-priority patent/GB9508745D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69529172D1 publication Critical patent/DE69529172D1/de
Application granted granted Critical
Publication of DE69529172T2 publication Critical patent/DE69529172T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69529172T 1994-10-07 1995-09-29 Zyklische hexapeptide mit antibiotischer aktivität Expired - Lifetime DE69529172T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9420425A GB9420425D0 (en) 1994-10-07 1994-10-07 New compound
GBGB9508745.8A GB9508745D0 (en) 1995-04-28 1995-04-28 New compound
PCT/JP1995/001983 WO1996011210A1 (en) 1994-10-07 1995-09-29 Cyclic hexapeptides having antibiotic activity

Publications (2)

Publication Number Publication Date
DE69529172D1 true DE69529172D1 (de) 2003-01-23
DE69529172T2 DE69529172T2 (de) 2003-04-17

Family

ID=26305774

Family Applications (2)

Application Number Title Priority Date Filing Date
DE122008000025C Active DE122008000025I2 (de) 1994-10-07 1995-09-29 Zyklische hexapeptide mit antibiotischer aktivität
DE69529172T Expired - Lifetime DE69529172T2 (de) 1994-10-07 1995-09-29 Zyklische hexapeptide mit antibiotischer aktivität

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE122008000025C Active DE122008000025I2 (de) 1994-10-07 1995-09-29 Zyklische hexapeptide mit antibiotischer aktivität

Country Status (27)

Country Link
US (2) US6107458A (de)
EP (1) EP0788511B1 (de)
JP (2) JP2897427B2 (de)
KR (1) KR100353303B1 (de)
CN (1) CN1203089C (de)
AR (1) AR041770A1 (de)
AT (1) ATE229541T1 (de)
AU (1) AU696949B2 (de)
BR (2) BRPI9504791B8 (de)
CA (1) CA2202058C (de)
DE (2) DE122008000025I2 (de)
DK (1) DK0788511T3 (de)
ES (1) ES2187575T3 (de)
FI (1) FI119988B (de)
FR (1) FR08C0028I2 (de)
HK (1) HK1004136A1 (de)
HU (1) HU228151B1 (de)
IL (1) IL115484A (de)
LU (1) LU91452I2 (de)
MX (1) MX9702531A (de)
NL (1) NL300352I2 (de)
NO (2) NO328483B1 (de)
OA (1) OA10475A (de)
PT (1) PT788511E (de)
RU (1) RU2165423C2 (de)
TR (1) TR199501229A2 (de)
WO (1) WO1996011210A1 (de)

