ATE228535T1 - Zyklische hexapeptide mit fungizider aktivität - Google Patents

Zyklische hexapeptide mit fungizider aktivität

Info

Publication number
ATE228535T1
ATE228535T1 AT96302362T AT96302362T ATE228535T1 AT E228535 T1 ATE228535 T1 AT E228535T1 AT 96302362 T AT96302362 T AT 96302362T AT 96302362 T AT96302362 T AT 96302362T AT E228535 T1 ATE228535 T1 AT E228535T1
Authority
AT
Austria
Prior art keywords
fungicidal activity
cyclic hexapeptides
hexapeptides
cyclic
fungicidal
Prior art date
Application number
AT96302362T
Other languages
English (en)
Inventor
Peter Stanley Borromeo
James Andrew Jamison
Michael John Rodriguez
William Wilson Turner Jr
Venkatraghavan Vasudevan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE228535T1 publication Critical patent/ATE228535T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96302362T 1995-04-07 1996-04-03 Zyklische hexapeptide mit fungizider aktivität ATE228535T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41834195A 1995-04-07 1995-04-07

Publications (1)

Publication Number Publication Date
ATE228535T1 true ATE228535T1 (de) 2002-12-15

Family

ID=23657711

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96302362T ATE228535T1 (de) 1995-04-07 1996-04-03 Zyklische hexapeptide mit fungizider aktivität

Country Status (29)

Country Link
US (1) US5646111A (de)
EP (1) EP0736541B1 (de)
JP (1) JPH11504005A (de)
KR (1) KR19980703646A (de)
CN (1) CN1185739A (de)
AR (2) AR004170A1 (de)
AT (1) ATE228535T1 (de)
AU (1) AU702841B2 (de)
BR (1) BR9604906A (de)
CA (1) CA2217048A1 (de)
CO (1) CO4700480A1 (de)
CZ (1) CZ291702B6 (de)
DE (1) DE69624966T2 (de)
EA (1) EA000464B1 (de)
ES (1) ES2187617T3 (de)
HU (1) HUP9800809A3 (de)
IL (1) IL117749A (de)
IN (1) IN181897B (de)
MX (1) MX9707611A (de)
MY (1) MY132116A (de)
NO (1) NO974562L (de)
NZ (1) NZ305735A (de)
PE (1) PE39097A1 (de)
PL (1) PL322821A1 (de)
TR (1) TR199701122T1 (de)
UA (1) UA46759C2 (de)
WO (1) WO1996031228A1 (de)
YU (1) YU22496A (de)
ZA (1) ZA962598B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965525A (en) * 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
AU1851797A (en) * 1996-02-01 1997-08-22 Eli Lilly And Company Cyclic peptide antifungal agents
CA2301184A1 (en) * 1997-08-04 1999-02-11 Eli Lilly And Company Cyclic peptide antifungal agents
UA72200C2 (uk) * 1997-12-10 2005-02-15 Авентіс Фарма С.А. Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція
FR2784993B1 (fr) * 1998-10-26 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
AU2003200556B2 (en) * 1997-12-10 2005-12-01 Novexel Echinocandin derivative and their preparation method
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
MA26663A1 (fr) 1998-07-23 2004-12-20 Hoffmann La Roche Nouvelles aerothricines et leurs applications antifongiques
EP1107981B1 (de) 1998-08-20 2005-01-26 Eli Lilly & Company Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen
WO2000034315A2 (en) 1998-12-09 2000-06-15 Eli Lilly And Company Purification of echinocandin cyclopeptide compounds
BR0008713A (pt) 1999-03-03 2001-12-26 Lilly Co Eli Processos para preparar formulações ecomposições farmacêuticas orais com ecb
ES2433678T3 (es) * 1999-03-03 2013-12-12 Eli Lilly & Company Formulaciones farmacéuticas de equinocandina que contienen tensioactivos formadores de micelas
EP1155034B1 (de) 1999-03-03 2006-08-30 Eli Lilly And Company Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b
AU772633B2 (en) * 1999-03-03 2004-05-06 Eli Lilly And Company Echinocandin/carbohydrate complexes
FR2794747B1 (fr) * 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
CA2396174C (en) 2000-01-17 2007-10-09 Basilea Pharmaceutica Ag Aerothricin analogs, their preparation and use
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
CN103570530B (zh) * 2012-07-26 2016-08-10 鲁南新时代生物技术有限公司 一种阿尼芬净侧链中间体的制备方法
CN104003895B (zh) * 2014-05-29 2016-02-24 黑龙江大学 一种钯催化的串联反应合成三联苯类化合物的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320052A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) * 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
FI912873A (fi) * 1990-06-18 1991-12-19 Fujisawa Pharmaceutical Co Ny polypeptidfoerening och foerfarande foer dess framstaellning.
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5233023A (en) * 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
IL122315A (en) * 1992-03-19 2002-03-10 Lilly Co Eli Cyclic peptides and antifungal pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EA000464B1 (ru) 1999-08-26
AR002731A1 (es) 1998-04-29
UA46759C2 (uk) 2002-06-17
CA2217048A1 (en) 1996-10-10
MX9707611A (es) 1997-12-31
US5646111A (en) 1997-07-08
AU702841B2 (en) 1999-03-04
IN181897B (de) 1998-10-24
JPH11504005A (ja) 1999-04-06
HUP9800809A2 (hu) 1998-08-28
ES2187617T3 (es) 2003-06-16
KR19980703646A (ko) 1998-12-05
NO974562D0 (no) 1997-10-02
YU22496A (sh) 1999-06-15
EP0736541A1 (de) 1996-10-09
IL117749A (en) 2000-06-01
NZ305735A (en) 1999-01-28
PL322821A1 (en) 1998-02-16
HUP9800809A3 (en) 1998-12-28
CZ291702B6 (cs) 2003-05-14
EP0736541B1 (de) 2002-11-27
IL117749A0 (en) 1996-08-04
PE39097A1 (es) 1997-10-13
ZA962598B (en) 1997-10-01
CN1185739A (zh) 1998-06-24
BR9604906A (pt) 1998-07-21
TR199701122T1 (xx) 1998-02-21
DE69624966T2 (de) 2003-03-27
AU5383496A (en) 1996-10-23
WO1996031228A1 (en) 1996-10-10
MY132116A (en) 2007-09-28
EA199700307A1 (ru) 1998-04-30
CZ310297A3 (cs) 1998-06-17
CO4700480A1 (es) 1998-12-29
AR004170A1 (es) 1998-11-04
NO974562L (no) 1997-11-28
DE69624966D1 (de) 2003-01-09

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Legal Events

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