DE69624966D1 - Zyklische Hexapeptide mit fungizider Aktivität - Google Patents

Zyklische Hexapeptide mit fungizider Aktivität

Info

Publication number
DE69624966D1
DE69624966D1 DE69624966T DE69624966T DE69624966D1 DE 69624966 D1 DE69624966 D1 DE 69624966D1 DE 69624966 T DE69624966 T DE 69624966T DE 69624966 T DE69624966 T DE 69624966T DE 69624966 D1 DE69624966 D1 DE 69624966D1
Authority
DE
Germany
Prior art keywords
fungicidal activity
cyclic hexapeptides
hexapeptides
cyclic
fungicidal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69624966T
Other languages
English (en)
Other versions
DE69624966T2 (de
Inventor
Peter Stanley Borromeo
James Andrew Jamison
Michael John Rodriguez
Turner, Jr
Venkatraghavan Vasudevan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69624966D1 publication Critical patent/DE69624966D1/de
Application granted granted Critical
Publication of DE69624966T2 publication Critical patent/DE69624966T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69624966T 1995-04-07 1996-04-03 Zyklische Hexapeptide mit fungizider Aktivität Expired - Fee Related DE69624966T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41834195A 1995-04-07 1995-04-07

Publications (2)

Publication Number Publication Date
DE69624966D1 true DE69624966D1 (de) 2003-01-09
DE69624966T2 DE69624966T2 (de) 2003-03-27

Family

ID=23657711

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69624966T Expired - Fee Related DE69624966T2 (de) 1995-04-07 1996-04-03 Zyklische Hexapeptide mit fungizider Aktivität

Country Status (29)

Country Link
US (1) US5646111A (de)
EP (1) EP0736541B1 (de)
JP (1) JPH11504005A (de)
KR (1) KR19980703646A (de)
CN (1) CN1185739A (de)
AR (2) AR002731A1 (de)
AT (1) ATE228535T1 (de)
AU (1) AU702841B2 (de)
BR (1) BR9604906A (de)
CA (1) CA2217048A1 (de)
CO (1) CO4700480A1 (de)
CZ (1) CZ291702B6 (de)
DE (1) DE69624966T2 (de)
EA (1) EA000464B1 (de)
ES (1) ES2187617T3 (de)
HU (1) HUP9800809A3 (de)
IL (1) IL117749A (de)
IN (1) IN181897B (de)
MX (1) MX9707611A (de)
MY (1) MY132116A (de)
NO (1) NO974562L (de)
NZ (1) NZ305735A (de)
PE (1) PE39097A1 (de)
PL (1) PL322821A1 (de)
TR (1) TR199701122T1 (de)
UA (1) UA46759C2 (de)
WO (1) WO1996031228A1 (de)
YU (1) YU22496A (de)
ZA (1) ZA962598B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965525A (en) * 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
WO1997027864A1 (en) * 1996-02-01 1997-08-07 Eli Lilly And Company Cyclic peptide antifungal agents
WO1999006062A1 (en) * 1997-08-04 1999-02-11 Eli Lilly And Company Cyclic peptide antifungal agents
AU2003200556B2 (en) * 1997-12-10 2005-12-01 Novexel Echinocandin derivative and their preparation method
FR2784993B1 (fr) * 1998-10-26 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
UA72200C2 (uk) 1997-12-10 2005-02-15 Авентіс Фарма С.А. Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
MA26663A1 (fr) 1998-07-23 2004-12-20 Hoffmann La Roche Nouvelles aerothricines et leurs applications antifongiques
PT1107981E (pt) 1998-08-20 2005-05-31 Lilly Co Eli Sintese de analogos peptidicos ciclicos de anel modificado
JP2003511345A (ja) 1998-12-09 2003-03-25 イーライ リリー アンド カンパニー Ｅｃｈｉｎｏｃａｎｄｉｎシクロペプチド化合物の精製
KR20020003864A (ko) * 1999-03-03 2002-01-15 피터 지. 스트링거 에키노칸딘/탄수화물 착물
IL145186A0 (en) 1999-03-03 2002-06-30 Lilly Co Eli Formation and anion-exchange of crystalline echinocandin ammonium salts
DK1582204T3 (da) * 1999-03-03 2013-11-04 Lilly Co Eli Echinocandin-farmaceutiske formuleringer, der indeholder miceldannende overfladeaktive stoffer
EP1156784A1 (de) 1999-03-03 2001-11-28 Eli Lilly And Company Verfahren zur herstellung pharmazeutischen oralen ecb zubereitungen und zusammensetzungen
FR2794747B1 (fr) * 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
DE60110209T2 (de) 2000-01-17 2006-05-11 Basilea Pharmaceutica Ag Aerothricin analoge, deren herstellung und verwendung
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
CN103570530B (zh) * 2012-07-26 2016-08-10 鲁南新时代生物技术有限公司 一种阿尼芬净侧链中间体的制备方法
CN104003895B (zh) * 2014-05-29 2016-02-24 黑龙江大学 一种钯催化的串联反应合成三联苯类化合物的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320052A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) * 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
IE990233A1 (en) * 1990-06-18 2000-11-15 Fujisawa Pharmaceutical Co New Polypeptide Compound and a Process for Preparation thereof
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5233023A (en) * 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
CA2091663C (en) * 1992-03-19 2007-10-30 Frederick Joseph Burkhardt Cyclic peptide antifungal agents and process for preparation thereof

Also Published As

Publication number Publication date
CA2217048A1 (en) 1996-10-10
AU5383496A (en) 1996-10-23
PE39097A1 (es) 1997-10-13
JPH11504005A (ja) 1999-04-06
EP0736541B1 (de) 2002-11-27
EA199700307A1 (ru) 1998-04-30
UA46759C2 (uk) 2002-06-17
BR9604906A (pt) 1998-07-21
NO974562D0 (no) 1997-10-02
ZA962598B (en) 1997-10-01
HUP9800809A3 (en) 1998-12-28
NO974562L (no) 1997-11-28
MX9707611A (es) 1997-12-31
EP0736541A1 (de) 1996-10-09
AR004170A1 (es) 1998-11-04
NZ305735A (en) 1999-01-28
DE69624966T2 (de) 2003-03-27
CZ310297A3 (cs) 1998-06-17
EA000464B1 (ru) 1999-08-26
IL117749A (en) 2000-06-01
TR199701122T1 (xx) 1998-02-21
CZ291702B6 (cs) 2003-05-14
HUP9800809A2 (hu) 1998-08-28
WO1996031228A1 (en) 1996-10-10
YU22496A (sh) 1999-06-15
KR19980703646A (ko) 1998-12-05
US5646111A (en) 1997-07-08
PL322821A1 (en) 1998-02-16
CN1185739A (zh) 1998-06-24
MY132116A (en) 2007-09-28
IN181897B (de) 1998-10-24
ES2187617T3 (es) 2003-06-16
ATE228535T1 (de) 2002-12-15
AU702841B2 (en) 1999-03-04
AR002731A1 (es) 1998-04-29
IL117749A0 (en) 1996-08-04
CO4700480A1 (es) 1998-12-29

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee