NO178764C - Fremgangsmåte ved fremstilling av oksetanoner - Google Patents
Fremgangsmåte ved fremstilling av oksetanonerInfo
- Publication number
- NO178764C NO178764C NO910712A NO910712A NO178764C NO 178764 C NO178764 C NO 178764C NO 910712 A NO910712 A NO 910712A NO 910712 A NO910712 A NO 910712A NO 178764 C NO178764 C NO 178764C
- Authority
- NO
- Norway
- Prior art keywords
- oxetanones
- preparation
- beta
- novel
- lactones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heat Treatment Of Steel (AREA)
- Examining Or Testing Airtightness (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH58990 | 1990-02-23 | ||
| CH392590 | 1990-12-12 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO910712D0 NO910712D0 (no) | 1991-02-22 |
| NO910712L NO910712L (no) | 1991-08-26 |
| NO178764B NO178764B (no) | 1996-02-19 |
| NO178764C true NO178764C (no) | 1996-05-29 |
Family
ID=25685045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO910712A NO178764C (no) | 1990-02-23 | 1991-02-22 | Fremgangsmåte ved fremstilling av oksetanoner |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US5245056A (pt) |
| EP (1) | EP0443449B1 (pt) |
| JP (1) | JP2912463B2 (pt) |
| KR (2) | KR0183034B1 (pt) |
| AT (1) | ATE153332T1 (pt) |
| AU (1) | AU644846B2 (pt) |
| CA (1) | CA2035972C (pt) |
| DE (1) | DE59108707D1 (pt) |
| DK (1) | DK0443449T3 (pt) |
| ES (1) | ES2103751T3 (pt) |
| FI (1) | FI115458B (pt) |
| GR (1) | GR3024420T3 (pt) |
| HU (1) | HU208686B (pt) |
| IE (1) | IE910608A1 (pt) |
| NO (1) | NO178764C (pt) |
| NZ (1) | NZ237132A (pt) |
| PT (1) | PT96857B (pt) |
| ZA (1) | ZA911153B (pt) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5274143A (en) * | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
| AT398579B (de) * | 1992-07-06 | 1994-12-27 | Chemie Linz Gmbh | Enzymatisches verfahren zur trennung racemischer gemische von delta-valerolactonen |
| DE4225817A1 (de) * | 1992-08-05 | 1994-02-10 | Chemie Linz Deutschland | Enzymatisches Verfahren zur Trennung racemischer Gemische von delta-Valerolactonen |
| US5481008A (en) * | 1993-09-13 | 1996-01-02 | Hoffmann-La Roche Inc. | Process for the preparation of optically active compounds |
| IL129871A (en) | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
| DE19703713A1 (de) * | 1997-01-23 | 1998-07-30 | Hans Prof Dr Schick | Verfahren für die Herstellung von Oxetan-2-onen und Zwischenprodukte |
| EP1017408B1 (en) * | 1997-02-05 | 2005-04-13 | F. Hoffmann-La Roche Ag | Use of tethrahydrolipstatin in the treatment of diabetes type ii |
| WO1999014210A1 (en) * | 1997-09-15 | 1999-03-25 | Warner-Lambert Company | Process for the preparation of substituted 5,6-dihydro-2h-pyran-2-ones |
| US7124221B1 (en) | 1999-10-19 | 2006-10-17 | Rambus Inc. | Low latency multi-level communication interface |
| US6552204B1 (en) * | 2000-02-04 | 2003-04-22 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
| US6545165B1 (en) * | 2000-02-04 | 2003-04-08 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
| EP1132389A1 (en) | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | New aza-indolyl derivatives for the treatment of obesity |
| BR0112800A (pt) * | 2000-07-28 | 2003-07-01 | Hoffmann La Roche | Utilização de um inibidor de lìpases e de um sequestrante de ácido de bìlis farmaceuticamente aceitáveis e processo para a prevenção e tratamento de enfermidades associadas com altos nìveis de colesterol de plasma |
| AU1212002A (en) | 2000-08-09 | 2002-02-18 | Hoffmann La Roche | Use of lipase inhibitors |
| US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| MXPA03003246A (es) | 2000-10-16 | 2003-06-06 | Hoffmann La Roche | Derivados de indolina y su uso como ligandos del receptor 5-ht2. |
| GB0030710D0 (en) * | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| ES2291374T3 (es) | 2000-12-27 | 2008-03-01 | F. Hoffmann-La Roche Ag | Derivados de indol y su empleo como ligandos receptores de 5-ht2b y 5-ht2c. |
| GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| US6730319B2 (en) | 2001-06-06 | 2004-05-04 | Hoffmann-La Roche Inc. | Pharmaceutical compositions having depressed melting points |
| US6787558B2 (en) | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| EP1458728A1 (en) * | 2001-12-13 | 2004-09-22 | Ranbaxy Laboratories Limited | Crystalline cefdinir potassium dihydrate |
| GB0202015D0 (en) * | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| EP1474145B1 (en) | 2002-02-04 | 2008-04-23 | F. Hoffmann-La Roche Ag | Quinoline derivatives as npy antagonists |
| ES2292992T3 (es) | 2002-02-28 | 2008-03-16 | F. Hoffmann-La Roche Ag | Derivados de tiazol como antagonistas del receptor npy. |
| AU2003226370A1 (en) * | 2002-04-17 | 2003-11-03 | The Burnham Institute | Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation |
| US7728153B2 (en) | 2002-04-17 | 2010-06-01 | The Burnham Institute For Medical Research | Method for the asymmetric synthesis of beta-lactone compounds |
| KR100647932B1 (ko) | 2002-07-05 | 2006-11-23 | 에프. 호프만-라 로슈 아게 | 퀴나졸린 유도체 |
| US8861667B1 (en) | 2002-07-12 | 2014-10-14 | Rambus Inc. | Clock data recovery circuit with equalizer clock calibration |
| WO2004014884A1 (en) | 2002-08-07 | 2004-02-19 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| RU2296759C2 (ru) | 2002-09-12 | 2007-04-10 | Ф.Хоффманн-Ля Рош Аг | N-замещенные 1н-индол-5-пропионовые кислоты, фармацевтическая композиция, содержащая эти соединения, и их применение (варианты) |
| US20040092735A1 (en) * | 2002-11-08 | 2004-05-13 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of cefuroxime sodium |
| MXPA05005445A (es) | 2002-11-25 | 2005-08-26 | Hoffmann La Roche | Derivados de indolilo. |
| GB0314967D0 (en) * | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| BRPI0413500A (pt) * | 2003-08-12 | 2006-10-10 | Hoffmann La Roche | compostos, processos para a sua preparação, composição farmacêutica que compreende os mesmos, utilização de um composto, métodos para o tratamento e profilaxia de artrite, diabetes, distúrbios alimentares e obesidade |
| WO2005014593A1 (en) * | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | Thiazole derivatives as npy antagonists |
| US7074822B2 (en) | 2004-02-23 | 2006-07-11 | Solvay Pharmaceuticals Gmbh | Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them |
| AU2006243243B2 (en) * | 2005-05-03 | 2009-05-14 | F. Hoffmann-La Roche Ag | Tetracyclic azapyrazinoindolines as 5-HT2 ligands |
| EP1945635B1 (en) | 2005-08-18 | 2009-05-06 | F.Hoffmann-La Roche Ag | Thiazolyl piperidine derivatives useful as h3 receptor modulators |