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US5696084A (en) * 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
AUPO371596A0 (en) * 1996-11-19 1996-12-12 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound
EP0994101A4 (de) * 1997-06-18 2002-05-02 Fujisawa Pharmaceutical Co Neues herstellungsverfahren
AU756792B2 (en) * 1998-02-09 2003-01-23 Fujisawa Pharmaceutical Co., Ltd. New compound
WO1999040108A1 (en) * 1998-02-09 1999-08-12 Fujisawa Pharmaceutical Co., Ltd. New compound
AU3492100A (en) * 1999-02-11 2000-08-29 Emisphere Technologies, Inc. Oxadiazole compounds and compositions for delivering active agents
US7084279B1 (en) * 1999-02-11 2006-08-01 Emisphere Technologies Inc. Oxadiazole compounds and compositions for delivering active agents
AUPP999799A0 (en) 1999-04-27 1999-05-20 Fujisawa Pharmaceutical Co., Ltd. New compound
AUPQ066399A0 (en) 1999-05-31 1999-06-24 Fujisawa Pharmaceutical Co., Ltd. Antifungal combination use
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
CA2380176A1 (en) * 1999-07-27 2001-02-01 Aventis Pharma Deutschland Gmbh Novel cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
AUPQ462399A0 (en) * 1999-12-13 2000-01-13 Fujisawa Pharmaceutical Co., Ltd. New use
TWI250992B (en) 2000-02-21 2006-03-11 Astellas Pharma Inc Polypeptide compounds for the prophylactic and/or therapeutic treatment of infectious diseases caused by pathogenic microorganisms
ES2191516B1 (es) * 2000-07-28 2005-01-01 Consejo Superior De Investigaciones Cientificas Antibioticos antifungicos de naturaleza peptidica inhibidores de la germinacion y el crecimiento de hongos fitopatogenos.
AUPQ938700A0 (en) * 2000-08-14 2000-09-07 Fujisawa Pharmaceutical Co., Ltd. Antifungal combination use
WO2002060446A1 (en) 2001-01-29 2002-08-08 Shionogi & Co., Ltd. Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient
JP2005053782A (ja) * 2001-08-31 2005-03-03 Fujisawa Pharmaceut Co Ltd 環状リポペプチド化合物の新規結晶
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
JP4784093B2 (ja) * 2002-08-08 2011-09-28 アステラス製薬株式会社 イソオキサゾリル安息香酸の製造法
AU2003903205A0 (en) * 2003-06-23 2003-07-10 Fujisawa Pharmaceutical Co., Ltd. New compound
WO2005018743A1 (en) * 2003-07-22 2005-03-03 Theravance, Inc. Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
JP2007504460A (ja) * 2003-09-05 2007-03-01 メルク　エンド　カムパニー　インコーポレーテッド 固定相及び該固定相を用いた精製プロセス
AU2004274309B2 (en) * 2003-09-22 2010-04-08 Msd K.K. Novel piperidine derivative
US7476673B2 (en) * 2003-12-30 2009-01-13 Allergan, Inc. Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors
EP2314584A1 (de) * 2004-05-20 2011-04-27 Foldrx Pharmaceuticals, Inc. 2-(heteroaryl)-Benzoxazol-Verbindungen und Derivate, Zusammensetzungen und Verfahren zur Stabilisierung von Transthyretin und zur Hemmung von Transthyretin-Fehlfaltung
JP4958786B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体および治療薬としてのそれらの使用
CA2580787A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
US8071603B2 (en) 2004-09-20 2011-12-06 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
BRPI0515488A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados de heterocìclicos e seu uso como agentes terapêuticos
WO2006034341A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
EP1799668A1 (de) 2004-09-20 2007-06-27 Xenon Pharmaceuticals Inc. Heterozyklische derivate und ihre verwendung als stearoyl-coa-desaturase-mediatoren
US7592343B2 (en) 2004-09-20 2009-09-22 Xenon Pharmaceuticals Inc. Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors
EP3067053A1 (de) * 2004-10-13 2016-09-14 PTC Therapeutics, Inc. Verbindungen zur nonsense-unterdrückung und verfahren zu deren verwendung
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
KR20080066938A (ko) * 2005-10-07 2008-07-17 깃세이 야쿠힌 고교 가부시키가이샤 질소 함유 복소환 화합물 및 그것을 함유하는 의약 조성물
CN101516387B (zh) * 2006-07-26 2014-06-04 桑多斯股份公司 卡泊芬净制剂
US8853392B2 (en) 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
EP2947080B1 (de) 2007-08-13 2017-10-25 Monsanto Technology LLC Zusammensetzungen und verfahren zur kontrolle von nematoden
KR20100075892A (ko) * 2007-10-29 2010-07-05 아스테라스 세이야쿠 가부시키가이샤 폴리펩티드 화합물
US8034806B2 (en) 2007-11-02 2011-10-11 Vanderbilt University Bicyclic mGluR5 positive allosteric modulators and methods of making and using same
EP2300442A2 (de) * 2008-06-24 2011-03-30 Irm Llc Verbindungen und verfahren zur modulierung von g-protein-gekoppelten rezeptoren
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
BR112013023531A2 (pt) * 2011-04-04 2016-12-06 Xellia Pharmaceuticals Aps processo de um único vaso para a fabricação de micafungina ou de um sal desta
KR101944512B1 (ko) 2011-04-20 2019-01-31 셀리아 파마슈티칼즈 에이피에스 미카펀진의 정제 방법
CN102775476B (zh) 2011-05-12 2015-01-07 上海天伟生物制药有限公司 一种米卡芬净钠盐的制备方法
US9156830B2 (en) 2011-05-17 2015-10-13 Shionogi & Co., Ltd. Heterocyclic compounds
DK2763971T3 (en) 2011-09-09 2016-07-18 Sandoz Ag Preparation of micafungin intermediates
CN102627688B (zh) 2012-03-30 2014-12-31 上海天伟生物制药有限公司 一种高纯度环肽化合物及其制备方法和用途
CN102659930B (zh) 2012-03-30 2014-04-23 上海天伟生物制药有限公司 一种高纯度环肽类物质的晶体及其制备方法和用途
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN104861043B (zh) * 2014-05-29 2019-03-01 上海天伟生物制药有限公司 一种环肽类化合物的组合物及其制备方法和用途
US10183973B2 (en) * 2014-05-29 2019-01-22 Shanghai Techwell Biopharmaceutical Co., Ltd. Solvate of cyclic peptide compound, preparation method for same, and uses thereof
EP3226885A4 (de) * 2014-10-07 2018-07-18 Alaparthi, Lakshmi Prasad Zwischenprodukte und verfahren zur herstellung von micafungin
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
EP3485873A1 (de) 2017-11-17 2019-05-22 Cadila Healthcare Limited Stabile pharmazeutische injizierbare zusammensetzungen von micafungin
CN108752430B (zh) * 2018-05-31 2022-02-18 杭州中美华东制药有限公司 米卡芬净钠新晶型及其制备方法
WO2020013116A1 (ja) * 2018-07-10 2020-01-16 京都薬品工業株式会社 Ｐｔｐ－１ｂ阻害剤およびその用途
CN110734408A (zh) * 2019-10-22 2020-01-31 重庆康乐制药有限公司 一种米卡芬净类衍生物侧链中间体的制备方法

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FI912873A (fi) * 1990-06-18 1991-12-19 Fujisawa Pharmaceutical Co Ny polypeptidfoerening och foerfarande foer dess framstaellning.
IL105048A (en) * 1992-03-19 2001-06-14 Eli Lilly And Company U S Antifungal substances of the cyclic peptide type and a process for their preparation

Also Published As

Publication number Publication date
AR041770A1 (es) 2005-06-01
DK0788511T3 (da) 2003-03-31
ATE229541T1 (de) 2002-12-15
WO1996011210A1 (en) 1996-04-18
DE122008000025I1 (de) 2008-08-21
CA2202058A1 (en) 1996-04-18
BR9504791B1 (pt) 2010-10-05
HU228151B1 (en) 2012-12-28
RU2165423C2 (ru) 2001-04-20
LU91452I2 (fr) 2008-08-04
MX9702531A (es) 1997-06-28
EP0788511B1 (de) 2002-12-11
EP0788511A1 (de) 1997-08-13
NL300352I1 (nl) 2008-08-01
AU696949B2 (en) 1998-09-24
OA10475A (en) 2002-04-08
AU3578095A (en) 1996-05-02
NO2010016I2 (no) 2011-10-17
FR08C0028I2 (de) 2009-11-20
KR100353303B1 (ko) 2003-01-15
CA2202058C (en) 2007-11-06
CN1203089C (zh) 2005-05-25
PT788511E (pt) 2003-04-30
TR199501229A2 (tr) 1996-07-21
FR08C0028I1 (de) 2008-08-15
NO328483B1 (no) 2010-03-01
JP3518665B2 (ja) 2004-04-12
JP2897427B2 (ja) 1999-05-31
FI971397A (fi) 1997-05-27
HK1004136A1 (en) 1998-11-20
US6107458A (en) 2000-08-22
IL115484A0 (en) 1996-01-19
JPH10507174A (ja) 1998-07-14
DE69529172T2 (de) 2003-04-17
NL300352I2 (nl) 2008-11-03
FI119988B (fi) 2009-05-29
NO2010016I1 (no) 2010-08-16
KR970707150A (ko) 1997-12-01
FI971397A0 (fi) 1997-04-04
NO971544L (no) 1997-06-04
CN1168675A (zh) 1997-12-24
ES2187575T3 (es) 2003-06-16
US6265536B1 (en) 2001-07-24
JPH10324695A (ja) 1998-12-08
DE122008000025I2 (de) 2011-02-17
BR9504791A (pt) 1996-10-22
HUT77736A (hu) 1998-07-28
IL115484A (en) 2000-07-16
BRPI9504791B8 (pt) 2019-12-31
NO971544D0 (no) 1997-04-04

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP

V448 Application of spc

Free format text: PRODUCT NAME: MYCAMINE-MICAFUNGIN; REGISTRATION NO/DATE: EU/1/08/448/001, EU/1/08/448/002; 20080425

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Free format text: PRODUCT NAME: MICAFUNGIN UND PHARMAZEUTISCH VERTRAEGLICHE SALZE DAVON; REGISTRATION NO/DATE: EU/1/08/448/001, EU/1/08/448/002; 20080425

Spc suppl protection certif: 12 2008 000 025

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Free format text: PRODUCT NAME: MICAFUNGIN UND PHARMAZEUTISCH VERTRAEGLICHE SALZE DAVON; REGISTRATION NO/DATE: EU/1/08/448/001, EU/1/08/448/002; 20080425

Spc suppl protection certif: 12 2008 000 025

Filing date: 20080523