BRPI0517752C1 - processo para a preparação de drospirenona - Google Patents

processo para a preparação de drospirenona

Info

Publication number
BRPI0517752C1
BRPI0517752C1 BRPI0517752A BRPI0517752A BRPI0517752C1 BR PI0517752 C1 BRPI0517752 C1 BR PI0517752C1 BR PI0517752 A BRPI0517752 A BR PI0517752A BR PI0517752 A BRPI0517752 A BR PI0517752A BR PI0517752 C1 BRPI0517752 C1 BR PI0517752C1
Authority
BR
Brazil
Prior art keywords
drospirenone
preparing drospirenone
preparing
antimineralocorticoid
progestogenic
Prior art date
Application number
BRPI0517752A
Other languages
English (en)
Inventor
Francesca Costantino
Roberto Lenna
Silvia Piuri
Original Assignee
Ind Chimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35840070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0517752(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl
Publication of BRPI0517752A publication Critical patent/BRPI0517752A/pt
Publication of BRPI0517752B1 publication Critical patent/BRPI0517752B1/pt
Publication of BRPI0517752B8 publication Critical patent/BRPI0517752B8/pt
Publication of BRPI0517752C1 publication Critical patent/BRPI0517752C1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pens And Brushes (AREA)
  • Macromonomer-Based Addition Polymer (AREA)

Abstract

processo para a preparação de drospirenona um processo é descrito para a preparação de drospirenona, um esteróide sintético com atividade progestogênica, antimineralocorticóidica e antiandrogênica, útil para preparação de composições farmacêuticas com ação contraceptiva; compreendendo a oxidação de 17alfa-(3-hidroxipropil) -6beta, 7beta; 15beta, 16beta-dimetileno-5beta-androstano-3beta, 5, 17beta-triol.
BRPI0517752A 2004-12-06 2005-11-14 processo para a preparação de drospirenona BRPI0517752C1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002338A ITMI20042338A1 (it) 2004-12-06 2004-12-06 Processo per la preparazione di drospirenone
PCT/EP2005/055963 WO2006061309A1 (en) 2004-12-06 2005-11-14 Process for the preparation of drospirenone

Publications (4)

Publication Number Publication Date
BRPI0517752A BRPI0517752A (pt) 2008-10-21
BRPI0517752B1 BRPI0517752B1 (pt) 2018-12-26
BRPI0517752B8 BRPI0517752B8 (pt) 2019-02-19
BRPI0517752C1 true BRPI0517752C1 (pt) 2021-05-25

Family

ID=35840070

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517752A BRPI0517752C1 (pt) 2004-12-06 2005-11-14 processo para a preparação de drospirenona

Country Status (20)

Country Link
US (3) US20080207575A1 (pt)
EP (2) EP1828222B9 (pt)
JP (1) JP5626616B2 (pt)
CN (1) CN101065396B (pt)
AT (1) ATE491716T1 (pt)
BR (1) BRPI0517752C1 (pt)
CA (1) CA2589928C (pt)
CL (1) CL2007001581A1 (pt)
CY (1) CY1111209T1 (pt)
DE (1) DE602005025396D1 (pt)
DK (1) DK1828222T3 (pt)
ES (2) ES2355982T3 (pt)
IL (1) IL183645A (pt)
IT (1) ITMI20042338A1 (pt)
MX (1) MX2007006701A (pt)
PL (1) PL1828222T3 (pt)
PT (1) PT1828222E (pt)
SI (1) SI1828222T1 (pt)
WO (1) WO2006061309A1 (pt)
ZA (1) ZA200705492B (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ565247A (en) 2005-07-21 2011-02-25 Bayer Schering Pharma Ag Process for the production drospirenone utilising the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes with TEMPO
SI1746101T2 (sl) * 2005-07-21 2014-09-30 Bayer Pharma Aktiengesellschaft Postopek za pripravo 3-okso-pregn-4-en-21,17-karbolaktonov z oksidacijo 17-(3-hidroksipropil)-3,17-dihidroksiandrostanov brez uporabe kovine
US7319154B2 (en) 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
WO2008137050A2 (en) * 2007-05-01 2008-11-13 Sicor Inc. A process for preparing drospirenone and intermediate thereof
DE102007027635A1 (de) * 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-19-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
EP2019114B1 (en) * 2007-07-26 2010-12-15 Newchem S.p.A. Process for the preparation of Drospirenone
US7960368B2 (en) * 2008-03-05 2011-06-14 Everstra, Inc. Bismethylene-17A carbolactones and related uses
US8222237B2 (en) * 2008-11-25 2012-07-17 Evestra, Inc. Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
EP2266998B1 (en) * 2009-06-16 2013-07-24 Crystal Pharma, S.A.U. Process for obtaining 17-spirolactones in steroids
CN101775057B (zh) * 2010-02-09 2014-07-16 浙江仙琚制药股份有限公司 屈螺酮及其中间体的制备方法
CN101830959B (zh) * 2010-05-27 2012-07-18 杭州龙山化工有限公司 一种曲螺酮的合成方法
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
ES2419663T3 (es) 2010-08-03 2013-08-21 Newchem S.P.A. Métodos para la preparación de Drospirenona y productos intermedios de la misma
CN102040650B (zh) * 2010-10-26 2014-03-26 西安科技大学 串联反应构建甾体-6β,7β-亚甲基结构的方法
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
ITMI20111383A1 (it) * 2011-07-25 2013-01-26 Ind Chimica Srl Processo per la preparazione di drospirenone
EP2597101A1 (en) 2011-11-22 2013-05-29 Industriale Chimica S.R.L. Process for the preparation of drospirenone
ITMI20120146A1 (it) * 2012-02-03 2013-08-04 Ind Chimica Srl Processo per la preparazione di composti policiclici insaturi dotati di attivita' farmacologica
EP2782924B1 (en) 2011-11-22 2016-09-21 Industriale Chimica S.R.L. Process for the preparation of drospirenone
CN102887934B (zh) * 2012-09-20 2015-05-27 杭州福斯特药业有限公司 一种屈螺酮的制备方法
ITMI20130183A1 (it) * 2013-02-08 2014-08-09 Ind Chimica Srl Processo per la preparazione di drospirenone.
WO2014128525A1 (en) * 2013-02-20 2014-08-28 Industriale Chimica S.R.L. Process for the preparation of drospirenone
ES2630331T3 (es) * 2013-04-12 2017-08-21 Industriale Chimica S.R.L. Proceso para la preparación de drospirenona
WO2014174338A1 (en) * 2013-04-22 2014-10-30 Industriale Chimica S.R.L. Process for preparing an intermediate useful in the production of drospirenone
CN104174341B (zh) * 2013-05-27 2017-09-26 乌鲁木齐益好天成新型节能材料有限公司 一种固相硅凝胶的制备方法
CN108025014B (zh) 2015-06-23 2021-10-22 莱昂实验室制药股份有限公司 用于过重女性患者的基于屈螺酮的避孕药
EP3108889A1 (en) 2015-06-23 2016-12-28 Philippe Perrin Drospirenone-based contraceptive for a female patient affected with excess weight
CN105017362A (zh) * 2015-07-22 2015-11-04 浙江圃瑞药业有限公司 将表雄酮氧化为雄烷二酮的清洁生产方法
CN110407905B (zh) * 2019-08-22 2021-09-28 武汉九珑人福药业有限责任公司 一种屈螺酮及其中间体的制备方法
EP4134082A1 (en) 2021-08-12 2023-02-15 Chemo Research, S.L. Method for treating endometriosis and providing effective contraception
CN114437169B (zh) * 2022-01-25 2023-04-07 台州仙琚药业有限公司 一种屈螺酮关键中间体溴代物的合成方法
WO2023152658A1 (en) 2022-02-10 2023-08-17 Lupin Limited Slow release drospirenone tablet composition
WO2023165988A1 (en) 2022-03-01 2023-09-07 Chemo Research, S.L. Chewable oral contraceptive

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
EP0075189B1 (en) * 1981-09-21 1985-08-28 Schering Aktiengesellschaft 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
DE3916112A1 (de) * 1989-05-16 1990-11-22 Schering Ag Dihydrospirorenon als antiandrogen
WO1995016698A1 (en) * 1993-12-17 1995-06-22 The Upjohn Company Conversion of bisnoralcohol to bisnoraldehyde
DE19633685C1 (de) * 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
WO2004016640A2 (en) * 2002-08-16 2004-02-26 Pharmacia & Upjohn Company Llc 5 ANDROSTEN-3β-OL STEROID INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION
RU2304144C2 (ru) * 2002-11-06 2007-08-10 Фармация Энд Апджон Компани Ллс 7-карбоксизамещенные стероиды, способ их получения, способы получения эплеренона
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
US7319154B2 (en) * 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes

Also Published As

Publication number Publication date
CY1111209T1 (el) 2015-06-11
CA2589928C (en) 2013-07-02
ES2355982T3 (es) 2011-04-01
EP2108652A3 (en) 2011-06-22
CN101065396B (zh) 2012-05-23
MX2007006701A (es) 2007-11-09
EP2108652A2 (en) 2009-10-14
JP5626616B2 (ja) 2014-11-19
EP1828222B1 (en) 2010-12-15
BRPI0517752B8 (pt) 2019-02-19
ITMI20042338A1 (it) 2005-03-06
US20120264723A1 (en) 2012-10-18
EP2108652B1 (en) 2016-08-17
DK1828222T3 (da) 2011-02-21
ES2602823T3 (es) 2017-02-22
JP2008522962A (ja) 2008-07-03
ZA200705492B (en) 2008-08-27
PT1828222E (pt) 2011-01-31
BRPI0517752A (pt) 2008-10-21
IL183645A (en) 2012-02-29
CN101065396A (zh) 2007-10-31
CA2589928A1 (en) 2006-06-15
ATE491716T1 (de) 2011-01-15
WO2006061309A1 (en) 2006-06-15
IL183645A0 (en) 2007-09-20
PL1828222T3 (pl) 2011-04-29
SI1828222T1 (sl) 2011-03-31
US20100331291A1 (en) 2010-12-30
EP1828222A1 (en) 2007-09-05
BRPI0517752B1 (pt) 2018-12-26
US8227596B2 (en) 2012-07-24
EP1828222B9 (en) 2011-08-31
CL2007001581A1 (es) 2008-01-04
DE602005025396D1 (de) 2011-01-27
US20080207575A1 (en) 2008-08-28

Similar Documents

Publication Publication Date Title
BRPI0517752C1 (pt) processo para a preparação de drospirenona
EP1571153A3 (en) A process for the preparation of drospirenone
TR200002774T2 (tr) Alzheimer hastalığının tedavisi için steroit sapogenler ve bunların türevleri
EP1632237A3 (en) Compositions comprising drospirenone and a complex between ethinyl-estradiol and a cyclodextrin
HUP0104718A3 (en) Micronized eplerenone compositions, process for their preparation and use thereof for the preparation of pharmaceutical compositions
BRPI0512993A (pt) uso de um antagonista de pr, kit farmaceuticamente últil, e, método de contracepção em uma fêmea em idade de parto
ME00298B (me) Farmaceutski preparat
HUP0202500A3 (en) Use of a pharmaceutical combination of ethinylestradiol and drospirenone for producing pharmaceutical compositions having contraceptive activity
BR0308660A (pt) C-17 espirolactonização e 6,7 oxidação de esteróides
DK1652526T3 (da) Anvendelse af (11beta, 17beta)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-on i behandling af svær depressionslidelse
BR9814136A (pt) Conjunto contraceptivo, processos de fabricação do mesmo e de tratamento de sangramento, usos de anti-progestogênio, de progestogênio e de anti-progestogênio, e, de um composto.
BR9908605A (pt) Kit anticoncepcional, uso de um composto esteróide, e, processo de contracepção
PE20020709A1 (es) Composiciones de complejos de estrogeno-ciclodextrina
HUP0301190A3 (en) 16,17-carbocyclic condensed steroid compounds having selective estrogenic activity, pharmaceutical compositions containing them and their use
PL1910398T3 (pl) 17-alfa-podstawione pochodne estradiolu wykazujące działanie gojenia ran
BR0113357A (pt) Composição oral
RU2002130065A (ru) Состав, обладающий контрацептивной активностью
MX356791B (es) Procedimiento para la preparacion de drospirenona.
DE29720263U1 (de) Beintrainer, insbesondere für die Benutzung durch ältere und behinderte Personen
ECSP993196A (es) Composiciones de isotretinoina y proceso para su produccion
PE20020520A1 (es) Uso de antiprogestinas para la profilaxis y el tratamiento de enfermedades dependientes de hormonas
DOP2010000130A (es) Combinacion de un gestageno y un estrogeno y uno o varios excipientes/portadores farmaceuticamente aceptables para ser aplicada como anticonceptivo para la anticoncepcion oral sin lactosa
TH17593B (th) องค์ประกอบสำหรับการทำเฝือกปูนพลาสเตอร์ชนิดม้วนและเฝือกปูนพลาสเตอร์ชนิดม้วนที่ได้จากองค์ประกอบนี้

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2018, OBSERVADAS AS CONDICOES LEGAIS. (CO) REFERENTE A RPI 2503 DE 26/12/2018, QUANTO A MONTAGEM DO CONJUNTO.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/11/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF