DE69820287D1 - Arzneimittel, das clodronat als wirkstoff und mit siliciumdioxid behandelte mikrokristalline cellulose als füllstoff enthält - Google Patents

Arzneimittel, das clodronat als wirkstoff und mit siliciumdioxid behandelte mikrokristalline cellulose als füllstoff enthält

Info

Publication number
DE69820287D1
DE69820287D1 DE69820287T DE69820287T DE69820287D1 DE 69820287 D1 DE69820287 D1 DE 69820287D1 DE 69820287 T DE69820287 T DE 69820287T DE 69820287 T DE69820287 T DE 69820287T DE 69820287 D1 DE69820287 D1 DE 69820287D1
Authority
DE
Germany
Prior art keywords
filler
silicon dioxide
active substance
product containing
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69820287T
Other languages
English (en)
Other versions
DE69820287T2 (de
Inventor
Veli-Matti Lehtola
Susanne Rantala
Tapani Rantala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Oy
Original Assignee
Schering Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Oy filed Critical Schering Oy
Publication of DE69820287D1 publication Critical patent/DE69820287D1/de
Application granted granted Critical
Publication of DE69820287T2 publication Critical patent/DE69820287T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69820287T 1997-09-19 1998-09-18 Pharmazeutische Zubereitung, die Chlodronat als Wirkstoff und silicifizierte mikrokristalline Cellulose als Exipienten umfasst Expired - Lifetime DE69820287T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI973733 1997-09-19
FI973733A FI109088B (fi) 1997-09-19 1997-09-19 Tabletti ja menetelmä sen valmistamiseksi
PCT/FI1998/000735 WO1999015155A1 (en) 1997-09-19 1998-09-18 Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient

Publications (2)

Publication Number Publication Date
DE69820287D1 true DE69820287D1 (de) 2004-01-15
DE69820287T2 DE69820287T2 (de) 2004-10-14

Family

ID=8549561

Family Applications (3)

Application Number Title Priority Date Filing Date
DE1027037T Pending DE1027037T1 (de) 1997-09-19 1998-09-18 Arzneimittel, das clodronat als wirkstoff und mit siliciumdioxid behandelte mikrokristalline cellulose als füllsstoff enhält
DE69820287T Expired - Lifetime DE69820287T2 (de) 1997-09-19 1998-09-18 Pharmazeutische Zubereitung, die Chlodronat als Wirkstoff und silicifizierte mikrokristalline Cellulose als Exipienten umfasst
DE29824938U Expired - Lifetime DE29824938U1 (de) 1997-09-19 1998-09-18 Pharmazeutische Zubereitung, die Clodronat als Wirkstoff und silifizierte mikrokristalline Cellulose als Exzipienten umfasst

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE1027037T Pending DE1027037T1 (de) 1997-09-19 1998-09-18 Arzneimittel, das clodronat als wirkstoff und mit siliciumdioxid behandelte mikrokristalline cellulose als füllsstoff enhält

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE29824938U Expired - Lifetime DE29824938U1 (de) 1997-09-19 1998-09-18 Pharmazeutische Zubereitung, die Clodronat als Wirkstoff und silifizierte mikrokristalline Cellulose als Exzipienten umfasst

Country Status (31)

Country Link
EP (1) EP1027037B1 (de)
JP (1) JP3589977B2 (de)
KR (1) KR20010024184A (de)
CN (1) CN1124130C (de)
AT (1) ATE255410T1 (de)
AU (1) AU737738B2 (de)
BG (1) BG64886B1 (de)
BR (1) BR9812480A (de)
CA (1) CA2301185C (de)
CZ (1) CZ298675B6 (de)
DE (3) DE1027037T1 (de)
DK (1) DK1027037T3 (de)
EA (1) EA002331B1 (de)
EE (1) EE04218B1 (de)
ES (1) ES2212341T3 (de)
FI (1) FI109088B (de)
HK (1) HK1031325A1 (de)
HR (1) HRP20000142B1 (de)
HU (1) HU226118B1 (de)
ID (1) ID24423A (de)
IL (1) IL135130A (de)
IS (1) IS5404A (de)
NO (1) NO327728B1 (de)
NZ (1) NZ503766A (de)
PL (1) PL191166B1 (de)
PT (1) PT1027037E (de)
SI (1) SI1027037T1 (de)
SK (1) SK284088B6 (de)
TR (1) TR200000722T2 (de)
UA (1) UA73078C2 (de)
WO (1) WO1999015155A1 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395303B1 (en) 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
SE9901272D0 (sv) * 1999-04-09 1999-04-09 Astra Ab New improved formulation
SE9903345D0 (sv) 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
DE10006125C2 (de) * 2000-02-11 2003-08-28 Kallies Feinchemie Ag Modifizierte Mikrocellulose
US6399101B1 (en) 2000-03-30 2002-06-04 Mova Pharmaceutical Corp. Stable thyroid hormone preparations and method of making same
US8052987B2 (en) * 2000-06-20 2011-11-08 Novartis Pharmaceuticals Corporation Method of administering bisphosphonates
EP1591122B1 (de) * 2000-06-20 2012-09-26 Novartis AG Methode zur Verabreichung von Biphosphonaten
US6753017B2 (en) 2001-11-07 2004-06-22 Jrs Pharma Lp Process for preparing dry extracts
EP1509204A4 (de) * 2001-11-29 2005-07-13 Rettenmaier & Soehne Gmbh & Co Agglomerierte teilchen mit einem wirkstoff, der zusammen mit verkieselter mikrokristalliner cellulose aufbereitet wird
GB0209265D0 (en) 2002-04-23 2002-06-05 Novartis Ag Organic compounds
US20040109889A1 (en) 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
DK2279731T3 (da) * 2008-04-23 2013-03-18 Farmasierra Mfg S L Forbedret farmaceutisk sammensætning, som indeholder ibuprofen og codein
US8603527B2 (en) * 2010-10-25 2013-12-10 Signal Pharmaceuticals, Llc Pharmaceutical formulations of a substituted diaminopurine
EP2811994A4 (de) * 2012-02-07 2016-01-13 Biogen Ma Inc Pharmazeutische zusammensetzungen mit dimethylfumarat
US9943531B2 (en) 2014-08-08 2018-04-17 Antecip Bioventures Ii Llc Osteoclast inhibitors such as zoledronic acid for low back pain treatment
US9782421B1 (en) 2012-05-14 2017-10-10 Antecip Bioventures Ii Llc Neridronic acid molecular complex for treating complex regional pain syndrome
US9700570B2 (en) 2014-05-27 2017-07-11 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US9827192B2 (en) 2012-05-14 2017-11-28 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US9616078B2 (en) 2012-05-14 2017-04-11 Antecip Bioventures Ii Llc Dosage forms for oral administration of zoledronic acid or related compounds for treating disease
US9211257B2 (en) 2012-05-14 2015-12-15 Antecip Bioventures Ii Llc Osteoclast inhibitors for knee conditions
US10004756B2 (en) 2014-05-15 2018-06-26 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US9861648B2 (en) 2012-05-14 2018-01-09 Antecip Boiventures Ii Llc Osteoclast inhibitors for knee conditions
US9999629B2 (en) 2012-05-14 2018-06-19 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US10111837B2 (en) 2012-05-14 2018-10-30 Antecip Bioventures Ii Llc Dosage forms for oral administration of zoledronic acid or related compounds
US9669040B2 (en) 2012-05-14 2017-06-06 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US9707247B2 (en) 2012-05-14 2017-07-18 Antecip Bioventures Ii Llc Compositions for administration of zoledronic acid or related compounds for treating low back pain
