|
SU6668A1
(ru)
|
1921-07-19 |
1924-09-15 |
А.Д. Несмеянов |
Центробежный распылитель дл жидкости
|
|
SU5416A1
(ru)
|
1926-06-03 |
1928-05-31 |
Тормейер Г. |
Двигатель компаунд внутреннего горени
|
|
US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
|
US3935230A
(en)
|
1972-10-24 |
1976-01-27 |
E. R. Squibb & Sons, Inc. |
α, α, α, α', α', α'-Hexafluorodi-m-tolylamine derivatives
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
DE4134467A1
(de)
|
1991-10-18 |
1993-04-22 |
Thomae Gmbh Dr K |
Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
DE69333807T2
(de)
|
1992-02-06 |
2006-02-02 |
Chiron Corp., Emeryville |
Marker für krebs und biosynthetisches bindeprotein dafür
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5441952A
(en)
|
1993-04-05 |
1995-08-15 |
Merck & Co., Inc. |
Fibrinogen receptor antagonists
|
|
EP0647450A1
(en)
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
EP0819127A1
(en)
|
1995-04-04 |
1998-01-21 |
Glaxo Group Limited |
IMIDAZO [1,2-a]PYRIDINE DERIVATIVES
|
|
DK0821671T3
(da)
|
1995-04-20 |
2001-04-23 |
Pfizer |
Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
|
ES2183905T3
(es)
|
1995-12-20 |
2003-04-01 |
Hoffmann La Roche |
Inhibidores de metaloproteasa de matriz.
|
|
HUP9802580A3
(en)
|
1995-12-22 |
1999-03-29 |
Novo Nordisk As |
Compounds with growth hormone releasing properties
|
|
ATE211134T1
(de)
|
1996-03-05 |
2002-01-15 |
|
4-anilinochinazolin derivate
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
JP4386967B2
(ja)
|
1996-07-13 |
2009-12-16 |
グラクソ、グループ、リミテッド |
プロテインチロシンキナーゼ阻害剤としての縮合複素環式化合物
|
|
ES2191187T3
(es)
|
1996-07-13 |
2003-09-01 |
Glaxo Group Ltd |
Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa.
|
|
HUP9903014A3
(en)
|
1996-07-18 |
2000-08-28 |
Pfizer |
Phosphinate derivatives having matrix metalloprotease inhibitor effect and medicaments containing the same
|
|
US6153609A
(en)
|
1996-08-23 |
2000-11-28 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
AU719392B2
(en)
|
1996-10-01 |
2000-05-11 |
Kyowa Hakko Kirin Co., Ltd. |
Nitrogen-containing heterocyclic compounds
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
AU5131998A
(en)
|
1997-01-06 |
1998-08-03 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
ES2202796T3
(es)
|
1997-02-03 |
2004-04-01 |
Pfizer Products Inc. |
Derivados de acidos arilsulfonilaminohidroxamicos.
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
BR9807678A
(pt)
|
1997-02-11 |
2000-02-15 |
Pfizer |
Derivados de ácidos arilsulfonil-hidroxâmicos
|
|
JP2002511852A
(ja)
|
1997-05-07 |
2002-04-16 |
スージェン・インコーポレーテッド |
蛋白質キナーゼ活性の調節剤としての２−インドリノン誘導体
|
|
AU734009B2
(en)
|
1997-05-30 |
2001-05-31 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
ID23668A
(id)
|
1997-08-08 |
2000-05-11 |
Pfizer Prod Inc |
Turunan asam ariloksiarilsulfonilamino hidroksamat
|
|
ATE368665T1
(de)
|
1997-08-22 |
2007-08-15 |
Astrazeneca Ab |
Oxindolylchinazolinderivate als angiogenesehemmer
|
|
CA2303830A1
(en)
|
1997-09-26 |
1999-04-08 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
NZ520093A
(en)
|
1997-11-11 |
2004-03-26 |
Pfizer Prod Inc |
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9800569D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
DE69917124T2
(de)
|
1998-04-10 |
2005-05-12 |
Pfizer Products Inc., Groton |
Cyclobutyl-Aryloxysulfonylamin-Hydroxamsäurederivate
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
IL139934A
(en)
|
1998-05-29 |
2007-10-31 |
Sugen Inc |
History 2 - Indulinone converted to pyrrole and pharmaceutical preparations containing them
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
ES2213985T3
(es)
|
1998-11-05 |
2004-09-01 |
Pfizer Products Inc. |
Derivados de hidroxiamida de acido 5-oxo-pirrolidin-2-carboxilico.
|
|
EP1143957A3
(en)
|
1998-12-16 |
2002-02-27 |
Warner-Lambert Company |
Treatment of arthritis with mek inhibitors
|
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
ATE297916T1
(de)
|
1999-02-11 |
2005-07-15 |
Pfizer Prod Inc |
Heteroaryl-substituierte chinolin-2-on derivate verwendbar als antikrebsmittel
|
|
IL129299A0
(en)
|
1999-03-31 |
2000-02-17 |
Mor Research Applic Ltd |
Monoclonal antibodies antigens and diagnosis of malignant diseases
|
|
EP3225632B1
(en)
|
1999-11-30 |
2020-05-06 |
Mayo Foundation for Medical Education and Research |
Antibodies binding to b7-h1, a novel immunoregulatory molecule
|
|
DE122008000002I1
(de)
|
2000-02-15 |
2008-04-17 |
Sugen Inc |
Pyrrol substituierte indolin-2-on protein kinase inhibitoren
|
|
MXPA02007957A
(es)
|
2000-02-17 |
2002-11-29 |
Amgen Inc |
Inhibidores de cinasas.
|
|
CA2416685C
(en)
|
2000-07-19 |
2008-10-07 |
Warner-Lambert Company |
Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
|
|
EP2277877A1
(en)
|
2000-08-18 |
2011-01-26 |
Millennium Pharmaceuticals, Inc. |
Quinazoline derivatives as kinase inhibitors
|
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
WO2003076424A1
(en)
|
2002-03-08 |
2003-09-18 |
Eisai Co. Ltd. |
Macrocyclic compounds useful as pharmaceuticals
|
|
DE60330227D1
(de)
|
2002-03-13 |
2010-01-07 |
Array Biopharma Inc |
N3-alkylierte benzimidazol-derivate als mek-hemmer
|
|
AU2003231231A1
(en)
|
2002-05-06 |
2003-11-11 |
Bayer Pharmaceuticals Corporation |
Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
|
|
IL149820A0
(en)
|
2002-05-23 |
2002-11-10 |
Curetech Ltd |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
|
|
EP2206517B1
(en)
|
2002-07-03 |
2023-08-02 |
Ono Pharmaceutical Co., Ltd. |
Immunopotentiating compositions comprising anti-PD-L1 antibodies
|
|
CA2503905A1
(en)
|
2002-09-16 |
2004-03-25 |
Plexxikon, Inc. |
Crystal structure of pim-1 kinase
|
|
ATE473980T1
(de)
|
2002-12-18 |
2010-07-15 |
Vertex Pharma |
Triazolopyridazine als proteinkinase-inhibitoren
|
|
CN1753912B
(zh)
|
2002-12-23 |
2011-11-02 |
惠氏公司 |
抗pd-1抗体及其用途
|
|
JP2006151810A
(ja)
|
2002-12-26 |
2006-06-15 |
Daiichi Asubio Pharma Co Ltd |
ジヒドロチエノキノリン誘導体及びそれを含む細胞接着阻害剤
|
|
ES2264795T3
(es)
*
|
2003-02-14 |
2007-01-16 |
Pfizer Products Inc. |
Triazolo-piridinas como compuestos antiinflamatorios.
|
|
US7514446B2
(en)
|
2003-02-20 |
2009-04-07 |
Smithkline Beecham Corporation |
Pyrimidine compounds
|
|
JP2007505858A
(ja)
|
2003-09-18 |
2007-03-15 |
ノバルティス アクチエンゲゼルシャフト |
増殖性障害の処置に有用な２，４−ジ（フェニルアミノ）ピリミジン
|
|
ES2344007T3
(es)
|
2003-10-14 |
2010-08-16 |
The Arizona Board Of Regents On Behalf Of The University Of Arizona |
Inhibidores proteina quinasa.
|
|
EP1778686B9
(en)
*
|
2004-08-12 |
2009-07-08 |
Pfizer Limited |
Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors
|
|
TW200633990A
(en)
|
2004-11-18 |
2006-10-01 |
Takeda Pharmaceuticals Co |
Amide compound
|
|
US7723340B2
(en)
|
2005-01-13 |
2010-05-25 |
Signal Pharmaceuticals, Llc |
Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
|
|
JP2008539277A
(ja)
|
2005-04-28 |
2008-11-13 |
スーパージェン， インコーポレイテッド |
プロテインキナーゼインヒビター
|
|
ES2720160T3
(es)
|
2005-05-09 |
2019-07-18 |
Ono Pharmaceutical Co |
Anticuerpos monoclonales humanos contra muerte programada 1(PD-1) y métodos para tratar el cáncer usando anticuerpos dirigidos contra PD-1 solos o junto con otras sustancias inmunoterapéuticas
|
|
EA019344B1
(ru)
|
2005-07-01 |
2014-03-31 |
МЕДАРЕКС, Эл.Эл.Си. |
Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения
|
|
ES2481402T3
(es)
|
2005-07-21 |
2014-07-30 |
Ardea Biosciences, Inc. |
Inhibidores de N-(arilamino)sulfonamida de MEK
|
|
EP1910369A1
(en)
*
|
2005-07-29 |
2008-04-16 |
Astellas Pharma Inc. |
Fused heterocycles as lck inhibitors
|
|
US7812025B2
(en)
|
2005-08-12 |
2010-10-12 |
Takeda Pharmaceutical Company Limited |
Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder
|
|
WO2007025090A2
(en)
|
2005-08-25 |
2007-03-01 |
Kalypsys, Inc. |
Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase
|
|
US7750000B2
(en)
|
2005-09-02 |
2010-07-06 |
Bayer Schering Pharma Ag |
Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
|
|
DE102005042742A1
(de)
|
2005-09-02 |
2007-03-08 |
Schering Ag |
Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
|
|
US7776865B2
(en)
|
2005-10-06 |
2010-08-17 |
Schering Corporation |
Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
|
RU2008133161A
(ru)
|
2006-01-13 |
2010-02-20 |
Фармасайкликс, Инк. (Us) |
Ингибиторы тирозин киназ и их применение
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
US20090012079A1
(en)
|
2006-02-09 |
2009-01-08 |
Russell Andrew Lewthwaite |
Triazolopyridine Compounds
|
|
EA200802417A1
(ru)
|
2006-06-09 |
2009-06-30 |
Икос Корпорейшн |
Замещенные фенилуксусные кислоты как dp-2-антагонисты
|
|
DE102006029447A1
(de)
|
2006-06-21 |
2007-12-27 |
Bayer Schering Pharma Ag |
Oxo-substituierte Imidazo[1,2b]pyridazine, deren Herstellung und Verwendung als Arzneimittel
|
|
EP1873157A1
(en)
|
2006-06-21 |
2008-01-02 |
Bayer Schering Pharma Aktiengesellschaft |
Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
|
|
EP1900739A1
(en)
|
2006-08-30 |
2008-03-19 |
Cellzome Ag |
Diazolodiazine derivatives as kinase inhibitors
|
|
CA2663091A1
(en)
|
2006-09-07 |
2008-03-13 |
Biogen Idec Ma Inc. |
Modulators of interleukin-1 receptor-associated kinase
|
|
EA018573B1
(ru)
|
2006-09-22 |
2013-09-30 |
Фармасайкликс, Инк. |
Ингибиторы тирозинкиназы брутона
|
|
RU2009115954A
(ru)
|
2006-09-29 |
2010-11-10 |
Новартис АГ (CH) |
Пиразолопиримидины в качестве ингибиторов липидной киназы р13к
|
|
JP2010508315A
(ja)
|
2006-10-30 |
2010-03-18 |
ノバルティス アーゲー |
抗炎症剤としてのヘテロ環式化合物
|
|
WO2008055233A1
(en)
|
2006-10-31 |
2008-05-08 |
Supergen, Inc. |
Protein kinase inhibitors
|
|
WO2008054827A2
(en)
|
2006-11-03 |
2008-05-08 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
|
US20120058997A1
(en)
|
2006-11-06 |
2012-03-08 |
Supergen, Inc. |
Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
|
|
WO2008058126A2
(en)
|
2006-11-06 |
2008-05-15 |
Supergen, Inc. |
Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
|
|
WO2008082839A2
(en)
|
2006-12-29 |
2008-07-10 |
Abbott Laboratories |
Pim kinase inhibitors as cancer chemotherapeutics
|
|
PT2114900T
(pt)
|
2007-01-31 |
2019-01-17 |
Ym Biosciences Australia Pty |
Compostos à base de tiopirimidina e as suas utilizações
|
|
ES2431163T3
(es)
|
2007-03-01 |
2013-11-25 |
Novartis Ag |
Inhibidores de PIM quinasa y métodos para su uso
|
|
KR20090129434A
(ko)
|
2007-03-01 |
2009-12-16 |
수퍼젠, 인크. |
피리미딘-2,4-디아민 유도체 및 ｊａｋ2 키나제 억제제로서의 이의 용도
|
|
US7834024B2
(en)
|
2007-03-26 |
2010-11-16 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
US8809273B2
(en)
|
2007-03-28 |
2014-08-19 |
Pharmacyclics, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
|
SG10201508035TA
(en)
|
2007-03-28 |
2015-10-29 |
Pharmacyclics Inc |
Inhibitors of bruton's tyrosine kinase
|
|
CA2682733A1
(en)
|
2007-04-13 |
2008-10-23 |
Supergen, Inc. |
Axl kinase inhibitors
|
|
US9244059B2
(en)
|
2007-04-30 |
2016-01-26 |
Immutep Parc Club Orsay |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
|
EP1987839A1
(en)
|
2007-04-30 |
2008-11-05 |
I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
|
JP5191537B2
(ja)
|
2007-06-18 |
2013-05-08 |
エム・エス・ディー・オス・ベー・フェー |
ヒトのプログラムされたデスレセプターｐｄ−１に対する抗体
|
|
WO2009017954A1
(en)
|
2007-08-01 |
2009-02-05 |
Phenomix Corporation |
Inhibitors of jak2 kinase
|
|
CA2699202C
(en)
|
2007-09-12 |
2016-09-27 |
F. Hoffmann-La Roche Ag |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
EP2044949A1
(en)
|
2007-10-05 |
2009-04-08 |
Immutep |
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
|
|
EP2214675B1
(en)
|
2007-10-25 |
2013-11-20 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
|
WO2009060197A1
(en)
|
2007-11-08 |
2009-05-14 |
Centro Nacional De Investigaciones Oncologicas (Cnio) |
Imidazopyridazines for use as protein kinase inhibitors
|
|
EP2217235A4
(en)
|
2007-11-15 |
2011-01-12 |
Musc Found For Res Dev |
INHIBITORS OF PIM PROTEIN KINASES, COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER
|
|
CN101932583A
(zh)
|
2007-12-19 |
2010-12-29 |
沃泰克斯药物股份有限公司 |
用作JAK2抑制剂的吡唑并[1,5-a]嘧啶类
|
|
EP2234986A2
(en)
|
2007-12-20 |
2010-10-06 |
Cellzome Limited |
Sulfamides as zap-70 inhibitors
|
|
UY31679A1
(es)
|
2008-03-03 |
2009-09-30 |
|
Inhibidores de cinasa pim y metodos para su uso
|
|
US8168794B2
(en)
|
2008-03-03 |
2012-05-01 |
Novartis Ag |
Pim kinase inhibitors and methods of their use
|
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
|
MX2010012703A
(es)
|
2008-05-21 |
2010-12-21 |
Ariad Pharma Inc |
Derivados fosforosos como inhibidores de cinasa.
|
|
AU2009259867A1
(en)
|
2008-06-20 |
2009-12-23 |
Genentech, Inc. |
Triazolopyridine JAK inhibitor compounds and methods
|
|
SG10201510696RA
(en)
|
2008-06-27 |
2016-01-28 |
Celgene Avilomics Res Inc |
Heteroaryl compounds and uses thereof
|
|
FR2933409B1
(fr)
|
2008-07-03 |
2010-08-27 |
Centre Nat Rech Scient |
NOUVEAUX PYRROLO °2,3-a! CARBAZOLES ET LEUR UTILISATION COMME INHIBITEURS DES KINASES PIM
|
|
CN105362277A
(zh)
|
2008-07-16 |
2016-03-02 |
药品循环有限公司 |
用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
|
|
CA2732791A1
(en)
|
2008-08-05 |
2010-02-11 |
Targegen, Inc. |
Methods of treating thalassemia
|
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
|
TWI496779B
(zh)
|
2008-08-19 |
2015-08-21 |
Array Biopharma Inc |
作為ｐｉｍ激酶抑制劑之三唑吡啶化合物
|
|
US8557809B2
(en)
|
2008-08-19 |
2013-10-15 |
Array Biopharma Inc. |
Triazolopyridine compounds as PIM kinase inhibitors
|
|
EP2328920A2
(en)
|
2008-08-25 |
2011-06-08 |
Amplimmune, Inc. |
Targeted costimulatory polypeptides and methods of use to treat cancer
|
|
CA2735782A1
(en)
|
2008-09-02 |
2010-03-11 |
Novartis Ag |
Heterocyclic pim-kinase inhibitors
|
|
CN104311480A
(zh)
|
2008-09-02 |
2015-01-28 |
诺华股份有限公司 |
作为激酶抑制剂的吡啶甲酰胺衍生物
|
|
BRPI0918496A2
(pt)
|
2008-09-02 |
2019-09-24 |
Novartis Ag |
composto inibidor bicíclico de quinase, uso do mesmo, composição farmacêutica e método para inibir a atividade da quinase pim em uma célula
|
|
US8927697B2
(en)
|
2008-09-12 |
2015-01-06 |
Isis Innovation Limited |
PD-1 specific antibodies and uses thereof
|
|
DK2350075T3
(da)
|
2008-09-22 |
2014-05-26 |
Array Biopharma Inc |
Substituerede imidazo[1,2b]pyridazinforbindelser som trk-kinase-inhibitorer
|
|
BRPI0919377A2
(pt)
|
2008-09-26 |
2016-09-27 |
Dana Farber Cancer Inst Inc |
anticorpo isolado ou um fragmento ligante de antígeno do memso, ácido nucleico isolado, vetor, célula hospedeira, composição farmacêutica, método de produzir o referido anticorpo ou fragmento, uso dos mesmos, e composição compreendendo o referido anticorpo ou fragmento
|
|
HUE065752T2
(hu)
|
2008-12-09 |
2024-06-28 |
Hoffmann La Roche |
Anti-PD-L1 antitestek és felhasználásuk T-sejt funkció elõsegítésére
|
|
WO2010071885A1
(en)
|
2008-12-19 |
2010-06-24 |
Cephalon, Inc. |
Pyrrolotriazines as alk and jak2 inhibitors
|
|
US20120053208A1
(en)
|
2009-04-15 |
2012-03-01 |
The Ohio State University Research Foundation |
Curcumin Analogs as Dual JAK2/STAT3 Inhibitors and Methods of Making and Using the Same
|
|
AU2010249493A1
(en)
|
2009-05-20 |
2011-12-08 |
Cylene Pharmaceuticals, Inc. |
Pyrazolopyrimidines and related heterocycles as kinase inhibitors
|
|
WO2010148351A1
(en)
|
2009-06-18 |
2010-12-23 |
Cylene Pharmaceuticals, Inc. |
Rhodanines and related heterocycles as kinase inhibitors
|
|
TW201107329A
(en)
|
2009-07-30 |
2011-03-01 |
Oncotherapy Science Inc |
Fused imidazole derivative having ttk inhibitory action
|
|
US7741330B1
(en)
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
|
EP2332917B1
(en)
|
2009-11-11 |
2012-08-01 |
Sygnis Bioscience GmbH & Co. KG |
Compounds for PIM kinase inhibition and for treating malignancy
|
|
PT2504364T
(pt)
|
2009-11-24 |
2017-11-14 |
Medimmune Ltd |
Agentes de ligação direcionados contra b7-h1
|
|
EP2504028A4
(en)
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
|
EP2515665B1
(en)
|
2009-12-22 |
2013-08-14 |
Unilever NV |
A process for preparing a tea product
|
|
US8563539B2
(en)
|
2009-12-23 |
2013-10-22 |
Jasco Pharmaceuticals, LLC |
Aminopyrimidine kinase inhibitors
|
|
UY33213A
(es)
|
2010-02-18 |
2011-09-30 |
Almirall Sa |
Derivados de pirazol como inhibidores de jak
|
|
CA2791930A1
(en)
|
2010-03-11 |
2011-09-15 |
Kerry Louise Tyson |
Pd-1 antibody
|
|
CA3007787C
(en)
|
2010-06-03 |
2020-03-10 |
Pharmacyclics Llc |
The use of inhibitors of bruton's tyrosine kinase (btk)
|
|
ES2682078T3
(es)
|
2010-06-11 |
2018-09-18 |
Kyowa Hakko Kirin Co., Ltd. |
Anticuerpo anti-TIM-3
|
|
WO2011159877A2
(en)
|
2010-06-18 |
2011-12-22 |
The Brigham And Women's Hospital, Inc. |
Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
|
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
|
JP2013530199A
(ja)
|
2010-07-06 |
2013-07-25 |
ノバルティス アーゲー |
キナーゼ阻害剤として有用な環状エーテル化合物
|
|
TWI541243B
(zh)
*
|
2010-09-10 |
2016-07-11 |
拜耳知識產權公司 |
經取代咪唑并嗒
|
|
RU2652638C2
(ru)
|
2010-12-17 |
2018-04-28 |
НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. |
Замещенные пиразолхиназолиновые производные в качестве ингибиторов киназы
|
|
PH12013501754A1
(en)
|
2011-02-25 |
2013-10-14 |
Array Biopharma Inc |
Triazolopyridine compounds as pim kinase inhibitors
|
|
UY33929A
(es)
|
2011-03-04 |
2012-10-31 |
Novartis Ag |
Compuestos de ciclohexilo tetrasustituido como inhibidores de quinasas
|
|
EP2688886A1
(en)
|
2011-03-22 |
2014-01-29 |
Amgen Inc. |
Azole compounds as pim inhibitors
|
|
JP6072771B2
(ja)
|
2011-04-20 |
2017-02-01 |
メディミューン，エルエルシー |
Ｂ７−ｈ１およびｐｄ−１に結合する抗体およびその他の分子
|
|
US20140113919A1
(en)
|
2011-06-14 |
2014-04-24 |
Novartis Ag |
Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm
|
|
PE20140832A1
(es)
|
2011-06-20 |
2014-07-14 |
Incyte Corp |
Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
|
|
WO2013006490A2
(en)
|
2011-07-01 |
2013-01-10 |
Cellerant Therapeutics, Inc. |
Antibodies that specifically bind to tim3
|
|
BR112014000653A2
(pt)
|
2011-07-13 |
2017-02-14 |
Pharmacyclics Inc |
inibidores de tirosina quinase de bruton
|
|
PL3409278T3
(pl)
|
2011-07-21 |
2021-02-22 |
Sumitomo Pharma Oncology, Inc. |
Heterocykliczne inhibitory kinazy białkowej
|
|
JP6240600B2
(ja)
|
2011-07-24 |
2017-11-29 |
キュアテク リミテッド |
ヒト化免疫モノクローナル抗体の変異体
|
|
CN102924444B
(zh)
|
2011-08-11 |
2015-07-08 |
上海吉铠医药科技有限公司 |
Pim激酶抑制剂及其制备方法与在制药中的应用
|
|
KR20250086805A
(ko)
|
2011-10-19 |
2025-06-13 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 인산화효소(btk)의 억제제의 용도
|
|
KR101981873B1
(ko)
|
2011-11-28 |
2019-05-23 |
메르크 파텐트 게엠베하 |
항-ｐｄ-ｌ1 항체 및 그의 용도
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
US8501724B1
(en)
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
|
US8969565B2
(en)
|
2012-03-09 |
2015-03-03 |
Lexicon Pharmaceuticals, Inc. |
Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use
|
|
WO2013173518A1
(en)
|
2012-05-16 |
2013-11-21 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
CA2873672A1
(en)
|
2012-05-21 |
2013-11-28 |
Novartis Ag |
Novel ring-substituted n-pyridinyl amides as kinase inhibitors
|
|
CN104736168B
(zh)
|
2012-05-31 |
2018-09-21 |
索伦托治疗有限公司 |
与pd-l1结合的抗原结合蛋白
|
|
EA201492082A1
(ru)
|
2012-06-04 |
2015-03-31 |
Фармасайкликс, Инк. |
Кристаллические формы ингибитора тирозинкиназы брутона
|
|
UY34887A
(es)
|
2012-07-02 |
2013-12-31 |
Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware |
Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
|
|
CA2879570A1
(en)
|
2012-07-24 |
2014-01-30 |
Pharmacyclics, Inc. |
Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
|
|
CN104936982B
(zh)
|
2012-08-03 |
2020-04-24 |
丹娜法伯癌症研究院 |
抗-pd-l1和pd-l2双结合抗体单一试剂及其使用方法
|
|
US8703981B2
(en)
|
2012-08-03 |
2014-04-22 |
Xerox Corporation |
Lignosulfonate compounds for solid ink applications
|
|
DK2880035T3
(en)
|
2012-08-06 |
2017-03-06 |
Acea Biosciences Inc |
Hitherto UNKNOWN PYRROLOPYRIMIDINE COMPOUNDS AS PROTEIN CHINAS INHIBITORS
|
|
KR101446742B1
(ko)
|
2012-08-10 |
2014-10-01 |
한국화학연구원 |
Ｎ2,ｎ4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
CN102880459A
(zh)
|
2012-08-14 |
2013-01-16 |
张涛 |
基于VisualLisp编程语言下的编译实现方法及系统
|
|
US9315514B2
(en)
|
2012-08-27 |
2016-04-19 |
Rhodes Technologies |
1,3-dioxanomorphides and 1,3-dioxanocodides
|
|
WO2014033631A1
(en)
|
2012-08-31 |
2014-03-06 |
Novartis Ag |
N-(3-pyridyl) biarylamides as kinase inhibitors
|
|
CN104812756A
(zh)
|
2012-09-26 |
2015-07-29 |
曼凯德公司 |
多激酶通路抑制剂
|
|
CA2886433C
(en)
|
2012-10-04 |
2022-01-04 |
Dana-Farber Cancer Institute, Inc. |
Human monoclonal anti-pd-l1 antibodies and methods of use
|
|
MX2015006168A
(es)
|
2012-11-15 |
2015-08-10 |
Pharmacyclics Inc |
Compuestos de pirrolopirimidina como inhibidores de quinasas.
