FI109088B - Tablett och förfarande för dess framställning - Google Patents
Tablett och förfarande för dess framställning Download PDFInfo
- Publication number
- FI109088B FI109088B FI973733A FI973733A FI109088B FI 109088 B FI109088 B FI 109088B FI 973733 A FI973733 A FI 973733A FI 973733 A FI973733 A FI 973733A FI 109088 B FI109088 B FI 109088B
- Authority
- FI
- Finland
- Prior art keywords
- weight
- silica
- microcrystalline cellulose
- microcrystalline
- dichloromethylene
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
Priority Applications (33)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI973733A FI109088B (sv) | 1997-09-19 | 1997-09-19 | Tablett och förfarande för dess framställning |
| JP2000512526A JP3589977B2 (ja) | 1997-09-19 | 1998-09-18 | 活性成分としてクロドロン酸塩および賦形剤としてケイ化微晶質セルロースを含む医薬製剤 |
| PT98945336T PT1027037E (pt) | 1997-09-19 | 1998-09-18 | Composicao farmaceutica que compreende clodronato como ingredientes activo e celulose microcristalina silicificada como excipiente |
| AU92685/98A AU737738B2 (en) | 1997-09-19 | 1998-09-18 | Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient |
| BR9812480-3A BR9812480A (pt) | 1997-09-19 | 1998-09-18 | "preparação farmacêutica compreendendo clodronato como ingrediente ativo e celulose microcristalina como excipiente, processo de fabricação e uso de celulose microcristalina siliciada na fabricação de dita preparação farmacêutica" |
| SI9830599T SI1027037T1 (en) | 1997-09-19 | 1998-09-18 | Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient |
| DE69820287T DE69820287T2 (de) | 1997-09-19 | 1998-09-18 | Pharmazeutische Zubereitung, die Chlodronat als Wirkstoff und silicifizierte mikrokristalline Cellulose als Exipienten umfasst |
| CZ20000787A CZ298675B6 (cs) | 1997-09-19 | 1998-09-18 | Farmaceutický prostredek obsahující klodronát a mikrokrystalickou celulózu s oxidem kremicitým |
| SK393-2000A SK284088B6 (sk) | 1997-09-19 | 1998-09-18 | Farmaceutický prostriedok obsahujúci klodronát ako aktívne činidlo, spôsob výroby prostriedku a použitie mikrokryštalickej celulózy na jeho výrobu |
| EEP200000096A EE04218B1 (et) | 1997-09-19 | 1998-09-18 | Toimeainena klodronaati ja ekstsipiendina ränistatud mikrokristallilist tselluloosi sisaldav farmatseutiline preparaat ning farmatseutilise preparaadi tootmismeetod |
| AT98945336T ATE255410T1 (de) | 1997-09-19 | 1998-09-18 | Arzneimittel, das clodronat als wirkstoff und mit siliciumdioxid behandelte mikrokristalline cellulose als füllstoff enthält |
| TR2000/00722T TR200000722T2 (tr) | 1997-09-19 | 1998-09-18 | Silikatlı küçük kristalli selüloz içeren farmakolojik ilaç. |
| PCT/FI1998/000735 WO1999015155A1 (en) | 1997-09-19 | 1998-09-18 | Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient |
| HU0004383A HU226118B1 (en) | 1997-09-19 | 1998-09-18 | Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient |
| EP98945336A EP1027037B1 (en) | 1997-09-19 | 1998-09-18 | Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient |
| DE1027037T DE1027037T1 (de) | 1997-09-19 | 1998-09-18 | Arzneimittel, das clodronat als wirkstoff und mit siliciumdioxid behandelte mikrokristalline cellulose als füllsstoff enhält |
| NZ503766A NZ503766A (en) | 1997-09-19 | 1998-09-18 | Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient |
| IDW20000735A ID24423A (id) | 1997-09-19 | 1998-09-18 | Sediaan farmasi yang terdiri dari klodronat sebagai bahan aktif dan selulosa mikrokristalin tersilisifikasi sebagai eksipien |
| CN98809173A CN1124130C (zh) | 1997-09-19 | 1998-09-18 | 含氯甲双磷酸盐活性成分和硅化微晶纤维素赋形剂的药物制剂 |
| CA002301185A CA2301185C (en) | 1997-09-19 | 1998-09-18 | Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient |
| DE29824938U DE29824938U1 (de) | 1997-09-19 | 1998-09-18 | Pharmazeutische Zubereitung, die Clodronat als Wirkstoff und silifizierte mikrokristalline Cellulose als Exzipienten umfasst |
| PL339290A PL191166B1 (pl) | 1997-09-19 | 1998-09-18 | Preparat farmaceutyczny zawierający klodronian, sposób jego wytwarzania i zastosowanie krzemionkowanej celulozy mikrokrystalicznej |
| UA2000042105A UA73078C2 (uk) | 1997-09-19 | 1998-09-18 | Фармацевтичний препарат у вигляді таблеток на основі солі дихлорметилендифосфорної кислоти та силікатованої мікрокристалічної целюлози та спосіб його одержання |
| ES98945336T ES2212341T3 (es) | 1997-09-19 | 1998-09-18 | Preparacion farmaceutica que comprende clodronato como ingrediente activo y celulosa microcristalina modificada con silice como excipiente. |
| IL13513098A IL135130A (en) | 1997-09-19 | 1998-09-18 | A pharmaceutical preparation containing claudronate as an active ingredient and microcrystalline cellulose that has undergone silification as an excipient |
| KR1020007002955A KR20010024184A (ko) | 1997-09-19 | 1998-09-18 | 활성 성분으로 클로드로네이트, 부형제로 실리시파이드미세결정성 셀룰로즈를 함유하는 의약 제제 |
| DK98945336T DK1027037T3 (da) | 1997-09-19 | 1998-09-18 | Farmaceutisk præparat som indeholder clodronat som aktiv ingrediens og forkislet mikrokrystallinsk cellulose som excipiens |
| EA200000317A EA002331B1 (ru) | 1997-09-19 | 1998-09-18 | Фармацевтический препарат, содержащий клодронат в качестве активного ингредиента и агрегат микрокристаллической целлюлозы и диоксида кремния в качестве наполнителя |
| HR20000142A HRP20000142B1 (en) | 1997-09-19 | 2000-03-13 | Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient |
| IS5404A IS5404A (is) | 1997-09-19 | 2000-03-14 | Lyfjablanda sem inniheldur klódrónat sem virkt innihaldsefni og síliseraðan örkristallaðan sellulósa sem burðarefni |
| NO20001417A NO327728B1 (no) | 1997-09-19 | 2000-03-17 | Farmasoytisk preparat omfattende klodronat som aktiv bestanddel samt silisifiert mikrokrystallinsk cellulose som eksipient |
| BG104265A BG64886B1 (bg) | 1997-09-19 | 2000-03-22 | Фармацевтичен препарат, съдържащ клодронат като активен компонент и силикатизирана микрокристална целулоза като пълнител |
| HK01100766A HK1031325A1 (en) | 1997-09-19 | 2001-02-02 | Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI973733A FI109088B (sv) | 1997-09-19 | 1997-09-19 | Tablett och förfarande för dess framställning |
| FI973733 | 1997-09-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI973733A0 FI973733A0 (fi) | 1997-09-19 |
| FI973733A FI973733A (sv) | 1999-03-20 |
| FI109088B true FI109088B (sv) | 2002-05-31 |
Family
ID=8549561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI973733A FI109088B (sv) | 1997-09-19 | 1997-09-19 | Tablett och förfarande för dess framställning |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP1027037B1 (sv) |
| JP (1) | JP3589977B2 (sv) |
| KR (1) | KR20010024184A (sv) |
| CN (1) | CN1124130C (sv) |
| AT (1) | ATE255410T1 (sv) |
| AU (1) | AU737738B2 (sv) |
| BG (1) | BG64886B1 (sv) |
| BR (1) | BR9812480A (sv) |
| CA (1) | CA2301185C (sv) |
| CZ (1) | CZ298675B6 (sv) |
| DE (3) | DE1027037T1 (sv) |
| DK (1) | DK1027037T3 (sv) |
| EA (1) | EA002331B1 (sv) |
| EE (1) | EE04218B1 (sv) |
| ES (1) | ES2212341T3 (sv) |
| FI (1) | FI109088B (sv) |
| HK (1) | HK1031325A1 (sv) |
| HR (1) | HRP20000142B1 (sv) |
| HU (1) | HU226118B1 (sv) |
| ID (1) | ID24423A (sv) |
| IL (1) | IL135130A (sv) |
| IS (1) | IS5404A (sv) |
| NO (1) | NO327728B1 (sv) |
| NZ (1) | NZ503766A (sv) |
| PL (1) | PL191166B1 (sv) |
| PT (1) | PT1027037E (sv) |
| SI (1) | SI1027037T1 (sv) |
| SK (1) | SK284088B6 (sv) |
| TR (1) | TR200000722T2 (sv) |
| UA (1) | UA73078C2 (sv) |
| WO (1) | WO1999015155A1 (sv) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395303B1 (en) | 1996-06-10 | 2002-05-28 | Edward Mendell Co., Inc. | Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose |
| SE9901272D0 (sv) * | 1999-04-09 | 1999-04-09 | Astra Ab | New improved formulation |
| SE9903345D0 (sv) | 1999-09-17 | 1999-09-17 | Astra Pharma Prod | Novel process |
| DE10006125C2 (de) * | 2000-02-11 | 2003-08-28 | Kallies Feinchemie Ag | Modifizierte Mikrocellulose |
| US6399101B1 (en) | 2000-03-30 | 2002-06-04 | Mova Pharmaceutical Corp. | Stable thyroid hormone preparations and method of making same |
| RU2288722C2 (ru) * | 2000-06-20 | 2006-12-10 | Новартис Аг | Способ введения бисфосфонатов |
| JP4722375B2 (ja) * | 2000-06-20 | 2011-07-13 | ノバルティス アーゲー | ビホスホネートの投与法 |
| US6753017B2 (en) | 2001-11-07 | 2004-06-22 | Jrs Pharma Lp | Process for preparing dry extracts |
| AU2002219964A1 (en) * | 2001-11-29 | 2003-06-17 | Penwest Pharmaceutical Company | Agglomerated particles including an active agent coprocessed with silicified microcrystalline cellulose |
| GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
| US20040109889A1 (en) | 2002-12-04 | 2004-06-10 | Bunick Frank J. | Surface treatment composition for soft substrates |
| US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| ES2400006T3 (es) * | 2008-04-23 | 2013-04-04 | Farmasierra Manufacturing, S.L. | Formulación farmacéutica mejorada a base de ibuprofeno y codeína |
| US8603527B2 (en) * | 2010-10-25 | 2013-12-10 | Signal Pharmaceuticals, Llc | Pharmaceutical formulations of a substituted diaminopurine |
| PE20150092A1 (es) * | 2012-02-07 | 2015-02-06 | Biogen Idec Inc | Composiciones farmaceuticas que contienen fumarato de dimetilo |
| US11654152B2 (en) | 2012-05-14 | 2023-05-23 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating disease |
| US9999629B2 (en) | 2012-05-14 | 2018-06-19 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9820999B2 (en) | 2012-05-14 | 2017-11-21 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US8865757B1 (en) | 2014-05-28 | 2014-10-21 | Antecip Bioventures Ii Llp | Therapeutic compositions comprising imidazole and imidazolium compounds |
| US9289441B2 (en) | 2014-08-08 | 2016-03-22 | Antecip Bioventures Ii Llc | Osteoclast inhibitors such as zoledronic acid for low back pain treatment |
| US10004756B2 (en) | 2014-05-15 | 2018-06-26 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9662343B2 (en) | 2012-05-14 | 2017-05-30 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10413560B2 (en) | 2012-05-14 | 2019-09-17 | Antecip Bioventures Ii Llc | Dosage forms for oral administration of zoledronic acid or related compounds for treating disease |
| US10463682B2 (en) | 2012-05-14 | 2019-11-05 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating low back pain |
| US9707247B2 (en) | 2012-05-14 | 2017-07-18 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| US10413561B2 (en) | 2012-05-14 | 2019-09-17 | Antecip Bioventures Ii Llc | Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases |
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| US10028969B2 (en) | 2012-05-14 | 2018-07-24 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
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| US20150051175A1 (en) * | 2012-05-14 | 2015-02-19 | Antecip Bioventures Ii Llc | Co-Administration of Steroids and Zoledronic Acid to Prevent and Treat Pain |
| US9925203B2 (en) | 2012-05-14 | 2018-03-27 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| US9655908B2 (en) | 2012-05-14 | 2017-05-23 | Antecip Bioventures Ii Llc | Neridronic acid molecular complex for treating complex regional pain syndrome |
| US9795622B2 (en) | 2012-05-14 | 2017-10-24 | Antecip Bioventures Ii Llc | Neridronic acid for treating pain associated with a joint |
| US9675626B2 (en) | 2012-05-14 | 2017-06-13 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9956237B2 (en) | 2012-05-14 | 2018-05-01 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for knee conditions |
| US9901589B2 (en) | 2012-05-14 | 2018-02-27 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9943531B2 (en) | 2014-08-08 | 2018-04-17 | Antecip Bioventures Ii Llc | Osteoclast inhibitors such as zoledronic acid for low back pain treatment |
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| US9211257B2 (en) | 2012-05-14 | 2015-12-15 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for knee conditions |
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| US9669040B2 (en) | 2012-05-14 | 2017-06-06 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9782421B1 (en) | 2012-05-14 | 2017-10-10 | Antecip Bioventures Ii Llc | Neridronic acid molecular complex for treating complex regional pain syndrome |
| US10350227B2 (en) | 2012-05-14 | 2019-07-16 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US9867840B2 (en) | 2014-05-27 | 2018-01-16 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9789128B2 (en) | 2012-05-14 | 2017-10-17 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10173986B2 (en) | 2012-05-14 | 2019-01-08 | Antecip Bioventures Ii Llc | Methods for the safe administration of imidazole or imidazolium compounds |
| US9895383B2 (en) | 2012-05-14 | 2018-02-20 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10028908B2 (en) | 2012-05-14 | 2018-07-24 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9770457B2 (en) | 2012-05-14 | 2017-09-26 | Antecip Bioventures Ii Llc | Neridronic acid for treating bone marrow lesion |
| US8802658B2 (en) | 2012-05-14 | 2014-08-12 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating disease |
| US9717747B2 (en) | 2012-05-14 | 2017-08-01 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for knee conditions |
| US9956238B2 (en) | 2014-05-15 | 2018-05-01 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| US10493085B2 (en) | 2012-05-14 | 2019-12-03 | Antecip Bioventures Ii Llc | Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases |
| US9877977B2 (en) | 2012-05-14 | 2018-01-30 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
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| EP3691687A1 (en) | 2017-10-04 | 2020-08-12 | Celgene Corporation | Compositions and methods of use of cis-4-[2-{[(3s,4r)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9h-purin-9-yl]-1-methylcyclohexane-1-carboxamide |
| JP2020536100A (ja) | 2017-10-04 | 2020-12-10 | セルジーン コーポレイション | シス−４−［２−｛［（３ｓ，４ｒ）−３−フルオロキサン−４−イル］アミノ｝−８−（２，４，６−トリクロロアニリノ）−９ｈ−プリン−９−イル］−１−メチルシクロヘキサン−１−カルボキサミドの製造プロセス |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0275468B1 (de) * | 1986-12-20 | 1991-02-06 | Roche Diagnostics GmbH | Clodronat-haltige Arzneimittel und Verfahren zur Herstellung derselben |
| NZ254765A (en) * | 1993-05-15 | 1997-02-24 | Boehringer Mannheim Gmbh | Tablet medicament; comprises dichloromethylene diphosphonic acid (clodronic acid) or a pharmaceutically acceptable salt thereof as active ingredient and microcrystalline cellulose as auxiliary |
| FI94926C (sv) * | 1993-11-12 | 1995-11-27 | Leiras Oy | Förfarande för framställning av ett klodronatpreparat |
| US5585115A (en) * | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
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