ES2602823T3 - Proceso para la preparación de drospirenona - Google Patents
Proceso para la preparación de drospirenona Download PDFInfo
- Publication number
- ES2602823T3 ES2602823T3 ES09159293.1T ES09159293T ES2602823T3 ES 2602823 T3 ES2602823 T3 ES 2602823T3 ES 09159293 T ES09159293 T ES 09159293T ES 2602823 T3 ES2602823 T3 ES 2602823T3
- Authority
- ES
- Spain
- Prior art keywords
- drospirenone
- preparation
- antimineralocorticoid
- progestogenic
- androstane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pens And Brushes (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Abstract
6ß,7ß;15ß,16ß-dimetilen-3ß,5ß-dihidroxi-17α-pregn-21,17-211α-carbolactol.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT002338A ITMI20042338A1 (it) | 2004-12-06 | 2004-12-06 | Processo per la preparazione di drospirenone |
ITMI20042338 | 2004-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2602823T3 true ES2602823T3 (es) | 2017-02-22 |
Family
ID=35840070
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09159293.1T Active ES2602823T3 (es) | 2004-12-06 | 2005-11-14 | Proceso para la preparación de drospirenona |
ES05819134T Active ES2355982T3 (es) | 2004-12-06 | 2005-11-14 | Procedimiento para la preparación de drospirenona. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES05819134T Active ES2355982T3 (es) | 2004-12-06 | 2005-11-14 | Procedimiento para la preparación de drospirenona. |
Country Status (20)
Country | Link |
---|---|
US (3) | US20080207575A1 (es) |
EP (2) | EP2108652B1 (es) |
JP (1) | JP5626616B2 (es) |
CN (1) | CN101065396B (es) |
AT (1) | ATE491716T1 (es) |
BR (1) | BRPI0517752C1 (es) |
CA (1) | CA2589928C (es) |
CL (1) | CL2007001581A1 (es) |
CY (1) | CY1111209T1 (es) |
DE (1) | DE602005025396D1 (es) |
DK (1) | DK1828222T3 (es) |
ES (2) | ES2602823T3 (es) |
IL (1) | IL183645A (es) |
IT (1) | ITMI20042338A1 (es) |
MX (1) | MX2007006701A (es) |
PL (1) | PL1828222T3 (es) |
PT (1) | PT1828222E (es) |
SI (1) | SI1828222T1 (es) |
WO (1) | WO2006061309A1 (es) |
ZA (1) | ZA200705492B (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2008000936A (es) * | 2005-07-21 | 2008-03-27 | Bayer Schering Pharma Ag | Proceso para producir 3-oxo-pregn-4-eno-21,17-carbolactonas por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihidroxia ndrostanos. |
US7319154B2 (en) | 2005-07-21 | 2008-01-15 | Bayer Schering Pharma Ag | Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes |
ES2311927T5 (es) * | 2005-07-21 | 2014-09-08 | Bayer Pharma Aktiengesellschaft | Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos |
MX2008016571A (es) * | 2007-05-01 | 2009-03-09 | Sicor Inc | Proceso para preparar drospirenona y su intermediarios. |
DE102007027635A1 (de) * | 2007-06-12 | 2008-12-18 | Bayer Schering Pharma Aktiengesellschaft | 17ß-Cyano-19-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel |
DE102007030596B3 (de) * | 2007-06-28 | 2009-03-12 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden |
DE602007011250D1 (de) * | 2007-07-26 | 2011-01-27 | Newchem S P A | Herstellungsverfahren für Drospirenon |
WO2009111574A2 (en) * | 2008-03-05 | 2009-09-11 | Evestra, Inc. | BISMETHYLENE-17α CARBOLACTONES AND RELATED USES |
US8222237B2 (en) * | 2008-11-25 | 2012-07-17 | Evestra, Inc. | Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones |
US8334375B2 (en) * | 2009-04-10 | 2012-12-18 | Evestra, Inc. | Methods for the preparation of drospirenone |
ES2432063T3 (es) * | 2009-06-16 | 2013-11-29 | Crystal Pharma, S.A.U. | Procedimiento para la obtención de 17-espirolactonas en esteroides |
CN101775057B (zh) * | 2010-02-09 | 2014-07-16 | 浙江仙琚制药股份有限公司 | 屈螺酮及其中间体的制备方法 |
CN101830959B (zh) * | 2010-05-27 | 2012-07-18 | 杭州龙山化工有限公司 | 一种曲螺酮的合成方法 |
US11351122B1 (en) | 2010-07-28 | 2022-06-07 | Laboratorios Leon Farma Sa | Synthetic progestogens and pharmaceutical compositions comprising the same |
AR081670A1 (es) | 2010-06-29 | 2012-10-10 | Leon Farma Sa Lab | Composicion farmaceutica que comprende drospirenona y kit anticonceptivo |
US10849857B2 (en) | 2010-07-28 | 2020-12-01 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
US9603860B2 (en) | 2010-07-28 | 2017-03-28 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
EP2415778B1 (en) | 2010-08-03 | 2013-05-15 | Newchem S.p.A. | Methods for the preparation of Drospirenone and intermediates thereof |
CN102040650B (zh) * | 2010-10-26 | 2014-03-26 | 西安科技大学 | 串联反应构建甾体-6β,7β-亚甲基结构的方法 |
WO2012107513A1 (en) | 2011-02-10 | 2012-08-16 | Crystal Pharma, S.A.U. | Process for obtaining drospirenone |
ITMI20111383A1 (it) * | 2011-07-25 | 2013-01-26 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
ITMI20120146A1 (it) * | 2012-02-03 | 2013-08-04 | Ind Chimica Srl | Processo per la preparazione di composti policiclici insaturi dotati di attivita' farmacologica |
CA2856324C (en) | 2011-11-22 | 2019-08-13 | Industriale Chimica S.R.L. | Process for the preparation of drospirenone |
EP2597101A1 (en) | 2011-11-22 | 2013-05-29 | Industriale Chimica S.R.L. | Process for the preparation of drospirenone |
CN102887934B (zh) * | 2012-09-20 | 2015-05-27 | 杭州福斯特药业有限公司 | 一种屈螺酮的制备方法 |
ITMI20130183A1 (it) * | 2013-02-08 | 2014-08-09 | Ind Chimica Srl | Processo per la preparazione di drospirenone. |
EP2958929B1 (en) * | 2013-02-20 | 2017-09-13 | Industriale Chimica S.R.L. | Process for the preparation of drospirenone |
DK2984100T3 (en) * | 2013-04-12 | 2017-07-10 | Ind Chimica Srl | Process for the preparation of drospirenone |
WO2014174338A1 (en) * | 2013-04-22 | 2014-10-30 | Industriale Chimica S.R.L. | Process for preparing an intermediate useful in the production of drospirenone |
CN104174341B (zh) * | 2013-05-27 | 2017-09-26 | 乌鲁木齐益好天成新型节能材料有限公司 | 一种固相硅凝胶的制备方法 |
EP3108889A1 (en) | 2015-06-23 | 2016-12-28 | Philippe Perrin | Drospirenone-based contraceptive for a female patient affected with excess weight |
BR112017028048A2 (pt) | 2015-06-23 | 2018-09-04 | Laboratorios Leon Farma Sa | drospirenona como o único ingrediente contraceptivo para uso |
CN105017362A (zh) * | 2015-07-22 | 2015-11-04 | 浙江圃瑞药业有限公司 | 将表雄酮氧化为雄烷二酮的清洁生产方法 |
CN110407905B (zh) * | 2019-08-22 | 2021-09-28 | 武汉九珑人福药业有限责任公司 | 一种屈螺酮及其中间体的制备方法 |
EP4134082A1 (en) | 2021-08-12 | 2023-02-15 | Chemo Research, S.L. | Method for treating endometriosis and providing effective contraception |
CN114437169B (zh) * | 2022-01-25 | 2023-04-07 | 台州仙琚药业有限公司 | 一种屈螺酮关键中间体溴代物的合成方法 |
WO2023152658A1 (en) | 2022-02-10 | 2023-08-17 | Lupin Limited | Slow release drospirenone tablet composition |
AR128632A1 (es) | 2022-03-01 | 2024-05-29 | Chemo Res S L | Anticonceptivo oral masticable de drospirenona |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3042136A1 (de) * | 1980-11-03 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden |
EP0075189B1 (en) * | 1981-09-21 | 1985-08-28 | Schering Aktiengesellschaft | 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation |
DE3916112A1 (de) * | 1989-05-16 | 1990-11-22 | Schering Ag | Dihydrospirorenon als antiandrogen |
NZ275951A (en) * | 1993-12-17 | 1997-12-19 | Upjohn Co | Bisnoraldehyde production from bisnoralcohol |
DE19633685C1 (de) * | 1996-08-12 | 1997-10-09 | Schering Ag | Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens |
MXPA05001857A (es) * | 2002-08-16 | 2005-06-03 | Upjohn Co | Intermedios esteroideos de 5-androsten-38-ol y procedimientos para su preparacion. |
JP3814284B2 (ja) * | 2002-11-06 | 2006-08-23 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 7−カルボキシ置換ステロイドの製造方法 |
ITMI20040367A1 (it) * | 2004-03-01 | 2004-06-01 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
HUP0402465A2 (en) * | 2004-11-30 | 2006-07-28 | Richter Gedeon Vegyeszet | Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process |
HUP0402466A2 (en) * | 2004-11-30 | 2006-07-28 | Richter Gedeon Vegyeszet | Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process |
US7319154B2 (en) * | 2005-07-21 | 2008-01-15 | Bayer Schering Pharma Ag | Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes |
-
2004
- 2004-12-06 IT IT002338A patent/ITMI20042338A1/it unknown
-
2005
- 2005-11-14 BR BRPI0517752A patent/BRPI0517752C1/pt active IP Right Grant
- 2005-11-14 PT PT05819134T patent/PT1828222E/pt unknown
- 2005-11-14 MX MX2007006701A patent/MX2007006701A/es active IP Right Grant
- 2005-11-14 DK DK05819134.7T patent/DK1828222T3/da active
- 2005-11-14 EP EP09159293.1A patent/EP2108652B1/en active Active
- 2005-11-14 CA CA2589928A patent/CA2589928C/en active Active
- 2005-11-14 DE DE602005025396T patent/DE602005025396D1/de active Active
- 2005-11-14 CN CN2005800407958A patent/CN101065396B/zh active Active
- 2005-11-14 SI SI200531215T patent/SI1828222T1/sl unknown
- 2005-11-14 WO PCT/EP2005/055963 patent/WO2006061309A1/en active Application Filing
- 2005-11-14 AT AT05819134T patent/ATE491716T1/de active
- 2005-11-14 ES ES09159293.1T patent/ES2602823T3/es active Active
- 2005-11-14 US US11/792,465 patent/US20080207575A1/en not_active Abandoned
- 2005-11-14 JP JP2007543825A patent/JP5626616B2/ja active Active
- 2005-11-14 EP EP05819134A patent/EP1828222B9/en not_active Revoked
- 2005-11-14 PL PL05819134T patent/PL1828222T3/pl unknown
- 2005-11-14 ES ES05819134T patent/ES2355982T3/es active Active
-
2007
- 2007-06-01 CL CL2007001581A patent/CL2007001581A1/es unknown
- 2007-06-04 IL IL183645A patent/IL183645A/en active IP Right Grant
- 2007-07-05 ZA ZA200705492A patent/ZA200705492B/xx unknown
-
2010
- 2010-08-04 US US12/850,246 patent/US8227596B2/en active Active
-
2011
- 2011-02-16 CY CY20111100198T patent/CY1111209T1/el unknown
-
2012
- 2012-05-30 US US13/483,229 patent/US20120264723A1/en not_active Abandoned
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