|
|
AR093984A1
(es)
|
2012-12-21 |
2015-07-01 |
Merck Sharp & Dohme |
Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
|
|
PE20191245A1
(es)
|
2013-01-15 |
2019-09-18 |
Incyte Holdings Corp |
Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
|
|
US9561228B2
(en)
|
2013-02-08 |
2017-02-07 |
Celgene Avilomics Research, Inc. |
ERK inhibitors and uses thereof
|
|
WO2014130411A1
(en)
|
2013-02-22 |
2014-08-28 |
Emory University |
Tgf-beta enhancing compositions for cartilage repair and methods related thereto
|
|
US9708326B2
(en)
|
2013-02-25 |
2017-07-18 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
WO2014159745A1
(en)
|
2013-03-14 |
2014-10-02 |
Pharmacyclics, Inc. |
Combinations of bruton's tyrosine kinase inhibitors and cyp3a4 inhibitors
|
|
RU2693480C2
(ru)
|
2013-03-14 |
2019-07-03 |
Толеро Фармасьютикалз, Инк. |
Ингибиторы jak2 и alk2 и способы их использования
|
|
HRP20201113T1
(hr)
|
2013-03-15 |
2020-10-30 |
Glaxosmithkline Intellectual Property Development Limited |
Vežući proteini protiv lag-3
|
|
WO2014168975A1
(en)
|
2013-04-08 |
2014-10-16 |
Pharmacyclics, Inc. |
Ibrutinib combination therapy
|
|
KR102243062B1
(ko)
|
2013-05-02 |
2021-04-21 |
아납티스바이오, 아이엔씨. |
예정된 사멸-1에 대한 항체
|
|
US9676853B2
(en)
|
2013-05-31 |
2017-06-13 |
Sorrento Therapeutics, Inc. |
Antigen binding proteins that bind PD-1
|
|
KR102094011B1
(ko)
|
2013-06-13 |
2020-03-26 |
삼성전자주식회사 |
전자 장치에서 노이즈를 제거하기 위한 장치 및 방법
|
|
WO2014209804A1
(en)
|
2013-06-24 |
2014-12-31 |
Biomed Valley Discoveries, Inc. |
Bispecific antibodies
|
|
JP6458018B2
(ja)
|
2013-07-02 |
2019-01-23 |
ファーマサイクリックス エルエルシー |
キナーゼ阻害剤としてのプリノン化合物
|
|
RU2016107813A
(ru)
|
2013-08-08 |
2017-09-14 |
Новартис Аг |
Комбинации ингибиторов киназы pim
|
|
CN105658653A
(zh)
|
2013-08-23 |
2016-06-08 |
因赛特公司 |
可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物
|
|
JP6623353B2
(ja)
|
2013-09-13 |
2019-12-25 |
ベイジーン スウィッツァーランド ゲーエムベーハー |
抗ｐｄ−１抗体並びにその治療及び診断のための使用
|
|
KR20160062103A
(ko)
|
2013-09-30 |
2016-06-01 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 키나제의 억제제
|
|
WO2015061668A1
(en)
|
2013-10-25 |
2015-04-30 |
Dana-Farber Cancer Institute, Inc. |
Anti-pd-l1 monoclonal antibodies and fragments thereof
|
|
WO2015081158A1
(en)
|
2013-11-26 |
2015-06-04 |
Bristol-Myers Squibb Company |
Method of treating hiv by disrupting pd-1/pd-l1 signaling
|
|
ES2746805T3
(es)
|
2013-12-12 |
2020-03-06 |
Shanghai hengrui pharmaceutical co ltd |
Anticuerpo de PD-1, fragmento de unión a antígeno del mismo y aplicación médica del mismo
|
|
EP4079321A1
(en)
|
2014-01-15 |
2022-10-26 |
Kadmon Corporation, LLC |
Immunomodulatory agents
|
|
TWI680138B
(zh)
|
2014-01-23 |
2019-12-21 |
美商再生元醫藥公司 |
抗ｐｄ-ｌ１之人類抗體
|
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對ｐｄ-１的人類抗體
|
|
ES2716685T3
(es)
|
2014-01-24 |
2019-06-14 |
Dana Farber Cancer Inst Inc |
Moléculas de anticuerpo para PD-1 y usos de las mismas
|
|
KR20160106762A
(ko)
|
2014-01-28 |
2016-09-12 |
브리스톨-마이어스 스큅 컴퍼니 |
혈액 악성종양을 치료하기 위한 항-lag-3 항체
|
|
DK3099717T3
(da)
|
2014-01-31 |
2019-07-01 |
Novartis Ag |
Antistofmolekyler med tim-3 og anvendelser deraf
|
|
TWI777174B
(zh)
|
2014-03-14 |
2022-09-11 |
瑞士商諾華公司 |
針對lag-3之抗體分子及其用途
|
|
KR20240153401A
(ko)
|
2014-04-08 |
2024-10-22 |
인사이트 홀딩스 코포레이션 |
Ｊａｋ 및 ｐｉ3ｋ 억제제 조합에 의한 ｂ-세포 악성종양의 치료
|
|
US20150306112A1
(en)
|
2014-04-25 |
2015-10-29 |
National Cheng Kung University |
Zhankuic acid A, a JAK2/3 tyrosine kinase inhibitor, and a potential therapeutic agent for hepatitis
|
|
ES2753360T3
(es)
|
2014-05-29 |
2020-04-08 |
Spring Bioscience Corp |
Anticuerpos contra PD-L1 y usos de los mismos
|
|
WO2015195163A1
(en)
|
2014-06-20 |
2015-12-23 |
R-Pharm Overseas, Inc. |
Pd-l1 antagonist fully human antibody
|
|
TWI693232B
(zh)
|
2014-06-26 |
2020-05-11 |
美商宏觀基因股份有限公司 |
與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
|
|
KR102003754B1
(ko)
|
2014-07-03 |
2019-07-25 |
베이진 엘티디 |
Pd-l1 항체와 이를 이용한 치료 및 진단
|
|
JO3663B1
(ar)
|
2014-08-19 |
2020-08-27 |
Merck Sharp & Dohme |
الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
|
|
UY36351A
(es)
|
2014-10-14 |
2016-06-01 |
Novartis Ag |
Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas
|
|
PL3215532T3
(pl)
|
2014-11-06 |
2020-03-31 |
F. Hoffmann-La Roche Ag |
Przeciwciała anty-TIM3 i sposoby ich zastosowania
|
|
TWI595006B
(zh)
|
2014-12-09 |
2017-08-11 |
禮納特神經系統科學公司 |
抗ｐｄ－１抗體類和使用彼等之方法
|
|
US20160200815A1
(en)
|
2015-01-05 |
2016-07-14 |
Jounce Therapeutics, Inc. |
Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
|
|
JP2018510151A
(ja)
|
2015-03-06 |
2018-04-12 |
ソレント・セラピューティクス・インコーポレイテッド |
Ｔｉｍ３に結合する抗体医薬
|
|
CN107847589B
(zh)
|
2015-04-01 |
2022-03-29 |
安奈普泰斯生物有限公司 |
针对t细胞免疫球蛋白和粘蛋白蛋白3(tim-3)的抗体
|
|
WO2016161248A1
(en)
|
2015-04-02 |
2016-10-06 |
Tolero Pharmaceuticals, Inc. |
Targeting pim kinases in combination with btk inhibition
|
|
CN105919955A
(zh)
|
2016-06-13 |
2016-09-07 |
佛山市腾瑞医药科技有限公司 |
一种鲁索利替尼制剂及其应用
|
|
CN117959303A
(zh)
|
2018-04-13 |
2024-05-03 |
住友制药肿瘤公司 |
用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂
|