JP6105578B2 - 複素環式プロテインキナーゼ阻害剤 - Google Patents

複素環式プロテインキナーゼ阻害剤 Download PDF

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JP6105578B2
JP6105578B2 JP2014521840A JP2014521840A JP6105578B2 JP 6105578 B2 JP6105578 B2 JP 6105578B2 JP 2014521840 A JP2014521840 A JP 2014521840A JP 2014521840 A JP2014521840 A JP 2014521840A JP 6105578 B2 JP6105578 B2 JP 6105578B2
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mmol
compound
stereoisomer
pharmaceutically acceptable
mixture
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JP2014520898A5 (enExample
JP2014520898A (ja
Inventor
ヨン スー，
ヨン スー，
ベンジャミン ゲイリー ブレニング，
ベンジャミン ゲイリー ブレニング，
スティーブン ジー． クルトゲン，
スティーブン ジー． クルトゲン，
シャオフイ リウ，
シャオフイ リウ，
マイケル サンダーズ，
マイケル サンダーズ，
コク−カン ホ，
コク−カン ホ，
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トレロ ファーマシューティカルズ， インコーポレイテッド
トレロ ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2014521840A 2011-07-21 2012-07-20 複素環式プロテインキナーゼ阻害剤 Active JP6105578B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161510207P 2011-07-21 2011-07-21
US201161632834P 2011-07-21 2011-07-21
US61/632,834 2011-07-21
US61/510,207 2011-07-21
US201261632826P 2012-03-01 2012-03-01
US61/632,826 2012-03-01
US201261608028P 2012-03-07 2012-03-07
US61/608,028 2012-03-07
PCT/US2012/047685 WO2013013188A1 (en) 2011-07-21 2012-07-20 Heterocyclic protein kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2014520898A JP2014520898A (ja) 2014-08-25
JP2014520898A5 JP2014520898A5 (enExample) 2015-09-10
JP6105578B2 true JP6105578B2 (ja) 2017-03-29

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JP2014521840A Active JP6105578B2 (ja) 2011-07-21 2012-07-20 複素環式プロテインキナーゼ阻害剤

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US (7) US9416132B2 (enExample)
EP (3) EP3409278B8 (enExample)
JP (1) JP6105578B2 (enExample)
CY (1) CY1123626T1 (enExample)
DK (2) DK2734205T3 (enExample)
ES (2) ES2671748T3 (enExample)
HU (1) HUE052198T2 (enExample)
PL (1) PL3409278T3 (enExample)
PT (1) PT3409278T (enExample)
WO (1) WO2013013188A1 (enExample)

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TWI662030B (zh) 2013-01-15 2019-06-11 英塞特控股公司 適用作ｐｉｍ激酶抑制劑之噻唑甲醯胺及吡啶甲醯胺化合物
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HUE072069T2 (hu) 2019-02-12 2025-10-28 Sumitomo Pharma America Inc 2-((1R,4R)-4-((3-(3-(trifluormetil)fenil)imidazo[1,2- b]piridazin-6-il)amino)ciklohexil)propán-2-ol sósavas sójának kristályos formája
IL296921B1 (en) * 2020-04-15 2026-08-01 Pyramid Biosciences Inc Methods for preparing receptor tyrosine kinase inhibitors
CN112430632B (zh) * 2020-11-18 2022-09-13 上海合全药物研发有限公司 2-((反式)-4-氨基环己烷基)异丙醇的制备方法
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US20250042918A1 (en) * 2021-12-01 2025-02-06 Fundación Del Sector Públlco Estatal Centro Nacional De Investigaciones Oncológicas Carlos III Compounds
CN116262753A (zh) * 2021-12-13 2023-06-16 杭州邦顺制药有限公司 一种新颖的pim激酶抑制剂
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