US10350227B2 (en) 2012-05-14 2019-07-16 Antecip Bioventures Ii Llc Neridronic acid for treating complex regional pain syndrome
US9827256B2 (en) 2014-05-27 2017-11-28 Antecip Bioventures Ii Llc Compositions for administration of zoledronic acid or related compounds for treating lower back pain
US9707245B2 (en) 2012-05-14 2017-07-18 Antecip Bioventures Ii Llc Neridronic acid for treating complex regional pain syndrome
US9820999B2 (en) 2012-05-14 2017-11-21 Antecip Bioventures Ii Llc Neridronic acid for treating complex regional pain syndrome
US9662343B2 (en) 2012-05-14 2017-05-30 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US9694023B2 (en) 2012-05-14 2017-07-04 Antecip Bioventures Ii Llc Methods for the safe administration of imidazole or imidazolium compounds
US10463682B2 (en) 2012-05-14 2019-11-05 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating low back pain
US9844559B2 (en) 2012-05-14 2017-12-19 Antecip Bioventures Ii Llc Neridronic acid for treating bone marrow lesions
US10092581B2 (en) 2014-05-15 2018-10-09 Antecip Bioventures Ii Llc Osteoclast inhibitors such as zoledronic acid for low back pain treatment
US9289441B2 (en) 2014-08-08 2016-03-22 Antecip Bioventures Ii Llc Osteoclast inhibitors such as zoledronic acid for low back pain treatment
US10080765B2 (en) 2012-05-14 2018-09-25 Antecip Bioventures Ii Llc Neridronic acid for treating complex regional pain syndrome
US10413560B2 (en) 2012-05-14 2019-09-17 Antecip Bioventures Ii Llc Dosage forms for oral administration of zoledronic acid or related compounds for treating disease
US9655908B2 (en) 2012-05-14 2017-05-23 Antecip Bioventures Ii Llc Neridronic acid molecular complex for treating complex regional pain syndrome
US9901589B2 (en) 2012-05-14 2018-02-27 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US10016446B2 (en) 2012-05-14 2018-07-10 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating Paget's disease of bone
US10039773B2 (en) 2012-05-14 2018-08-07 Antecip Bioventures Ii Llc Neridronic acid for treating arthritis
US9795622B2 (en) 2012-05-14 2017-10-24 Antecip Bioventures Ii Llc Neridronic acid for treating pain associated with a joint
US9956238B2 (en) 2014-05-15 2018-05-01 Antecip Bioventures Ii Llc Compositions for administration of zoledronic acid or related compounds for treating low back pain
US9789128B2 (en) 2012-05-14 2017-10-17 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US9877977B2 (en) 2012-05-14 2018-01-30 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US10034890B2 (en) 2012-05-14 2018-07-31 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US10016445B2 (en) 2012-05-14 2018-07-10 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US10173986B2 (en) 2012-05-14 2019-01-08 Antecip Bioventures Ii Llc Methods for the safe administration of imidazole or imidazolium compounds
US10028969B2 (en) 2012-05-14 2018-07-24 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US9895383B2 (en) 2012-05-14 2018-02-20 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US20150051175A1 (en) * 2012-05-14 2015-02-19 Antecip Bioventures Ii Llc Co-Administration of Steroids and Zoledronic Acid to Prevent and Treat Pain
US10028908B2 (en) 2012-05-14 2018-07-24 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US8865757B1 (en) 2014-05-28 2014-10-21 Antecip Bioventures Ii Llp Therapeutic compositions comprising imidazole and imidazolium compounds
US9925203B2 (en) 2012-05-14 2018-03-27 Antecip Bioventures Ii Llc Compositions for administration of zoledronic acid or related compounds for treating low back pain
US10493085B2 (en) 2012-05-14 2019-12-03 Antecip Bioventures Ii Llc Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases
US11654152B2 (en) 2012-05-14 2023-05-23 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating disease
US8802658B2 (en) 2012-05-14 2014-08-12 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating disease
US9867839B2 (en) 2012-05-14 2018-01-16 Antecip Bioventures Ii Llc Osteoclast inhibitors for joint conditions
US9770457B2 (en) 2012-05-14 2017-09-26 Antecip Bioventures Ii Llc Neridronic acid for treating bone marrow lesion
US9867840B2 (en) 2014-05-27 2018-01-16 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US9956234B2 (en) 2012-05-14 2018-05-01 Antecip Bioventures Ii Llc Osteoclast inhibitors for joint conditions
US9717747B2 (en) 2012-05-14 2017-08-01 Antecip Bioventures Ii Llc Osteoclast inhibitors for knee conditions
US9675626B2 (en) 2012-05-14 2017-06-13 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US9999628B2 (en) 2012-05-14 2018-06-19 Antecip Bioventures Ii Llc Neridronic acid for treating complex regional pain syndrome
US10413561B2 (en) 2012-05-14 2019-09-17 Antecip Bioventures Ii Llc Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases
US9956237B2 (en) 2012-05-14 2018-05-01 Antecip Bioventures Ii Llc Osteoclast inhibitors for knee conditions
US9949993B2 (en) 2012-05-14 2018-04-24 Antecip Bioventures Ii Llc Compositions for administration of zoledronic acid or related compounds for treating low back pain
CN102671206B (zh) * 2012-05-29 2013-07-10 安吉东来药用辅料有限责任公司 低聚果糖片剂赋形剂、药物片剂及药物片剂的制备方法
CN102698281B (zh) * 2012-05-29 2013-07-03 安吉东来药用辅料有限责任公司 海带多糖片剂赋形剂、药物片剂及药物片剂的制备方法
CN102671203B (zh) * 2012-05-29 2013-07-10 安吉东来药用辅料有限责任公司 裙带菜多糖片剂赋形剂、药物片剂及药物片剂的制备方法
CN102671205B (zh) * 2012-05-29 2013-07-10 安吉东来药用辅料有限责任公司 紫菜多糖片剂赋形剂、药物片剂及药物片剂的制备方法
CN102697744B (zh) * 2012-05-29 2013-11-27 安吉东来药用辅料有限责任公司 阿洛糖片剂赋形剂、药物片剂及药物片剂的制备方法
CN102688206B (zh) * 2012-05-29 2014-08-20 石药集团中奇制药技术（石家庄）有限公司 一种匹伐他汀钙片及其制备方法
CN102671204B (zh) * 2012-05-29 2013-07-10 安吉东来药用辅料有限责任公司 古洛糖片剂赋形剂、药物片剂及药物片剂的制备方法
CN102698280B (zh) * 2012-05-29 2013-07-10 安吉东来药用辅料有限责任公司 塔格糖片剂赋形剂、药物片剂及药物片剂的制备方法
CN102671200B (zh) * 2012-05-29 2013-07-10 安吉东来药用辅料有限责任公司 低聚异麦芽糖片剂赋形剂、药物片剂及制备方法
US9127069B1 (en) 2014-06-11 2015-09-08 Antecip Bioventures LLC Compositions comprising rank/rankl antagonists and related compounds for treating pain
SG10202009598VA (en) 2014-10-06 2020-10-29 Signal Pharm Llc Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
CN104771761A (zh) * 2015-03-19 2015-07-15 深圳国源国药有限公司 一种创新药用辅料硅化微晶纤维素及其制备方法
MX2018011970A (es) 2016-04-01 2019-05-20 Signal Pharm Llc Formas sólidas de (1s,4s)-4-(2-(((3s,4r)-3-fluorotetrahidro-2h-pir an-4-il)amino)-8-((2,4,6-triclorofenilo)amino)-9h-purin-9-il)-1-m etilciclohexano-1-carboxamida y métodos para utilizarlas.
EA039392B1 (ru) 2016-04-01 2022-01-21 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Способ лечения рака с применением замещенного аминопуринового соединения
KR20200061363A (ko) 2017-10-04 2020-06-02 셀진 코포레이션 시스-4-[2-｛[(3ｓ,4ｒ)-3-플루오로옥산-4-일]아미노｝-8-(2,4,6-트리클로로아닐리노)-9ｈ-퓨린-9-일]-1-메틸사이클로헥산-1-카르복스아미드의 제조 공정
BR122022005778B1 (pt) 2017-10-04 2024-01-09 Celgene Corporation Cápsula compreendendo cis-4-[2-{[(3s,4r)-3-fluoro-oxan-4-il]amino}-8-(2,4,6-tricloroanilino)-9h-purin-9-il]-1-metilciclohexano-1-carboxamida
CN110787140A (zh) * 2018-08-01 2020-02-14 北京万全德众医药生物技术有限公司 比拉斯汀片剂及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3767998D1 (de) * 1986-12-20 1991-03-14 Boehringer Mannheim Gmbh Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
SK281193B6 (sk) * 1993-05-15 2001-01-18 Roche Diagnostics Gmbh Tableta so zlepšenou biodostupnosťou účinnej látky, kyseliny klodrónovej, spôsob jej výroby a použitie mikrokryštalickej celulózy
FI94926C (fi) * 1993-11-12 1995-11-27 Leiras Oy Menetelmä klodronaattivalmisteen valmistamiseksi
US5585115A (en) * 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability

Also Published As

Publication number Publication date
PT1027037E (pt) 2004-04-30
HRP20000142A2 (en) 2000-06-30
HU226118B1 (en) 2008-04-28
BR9812480A (pt) 2000-09-26
IL135130A (en) 2004-09-27
CA2301185C (en) 2006-11-28
JP3589977B2 (ja) 2004-11-17
EA200000317A1 (ru) 2000-10-30
DK1027037T3 (da) 2004-03-15
CZ2000787A3 (cs) 2000-08-16
SK284088B6 (sk) 2004-09-08
EA002331B1 (ru) 2002-04-25
PL191166B1 (pl) 2006-03-31
HK1031325A1 (en) 2001-06-15
DE1027037T1 (de) 2002-11-28
FI973733A0 (fi) 1997-09-19
EP1027037A1 (de) 2000-08-16
NO20001417L (no) 2000-05-19
ATE255410T1 (de) 2003-12-15
NZ503766A (en) 2002-02-01
DE29824938U1 (de) 2003-07-31
WO1999015155A1 (en) 1999-04-01
SI1027037T1 (en) 2004-04-30
CN1124130C (zh) 2003-10-15
SK3932000A3 (en) 2000-11-07
NO327728B1 (no) 2009-09-14
JP2001517616A (ja) 2001-10-09
ID24423A (id) 2000-07-20
PL339290A1 (en) 2000-12-04
AU737738B2 (en) 2001-08-30
CZ298675B6 (cs) 2007-12-19
IS5404A (is) 2000-03-14
NO20001417D0 (no) 2000-03-17
KR20010024184A (ko) 2001-03-26
UA73078C2 (uk) 2005-06-15
AU9268598A (en) 1999-04-12
EE200000096A (et) 2000-12-15
CN1270516A (zh) 2000-10-18
EP1027037B1 (de) 2003-12-03
HUP0004383A3 (en) 2006-06-28
HUP0004383A2 (hu) 2001-08-28
BG104265A (en) 2000-11-30
CA2301185A1 (en) 1999-04-01
FI973733A (fi) 1999-03-20
IL135130A0 (en) 2001-05-20
HRP20000142B1 (en) 2004-06-30
BG64886B1 (bg) 2006-08-31
ES2212341T3 (es) 2004-07-16
FI109088B (fi) 2002-05-31
EE04218B1 (et) 2004-02-16
DE69820287T2 (de) 2004-10-14
TR200000722T2 (tr) 2000-11-21

Similar Documents

Publication Publication Date Title
DE69820287D1 (de) Arzneimittel, das clodronat als wirkstoff und mit siliciumdioxid behandelte mikrokristalline cellulose als füllstoff enthält
GB8908085D0 (en) New therapeutic use
NO166639C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte, basiske 2-aminotetraliner.
HUP0104795A2 (hu) CCR5 modulátor hatású azabicikloalkán vegyületek, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk
NO159166C (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive benzoazepinderivater.
TNSN03106A1 (fr) Procede pour la production d'une composition pharmaceutique a faible dose ayant une distribution et activite medicamenteuse uniforme
SE9700885D0 (sv) New pharmaceutical formulation
DE59907481D1 (de) Kontrolliert freisetzende pharmazeutische zusammensetzung mit tilidinmesylat als wirkstoff
HU9301672D0 (en) Method for manufacturing solid dosing forms of medicaments with controlled releasing of active agents
NO870049L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
MX9603606A (es) N-metil-n-[(1s)-1-fenil-2-((3s)-3-hidroxipirrolidin-1-il) etil]-2,2-difenil-acetamida.
NO165104C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 1, 1-disubstituerte cyklopropanderivater.
NO891114D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive arakidonsyre-derivater.
AP9901474A0 (en) Pharmaceutical composition for treating viral diseases.
NO20013601L (no) Nye morfolinobenzamidsalter
IL134039A0 (en) Polyhydroxybutylpyrazines, their preparation and medicines containing them
ATE38470T1 (de) Pharmazeutisches produkt zur behandlung der hypertonie und thromboembolischer krankheiten.
NO20014889D0 (no) Fremgangsmåte for fremstilling av medisinske midler
MX9606264A (es) Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol como sustancias farmacologicas activas.
MY102368A (en) Solid sustained-release composition
IT1279386B1 (it) 1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
NO911040L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte imidazol-forbindelser.
NO871195D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk aktiv 1-cyklopropyl-6-fluor-1,4-dihydro-4-okso-7-piperazino-kinolin-3-karboksylsyre.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition