FI115458B - Menetelmä oksetanonien valmistamiseksi - Google Patents

Menetelmä oksetanonien valmistamiseksi Download PDF

Info

Publication number
FI115458B
FI115458B FI910857A FI910857A FI115458B FI 115458 B FI115458 B FI 115458B FI 910857 A FI910857 A FI 910857A FI 910857 A FI910857 A FI 910857A FI 115458 B FI115458 B FI 115458B
Authority
FI
Finland
Prior art keywords
formula
hydroxy
acid
ester
keto
Prior art date
Application number
FI910857A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI910857A0 (fi
FI910857A (fi
Inventor
Martin Karpf
Ulrich Zutter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI910857A0 publication Critical patent/FI910857A0/fi
Publication of FI910857A publication Critical patent/FI910857A/fi
Application granted granted Critical
Publication of FI115458B publication Critical patent/FI115458B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Treatment Of Steel (AREA)
  • Examining Or Testing Airtightness (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI910857A 1990-02-23 1991-02-22 Menetelmä oksetanonien valmistamiseksi FI115458B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH58990 1990-02-23
CH58990 1990-02-23
CH392590 1990-12-12
CH392590 1990-12-12

Publications (3)

Publication Number Publication Date
FI910857A0 FI910857A0 (fi) 1991-02-22
FI910857A FI910857A (fi) 1991-08-24
FI115458B true FI115458B (fi) 2005-05-13

Family

ID=25685045

Family Applications (1)

Application Number Title Priority Date Filing Date
FI910857A FI115458B (fi) 1990-02-23 1991-02-22 Menetelmä oksetanonien valmistamiseksi

Country Status (18)

Country Link
US (2) US5245056A (pt)
EP (1) EP0443449B1 (pt)
JP (1) JP2912463B2 (pt)
KR (2) KR0183034B1 (pt)
AT (1) ATE153332T1 (pt)
AU (1) AU644846B2 (pt)
CA (1) CA2035972C (pt)
DE (1) DE59108707D1 (pt)
DK (1) DK0443449T3 (pt)
ES (1) ES2103751T3 (pt)
FI (1) FI115458B (pt)
GR (1) GR3024420T3 (pt)
HU (1) HU208686B (pt)
IE (1) IE910608A1 (pt)
NO (1) NO178764C (pt)
NZ (1) NZ237132A (pt)
PT (1) PT96857B (pt)
ZA (1) ZA911153B (pt)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5274143A (en) * 1991-07-23 1993-12-28 Hoffmann-La Roche Inc. Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione
AT398579B (de) * 1992-07-06 1994-12-27 Chemie Linz Gmbh Enzymatisches verfahren zur trennung racemischer gemische von delta-valerolactonen
DE4225817A1 (de) * 1992-08-05 1994-02-10 Chemie Linz Deutschland Enzymatisches Verfahren zur Trennung racemischer Gemische von delta-Valerolactonen
US5481008A (en) * 1993-09-13 1996-01-02 Hoffmann-La Roche Inc. Process for the preparation of optically active compounds
IL129871A (en) 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
DE19703713A1 (de) * 1997-01-23 1998-07-30 Hans Prof Dr Schick Verfahren für die Herstellung von Oxetan-2-onen und Zwischenprodukte
EP1017408B1 (en) * 1997-02-05 2005-04-13 F. Hoffmann-La Roche Ag Use of tethrahydrolipstatin in the treatment of diabetes type ii
WO1999014210A1 (en) * 1997-09-15 1999-03-25 Warner-Lambert Company Process for the preparation of substituted 5,6-dihydro-2h-pyran-2-ones
US7124221B1 (en) 1999-10-19 2006-10-17 Rambus Inc. Low latency multi-level communication interface
US6552204B1 (en) * 2000-02-04 2003-04-22 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
US6545165B1 (en) * 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
EP1132389A1 (en) 2000-03-06 2001-09-12 Vernalis Research Limited New aza-indolyl derivatives for the treatment of obesity
BR0112800A (pt) * 2000-07-28 2003-07-01 Hoffmann La Roche Utilização de um inibidor de lìpases e de um sequestrante de ácido de bìlis farmaceuticamente aceitáveis e processo para a prevenção e tratamento de enfermidades associadas com altos nìveis de colesterol de plasma
AU1212002A (en) 2000-08-09 2002-02-18 Hoffmann La Roche Use of lipase inhibitors
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
MXPA03003246A (es) 2000-10-16 2003-06-06 Hoffmann La Roche Derivados de indolina y su uso como ligandos del receptor 5-ht2.
GB0030710D0 (en) * 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
ES2291374T3 (es) 2000-12-27 2008-03-01 F. Hoffmann-La Roche Ag Derivados de indol y su empleo como ligandos receptores de 5-ht2b y 5-ht2c.
GB0106177D0 (en) 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
US20030027786A1 (en) 2001-06-06 2003-02-06 Karsten Maeder Lipase inhibiting composition
US6730319B2 (en) 2001-06-06 2004-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions having depressed melting points
US6787558B2 (en) 2001-09-28 2004-09-07 Hoffmann-La Roche Inc. Quinoline derivatives
EP1458728A1 (en) * 2001-12-13 2004-09-22 Ranbaxy Laboratories Limited Crystalline cefdinir potassium dihydrate
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
EP1474145B1 (en) 2002-02-04 2008-04-23 F. Hoffmann-La Roche Ag Quinoline derivatives as npy antagonists
ES2292992T3 (es) 2002-02-28 2008-03-16 F. Hoffmann-La Roche Ag Derivados de tiazol como antagonistas del receptor npy.
AU2003226370A1 (en) * 2002-04-17 2003-11-03 The Burnham Institute Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
US7728153B2 (en) 2002-04-17 2010-06-01 The Burnham Institute For Medical Research Method for the asymmetric synthesis of beta-lactone compounds
KR100647932B1 (ko) 2002-07-05 2006-11-23 에프. 호프만-라 로슈 아게 퀴나졸린 유도체
US8861667B1 (en) 2002-07-12 2014-10-14 Rambus Inc. Clock data recovery circuit with equalizer clock calibration
WO2004014884A1 (en) 2002-08-07 2004-02-19 F. Hoffmann-La Roche Ag Thiazole derivatives
RU2296759C2 (ru) 2002-09-12 2007-04-10 Ф.Хоффманн-Ля Рош Аг N-замещенные 1н-индол-5-пропионовые кислоты, фармацевтическая композиция, содержащая эти соединения, и их применение (варианты)
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
MXPA05005445A (es) 2002-11-25 2005-08-26 Hoffmann La Roche Derivados de indolilo.
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
BRPI0413500A (pt) * 2003-08-12 2006-10-10 Hoffmann La Roche compostos, processos para a sua preparação, composição farmacêutica que compreende os mesmos, utilização de um composto, métodos para o tratamento e profilaxia de artrite, diabetes, distúrbios alimentares e obesidade
WO2005014593A1 (en) * 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag Thiazole derivatives as npy antagonists
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
AU2006243243B2 (en) * 2005-05-03 2009-05-14 F. Hoffmann-La Roche Ag Tetracyclic azapyrazinoindolines as 5-HT2 ligands
EP1945635B1 (en) 2005-08-18 2009-05-06 F.Hoffmann-La Roche Ag Thiazolyl piperidine derivatives useful as h3 receptor modulators
KR101047204B1 (ko) 2005-11-30 2011-07-06 에프. 호프만-라 로슈 아게 Ｈ3 조절제로서 사용하기 위한1,1-다이옥소-싸이오모폴린일 인돌일 메탄온 유도체
JP2009517434A (ja) 2005-11-30 2009-04-30 エフ．ホフマン−ラ ロシュ アーゲー ５−置換インドール−２−カルボキサミド誘導体
KR101124156B1 (ko) 2005-11-30 2012-03-23 에프. 호프만-라 로슈 아게 1,5-치환된 인돌-2-일 아마이드 유도체
DE602006010433D1 (de) 2005-12-09 2009-12-24 Hoffmann La Roche Für die behandlung von obesitas geeignete tricyclische amidderivate
JP2009519290A (ja) 2005-12-15 2009-05-14 エフ．ホフマン−ラ ロシュ アーゲー ピロロ［２，３−ｃ］ピリジン誘導体
BRPI0619985A2 (pt) 2005-12-16 2011-10-25 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas, métodos para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, de obesidade e de diabetes do tipo ii em um ser humano ou animal e usos dos compostos
EP1976840A1 (en) * 2006-01-13 2008-10-08 F.Hoffmann-La Roche Ag Cyclohexyl piperazinyl methanone derivatives and their use as histamine h3 receptor modulators
ATE479656T1 (de) * 2006-01-23 2010-09-15 Hoffmann La Roche Cyclohexyl-sulfonamid-derivate mit h3- rezeptoraktivität
US7432255B2 (en) 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
US7902184B2 (en) 2006-05-30 2011-03-08 Hoffmann-La Roche Inc. Piperazinyl pyrimidine derivatives
US7514433B2 (en) 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US20080146559A1 (en) 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
CN101348475B (zh) * 2007-07-20 2011-03-30 重庆人本药物研究院 一种奥利司他合成方法、中间体化合物及其制备方法
KR20100027231A (ko) * 2007-07-25 2010-03-10 에프. 호프만-라 로슈 아게 벤조퓨란- 및 벤조[ｂ]티오펜-2-카복실산 아마이드 유도체 및 이의 히스타민 3 수용체 조절제로서의 용도
KR101076680B1 (ko) * 2007-11-01 2011-10-26 한미홀딩스 주식회사 (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체
KR101126084B1 (ko) * 2008-11-04 2012-03-29 한미홀딩스 주식회사 (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체
EP2646048B1 (en) 2010-11-30 2017-11-01 The Board of Trustees of the University of Illionis Stable helical ionic polypeptides
CN103588735A (zh) * 2013-11-13 2014-02-19 大连九信生物化工科技有限公司 一种奥利司他的结晶提纯方法
FR3017878B1 (fr) * 2014-02-27 2017-12-08 Charabot Procede de production de lactones a partir d'une souche d'aureobasidium pullulans
WO2018140613A1 (en) 2017-01-25 2018-08-02 The Board Of Trustees Of The University Of Illinois Conformation switchable antimicrobial peptides and methods of using the same
CN112625009A (zh) * 2020-12-18 2021-04-09 植恩生物技术股份有限公司 一种奥利司他关键中间体的精制方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3457193A (en) * 1965-06-30 1969-07-22 Union Carbide Corp Epoxyoxacyclobutanes and polymers thereof
DE2400429A1 (de) * 1974-01-05 1975-07-17 Basf Ag Verfahren zur herstellung von 4-ketotetrahydro-alpha-pyronen
US4395561A (en) * 1982-05-14 1983-07-26 The United States Of America As Represented By The Secretary Of The Navy Synthesis of 3-hydroxyoxetane
CA1328881C (en) * 1984-12-21 1994-04-26 Pierre Barbier Process for the manufacture of oxetanones
CA1270837A (en) * 1984-12-21 1990-06-26 Hoffmann-La Roche Limited Oxetanones
EP0365539A4 (en) * 1987-06-17 1990-12-05 Australian Commercial Research & Development Limited Human leucocyte elastase inhibitor compounds
HU202851B (en) * 1988-04-04 1991-04-29 Sandoz Ag Herbicidal or acaricidal compositions and process for producing the active ingredient aryldione derivatives
US5149835A (en) * 1989-04-27 1992-09-22 University Of New Mexico Substituted mevalonolactones, and methods for stereoselective preparation thereof and desmethyl homologues thereof
US5036008A (en) * 1989-07-12 1991-07-30 Bristol-Myers Company Antitumor antibiotic BU-3285T
US5110825A (en) * 1989-12-28 1992-05-05 Shionogi & Co., Ltd. Benzofuran derivative
IL97148A (en) * 1990-02-26 1996-11-14 Hoffmann La Roche Oxtanones, the process for their preparation and the pharmaceutical preparations containing them

Also Published As

Publication number Publication date
KR0183034B1 (ko) 1999-05-01
ZA911153B (en) 1991-11-27
CA2035972C (en) 2006-07-11
FI910857A0 (fi) 1991-02-22
DE59108707D1 (de) 1997-06-26
EP0443449A2 (de) 1991-08-28
NO178764C (no) 1996-05-29
FI910857A (fi) 1991-08-24
HU208686B (en) 1993-12-28
KR100191365B1 (ko) 1999-06-15
US5245056A (en) 1993-09-14
DK0443449T3 (da) 1997-11-24
IE910608A1 (en) 1991-08-28
PT96857A (pt) 1991-10-31
HUT56558A (en) 1991-09-30
AU644846B2 (en) 1993-12-23
PT96857B (pt) 1998-07-31
US5399720A (en) 1995-03-21
NO178764B (no) 1996-02-19
ES2103751T3 (es) 1997-10-01
AU7116691A (en) 1991-08-29
JP2912463B2 (ja) 1999-06-28
GR3024420T3 (en) 1997-11-28
CA2035972A1 (en) 1991-08-24
KR910021393A (ko) 1991-12-20
NO910712L (no) 1991-08-26
EP0443449A3 (en) 1991-12-04
EP0443449B1 (de) 1997-05-21
JPH04211675A (ja) 1992-08-03
ATE153332T1 (de) 1997-06-15
NZ237132A (en) 1993-04-28
NO910712D0 (no) 1991-02-22

Similar Documents

Publication Publication Date Title
FI115458B (fi) Menetelmä oksetanonien valmistamiseksi
FI91403C (fi) Menetelmä terapeuttisesti käyttökelpoisten oksetanonien valmistamiseksi
HU202856B (en) Process for producing intermediates of 3-dimethyl-mevalonic acid derivatives
JP3119663B2 (ja) （＋）−コンパクチンおよび（＋）−メビノリンの類似体であるβ−ヒドロキシ−δ−ラクトン基を含有する化合物の調製方法
KR20070121063A (ko) 2-(6-치환-1,3-디옥산-4-일)아세트산 유도체의 제조위한개시 화합물
US4866090A (en) Novel HMG-CoA reductase inhibitors
US4857547A (en) Novel HMG-CoA reductase inhibitors
US5599954A (en) N-substituted-7-amino-5-hydroxy-3-oxoheptanoic acid derivatives and method for producing the same
US5681970A (en) Method for the preparation of β-phenylisoserine derivatives
US4645854A (en) Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit
PL178517B1 (pl) Sposób wytwarzania farmakologicznie aktywnych pochodnych piperazyny
Le Sann et al. Assembly intermediates in polyketide biosynthesis: enantioselective syntheses of β-hydroxycarbonyl compounds
KR100638776B1 (ko) 7-카르복시 치환된 스테로이드의 제조 방법
EP0296810A1 (en) Novel intermediates and processes for preparing HMG-COA reductase inhibitors
US5208258A (en) Antihypercholesterolemic compounds and synthesis thereof
KR20170078033A (ko) 신규한 스타틴 중간체, 이의 제조방법 및 이를 이용한 로수바스타틴의 제조방법
JPH06279409A (ja) 光学活性１，４−ジヒドロピリジン誘導体およびその製造方法
RU2127735C1 (ru) Способ получения 4-метокси-10-(1-гидроксиэтил)-11-оксо-1-азатрицикло- (7.2.0.03,8)-ундека-2-ен карбоновой кислоты или ее солей, 4-третбутилбензил- (4s, 8s, 9r, 10s, 12r)-4-метокси-10-(1-гидроксиэтил)-11-оксо-1-азатрицикло- (7.2.0.03,8)-ундека-2-ен-2-карбоксилат
JPH0570394A (ja) ネオカルジリン類の製造法
JPH0196151A (ja) 新規なＨＭＧ−ＣｏＡ還元酵素阻害剤
WO1999018109A1 (en) Ring e-modified analogues of (-)-podophyllotoxin and etoposide and a method for their synthesis
MXPA01013341A (es) Proceso novedoso para la preparacion de derivados espiro ((4-ciclohexanona)-(3h)indol)-2'-(1'h)ona.
JPH0427980B2 (pt)
JPH03264572A (ja) 含フッ素２―ブテノリド誘導体
JPS61148142A (ja) グリチルレチン酸セコ型誘導体

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 115458

Country of ref document: FI