| KR101047204B1 (ko) | 2005-11-30 | 2011-07-06 | 에프. 호프만-라 로슈 아게 | Ｈ3 조절제로서 사용하기 위한1,1-다이옥소-싸이오모폴린일 인돌일 메탄온 유도체 |
| JP2009517434A (ja) | 2005-11-30 | 2009-04-30 | エフ．ホフマン−ラ ロシュ アーゲー | ５−置換インドール−２−カルボキサミド誘導体 |
| KR101124156B1 (ko) | 2005-11-30 | 2012-03-23 | 에프. 호프만-라 로슈 아게 | 1,5-치환된 인돌-2-일 아마이드 유도체 |
| DE602006010433D1 (de) | 2005-12-09 | 2009-12-24 | Hoffmann La Roche | Für die behandlung von obesitas geeignete tricyclische amidderivate |
| JP2009519290A (ja) | 2005-12-15 | 2009-05-14 | エフ．ホフマン−ラ ロシュ アーゲー | ピロロ［２，３−ｃ］ピリジン誘導体 |
| BRPI0619985A2 (pt) | 2005-12-16 | 2011-10-25 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas, métodos para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, de obesidade e de diabetes do tipo ii em um ser humano ou animal e usos dos compostos |
| EP1976840A1 (en) * | 2006-01-13 | 2008-10-08 | F.Hoffmann-La Roche Ag | Cyclohexyl piperazinyl methanone derivatives and their use as histamine h3 receptor modulators |
| ATE479656T1 (de) * | 2006-01-23 | 2010-09-15 | Hoffmann La Roche | Cyclohexyl-sulfonamid-derivate mit h3- rezeptoraktivität |
| US7432255B2 (en) | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| US7902184B2 (en) | 2006-05-30 | 2011-03-08 | Hoffmann-La Roche Inc. | Piperazinyl pyrimidine derivatives |
| US7514433B2 (en) | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| US20080146559A1 (en) | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
| CN101348475B (zh) * | 2007-07-20 | 2011-03-30 | 重庆人本药物研究院 | 一种奥利司他合成方法、中间体化合物及其制备方法 |
| KR20100027231A (ko) * | 2007-07-25 | 2010-03-10 | 에프. 호프만-라 로슈 아게 | 벤조퓨란- 및 벤조[ｂ]티오펜-2-카복실산 아마이드 유도체 및 이의 히스타민 3 수용체 조절제로서의 용도 |
| KR101076680B1 (ko) * | 2007-11-01 | 2011-10-26 | 한미홀딩스 주식회사 | (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체 |
| KR101126084B1 (ko) * | 2008-11-04 | 2012-03-29 | 한미홀딩스 주식회사 | (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체 |
| EP2646048B1 (en) | 2010-11-30 | 2017-11-01 | The Board of Trustees of the University of Illionis | Stable helical ionic polypeptides |
| CN103588735A (zh) * | 2013-11-13 | 2014-02-19 | 大连九信生物化工科技有限公司 | 一种奥利司他的结晶提纯方法 |
| FR3017878B1 (fr) * | 2014-02-27 | 2017-12-08 | Charabot | Procede de production de lactones a partir d'une souche d'aureobasidium pullulans |
| WO2018140613A1 (en) | 2017-01-25 | 2018-08-02 | The Board Of Trustees Of The University Of Illinois | Conformation switchable antimicrobial peptides and methods of using the same |
| CN112625009A (zh) * | 2020-12-18 | 2021-04-09 | 植恩生物技术股份有限公司 | 一种奥利司他关键中间体的精制方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3457193A (en) * | 1965-06-30 | 1969-07-22 | Union Carbide Corp | Epoxyoxacyclobutanes and polymers thereof |
| DE2400429A1 (de) * | 1974-01-05 | 1975-07-17 | Basf Ag | Verfahren zur herstellung von 4-ketotetrahydro-alpha-pyronen |
| US4395561A (en) * | 1982-05-14 | 1983-07-26 | The United States Of America As Represented By The Secretary Of The Navy | Synthesis of 3-hydroxyoxetane |
| CA1328881C (en) * | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| CA1270837A (en) * | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
| EP0365539A4 (en) * | 1987-06-17 | 1990-12-05 | Australian Commercial Research & Development Limited | Human leucocyte elastase inhibitor compounds |
| HU202851B (en) * | 1988-04-04 | 1991-04-29 | Sandoz Ag | Herbicidal or acaricidal compositions and process for producing the active ingredient aryldione derivatives |
| US5149835A (en) * | 1989-04-27 | 1992-09-22 | University Of New Mexico | Substituted mevalonolactones, and methods for stereoselective preparation thereof and desmethyl homologues thereof |
| US5036008A (en) * | 1989-07-12 | 1991-07-30 | Bristol-Myers Company | Antitumor antibiotic BU-3285T |
| US5110825A (en) * | 1989-12-28 | 1992-05-05 | Shionogi & Co., Ltd. | Benzofuran derivative |
| IL97148A (en) * | 1990-02-26 | 1996-11-14 | Hoffmann La Roche | Oxtanones, the process for their preparation and the pharmaceutical preparations containing them |
-
1991
- 1991-02-07 CA CA002035972A patent/CA2035972C/en not_active Expired - Lifetime
- 1991-02-11 US US07/653,846 patent/US5245056A/en not_active Expired - Lifetime
- 1991-02-15 DE DE59108707T patent/DE59108707D1/de not_active Expired - Lifetime
- 1991-02-15 DK DK91102150.9T patent/DK0443449T3/da active
- 1991-02-15 AT AT91102150T patent/ATE153332T1/de not_active IP Right Cessation
- 1991-02-15 NZ NZ237132A patent/NZ237132A/xx unknown
- 1991-02-15 ZA ZA911153A patent/ZA911153B/xx unknown
- 1991-02-15 EP EP91102150A patent/EP0443449B1/de not_active Expired - Lifetime
- 1991-02-15 ES ES91102150T patent/ES2103751T3/es not_active Expired - Lifetime
- 1991-02-18 AU AU71166/91A patent/AU644846B2/en not_active Expired
- 1991-02-20 JP JP3045629A patent/JP2912463B2/ja not_active Expired - Lifetime
- 1991-02-20 HU HU91559A patent/HU208686B/hu unknown
- 1991-02-22 NO NO910712A patent/NO178764C/no not_active IP Right Cessation
- 1991-02-22 IE IE060891A patent/IE910608A1/en not_active IP Right Cessation
- 1991-02-22 KR KR1019910002903A patent/KR0183034B1/ko not_active IP Right Cessation
- 1991-02-22 PT PT96857A patent/PT96857B/pt not_active IP Right Cessation
- 1991-02-22 FI FI910857A patent/FI115458B/fi active IP Right Grant
-
1993
- 1993-06-15 US US08/077,475 patent/US5399720A/en not_active Expired - Lifetime
-
1997
- 1997-08-13 GR GR970402063T patent/GR3024420T3/el unknown
-
1998
- 1998-09-16 KR KR1019980038144A patent/KR100191365B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR0183034B1 (ko) | 1999-05-01 |
| ZA911153B (en) | 1991-11-27 |
| CA2035972C (en) | 2006-07-11 |
| FI910857A0 (fi) | 1991-02-22 |
| DE59108707D1 (de) | 1997-06-26 |
| EP0443449A2 (de) | 1991-08-28 |
| FI910857A (fi) | 1991-08-24 |
| HU208686B (en) | 1993-12-28 |
| KR100191365B1 (ko) | 1999-06-15 |
| US5245056A (en) | 1993-09-14 |
| DK0443449T3 (da) | 1997-11-24 |
| IE910608A1 (en) | 1991-08-28 |
| FI115458B (fi) | 2005-05-13 |
| PT96857A (pt) | 1991-10-31 |
| HUT56558A (en) | 1991-09-30 |
| AU644846B2 (en) | 1993-12-23 |
| PT96857B (pt) | 1998-07-31 |
| US5399720A (en) | 1995-03-21 |
| NO178764B (no) | 1996-02-19 |
| ES2103751T3 (es) | 1997-10-01 |
| AU7116691A (en) | 1991-08-29 |
| JP2912463B2 (ja) | 1999-06-28 |
| GR3024420T3 (en) | 1997-11-28 |
| CA2035972A1 (en) | 1991-08-24 |
| KR910021393A (ko) | 1991-12-20 |
| NO910712L (no) | 1991-08-26 |
| EP0443449A3 (en) | 1991-12-04 |
| EP0443449B1 (de) | 1997-05-21 |
| JPH04211675A (ja) | 1992-08-03 |
| ATE153332T1 (de) | 1997-06-15 |
| NZ237132A (en) | 1993-04-28 |
| NO910712D0 (no) | 1991-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |