FI109088B - Tablett och förfarande för dess framställning - Google Patents

Tablett och förfarande för dess framställning Download PDF

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Publication number
FI109088B
FI109088B FI973733A FI973733A FI109088B FI 109088 B FI109088 B FI 109088B FI 973733 A FI973733 A FI 973733A FI 973733 A FI973733 A FI 973733A FI 109088 B FI109088 B FI 109088B
Authority
FI
Finland
Prior art keywords
weight
silica
microcrystalline cellulose
microcrystalline
dichloromethylene
Prior art date
Application number
FI973733A
Other languages
English (en)
Finnish (fi)
Other versions
FI973733A0 (fi
FI973733A (sv
Inventor
Pertti Tapani Rantala
Veli-Matti Lehtola
Eeva-Maria Susanne Rantala
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of FI973733A0 publication Critical patent/FI973733A0/fi
Priority to FI973733A priority Critical patent/FI109088B/sv
Priority to DE29824938U priority patent/DE29824938U1/de
Priority to SI9830599T priority patent/SI1027037T1/xx
Priority to EP98945336A priority patent/EP1027037B1/en
Priority to DK98945336T priority patent/DK1027037T3/da
Priority to EEP200000096A priority patent/EE04218B1/xx
Priority to CZ20000787A priority patent/CZ298675B6/cs
Priority to PL339290A priority patent/PL191166B1/pl
Priority to DE1027037T priority patent/DE1027037T1/de
Priority to HU0004383A priority patent/HU226118B1/hu
Priority to NZ503766A priority patent/NZ503766A/en
Priority to CA002301185A priority patent/CA2301185C/en
Priority to SK393-2000A priority patent/SK284088B6/sk
Priority to PCT/FI1998/000735 priority patent/WO1999015155A1/en
Priority to DE69820287T priority patent/DE69820287T2/de
Priority to KR1020007002955A priority patent/KR20010024184A/ko
Priority to EA200000317A priority patent/EA002331B1/ru
Priority to BR9812480-3A priority patent/BR9812480A/pt
Priority to JP2000512526A priority patent/JP3589977B2/ja
Priority to ES98945336T priority patent/ES2212341T3/es
Priority to IDW20000735A priority patent/ID24423A/id
Priority to CN98809173A priority patent/CN1124130C/zh
Priority to UA2000042105A priority patent/UA73078C2/uk
Priority to AU92685/98A priority patent/AU737738B2/en
Priority to TR2000/00722T priority patent/TR200000722T2/xx
Priority to AT98945336T priority patent/ATE255410T1/de
Priority to IL13513098A priority patent/IL135130A/en
Priority to PT98945336T priority patent/PT1027037E/pt
Publication of FI973733A publication Critical patent/FI973733A/sv
Priority to HR20000142A priority patent/HRP20000142B1/xx
Priority to IS5404A priority patent/IS5404A/is
Priority to NO20001417A priority patent/NO327728B1/no
Priority to BG104265A priority patent/BG64886B1/bg
Priority to HK01100766A priority patent/HK1031325A1/xx
Application granted granted Critical
Publication of FI109088B publication Critical patent/FI109088B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI973733A 1997-09-19 1997-09-19 Tablett och förfarande för dess framställning FI109088B (sv)

Priority Applications (33)

Application Number Priority Date Filing Date Title
FI973733A FI109088B (sv) 1997-09-19 1997-09-19 Tablett och förfarande för dess framställning
EA200000317A EA002331B1 (ru) 1997-09-19 1998-09-18 Фармацевтический препарат, содержащий клодронат в качестве активного ингредиента и агрегат микрокристаллической целлюлозы и диоксида кремния в качестве наполнителя
JP2000512526A JP3589977B2 (ja) 1997-09-19 1998-09-18 活性成分としてクロドロン酸塩および賦形剤としてケイ化微晶質セルロースを含む医薬製剤
EP98945336A EP1027037B1 (en) 1997-09-19 1998-09-18 Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient
SI9830599T SI1027037T1 (en) 1997-09-19 1998-09-18 Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient
EEP200000096A EE04218B1 (et) 1997-09-19 1998-09-18 Toimeainena klodronaati ja ekstsipiendina ränistatud mikrokristallilist tselluloosi sisaldav farmatseutiline preparaat ning farmatseutilise preparaadi tootmismeetod
ES98945336T ES2212341T3 (es) 1997-09-19 1998-09-18 Preparacion farmaceutica que comprende clodronato como ingrediente activo y celulosa microcristalina modificada con silice como excipiente.
PL339290A PL191166B1 (pl) 1997-09-19 1998-09-18 Preparat farmaceutyczny zawierający klodronian, sposób jego wytwarzania i zastosowanie krzemionkowanej celulozy mikrokrystalicznej
DE1027037T DE1027037T1 (de) 1997-09-19 1998-09-18 Arzneimittel, das clodronat als wirkstoff und mit siliciumdioxid behandelte mikrokristalline cellulose als füllsstoff enhält
HU0004383A HU226118B1 (en) 1997-09-19 1998-09-18 Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient
NZ503766A NZ503766A (en) 1997-09-19 1998-09-18 Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient
CA002301185A CA2301185C (en) 1997-09-19 1998-09-18 Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient
SK393-2000A SK284088B6 (sk) 1997-09-19 1998-09-18 Farmaceutický prostriedok obsahujúci klodronát ako aktívne činidlo, spôsob výroby prostriedku a použitie mikrokryštalickej celulózy na jeho výrobu
PCT/FI1998/000735 WO1999015155A1 (en) 1997-09-19 1998-09-18 Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient
DE69820287T DE69820287T2 (de) 1997-09-19 1998-09-18 Pharmazeutische Zubereitung, die Chlodronat als Wirkstoff und silicifizierte mikrokristalline Cellulose als Exipienten umfasst
KR1020007002955A KR20010024184A (ko) 1997-09-19 1998-09-18 활성 성분으로 클로드로네이트, 부형제로 실리시파이드미세결정성 셀룰로즈를 함유하는 의약 제제
DE29824938U DE29824938U1 (de) 1997-09-19 1998-09-18 Pharmazeutische Zubereitung, die Clodronat als Wirkstoff und silifizierte mikrokristalline Cellulose als Exzipienten umfasst
BR9812480-3A BR9812480A (pt) 1997-09-19 1998-09-18 "preparação farmacêutica compreendendo clodronato como ingrediente ativo e celulose microcristalina como excipiente, processo de fabricação e uso de celulose microcristalina siliciada na fabricação de dita preparação farmacêutica"
DK98945336T DK1027037T3 (da) 1997-09-19 1998-09-18 Farmaceutisk præparat som indeholder clodronat som aktiv ingrediens og forkislet mikrokrystallinsk cellulose som excipiens
CZ20000787A CZ298675B6 (cs) 1997-09-19 1998-09-18 Farmaceutický prostredek obsahující klodronát a mikrokrystalickou celulózu s oxidem kremicitým
IDW20000735A ID24423A (id) 1997-09-19 1998-09-18 Sediaan farmasi yang terdiri dari klodronat sebagai bahan aktif dan selulosa mikrokristalin tersilisifikasi sebagai eksipien
CN98809173A CN1124130C (zh) 1997-09-19 1998-09-18 含氯甲双磷酸盐活性成分和硅化微晶纤维素赋形剂的药物制剂
UA2000042105A UA73078C2 (uk) 1997-09-19 1998-09-18 Фармацевтичний препарат у вигляді таблеток на основі солі дихлорметилендифосфорної кислоти та силікатованої мікрокристалічної целюлози та спосіб його одержання
AU92685/98A AU737738B2 (en) 1997-09-19 1998-09-18 Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient
TR2000/00722T TR200000722T2 (tr) 1997-09-19 1998-09-18 Silikatlı küçük kristalli selüloz içeren farmakolojik ilaç.
AT98945336T ATE255410T1 (de) 1997-09-19 1998-09-18 Arzneimittel, das clodronat als wirkstoff und mit siliciumdioxid behandelte mikrokristalline cellulose als füllstoff enthält
IL13513098A IL135130A (en) 1997-09-19 1998-09-18 A pharmaceutical preparation containing claudronate as an active ingredient and microcrystalline cellulose that has undergone silification as an excipient
PT98945336T PT1027037E (pt) 1997-09-19 1998-09-18 Composicao farmaceutica que compreende clodronato como ingredientes activo e celulose microcristalina silicificada como excipiente
HR20000142A HRP20000142B1 (en) 1997-09-19 2000-03-13 Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient
IS5404A IS5404A (is) 1997-09-19 2000-03-14 Lyfjablanda sem inniheldur klódrónat sem virkt innihaldsefni og síliseraðan örkristallaðan sellulósa sem burðarefni
NO20001417A NO327728B1 (no) 1997-09-19 2000-03-17 Farmasoytisk preparat omfattende klodronat som aktiv bestanddel samt silisifiert mikrokrystallinsk cellulose som eksipient
BG104265A BG64886B1 (bg) 1997-09-19 2000-03-22 Фармацевтичен препарат, съдържащ клодронат като активен компонент и силикатизирана микрокристална целулоза като пълнител
HK01100766A HK1031325A1 (en) 1997-09-19 2001-02-02 Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI973733 1997-09-19
FI973733A FI109088B (sv) 1997-09-19 1997-09-19 Tablett och förfarande för dess framställning

Publications (3)

Publication Number Publication Date
FI973733A0 FI973733A0 (fi) 1997-09-19
FI973733A FI973733A (sv) 1999-03-20
FI109088B true FI109088B (sv) 2002-05-31

Family

ID=8549561

Family Applications (1)

Application Number Title Priority Date Filing Date
FI973733A FI109088B (sv) 1997-09-19 1997-09-19 Tablett och förfarande för dess framställning

Country Status (31)

Country Link
EP (1) EP1027037B1 (sv)
JP (1) JP3589977B2 (sv)
KR (1) KR20010024184A (sv)
CN (1) CN1124130C (sv)
AT (1) ATE255410T1 (sv)
AU (1) AU737738B2 (sv)
BG (1) BG64886B1 (sv)
BR (1) BR9812480A (sv)
CA (1) CA2301185C (sv)
CZ (1) CZ298675B6 (sv)
DE (3) DE1027037T1 (sv)
DK (1) DK1027037T3 (sv)
EA (1) EA002331B1 (sv)
EE (1) EE04218B1 (sv)
ES (1) ES2212341T3 (sv)
FI (1) FI109088B (sv)
HK (1) HK1031325A1 (sv)
HR (1) HRP20000142B1 (sv)
HU (1) HU226118B1 (sv)
ID (1) ID24423A (sv)
IL (1) IL135130A (sv)
IS (1) IS5404A (sv)
NO (1) NO327728B1 (sv)
NZ (1) NZ503766A (sv)
PL (1) PL191166B1 (sv)
PT (1) PT1027037E (sv)
SI (1) SI1027037T1 (sv)
SK (1) SK284088B6 (sv)
TR (1) TR200000722T2 (sv)
UA (1) UA73078C2 (sv)
WO (1) WO1999015155A1 (sv)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
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SE9901272D0 (sv) * 1999-04-09 1999-04-09 Astra Ab New improved formulation
SE9903345D0 (sv) 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
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US6399101B1 (en) 2000-03-30 2002-06-04 Mova Pharmaceutical Corp. Stable thyroid hormone preparations and method of making same
US8052987B2 (en) * 2000-06-20 2011-11-08 Novartis Pharmaceuticals Corporation Method of administering bisphosphonates
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US6753017B2 (en) 2001-11-07 2004-06-22 Jrs Pharma Lp Process for preparing dry extracts
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US20040109889A1 (en) 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
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