ES8607297A1 - Un procedimiento para la preparacion de nuevos derivados de tiazolidina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de tiazolidina.

Info

Publication number
ES8607297A1
ES8607297A1 ES535552A ES535552A ES8607297A1 ES 8607297 A1 ES8607297 A1 ES 8607297A1 ES 535552 A ES535552 A ES 535552A ES 535552 A ES535552 A ES 535552A ES 8607297 A1 ES8607297 A1 ES 8607297A1
Authority
ES
Spain
Prior art keywords
different
same
group
represents hydrogen
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535552A
Other languages
English (en)
Other versions
ES535552A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES8607297A1 publication Critical patent/ES8607297A1/es
Publication of ES535552A0 publication Critical patent/ES535552A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

SINTESIS DE DERIVADOS DE TIAZOLIDINA MEJORADORES DEL METABOLISMO DE LIPIDOS DE LA SANGRE. COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON TIOUREA, EN RELACION MOLAR 1 A 1 O 2, DURANTE 1 A 20 HORAS, ENTRE 80 Y 150JC, EN UN DISOLVENTE ELEGIDO ENTRE ALCANOLES DE C 1 A 4, T.H.F., DIOXANO, ACETONA Y OTROS, PARA OBTENER UN COMPUESTO DE FORMULA (I); Y B) FORMAR SALES FARMACEUTICAMENTE ACEPTABLES DEL COMPUESTO DE FORMULA (I). SIENDO: R1 Y R2 IGUALES O DIFERENTES, H O ALQUILO DE C 1 A 5; R3, H, GRUPO ACILO ALIFATICO DE C 1 A 5 Y OTROS; R4 Y R5, INDEPENDIENTEMENTE, H, ALCOXI DE C 1 A 5 Y OTROS; O R4 Y R5, JUNTOS, ALQUILANDOXI DE C 1 A 4; A, CIANO, CARBOXI Y OTROS; W, -CH2-, FCO, Y OTROS; Y Y Z INDEPENDIENTEMENTE, UN ATOMO DE OXIGENO O EL GRUPO IMINO; X, HALOGENO; Y N 1, 2 O 3. SE UTILIZAN EN FARMACOLOGIA POR DISMINUIR LOS NIVELES DE PEROXIDOS DE LIPIDOS, TRIGLICERIDOS Y EL COLESTEROL DE LA SANGRE.
ES535552A 1983-08-30 1984-08-30 Un procedimiento para la preparacion de nuevos derivados de tiazolidina. Expired ES8607297A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58158375A JPS6051189A (ja) 1983-08-30 1983-08-30 チアゾリジン誘導体およびその製造法

Publications (2)

Publication Number Publication Date
ES8607297A1 true ES8607297A1 (es) 1986-05-16
ES535552A0 ES535552A0 (es) 1986-05-16

Family

ID=15670325

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535552A Expired ES8607297A1 (es) 1983-08-30 1984-08-30 Un procedimiento para la preparacion de nuevos derivados de tiazolidina.

Country Status (12)

Country Link
US (1) US4572912A (es)
EP (1) EP0139421B1 (es)
JP (1) JPS6051189A (es)
KR (1) KR890000370B1 (es)
AT (1) ATE33838T1 (es)
AU (1) AU570067B2 (es)
CA (1) CA1263395A (es)
DE (1) DE3470742D1 (es)
DK (1) DK164701C (es)
ES (1) ES8607297A1 (es)
FI (1) FI80693C (es)
IE (1) IE58036B1 (es)

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* Cited by examiner, † Cited by third party
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DK415184D0 (da) 1984-08-30
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KR850001739A (ko) 1985-04-01
FI843422A0 (fi) 1984-08-30
JPH0231079B2 (es) 1990-07-11
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EP0139421B1 (en) 1988-04-27
DK415184A (da) 1985-03-01
DK164701C (da) 1992-12-21
ATE33838T1 (de) 1988-05-15
IE58036B1 (en) 1993-06-16
AU3255984A (en) 1985-03-07
ES535552A0 (es) 1986-05-16
US4572912A (en) 1986-02-25

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