ES2671748T3 - Inhibidores heterocíclicos de proteína quinasas - Google Patents
Inhibidores heterocíclicos de proteína quinasas Download PDFInfo
- Publication number
- ES2671748T3 ES2671748T3 ES12815055.4T ES12815055T ES2671748T3 ES 2671748 T3 ES2671748 T3 ES 2671748T3 ES 12815055 T ES12815055 T ES 12815055T ES 2671748 T3 ES2671748 T3 ES 2671748T3
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- Prior art keywords
- cancer
- compound
- pim
- shrna
- days
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- 125000000623 heterocyclic group Chemical group 0.000 title description 5
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title description 4
- 239000003909 protein kinase inhibitor Substances 0.000 title description 4
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161510207P | 2011-07-21 | 2011-07-21 | |
| US201161632834P | 2011-07-21 | 2011-07-21 | |
| US201161510207P | 2011-07-21 | ||
| US201161632834P | 2011-07-21 | ||
| US201261632826P | 2012-03-01 | 2012-03-01 | |
| US201261632826P | 2012-03-01 | ||
| US201261608028P | 2012-03-07 | 2012-03-07 | |
| US201261608028P | 2012-03-07 | ||
| PCT/US2012/047685 WO2013013188A1 (en) | 2011-07-21 | 2012-07-20 | Heterocyclic protein kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2671748T3 true ES2671748T3 (es) | 2018-06-08 |
Family
ID=47558512
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12815055.4T Active ES2671748T3 (es) | 2011-07-21 | 2012-07-20 | Inhibidores heterocíclicos de proteína quinasas |
| ES18162853T Active ES2834093T3 (es) | 2011-07-21 | 2012-07-20 | Inhibidores de proteína quinasa heterocíclicos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18162853T Active ES2834093T3 (es) | 2011-07-21 | 2012-07-20 | Inhibidores de proteína quinasa heterocíclicos |
Country Status (10)
| Country | Link |
|---|---|
| US (7) | US9416132B2 (enExample) |
| EP (3) | EP3409278B8 (enExample) |
| JP (1) | JP6105578B2 (enExample) |
| CY (1) | CY1123626T1 (enExample) |
| DK (2) | DK2734205T3 (enExample) |
| ES (2) | ES2671748T3 (enExample) |
| HU (1) | HUE052198T2 (enExample) |
| PL (1) | PL3409278T3 (enExample) |
| PT (1) | PT3409278T (enExample) |
| WO (1) | WO2013013188A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2734205T3 (en) | 2011-07-21 | 2018-06-14 | Tolero Pharmaceuticals Inc | Heterocyclic Protein Kinase Inhibitors |
| DK2834243T3 (en) * | 2012-03-09 | 2018-07-23 | Lexicon Pharmaceuticals Inc | Pyrazole [1,5-a] pyrimidine-based compounds, compositions comprising them and methods for their use |
| JP6166289B2 (ja) * | 2012-03-14 | 2017-07-19 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 置換イミダゾピリダジン |
| EP2920181B1 (en) | 2012-11-16 | 2019-01-09 | University Health Network | Pyrazolopyrimidine compounds |
| EP2943485B1 (en) | 2013-01-14 | 2017-09-20 | Incyte Holdings Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| TWI662030B (zh) | 2013-01-15 | 2019-06-11 | 英塞特控股公司 | 適用作ｐｉｍ激酶抑制劑之噻唑甲醯胺及吡啶甲醯胺化合物 |
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| US20200102313A1 (en) | 2020-04-02 |
| US20250320217A1 (en) | 2025-10-16 |
| PL3409278T3 (pl) | 2021-02-22 |
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| EP2734205A1 (en) | 2014-05-28 |
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| US20250129085A1 (en) | 2025-04-24 |
| US9416132B2 (en) | 2016-08-16 |
| US10047093B2 (en) | 2018-08-14 |
| EP3409278B1 (en) | 2020-09-16 |
| EP3812387A1 (en) | 2021-04-28 |
| HK1198360A1 (en) | 2015-04-10 |
| WO2013013188A1 (en) | 2013-01-24 |
| ES2834093T3 (es) | 2021-06-16 |
| EP3409278A1 (en) | 2018-12-05 |
| JP2014520898A (ja) | 2014-08-25 |
| DK2734205T3 (en) | 2018-06-14 |
| EP3409278B8 (en) | 2020-11-04 |
| EP2734205B1 (en) | 2018-03-21 |
| DK3409278T3 (da) | 2020-11-09 |
| US20190071446A1 (en) | 2019-03-07 |
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